Chrysavgis L, Giannakodimos I, Diamantopoulou P, Cholongitas E. Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link. World J Gastroenterol 2022; 28(3): 310-331 [PMID: 35110952 DOI: 10.3748/wjg.v28.i3.310]
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05424290
Submitted on:
January 26, 2022, 13:11
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Reader Comments:
The authors have extensively reviewed the literature in NASH related HCC; its risk stratification, screening and surveillance strategies.
NASH is liver manifestation of metabolic derangements affecting multiple organs including heart, lungs, kidneys etc. It is time to recognise the need for multidisciplinary approach towards a patient with diabetes, obesity and metabolic syndrome to address all issues related to liver, heart etc. Genetic and molecular signatures though very accurate are not cost effective and practical in large population. Large prospective, multicentric studies including diverse geographical regions and dietary habits are needed to evaluate for risk stratification in these patients regarding need for HCC surveillance. The impact of environmental pollutants and toxins as a causative factor in NASH especially lean patient population should also be considered.
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