Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations

doi:10.4291/wjgp.v16.i3.107954

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Sep 22, 2025 (publication date) through Oct 8, 2025

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World Journal of Gastrointestinal Pathophysiology

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World J Gastrointest Pathophysiol. Sep 22, 2025; 16(3): 107954
Published online Sep 22, 2025. doi: 10.4291/wjgp.v16.i3.107954

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Figure 1 Association of specific kirsten rat sarcoma viral oncogene homolog, neuroblastoma RAS viral oncogene homolog, and v-raf murine sarcoma viral oncogene homolog B1 hot-spot mutations with tumor’s pathological stage. A statistically significant at P < 0.05. Regression models were adjusted for age at diagnosis, sex, race/ethnicity, primary tumor site, DNA mismatch repair status, familial cancer risk, number of comorbidities, and tobacco use. BRAF: V-raf murine sarcoma viral oncogene homolog B1; KRAS: Kirsten rat sarcoma viral oncogene homolog; NC: Not calculated; NRAS: Neuroblastoma RAS viral oncogene homolog; CI: Confidence interval; OR: Odds ratio; pT: Pathological stage.

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Figure 2 Association of specific kirsten rat sarcoma viral oncogene homolog, neuroblastoma RAS viral oncogene homolog, and v-raf murine sarcoma viral oncogene homolog B1 hot-spot mutations with regional lymph node and distant metastasis. A statistically significant at P < 0.05. Regression models were adjusted for age at diagnosis, sex, race/ethnicity, primary tumor site, DNA mismatch repair status, familial cancer risk, number of comorbidities, and tobacco use. BRAF: V-raf murine sarcoma viral oncogene homolog B1; KRAS: Kirsten rat sarcoma viral oncogene homolog; NC: Not calculated; NRAS: Neuroblastoma RAS viral oncogene homolog; CI: Confidence interval; OR: Odds ratio.

Citation: Abdelgadir O, Kuo YF, Khan MF, Okorodudu AO, Cheng YWO, Dong J. Colorectal cancer tumor phenotypes associated with KRAS, NRAS, and BRAF hot-spot mutations. World J Gastrointest Pathophysiol 2025; 16(3): 107954
URL: https://www.wjgnet.com/2150-5330/full/v16/i3/107954.htm
DOI: https://dx.doi.org/10.4291/wjgp.v16.i3.107954