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Pal A, Ali A, Young TR, Oostenbrink J, Prabhakar A, Prabhakar A, Deacon N, Arnold A, Eltayeb A, Yap C, Young DM, Tang A, Lakshmanan S, Lim YY, Pokarowski M, Kakodkar P. Comprehensive literature review on the radiographic findings, imaging modalities, and the role of radiology in the COVID-19 pandemic. World J Radiol 2021; 13:258-282. [PMID: 34630913 PMCID: PMC8473437 DOI: 10.4329/wjr.v13.i9.258] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/06/2021] [Revised: 03/28/2021] [Accepted: 08/04/2021] [Indexed: 02/06/2023] Open
Abstract
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, over 103214008 cases have been reported, with more than 2231158 deaths as of January 31, 2021. Although the gold standard for diagnosis of this disease remains the reverse-transcription polymerase chain reaction of nasopharyngeal and oropharyngeal swabs, its false-negative rates have ignited the use of medical imaging as an important adjunct or alternative. Medical imaging assists in identifying the pathogenesis, the degree of pulmonary damage, and the characteristic features in each imaging modality. This literature review collates the characteristic radiographic findings of COVID-19 in various imaging modalities while keeping the preliminary focus on chest radiography, computed tomography (CT), and ultrasound scans. Given the higher sensitivity and greater proficiency in detecting characteristic findings during the early stages, CT scans are more reliable in diagnosis and serve as a practical method in following up the disease time course. As research rapidly expands, we have emphasized the CO-RADS classification system as a tool to aid in communicating the likelihood of COVID-19 suspicion among healthcare workers. Additionally, the utilization of other scoring systems such as MuLBSTA, Radiological Assessment of Lung Edema, and Brixia in this pandemic are reviewed as they integrate the radiographic findings into an objective scoring system to risk stratify the patients and predict the severity of disease. Furthermore, current progress in the utilization of artificial intelligence via radiomics is evaluated. Lastly, the lesson from the first wave and preparation for the second wave from the point of view of radiology are summarized.
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Affiliation(s)
- Aman Pal
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Abulhassan Ali
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Timothy R Young
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Juan Oostenbrink
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Akul Prabhakar
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Amogh Prabhakar
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Nina Deacon
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Amar Arnold
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Ahmed Eltayeb
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Charles Yap
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - David M Young
- Department of Computer Science, Yale University, New Haven, CO 06520, United States
| | - Alan Tang
- Department of Health Science, Duke University, Durham, NC 27708, United States
| | - Subramanian Lakshmanan
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Ying Yi Lim
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
| | - Martha Pokarowski
- The Hospital for Sick Kids, University of Toronto, Toronto M5S, Ontario, Canada
| | - Pramath Kakodkar
- School of Medicine, National University of Ireland Galway, Galway H91 TK33, Galway, Ireland
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Cabrera Gaytán DA, Pérez Andrade Y, Espíritu Valenzo Y. Pneumothorax due to COVID-19: Analysis of case reports. Respir Med Case Rep 2021; 34:101490. [PMID: 34336592 PMCID: PMC8312092 DOI: 10.1016/j.rmcr.2021.101490] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/10/2021] [Revised: 07/14/2021] [Accepted: 07/23/2021] [Indexed: 02/07/2023] Open
Abstract
Cases of pneumothorax/pneumomediastinum have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the time to onset and hospital stay have rarely been studied. Coronavirus disease 2019 (COVID-19) patients with these complications are described to determine the time to onset, associated comorbidities, and location and duration of pneumothorax. A search in PubMed yielded simple frequencies and a bivariate analysis of deaths. There were 113 confirmed cases in 67 articles. The median time from the date of hospital admission to the presence of pneumothorax was 8 days. Right hemithorax was the most frequent form of pneumothorax. Almost half of the patients required intubation for invasive mechanical ventilation. Although the frequency of this phenomenon was not high among hospitalized patients with confirmed SARS-CoV-2, it was high among those who developed acute respiratory distress syndrome (ARDS). This study contributes to the literature because it presents a large number of patients who developed pneumothorax after admission, which was characterized by clinical deterioration (dyspnea, tachypnea, pleuritic chest pain, and subcutaneous emphysema) and low oxygen saturation levels. Pneumothorax/pneumomediastinum is recommended as a differential diagnosis, even without considering the presence of chronic pulmonary comorbidities or invasive mechanical ventilation.
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Affiliation(s)
- David Alejandro Cabrera Gaytán
- Coordinación de Investigación en Salud, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc # 330 Block “B” 4° Floor, Annex to the Unidad de Congresos del Centro Médico Nacional Siglo XXI, Neighborhood Doctores, Alcaldía Cuauhtmoc, CP. 06720, Mexico City, Mexico
| | - Yadira Pérez Andrade
- Coordinación de Vigilancia Epidemiológica, Instituto Mexicano del Seguro Social, Mier y Pesado No. 120, Neighborhood Del Valle Benito Juárez, CP. 03100, Mexico City, Mexico
| | - Yuridia Espíritu Valenzo
- Hospital General Regional No. 72, Instituto Mexicano del Seguro Social, Av. Gustavo Baz Prada S/N, Neighborhood Centro Industrial Tlalnepantla, CP 54000, Tlalnepantla de Baz, Estado de México, Mexico
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