Comparisons between glucose analogue 2-deoxy-2-(18F)fluoro-D-glucose and 18F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions

Table 1 Patient characteristics (n = 45)

Demography
Age (yr)	61 ± 10
Stage at diagnosis
I	5
II	21
III	14
IV	5
Histology
Ductal	35
Lobular	8
Other	2
Tumor receptor (+/-/unknown)
Estrogen receptor	39/2/4
PgR	29/11/5
c-erb B2	14/24/7
Site of metastatic disease other than bone
Lung	27%
Liver	20%
Lymph nodes	30%
Systemic therapy
First-line	81%
Second-line	62%
Third-line	36%
Bisphosphonates	22%
Follow-up (mean 28 mo range 22-39)
Patients with disease progression	58%
Patients dead from disease	30%

Table 2 Patient-based analysis: Performance comparisons between 2-deoxy-2-(¹⁸F)fluoro-D-glucose and ¹⁸F-sodium positron emission tomography/computed tomography

	18F-FDG	18F-NaF
Sensitivity (%)	75.00 (55.10-88.00)	91.67 (74.15-97.68)
Specificity (%)	99.00 (84.54-100)	76.19 (54.91-89.37)
Positive predictive value (%)	99.00 (82.41-100)	81.48 (63.3 91.82)
Negative predictive value (%)	77.78 (59.24-89.39)	88.89 (67.2-96.90)
Error rate (%)	13.33 (6.26-26.18)	15.56 (7.75-28.78)
Accuracy (%)	86.67 (73.82-93.74)	84.44 (71.22-92.25)
Youden's index	0.75 (0.75-0.74)	0.6786 (0.68-0.6718)

Estimated parameters corresponding to each technique are presented with 95%CI between square brackets. ¹⁸F-FDG: 2-deoxy-2-(¹⁸F)fluoro-D-glucose; ¹⁸F-NaF: ¹⁸F-sodium.

Table 3 Sites and density characteristics showing different performance between 2-deoxy-2-(¹⁸F)fluoro-D-glucose and ¹⁸F-sodium positron emission tomography/computed tomography

	n	18F-FDG	18F-NaF	P
Density
Osteosclerotic	89			0.005
Sensitivity (%):		42.86 (15.82-74.95)	99.00 (64.57-99.00)
Specificity (%):		97.00 (60.97-97.00)	48.15 (35.39-61.15)
No lesion/bone marrow	29			0.002
Sensitivity(%):		100.00 (60.97-100.00)	48.15 (30.74-66.01)
Specificity(%):		100.00 (34.24-100.00)	100.00 (34.24-100.00)
Site
Spine	81			0.002
Sensitivity (%):		65.38 (51.80-76.85)	100.00 (93.12-100.00)
Specificity (%):		98.00 (88.30-98.00)	13.45 (0.61-27.18)
Ribs	118			0.04
Sensitivity (%):		83.96 (75.81-89.74)	96.23 (90.70-98.52)
Specificity (%):		78.37 (52.33-92.50)	78.57 (52.41-92.43)

¹⁸F-FDG: 2-deoxy-2-(¹⁸F)fluoro-D-glucose; ¹⁸F-NaF: ¹⁸F-sodium.