Comparison of point and two-dimensional shear wave elastography of the spleen in healthy subjects

Table 1 Characteristics of subjects included in study arms A and B and their overlap, n (%)

	Study arm A (n = 200)		Study arm B (n = 113)		Overlap C (n = 44)
	Frequency	mean ± SD	Frequency	mean ± SD	Frequency	mean ± SD
Gender
Male	78 (39.00)		38 (30.6)		10 (22.73)
Female	122 (61.00)		75 (66.4)		34 (77.27)
Age		27.93 ± 8.13		25.95 ± 6.26		27.11 ± 5.64
< 30 yr	154 (77.00)		98 (86.7)		34 (77.27)
≥ 30 yr	46 (23.00)		15 (13.3)		10 (22.73)
BMI		22.56 ± 2.57		21.64 ± 2.24		21.60 ± 2.67
BMI < 25	166 (83.0)		103 (91.2)		38 (86.36)
BMI ≥25	34 (17.00)		10 (8.9)		6 (13.64)
Alcohol consumption		8.17 ± 9.70		6.73 ± 8.35		6.22 ± 7.95
None	18 (9.00)		9 (8.0)		9 (20.45)
Less 1/mo	28 (14.00)		17 (15.0)		3 (6.82)
Several times per month	106 (53.00)		71 (62.8)		28 (63.64)
Several times per week	48 (24.00)		16 (14.2)		4 (9.09)
Fasting time		3.74 ± 1.84		4.47 ± 2.80		4.11 ± 1.65
Spleen length (mm)		105.44 ± 14.80		105.53 ± 14.16		101.66 ± 13.78
Median (min-max)		105.50 (61-144)		106.00 (65-144)		100.50 (75-137)
Spleen depth (mm)		35.38 ± 6.19		35.28 ± 6.38		34.25 ± 5.59
Median (min-max)		35.50 (21-56)		35.00 (21-56)		34.00 (24-48)

BMI: Body mass index.

Table 2 Location and dispersion measures of shear wave velocity at the spleen measured with the Toshiba Aplio 500 version 5.0 and version 6.0, Siemens S3000, GE Logiq E9, and Philips Epiq 7 devices, n (%)

	Study arm A (n = 200)			Study arm B (n = 131)
	Upper pole	Middle pole	Lower pole	Upper pole	Middle pole	Lower pole
Toshiba Aplio 500, mean ± SD	3.35 ± 0.92	2.90 ± 0.45	3.38 ± 0.65	2.34 ± 0.29	2.48 ± 0.26	2.48 ± 0.28
Median (Min-Max)	3.12 (2.20-6.94)	2.84 (1.94-4.86)	3.36 (1.50-5.92)	2.36 (1.42-3.36)	2.48 (1.82-3.02)	2.45 (1.84-3.25)
Siemens S3000, mean ± SD	2.05 ± 0.54	2.53 ± 0.44	2.53 ± 0.58	2.39 ± 0.33	2.63 ± 0.28	2.49 ± 0.34
Median (Min-Max)	2.04 (0.73-3.77)	2.49 (1.27-3.73)	2.47 (1.39-4.59)	2.39 (1.52-3.86)	2.62 (1.97-3.36)	2.50 (1.53-3.58)
GE Logiq E9, mean ± SD	2.20 ± 0.51	1.86 ± 0.44	1.53 ± 0.44	-	-	-
Median (Min-Max)	2.23 (1.10-6.26)	1.88 (0.71-3.02)	1.48 (0.77-2.84)
Philips Epiq 7, mean ± SD	1.88 ± 0.40	1.89 ± 0.38	2.30 ± 0.87	-	-	-
Median (Min-Max)	1.90 (0.88-3.10)	1.91 (0.93-3.12)	2.17 (0.99-10.62)

Table 3 Position and stress measurements of shear wave velocities measured with the Toshiba Aplio 500 version 5.0 and version 6.0

Overlap C (n = 44)	Upper pole	Middle pole	Lower pole
Toshiba Aplio 500 V.5.0, mean ± SD	3.46 ± 0.52	2.94 ± 0.52	3.38 ± 1.02
Median (Min-Max)	3.45 (2.54-5.13)	2.80 (2.27-4.86)	3.14 (2.25-6.53)
Toshiba Aplio 500 V.6.0, mean ± SD	2.32 ± 0.34	2.53 ± 0.25	2.52 ± 0.29
Median (Min-Max)	2.36 (1.42-3.36)	2.56 (1.85-2.94)	2.46 (1.93-3.25)

Table 4 Correlation of the heavy wave velocities of the Toshiba Aplio 500 version 5.0 and version 6.0, GE Logiq E9, and Philips Epiq 7 devices with the Siemens S3000

		Siemens S3000
		Study arm A (n = 200)		Study arm B (n = 131)
Device	Pole	R value	P value	R value	P value
Toshiba Aplio 500	Lower pole	-0.08792	0.2193	0.19863	0.0375
	Middle pole	0.13632	0.0561	0.13438	0.1616
	Upper pole	0.03951	0.5815	0.24951	0.0086
GE Logiq E9	Lower pole	-0.03307	0.6446	-	-
	Middle pole	-0.04941	0.4905	-	-
	Upper pole	0.04744	0.5079	-	-
Philips Epiq 7	Lower pole	0.04894	0.4947	-	-
	Middle pole	0.12321	0.0845	-	-
	Upper pole	0.33088	< 0.0001	-	-