Radiofrequency ablation of hepatocellular carcinoma: Current status

Table 1 Studies comparing radiofrequency ablation vs hepatic resection for hepatocellular carcinoma

Author, yr	Study type	RFA/resection	RFA/resection (mean tumor size, cm)	RFA vs resection (%) (overall survival)	P
Chen, 2006	RCT	90/90	-/-	65.9 vs 64.0 (4-yr)	NS
Takayama, 2009	Retrospective	1315/1235	1.6/1.8	95 vs 94 (2-yr)	0.28
Ueno, 2009	Retrospective	123/110	2.0/2.7	63 vs 80 (5-yr)	0.06
Hiraoka, 2008	Retrospective	105/59	-/-	59.3 vs 59.4 (5-yr)	NS
Abu-Hilal, 2008	Retrospective	34/34	3.0/3.8	57 vs 56 (5-yr)	0.3
Gnglielmi, 2008	Retrospective	23/33	-/-	45 vs 55 (5-yr)	0.7
Wakai, 2006	Retrospective	64/85	-/-	30 vs 53 (10-yr)	0.012
Ogihara, 2005	Retrospective	40/47	4.6/7.4	39 vs 31 (5-yr)	0.79
Montorsi, 2005	Prospective	58/40	-/-	30 vs 53 (4-yr)	0.018
Vivarelli, 2004	Retrospective	79/79	-/-	33 vs 65 (3-yr)	0.002

RFA: Radiofrequency ablation; RCT: Randomized control trial; NS: Not significant.

Table 2 Studies comparing local tumor progression rates of radiofrequency ablation for hepatocellular carcinoma

Author	Yr	n	Tumor size (mean, cm)	Follow-up period (mean, mo)	Local tumor progression rate (%)
Rossi et al[63]	1996	41	2.3	22.6	5.0
Buscarini et al[64]	2001	60	-	26.8	14
Choi et al[65]	2004	53	2.1	23	21
Lu et al[66]	2005	87	2.5	12.7	5.8
Shiina et al[67]	2005	118	-	34.8	1.7
Solmi et al[68]	2006	63	2.8	32.3	41
Hänsler et al[69]	2007	21	4.2	-	21
Waki et al[70]	2010	88	-	36	4.8