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Narasimhamurthy R, Venkidesh BS, Vasishta S, Joshi MB, Rao BS, Sharan K, Dattaram Mumbrekar K. Low-Dose Radiation Induces Alterations in Fatty Acid and Tyrosine Metabolism in the Mouse Hippocampus: Insights from Integrated Multiomics. ACS Chem Neurosci 2024; 15:3311-3320. [PMID: 39185768 PMCID: PMC11413841 DOI: 10.1021/acschemneuro.4c00231] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/16/2024] [Revised: 08/16/2024] [Accepted: 08/16/2024] [Indexed: 08/27/2024] Open
Abstract
In recent years, there has been a drastic surge in neurological disorders with sporadic cases contributing more than ever to their cause. Radiation exposure through diagnostic or therapeutic routes often results in neurological injuries that may lead to neurodegenerative pathogenesis. However, the underlying mechanisms regulating the neurological impact of exposure to near-low doses of ionizing radiation are not known. In particular, the neurological changes caused by metabolomic reprogramming have not yet been elucidated. Hence, in the present study, C57BL/6 mice were exposed to a single whole-body X-ray dose of 0.5 Gy, and 14 days post-treatment, the hippocampus was subjected to metabolomic analysis. The hippocampus of the irradiated animals showed significant alterations in 15 metabolites, which aligned with altered tyrosine, phenylalanine, and alpha-linolenic acid metabolism and the biosynthesis of unsaturated fatty acids. Furthermore, a multiomics interaction network comprising metabolomics and RNA sequencing data analysis provided insights into gene-metabolite interactions. Tyrosine metabolism was revealed to be the most altered, which was demonstrated by the interaction of several crucial genes and metabolites. The present study revealed the regulation of low-dose radiation-induced neurotoxicity at the metabolomic level and its implications for the pathogenesis of neurological disorders. The present study also provides novel insights into metabolomic pathways altered following near-low-dose IR exposure and its link with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
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Affiliation(s)
- Rekha
Koravadi Narasimhamurthy
- Department
of Radiation Biology & Toxicology, Manipal
School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
| | - Babu Santhi Venkidesh
- Department
of Radiation Biology & Toxicology, Manipal
School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
| | - Sampara Vasishta
- Department
of Ageing Research, Manipal School of Life
Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
| | - Manjunath B. Joshi
- Department
of Ageing Research, Manipal School of Life
Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
| | - Bola Sadashiva
Satish Rao
- Department
of Radiation Biology & Toxicology, Manipal
School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
- Directorate
of Research, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
| | - Krishna Sharan
- Department
of Radiation Therapy and Oncology, K S Hegde
Medical Academy (KSHEMA), Nitte (Deemed to be University), Mangalore, Karnataka 575018, India
| | - Kamalesh Dattaram Mumbrekar
- Department
of Radiation Biology & Toxicology, Manipal
School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India
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Slave O, Mahomed N. An audit of patient radiation doses in interventional radiology at a South African hospital. SA J Radiol 2023; 27:2559. [PMID: 36756356 PMCID: PMC9900283 DOI: 10.4102/sajr.v27i1.2559] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2022] [Accepted: 11/11/2022] [Indexed: 02/04/2023] Open
Abstract
Background Interventional radiology (IR) is becoming more relevant in patient care and is associated with increased patient radiation exposure and radiation-induced adverse effects. Diagnostic reference levels (DRLs) are crucial for radiation control. There is a paucity of published DRLs for IR in South Africa and sub-Saharan Africa. Objectives This study aimed to determine local DRLs for fluoroscopically-guided IR procedures and compare the achieved DRLs with published local and international DRLs. Method Retrospective, descriptive, single-centre study. Kerma air product (KAP), reference point air kerma (Ka,r) and fluoroscopy time (FT) were collected for patients (12 years and older) who underwent IR procedures at a university hospital from 01 January 2019 to 31 December 2019. The 75th percentile of the distribution of each dose parameter (KAP, Ka,r and FT) per procedure was calculated and taken as the local diagnostic reference levels (LDRL). The established LDRLs were compared to published DRLs. Results A total of 564 cases were evaluated. The 13 most frequent procedures (with 15 or more cases) represented 86.1% (487/564). Percutaneous transhepatic biliary drainage was the most common procedure (n = 146, 25.9%). Diagnostic cerebral angiogram DRLs exceeded the published DRL data ranges for all parameters (DRL 209.3), and interventional cerebral angiogram exceeded published ranges (DRL 275). Uterine artery embolisation (UAE) exceeded these ranges for KAP and Ka,r. (KAP-954.9 Gy/cm2, Ka,r-2640.8 mGy). Conclusion The LDRLs for diagnostic cerebral angiogram, interventional cerebral angiogram and UAE exceeded published international DRL ranges. These procedures require radiation optimisation as recommended by the International Commission on Radiological Protection (ICRP). Contribution In addition to informing radiation protection practices at the level of the institution, the established LDRLs contribute towards Regional and National DRLs.
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Affiliation(s)
- Oneile Slave
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
| | - Nasreen Mahomed
- Department of Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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Narasimhamurthy RK, Mumbrekar KD, Satish Rao BS. Effects of low dose ionizing radiation on the brain- a functional, cellular, and molecular perspective. Toxicology 2021; 465:153030. [PMID: 34774978 DOI: 10.1016/j.tox.2021.153030] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/31/2021] [Revised: 10/16/2021] [Accepted: 11/08/2021] [Indexed: 02/08/2023]
Abstract
Over the years, the advancement of radio diagnostic imaging tools and techniques has radically improved the diagnosis of different pathophysiological conditions, accompanied by increased exposure to low-dose ionizing radiation. Though the consequences of high dose radiation exposure on humans are very well comprehended, the more publicly relevant effects of low dose radiation (LDR) (≤100 mGy) exposure on the biological system remain ambiguous. The central nervous system, predominantly the developing brain with more neuronal precursor cells, is exceptionally radiosensitive and thus more liable to neurological insult even at low doses, as shown through several rodent studies. Further molecular studies have unraveled the various inflammatory and signaling mechanisms involved in cellular damage and repair that drive these physiological alterations that lead to functional alterations. Interestingly, few studies also claim that LDR exerts therapeutic effects on the brain by initiating an adaptive response. The present review summarizes the current understanding of the effects of low dose radiation at functional, cellular, and molecular levels and the various risks and benefits associated with it based on the evidence available from in vitro, in vivo, and clinical studies. Although the consensus indicates minimum consequences, the overall evidence suggests that LDR can bring about considerable neurological effects in the exposed individual, and hence a re-evaluation of the LDR usage levels and frequency of exposure is required.
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Affiliation(s)
- Rekha K Narasimhamurthy
- Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
| | - Kamalesh D Mumbrekar
- Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
| | - B S Satish Rao
- Research Directorate Office, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
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Sommer F, Goldberg JL, McGrath L, Kirnaz S, Medary B, Härtl R. Image Guidance in Spinal Surgery: A Critical Appraisal and Future Directions. Int J Spine Surg 2021; 15:S74-S86. [PMID: 34675032 DOI: 10.14444/8142] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/12/2022] Open
Abstract
BACKGROUND Image-guided spinal surgery (IGSS) underwent rapid development over the past decades. The goal of IGSS is to increase patient safety and improve workflow. We present an overview of the history of IGSS, illustrate its current state, and highlight future developments. Currently, IGSS requires an image set, a tracking system, and a calibration method. IMAGING Two-dimensional images have many disadvantages as a source for navigation. Currently, the most common navigation technique is three-dimensional (3D) navigation based on cross-sectional imaging techniques such as cone-beam computed tomography (CT) or fan-beam CT. TRACKING Electromagnetic tracking uses an electromagnetic field to localize instruments. Optical tracking using infrared cameras has currently become one of the most common tracking methods in IGSS. CALIBRATION The three most common techniques currently used are the point-matching registration technique, the surface-matching registration technique, and the automated registration technique. FUTURE Augmented reality (AR) describes a computer-generated image that can be superimposed onto the real-world environment. Marking pathologies and anatomical landmarks are a few examples of many possible future applications. Additionally, AR offers a wide range of possibilities in surgical training. The latest development in IGSS is robotic-assisted surgery (RAS). The presently available data on RAS are very encouraging, but further improvements of these procedures is expected. CONCLUSION IGSS significantly evolved since its inception and is becoming a routinely used technology. In the future, IGSS will combine the advantages of "active/freehand 3D navigation" with AR and RAS and will one day find its way into all aspects of spinal surgery, not only in instrumented procedures.
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Affiliation(s)
- Fabian Sommer
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
| | - Jacob L Goldberg
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
| | - Lynn McGrath
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
| | - Sertac Kirnaz
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
| | - Branden Medary
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
| | - Roger Härtl
- Department of Neurological Surgery, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York
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Estimating Specific Patient Organ Dose for Chest CT Examinations with Monte Carlo Method. APPLIED SCIENCES-BASEL 2021. [DOI: 10.3390/app11198961] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
Abstract
Purpose: The purpose of this study was to preliminarily estimate patient-specific organ doses in chest CT examinations for Chinese adults, and to investigate the effect of patient size on organ doses. Methods: By considering the body-size and body-build effects on the organ doses and taking the mid-chest water equivalent diameter (WED) as a body-size indicator, the chest scan images of 18 Chinese adults were acquired on a multi-detector CT to generate the regional voxel models. For each patient, the lungs, heart, and breasts (glandular breast tissues for both breasts) were segmented, and other organs were semi-automated segmented based on their HU values. The CT scanner and patient models simulated by MCNPX 2.4.0 software (Los Alamos National LaboratoryLos Alamos, USA) were used to calculate lung, breast, and heart doses. CTDIvol values were used to normalize simulated organ doses, and the exponential estimation model between the normalized organ dose and WED was investigated. Results: Among the 18 patients in this study, the simulated doses of lung, heart, and breast were 18.15 ± 2.69 mGy, 18.68 ± 2.87 mGy, and 16.11 ± 3.08 mGy, respectively. Larger patients received higher organ doses than smaller ones due to the higher tube current used. The ratios of lung, heart, and breast doses to the CTDIvol were 1.48 ± 0.22, 1.54 ± 0.20, and 1.41 ± 0.13, respectively. The normalized organ doses of all the three organs decreased with the increase in WED, and the normalized doses decreased more obviously in the lung and the heart than that in the breasts. Conclusions: The output of CT scanner under ATCM is positively related to the attenuation of patients, larger-size patients receive higher organ doses. The organ dose normalized by CTDIvol was negatively correlated with patient size. The organ doses could be estimated by using the indicated CTDIvol combined with the estimated WED.
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Bogdanova NV, Jguburia N, Ramachandran D, Nischik N, Stemwedel K, Stamm G, Werncke T, Wacker F, Dörk T, Christiansen H. Persistent DNA Double-Strand Breaks After Repeated Diagnostic CT Scans in Breast Epithelial Cells and Lymphocytes. Front Oncol 2021; 11:634389. [PMID: 33968734 PMCID: PMC8103218 DOI: 10.3389/fonc.2021.634389] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/27/2020] [Accepted: 03/22/2021] [Indexed: 12/14/2022] Open
Abstract
DNA double-strand break (DSB) induction and repair have been widely studied in radiation therapy (RT); however little is known about the impact of very low exposures from repeated computed tomography (CT) scans for the efficiency of repair. In our current study, DSB repair and kinetics were investigated in side-by-side comparison of RT treatment (2 Gy) with repeated diagnostic CT scans (≤20 mGy) in human breast epithelial cell lines and lymphoblastoid cells harboring different mutations in known DNA damage repair proteins. Immunocytochemical analysis of well known DSB markers γH2AX and 53BP1, within 48 h after each treatment, revealed highly correlated numbers of foci and similar appearance/disappearance profiles. The levels of γH2AX and 53BP1 foci after CT scans were up to 30% of those occurring 0.5 h after 2 Gy irradiation. The DNA damage repair after diagnostic CT scans was monitored and quantitatively assessed by both γH2AX and 53BP1 foci in different cell types. Subsequent diagnostic CT scans in 6 and/or 12 weeks intervals resulted in elevated background levels of repair foci, more pronounced in cells that were prone to genomic instability due to mutations in known regulators of DNA damage response (DDR). The levels of persistent foci remained enhanced for up to 6 months. This “memory effect” may reflect a radiation-induced long-term response of cells after low-dose x-ray exposure.
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Affiliation(s)
- Natalia V Bogdanova
- Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
| | - Nina Jguburia
- Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
| | | | - Nora Nischik
- Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.,Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
| | - Katharina Stemwedel
- Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
| | - Georg Stamm
- Department of Radiology, Hannover Medical School, Hannover, Germany.,Department of Diagnostic and Interventional Radiology, University Medical Center, Göttingen, Germany
| | - Thomas Werncke
- Department of Radiology, Hannover Medical School, Hannover, Germany
| | - Frank Wacker
- Department of Radiology, Hannover Medical School, Hannover, Germany
| | - Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School, Hannover, Germany
| | - Hans Christiansen
- Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany
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Armao D, Hartman TS, Katz L, Shea CM, Koschnitzky J, Yang R, Smith JK, Quinsey C. Radiation safety education and diagnostic imaging in pediatric patients with surgically treated hydrocephalus: the patient and family perspective. Childs Nerv Syst 2021; 37:491-497. [PMID: 32710252 DOI: 10.1007/s00381-020-04822-0] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/07/2020] [Accepted: 07/17/2020] [Indexed: 11/30/2022]
Abstract
PURPOSE Surgically treated hydrocephalus patients are frequently imaged with head computed tomography (CT), and risk/benefit communication with families is inconsistent and unknown. We aimed to educate patients and caregivers about radiation safety in CT and explore their communication preferences. METHODS We conducted a pediatric CT radiation safety and diagnostic imaging educational workshop for patients and caregivers at a national conference on hydrocephalus to characterize current practice and desired communication about CT imaging. Our workshop consisted of an interactive educational intervention with pre-/post-session surveys followed by feedback from participants. RESULTS Our session included 34 participants (100% response rate for surveys) with 28 being parents of individuals with hydrocephalus. A total of 76% (n = 26) participants showed an increase in knowledge after the session (p < 0.01). All participants (N = 34) uniformly desired risk/benefit discussions before CT scans. However, 71% stated that they were not informed of risks/benefits of CT scans by a medical professional. Following the session, the number of participants indicating that informed consent should be obtained before CT scans increased from 30 to 33. Respondents also revealed that 14% of children and young adults had received > 100 CT scans for shunt evaluation with the median being 25 scans (IQR 20). CONCLUSIONS Caregivers desire and deserve to be empowered through education and social support, and continuously engaged through sharing decisions and co-designing care plans. The neurosurgical community is in an ideal position to collaborate with radiologists, primary care providers, and parents in the development and testing of credible, high-quality online and social media resources.
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Affiliation(s)
- Diane Armao
- Department of Radiology, University of North Carolina, Campus Box 7510, Chapel Hill, NC, 27599-7510, USA. .,Department of Pathology and Laboratory Medicine, University of North Carolina, Campus Box 7510, Chapel Hill, NC, 27599-7510, USA.
| | - Terry S Hartman
- Department of Radiology, University of North Carolina, Campus Box 7510, Chapel Hill, NC, 27599-7510, USA.,Department of Health Informatics, School of Health Professionals, Rutgers University, Newark, NJ, USA
| | - Laurence Katz
- Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC, USA
| | - Christopher M Shea
- Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
| | | | - Richard Yang
- School of Osteopathic Medicine, Campbell University, Buies Creek, NC, USA
| | - J Keith Smith
- Department of Radiology, University of North Carolina, Campus Box 7510, Chapel Hill, NC, 27599-7510, USA
| | - Carolyn Quinsey
- Department of Neurosurgery, University of North Carolina, Chapel Hill, NC, USA
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8
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Vogel E, Leaver T, Wall F, Johnson B, Uglow M, Aarvold A. Repeated Pelvic Radiographs in Infants, After Harness Treatment for Developmental Dysplasia of the Hip, Carry Very Low Radiation Risk. Indian J Orthop 2020; 55:1543-1548. [PMID: 34987727 PMCID: PMC8688633 DOI: 10.1007/s43465-021-00438-x] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/31/2021] [Accepted: 06/02/2021] [Indexed: 02/04/2023]
Abstract
OBJECTIVE There are no data on the effect of X-Ray irradiation to the vulnerable pelvic organs of babies during DDH follow-up. This study aims to calculate, for the first time, the radiation exposure to infants during follow-up for DDH harness treatment, and thus quantify the lifetime risk of malignancy. METHODS Patients who had completed 5 years' follow-up following successful Pavlik harness treatment were identified from the hospital DDH database. The radiation dose was extracted from the Computerised Radiology Information System database for every radiograph of every patient. The effective dose (ED) was calculated using conversion coefficients for age, sex and body region irradiated. Cumulative ED was compared to Health Protection Agency standards to calculate lifetime risk of malignancy from the radiographs. RESULTS All radiographs of 40 infants, successfully treated in Pavlik harness for DDH, were assessed. The mean number of AP pelvis radiographs was 7.00 (range: 6-9, mode: 7). The mean cumulative ED was 0.25 mSv (Range: 0.11-0.46, SD: 0.07). This is far lower than the annual 'safe' limit for healthcare workers of 20 mSv and is categorised as "Very Low Risk". CONCLUSION Clinicians involved in the treatment DDH can be re-assured that the cumulative radiation exposure from pelvic radiographs following Pavlik harness treatment is "Very Low Risk". Whilst being mindful of any radiation exposure in children, this study provides a scientific answer that help addresses parental concerns.
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Affiliation(s)
- Elizabeth Vogel
- Southampton Medical School, Southampton University, Southampton, UK
| | - Thomas Leaver
- Southampton Medical School, Southampton University, Southampton, UK
| | - Fiona Wall
- Medical Physics Department, University Hospital Southampton, Southampton, UK
| | - Ben Johnson
- Medical Physics Department, University Hospital Southampton, Southampton, UK
| | - Michael Uglow
- Paediatric Orthopaedics, Southampton Children’s Hospital, Southampton, UK
| | - Alexander Aarvold
- Southampton Medical School, Southampton University, Southampton, UK
- Paediatric Orthopaedics, Southampton Children’s Hospital, Southampton, UK
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Thurley P, Bowker R, Bhatti I, Skelly R, Law R, Salaman R, Young B, Fogarty A. Development and evaluation of a brief educational cartoon on trainee clinicians' awareness of risks of ionising-radiation exposure: a feasibility pre-post intervention study of a novel educational tool to promote patient safety. BMJ Open Qual 2020; 9:bmjoq-2019-000900. [PMID: 33246934 PMCID: PMC7703407 DOI: 10.1136/bmjoq-2019-000900] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2019] [Revised: 10/07/2020] [Accepted: 10/18/2020] [Indexed: 11/23/2022] Open
Abstract
Background Over recent decades, CT scans have become routinely available and are used in both acute medical and outpatient environments. However, there is a small increase in the risk of adverse consequences, including an increase in the risk of both malignancy and cataracts. Clinicians are often unaware of these facts, and this represents a challenge for medical educators in England, where almost 5 million CT scans are done annually. New whiteboard methodologies permit development of innovative educational tools that are efficient and scalable in communicating simple educational messages that promote patient safety. Methods A short educational whiteboard cartoon was developed to explore the prior observation that adolescents under the care of paediatricians had a much lower risk of receiving a CT scan than those under the care of clinicians who care for adults. This explored the risks after receiving a CT scan and strategies that can be used to avoid them. The educational cartoon was piloted on new doctors who were attending induction training at a busy teaching hospital. Results The main output was the educational whiteboard cartoon itself. Before the new medical trainees’ induction, 56% (25/45) had received no formal training in radiation awareness, and this decreased to 26% (6/23) after the exposure to the educational cartoon (p=0.02). At baseline, 60% (27/45) of respondents considered that young females were at highest risk from exposure to ionising radiation, and this increased to 87% (20/23) after exposure to the educational cartoon (p=0.06). Conclusions This proof-of-concept feasibility study demonstrates that whiteboard cartoons provide a novel and feasible approach to efficiently promote patient safety issues, where a short succinct message is often appropriate.
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Affiliation(s)
- Pete Thurley
- Department of Radiology, Royal Derby Hospital, Derby, UK
| | - Richard Bowker
- Department of Peadiatrics, Royal Derby Hospital, Derby, UK
| | - Imran Bhatti
- Department of Surgery, Royal Derby Hospital, Derby, UK
| | - Rob Skelly
- Department of Geriatrics, Royal Derby Hospital, Derby, UK
| | | | | | - Ben Young
- Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
| | - Andrew Fogarty
- Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
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Wang Q, Liu Y, Zhu Z, Hu J, Li L, Wang S. A comparison of the delivery of inhaled drugs by jet nebulizer and vibrating mesh nebulizer using dual-source dual-energy computed tomography in rabbits: a preliminary in vivo study. ANNALS OF TRANSLATIONAL MEDICINE 2020; 8:1072. [PMID: 33145291 PMCID: PMC7575981 DOI: 10.21037/atm-20-1584] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 11/06/2022]
Abstract
Background Radionuclide imaging is the primary method of visually evaluating drug deposition in the lungs. Here, we used a new imaging technique, dual-source dual-energy computed tomography (DSDECT), to compare the ability of two nebulizers commonly used in clinical practice to deposit drugs in the lungs. Methods Male New Zealand White rabbits were randomly divided into a vibrating mesh nebulizer group and a small volume jet nebulizer group. First, two rabbits received methylene blue-iohexol-normal saline by inhalation to confirm that DSDECT was a feasible method of assessing aerosol inhalation. Then, 10 rabbits were subjected to DSDECT scan before and after receiving a iohexol-normal saline mixture by inhalation. All images were transferred and reconstructed on a workstation computer equipped with dedicated software. Results DSDECT revealed the same iodine distribution as tracheobronchial methylene blue staining on dissection. Significant differences between the groups in average CT value and iodine concentration were noted in the right upper lobe (P<0.05), but no other lobes showed statistically significant differences. The regional distribution of drugs in different lobes of the lung varied by nebulizer. Conclusions DSDECT is a useful method of evaluating drug deposition in the lungs, and vibrating mesh nebulizers deposit more drugs than small volume jet nebulizers.
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Affiliation(s)
- Qixing Wang
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
| | - Yuhao Liu
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
| | - Zhengfang Zhu
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
| | - Jian Hu
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
| | - Li Li
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
| | - Sheng Wang
- Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
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Guleng A, Bolstad K, Dalehaug I, Flatabø S, Aadnevik D, Pettersen HES. Spatial Distribution of Noise Reduction in Four Iterative Reconstruction Algorithms in CT—A Technical Evaluation. Diagnostics (Basel) 2020; 10:diagnostics10090647. [PMID: 32872274 PMCID: PMC7555695 DOI: 10.3390/diagnostics10090647] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2020] [Revised: 08/19/2020] [Accepted: 08/25/2020] [Indexed: 11/24/2022] Open
Abstract
Iterative reconstruction (IR) is a computed tomgraphy (CT) reconstruction algorithm aiming at improving image quality by reducing noise in the image. During this process, IR also changes the noise properties in the images. To assess how IR algorithms from four vendors affect the noise properties in CT images, an anthropomorphic phantom was scanned and images reconstructed with filtered back projection (FBP), and a medium and high level of IR. Each image acquisition was performed 30 times at the same slice position, to create noise maps showing the inter-image pixel standard deviation through the 30 images. We observed that IR changed the noise properties in the CT images by reducing noise more in homogeneous areas than at anatomical edges between structures of different densities. This difference increased with increasing IR level, and with increasing difference in density between two adjacent structures. Each vendor’s IR algorithm showed slightly different noise reduction properties in how much noise was reduced at different positions in the phantom. Users need to be aware of these differences when working with optimization of protocols using IR across scanners from different vendors.
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Affiliation(s)
- Anette Guleng
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
- Correspondence:
| | - Kirsten Bolstad
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
| | - Ingvild Dalehaug
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
- Department of Diagnostic Physics, Oslo University Hospital, 0424 Oslo, Norway
| | - Silje Flatabø
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
| | - Daniel Aadnevik
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
| | - Helge E. S. Pettersen
- Department of Oncology and Medical Physics, Haukeland University Hospital, 5021 Bergen, Norway; (K.B.); (I.D.); (S.F.); (D.A.); (H.E.S.P.)
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12
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Gao Y, Mahmood U, Liu T, Quinn B, Gollub MJ, Xu XG, Dauer LT. Patient-Specific Organ and Effective Dose Estimates in Adult Oncologic CT. AJR Am J Roentgenol 2020; 214:738-746. [PMID: 31414882 PMCID: PMC7393764 DOI: 10.2214/ajr.19.21197] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022]
Abstract
OBJECTIVE. Patient-specific organ and effective dose provides essential information for CT protocol optimization. However, such information is not readily available in the scan records. The purpose of this study was to develop a method to obtain accurate examination- and patient-specific organ and effective dose estimates by use of available scan data and patient body size information for a large cohort of patients. MATERIALS AND METHODS. The data were randomly collected for 1200 patients who underwent CT in a 2-year period. Physical characteristics of the patients and CT technique were processed as inputs for the dose estimator. Organ and effective doses were estimated by use of the inputs and computational human phantoms matched to patients on the basis of sex and effective diameter. Size-based ratios were applied to correct for patient-phantom body size differences. RESULTS. Patients received a mean of 59.9 mGy to the lens of the eye per brain scan, 10.1 mGy to the thyroid per chest scan, 17.5 mGy to the liver per abdomen and pelvis scan, and 19.0 mGy to the liver per body scan. A factor of 2 difference in dose estimates was observed between patients of various habitus. CONCLUSION. Examination- and patient-specific organ and effective doses were estimated for 1200 adult oncology patients undergoing CT. The dose conversion factors calculated facilitate rapid organ and effective dose estimation in clinics. Compared with nonspecific dose estimation methods, patient dose estimations with data specific to the patient and examination can differ by a factor of 2.
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Affiliation(s)
- Yiming Gao
- Department of Medical Physics, Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
| | - Usman Mahmood
- Department of Medical Physics, Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
| | - Tianyu Liu
- Department of Mechanical, Aerospace, and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
| | - Brian Quinn
- Department of Medical Physics, Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
| | - Marc J. Gollub
- Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
| | - X. George Xu
- Department of Mechanical, Aerospace, and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
| | - Lawrence T. Dauer
- Department of Medical Physics, Box 84, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
- Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
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13
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Abstract
OBJECTIVES The aim of this study was to examine computed tomography (CT) and ultrasound (US) utilization trends in incident and prevalent pediatric emergency department (ED) urolithiasis patients before and after imaging guideline release. METHODS We reviewed imaging modalities for children with 2 or more ED encounters between January 1, 2006, and September 1, 2013, for urolithiasis using the Pediatric Health Information System database. Z scores compared the proportion of patient encounters receiving CT and US before (January 1, 2006, to December 31, 2010) and after (January 1, 2011, to September 1, 2013) the release of imaging guidelines. McNemar test for paired proportions compared the percentage of US and CT use between initial versus subsequent visits. Piecewise logistic regression was used to determine the probability of US use and CT use over time before and after the implementation of imaging guidance. RESULTS Analysis was completed on 2041 patients with 4930 unique encounters for urolithiasis. During 1758 encounters (35.7%), CT was performed initially. Ultrasound was performed 1585 times (32.2%). Fourteen percent fewer CT procedures were performed during first urolithiasis visits after guideline release (P < 0.01), whereas US use increased by 15% (P < 0.01). Fewer CT procedures were performed at later visits compared with the first (P < 0.05), and US was used more during second or later visits than the first (P < 0.05). CONCLUSIONS Medical providers at large academic pediatric EDs have decreased use of CT and increased use of US over the study time frame to diagnose urolithiasis and are now similar during initial visits (US 36.4% vs CT 36.2%, P = 0.94). Physicians are still more likely to use US as the initial urolithiasis imaging modality during second and later encounters.
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14
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Averbeck D, Candéias S, Chandna S, Foray N, Friedl AA, Haghdoost S, Jeggo PA, Lumniczky K, Paris F, Quintens R, Sabatier L. Establishing mechanisms affecting the individual response to ionizing radiation. Int J Radiat Biol 2020; 96:297-323. [PMID: 31852363 DOI: 10.1080/09553002.2019.1704908] [Citation(s) in RCA: 30] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/17/2022]
Abstract
Purpose: Humans are increasingly exposed to ionizing radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas doses above 100 mGy are needed to promote tissue or cell damage. 10-15% of radiotherapy (RT) patients suffer adverse reactions, described as displaying radiosensitivity (RS). Sensitivity to IR's stochastic effects is termed radiosusceptibility (RSu). To optimize radiation protection we need to understand the range of individual variability and underlying mechanisms. We review the potential mechanisms contributing to RS/RSu focusing on RS following RT, the most tractable RS group.Conclusions: The IR-induced DNA damage response (DDR) has been well characterized. Patients with mutations in the DDR have been identified and display marked RS but they represent only a small percentage of the RT patients with adverse reactions. We review the impacting mechanisms and additional factors influencing RS/RSu. We discuss whether RS/RSu might be genetically determined. As a recommendation, we propose that a prospective study be established to assess RS following RT. The study should detail tumor site and encompass a well-defined grading system. Predictive assays should be independently validated. Detailed analysis of the inflammatory, stress and immune responses, mitochondrial function and life style factors should be included. Existing cohorts should also be optimally exploited.
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Affiliation(s)
| | - Serge Candéias
- CEA, CNRS, LCMB, University of Grenoble Alpes, Grenoble, France
| | - Sudhir Chandna
- Division of Radiation Biosciences, Institute of Nuclear Medicine & Allied Sciences, Delhi, India
| | - Nicolas Foray
- Inserm UA8 Unit Radiations: Defense, Health and Environment, Lyon, France
| | - Anna A Friedl
- Department of Radiation Oncology, University Hospital, LMU, Munich, Germany
| | - Siamak Haghdoost
- Cimap-Laria, Advanced Resource Center for HADrontherapy in Europe (ARCHADE,), University of Caen Normandy, France.,Centre for Radiation Protection Research, Department of Molecular Bioscience, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
| | - Penelope A Jeggo
- Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK
| | - Katalin Lumniczky
- Department of Radiation Medicine, Division of Radiobiology and Radiohygiene, National Public Health Center, Budapest, Hungary
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15
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Esposito S, Principi N. Defining the aetiology of paediatric community-acquired pneumonia: an unsolved problem. Expert Rev Respir Med 2019; 13:153-161. [DOI: 10.1080/17476348.2019.1562341] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/17/2022]
Affiliation(s)
- Susanna Esposito
- Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy
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16
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Lengert N, Mirsch J, Weimer RN, Schumann E, Haub P, Drossel B, Löbrich M. AutoFoci, an automated high-throughput foci detection approach for analyzing low-dose DNA double-strand break repair. Sci Rep 2018; 8:17282. [PMID: 30470760 PMCID: PMC6251879 DOI: 10.1038/s41598-018-35660-5] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/10/2018] [Accepted: 11/07/2018] [Indexed: 12/31/2022] Open
Abstract
Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an automated DSB quantification method based on the analysis of γH2AX and 53BP1 foci as markers for DSBs. We establish a combination of object properties, combined in the object evaluation parameter (OEP), which correlates with manual object classification. Strikingly, OEP histograms show a bi-modal distribution with two maxima and a minimum in between, which correlates with the manually determined transition between background signals and foci. We used algorithms to detect the minimum, thus separating foci from background signals and automatically assessing DSB levels. To demonstrate the validity of this method, we analyzed over 600.000 cells to verify results of previous studies showing that DSBs induced by low doses are less efficiently repaired compared with DSBs induced by higher doses. Thus, the automated foci counting method, called AutoFoci, provides a valuable tool for high-throughput image analysis of thousands of cells which will prove useful for many biological screening approaches.
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Affiliation(s)
- Nicor Lengert
- Theory of Complex Systems, Darmstadt University of Technology, Hochschulstr. 6, 64289, Darmstadt, Germany.
| | - Johanna Mirsch
- Radiation Biology and DNA Repair, Darmstadt University of Technology, Schnittspahnstr. 13, 64287, Darmstadt, Germany
| | - Ratna N Weimer
- Radiation Biology and DNA Repair, Darmstadt University of Technology, Schnittspahnstr. 13, 64287, Darmstadt, Germany
| | - Eik Schumann
- Radiation Biology and DNA Repair, Darmstadt University of Technology, Schnittspahnstr. 13, 64287, Darmstadt, Germany
| | - Peter Haub
- Image Consulting, 68804, Altlußheim, Germany
| | - Barbara Drossel
- Theory of Complex Systems, Darmstadt University of Technology, Hochschulstr. 6, 64289, Darmstadt, Germany
| | - Markus Löbrich
- Radiation Biology and DNA Repair, Darmstadt University of Technology, Schnittspahnstr. 13, 64287, Darmstadt, Germany.
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17
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Precht H, Gerke O, Thygesen J, Egstrup K, Auscher S, Waaler D, Lambrechtsen J. Image quality in coronary computed tomography angiography: influence of adaptive statistical iterative reconstruction at various radiation dose levels. Acta Radiol 2018; 59:1194-1202. [PMID: 29359950 DOI: 10.1177/0284185117753657] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/06/2023]
Abstract
Background Computed tomography (CT) technology is rapidly evolving and software solution developed to optimize image quality and/or lower radiation dose. Purpose To investigate the influence of adaptive statistical iterative reconstruction (ASIR) at different radiation doses in coronary CT angiography (CCTA) in detailed image quality. Material and Methods A total of 160 CCTA were reconstructed as follows: 55 scans with filtered back projection (FBP) (650 mA), 51 scans (455 mA) with 30% ASIR (ASIR30), and 54 scans (295 mA) with 60% ASIR (ASIR60). For each reconstruction, subjective image quality was assessed by five independent certified cardiologists using a visual grading analysis (VGA) with five predefined image quality criteria consisting of a 5-point scale. Objective measures were contrast, noise, and contrast-to-noise ratio (CNR). Results The CTDIvol resulted in 10.3 mGy, 7.4 mGy, and 4.6 mGy for FBP, ASIR30, and ASIR60, respectively. Homogeneity of the left ventricular lumen was the sole aspect in which reconstruction algorithms differed with a decreasing effect for ASIR60 compared to FBP (estimated odds ratio [OR] = 0.49 [95% confidence interval (CI) = 0.32-0.76; P = 0.001]). Decreased sharpness and spatial- and low-contrast resolutions were observed when using ASIR instead of FBP, but differences were not statistically significant. Concerning objective measurements, noise increased significantly for ASIR30 (OR = 1.08; 95% CI = 1.02-1.14; P = 0.006) and ASIR60 (OR = 1.06; 95% CI = 1.01-1.12; P = 0.034) compared to FBP. Conclusion ASIR significantly decreased the subjectively assessed homogeneity of the left ventricular lumen and increased the objectively measured noise compared to FBP. Considering these results, ASIR at a reduced radiation dose should be implemented with caution.
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Affiliation(s)
- Helle Precht
- 1 Department of Medical Research, Odense University Hospital Svendborg, Svendborg, Denmark
- 2 Conrad Research Center, University College Lillebelt, Odense, Denmark
| | - Oke Gerke
- 3 Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
- 4 Centre of Health Economics Research, University of Southern Denmark, Odense, Denmark
| | - Jesper Thygesen
- 5 Department of Clinical Engineering, Central Denmark Region, Århus, Denmark
| | - Kenneth Egstrup
- 1 Department of Medical Research, Odense University Hospital Svendborg, Svendborg, Denmark
| | - Søren Auscher
- 1 Department of Medical Research, Odense University Hospital Svendborg, Svendborg, Denmark
| | - Dag Waaler
- 6 Norwegian University of Science and Technology, Gjøvik, Norway
| | - Jess Lambrechtsen
- 1 Department of Medical Research, Odense University Hospital Svendborg, Svendborg, Denmark
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18
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Mercier F, Dagbert F, Pocard M, Goéré D, Quenet F, Wernert R, Dumont F, Brigand C, Passot G, Glehen O. Recurrence of pseudomyxoma peritonei after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. BJS Open 2018; 3:195-202. [PMID: 30957067 PMCID: PMC6433307 DOI: 10.1002/bjs5.97] [Citation(s) in RCA: 31] [Impact Index Per Article: 4.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2018] [Accepted: 07/05/2018] [Indexed: 11/26/2022] Open
Abstract
Background Pseudomyxoma peritonei (PMP) is a rare clinical condition characterized by mucinous ascites, typically related to appendiceal or ovarian tumours. Current standard treatment involves cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), but recurrences occur in 20–30 per cent of patients. The aim of this study was to define the timing and patterns of recurrence to provide a basis for modifying follow‐up of these patients. Methods This observational study examined a prospectively developed multicentre national database (RENAPE working group) to identify patients with recurrence after optimal CRS and HIPEC for PMP. Postoperative complications, long‐term outcomes and potential prognostic factors were evaluated. Results Of 1411 patients with proven PMP, 948 were identified who had undergone curative CRS and HIPEC. Among these patients, 229 first recurrences (24·2 per cent) were identified: 196 (20·7 per cent) occurred within the first 5 years (early recurrence) and 30 (3·2 per cent) occurred between 5 and 10 years. Three patients developed a first recurrence more than 10 years after the original treatment. The mean(s.d.) time to first recurrence was 2·36(2·21) years. Preoperative chemotherapy and high‐grade pathology were significant factors for early recurrence. Overall survival for the entire group was 77·9 and 63·1 per cent at 5 and 10 years respectively. The principal site of recurrence was the peritoneum. Conclusion Recurrence of PMP was rare after 5 years and exceptional after 10 years.
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Affiliation(s)
- F Mercier
- Department of Digestive Surgery, Centre Hospitalier Lyon Sud, Université Claude Bernard Lyon 1, Lyon, France
| | - F Dagbert
- Department of Digestive Surgery, Centre Hospitalier Universitaire de Montreal, Montreal, Quebec, Canada
| | - M Pocard
- Surgical Oncological and Digestive Unit, Lariboisière University Hospital, Paris, France
| | - D Goéré
- Department of Surgery, Gustave Roussy Institute, Villejuif, France
| | - F Quenet
- Department of Surgical Oncology, Institut du Cancer de Montpellier, Montpellier, France
| | - R Wernert
- Department of Surgical Oncology, Institut de Cancérologie de l'Ouest (ICO) Paul Papin Cancer Centre, Angers, France
| | - F Dumont
- Department of Surgical Oncology, ICO René Gauducheau Cancer Centre, St Herblain, France
| | - C Brigand
- Department of Digestive Surgery, Hautepierre University Hospital, Strasbourg, France
| | - G Passot
- Department of Digestive Surgery, Centre Hospitalier Lyon Sud, Université Claude Bernard Lyon 1, Lyon, France.,Equipe Mixte de Recherche 3738, Université Claude Bernard Lyon 1, Lyon, France
| | - O Glehen
- Department of Digestive Surgery, Centre Hospitalier Lyon Sud, Université Claude Bernard Lyon 1, Lyon, France.,Equipe Mixte de Recherche 3738, Université Claude Bernard Lyon 1, Lyon, France
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19
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Mothersill C, Seymour C. Old Data-New Concepts: Integrating "Indirect Effects" Into Radiation Protection. HEALTH PHYSICS 2018; 115:170-178. [PMID: 29787443 DOI: 10.1097/hp.0000000000000876] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/08/2023]
Abstract
PURPOSE To address the following key question, what are the consequences of nontargeted and delayed effects for linear nonthreshold models of radiation risk? This paper considers low-dose "indirect" or nontargeted effects and how they might impact radiation protection, particularly at the level of the environment. Nontargeted effects refer to effects in cells, tissues, or organisms that were not targeted by irradiation and that did not receive direct energy deposition. They include genomic instability and lethal mutations in progeny of irradiated cells and bystander effects in neighboring cells, tissues, or organisms. Low-dose hypersensitivity and adaptive responses are sometimes included under the nontargeted effects umbrella, but these are not considered in this paper. Some concepts emerging in the nontargeted effects field that could be important include historic dose. This suggests that the initial exposure to radiation initiates the instability phenotype which is passed to progeny leading to a transgenerational radiation-response phenotype, which suggests that the system response rather than the individual response is critical in determining outcome. CONCLUSION Nontargeted effects need to be considered, and modeling, experimental, and epidemiological approaches could all be used to determine the impact of nontargeted effects on the currently used linear nonthreshold model in radiation protection.
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Affiliation(s)
- Carmel Mothersill
- 1Medical Physics and Applied Radiation Sciences Department, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
| | - Colin Seymour
- Medical Physics and Applied Radiation Sciences Department, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
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20
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Tsuchiya N, Beek EJRV, Ohno Y, Hatabu H, Kauczor HU, Swift A, Vogel-Claussen J, Biederer J, Wild J, Wielpütz MO, Schiebler ML. Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging. World J Radiol 2018; 10:52-64. [PMID: 29988845 PMCID: PMC6033703 DOI: 10.4329/wjr.v10.i6.52] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/27/2018] [Revised: 04/25/2018] [Accepted: 05/30/2018] [Indexed: 02/06/2023] Open
Abstract
Pulmonary contrast enhanced magnetic resonance angiography (CE-MRA) is useful for the primary diagnosis of pulmonary embolism (PE). Many sites have chosen not to use CE-MRA as a first line of diagnostic tool for PE because of the speed and higher efficacy of computerized tomographic angiography (CTA). In this review, we discuss the strengths and weaknesses of CE-MRA and the appropriate imaging scenarios for the primary diagnosis of PE derived from our unique multi-institutional experience in this area. The optimal patient for this test has a low to intermediate suspicion for PE based on clinical decision rules. Patients in extremis are not candidates for this test. Younger women (< 35 years of age) and patients with iodinated contrast allergies are best served by using this modality We discuss the history of the use of this test, recent technical innovations, artifacts, direct and indirect findings for PE, ancillary findings, and the effectiveness (patient outcomes) of CE-MRA for the exclusion of PE. Current outcomes data shows that CE-MRA and NM V/Q scans are effective alternative tests to CTA for the primary diagnosis of PE.
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Affiliation(s)
- Nanae Tsuchiya
- Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa 903-0215, Japan
- Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, United States
| | - Edwin JR van Beek
- Edinburgh Imaging, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
| | - Yoshiharu Ohno
- Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
| | - Hiroto Hatabu
- Department of Radiology, Brigham and Women’s Hospital, Boston, MA 02115, United States
| | - Hans-Ulrich Kauczor
- Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg 69120, Germany
| | - Andrew Swift
- Department of Radiology, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, United Kingdom
| | - Jens Vogel-Claussen
- Department of Radiology, Carl-Neuberg Strasse 1, Hannover-Gr-Buchholz 30625, Germany
| | - Jürgen Biederer
- Radiology Darmstadt, Gross-Gerau County Hospital, Gross-Gerau 64521, Germany
| | - James Wild
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2JF, United Kingdom
| | - Mark O Wielpütz
- Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg 69120, Germany
| | - Mark L Schiebler
- Department of Radiology, University of Wisconsin-Madison, Madison, WI 53792, United States
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21
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Korsholm K, Jensen JM, Nielsen-Kudsk JE. Cardiac Computed Tomography for Left Atrial Appendage Occlusion: Acquisition, Analysis, Advantages, and Limitations. Interv Cardiol Clin 2018. [PMID: 29526291 DOI: 10.1016/j.iccl.2017.12.004] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/18/2022]
Abstract
Transcatheter left atrial appendage occlusion is increasingly used for stroke prevention in atrial fibrillation. The technique has proven effective and safe in randomized trials and multiple observational studies. The procedure is challenging due to the complex anatomy of the left atrial appendage; accurate cardiac imaging is essential for procedural guidance. Transesophageal echocardiography is the gold standard, but cardiac computed tomography (CT) has gained increasing interest within recent years. Cardiac CT offers high-resolution imaging allowing for preprocedural anatomic evaluation and device sizing, but may also be useful for exclusion of left atrial appendage thrombus, and follow-up assessment of residual peri-device leaks.
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Affiliation(s)
- Kasper Korsholm
- Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N DK-8200, Denmark
| | - Jesper Møller Jensen
- Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N DK-8200, Denmark
| | - Jens Erik Nielsen-Kudsk
- Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N DK-8200, Denmark.
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22
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Gomolka M, Oestreicher U, Rößler U, Samaga D, Endesfelder D, Lang P, Neumaier K, Belka C, Niemeyer M, Kiechle M, Hasbargen U, Hübener C, Kirlum HJ, Kulka U, Rosenberger A, Walsh L, Baatout S, Kesminiene A, Lindholm C. Age-dependent differences in DNA damage after in vitro CT exposure. Int J Radiat Biol 2018; 94:272-281. [PMID: 29319401 DOI: 10.1080/09553002.2018.1419302] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/31/2017] [Revised: 11/13/2017] [Accepted: 12/04/2017] [Indexed: 12/20/2022]
Abstract
PURPOSE Age dependent radiation sensitivity for DNA damage after in vitro blood exposure by computer tomography (CT) was investigated. MATERIALS AND METHODS Radiation biomarkers (dicentrics and gammaH2AX) in blood samples of newborns, children under five years and adults after sham exposure (0 mGy), low-dose (41 mGy) and high-dose (978 mGy) in vitro CT exposure were analyzed. RESULTS Significantly higher levels of dicentric induction were found for the single and combined newborns/children group compared to adults, by a factor of 1.48 (95% CI 1.30-1.68), after exposure to 978 mGy. Although a significant dose response for damage induction and dose-dependent repair was found, the gammaH2AX assay did not show an age-dependent increase in DNA damage in newborns/children compared to adults. This was the case for the gammaH2AX levels after repair time intervals of 30 minutes and 24 hours, after correcting for the underlying background damage. For the low dose of 41 mGy, the power of the dicentric assay was also not sufficient to detect an age-dependent effect in the sample size investigated. CONCLUSION A 1.5-fold increased level of dicentric aberrations is detected in newborns and children under five years after 1 Gy radiation exposure.
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Affiliation(s)
- Maria Gomolka
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - Ursula Oestreicher
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - Ute Rößler
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - Daniel Samaga
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - David Endesfelder
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - Peter Lang
- b LMU, Klinik und Poliklinik für Strahlentherapie und Radioonkologie , München , Germany
| | - Klement Neumaier
- b LMU, Klinik und Poliklinik für Strahlentherapie und Radioonkologie , München , Germany
| | - Claus Belka
- b LMU, Klinik und Poliklinik für Strahlentherapie und Radioonkologie , München , Germany
| | - Markus Niemeyer
- c TUM, Klinikum Rechts der Isar, Frauenklinik , München , Germany
| | - Marion Kiechle
- c TUM, Klinikum Rechts der Isar, Frauenklinik , München , Germany
| | - Uwe Hasbargen
- d LMU, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Großhadern , München , Germany
| | - Christoph Hübener
- d LMU, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Großhadern , München , Germany
| | | | - Ulrike Kulka
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
| | - Albert Rosenberger
- f Universitätsmedizin Göttingen, Institut für Genetische Epidemiologie , Humboldtallee 32 , Göttingen , Germany
| | - Linda Walsh
- a Bundesamt für Strahlenschutz, BfS , Ingolstädter Landstrasse 1 , Neuherberg , Germany
- g Medical Physics Group, University of Zurich , Switzerland
| | - Sarah Baatout
- h Belgian Nuclear Research Center, SCK-CEN , Mol , Belgium
| | | | - Carita Lindholm
- j Radiation and Nuclear Safety Authority , STUK , Helsinki , Finland
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Thurley P, Crookdake J, Norwood M, Sturrock N, Fogarty AW. Demand for CT scans increases during transition from paediatric to adult care: an observational study from 2009 to 2015. Br J Radiol 2018; 91:20170467. [PMID: 29144163 PMCID: PMC5965482 DOI: 10.1259/bjr.20170467] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/22/2017] [Revised: 11/08/2017] [Accepted: 11/13/2017] [Indexed: 12/26/2022] Open
Abstract
OBJECTIVE Avoiding unnecessary radiation exposure is a clinical priority in children and young adults. We aimed to explore demand for CT scans in a busy general hospital with particular interest in the period of transition from paediatric to adult medical care. METHODS We used an observational epidemiological study based in a teaching hospital. Data were obtained on numbers and rates of CT scans from 2009 to 2015. The main outcome was age-stratified rates of receiving a CT scan. RESULTS There were a total of 262,221 CT scans. There was a large step change in the rate of CT scans over the period of transition from paediatric to adult medical care. Individuals aged 10-15 years experienced 6.7 CT scans per 1000 clinical episodes, while those aged 19-24 years experienced 19.8 CT scans per 1000 clinical episodes (p < 0.001). This difference remained significant for all sensitivity analyses. CONCLUSION There is almost a threefold increase in rates of CT scans in the two populations before and after the period of transition from paediatric to adult medical care. While we were unable to adjust for case mix or quantify radiation exposure, paediatricians' diagnostic strategies to minimize radiation exposure may have clinical relevance for adult physicians, and hence enable reductions in ionizing radiation to patients. Advances in knowledge: A large increase in rates of CT scans occurs during adolescence, and considering paediatricians' strategies to minimize radiation exposure may enable reductions to all patients.
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Affiliation(s)
| | | | | | | | - Andrew W Fogarty
- Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, UK
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Dabrowska M, Przybylo Z, Zukowska M, Kobylecka M, Maskey-Warzechowska M, Krenke R. SHOULD WE BE CONCERNED ABOUT THE DOSES OF IONIZING RADIATION RELATED TO DIAGNOSTIC AND FOLLOW-UP IMAGING IN PATIENTS WITH SOLITARY PULMONARY NODULES? RADIATION PROTECTION DOSIMETRY 2018; 178:201-207. [PMID: 28981871 DOI: 10.1093/rpd/ncx099] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/14/2017] [Accepted: 07/09/2017] [Indexed: 06/07/2023]
Abstract
Diagnosing solitary pulmonary nodules (SPNs) frequently requires radiological follow up associated with exposure to ionizing radiation. The aim of this study was to estimate the effective dose of ionizing radiation in patients diagnosed and followed up due to SPNs, which were found beyond lung cancer screening programs. We estimated the exposure to ionizing radiation as effective doses (ED) of all imaging techniques using ionizing radiation: chest computed tomography (CT), contrast enhanced CT (CECT) and positron emission tomography combined with CT (PET/CT) in each patient. The median ED related to CT, CECT and PET/CT were 27.8, 17.2 and 20.4 mSv, respectively. The total ED related to all imaging examinations performed during 2 years of radiological follow-up was 33.9 mSv (range: 3.2-122.4) per patient. Majority (59%) of radiation exposure resulted from repeated chest CT. In conclusion, diagnosis and follow up of patients with SPN with different radiological techniques is associated with high exposure to ionizing radiation.
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Affiliation(s)
- Marta Dabrowska
- Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
| | - Zuzanna Przybylo
- Students' Research Group 'Alveolus', Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
| | - Malgorzata Zukowska
- 2nd Department of Clinical Radiology, Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
| | - Malgorzata Kobylecka
- Department of Nuclear Medicine, Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
| | - Marta Maskey-Warzechowska
- Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
| | - Rafal Krenke
- Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1 A, 02-097 Warsaw, Poland
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Principi N, Esposito A, Giannitto C, Esposito S. Lung ultrasonography to diagnose community-acquired pneumonia in children. BMC Pulm Med 2017; 17:212. [PMID: 29258484 PMCID: PMC5735901 DOI: 10.1186/s12890-017-0561-9] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/13/2017] [Accepted: 12/08/2017] [Indexed: 12/26/2022] Open
Abstract
Background Early diagnosis of community-acquired pneumonia (CAP) is essential to reduce the total burden of this disease. Traditionally, chest radiography (CR) is used to identify true CAP. However, CR is not a perfect diagnostic test for CAP. The use of lung ultrasonography (LUS) has been suggested as an alternative to overcome the problems associated with CR and increase the feasibility and accuracy of CAP diagnosis. LUS has largely been used for the diagnosis of several lung problems, including CAP, in adult patients with satisfactory results. Experience with LUS in children has grown over recent years. The main aim of this paper is to discuss the advantages and limits of LUS in the diagnosis of paediatric CAP. Discussion The presence of a consolidation pattern during LUS may represent pneumonia or atelectasis, although this conclusion is operator dependent. An overall agreement between LUS and CR was observed in most of the studies that were examined. In most reports where a disagreement between the two methods was found, CR was not able to identify the cases that were correctly diagnosed by LUS, particularly when CR was performed only with postero-anterior/antero-posterior projection and consolidation was observed in lung areas that are poorly visualized by CR. However, the lack of standardized LUS methods is problematic. Finally, the real advantage of LUS for the diagnosis of CAP in children remains unclear. Summary LUS is an interesting diagnostic modality that appears a useful first imaging test in children with suspected CAP. However, the methods used to perform LUS in children are not precisely standardized, and the diagnosis of interstitial CAP is inaccurate. Further studies are needed before LUS can be routinely used in everyday paediatric practice.
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Affiliation(s)
- Nicola Principi
- Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
| | - Andrea Esposito
- Unit of Radiology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
| | | | - Susanna Esposito
- Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Piazza Menghini 1, 06129, Perugia, Italy.
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Habash M, Bohorquez LC, Kyriakou E, Kron T, Martin OA, Blyth BJ. Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer. Cancers (Basel) 2017; 9:cancers9110147. [PMID: 29077012 PMCID: PMC5704165 DOI: 10.3390/cancers9110147] [Citation(s) in RCA: 29] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/22/2017] [Revised: 10/24/2017] [Accepted: 10/24/2017] [Indexed: 01/10/2023] Open
Abstract
Whilst the near instantaneous physical interaction of radiation energy with living cells leaves little opportunity for inter-individual variation in the initial yield of DNA damage, all the downstream processes in how damage is recognized, repaired or resolved and therefore the ultimate fate of cells can vary across the population. In the clinic, this variability is observed most readily as rare extreme sensitivity to radiotherapy with acute and late tissue toxic reactions. Though some radiosensitivity can be anticipated in individuals with known genetic predispositions manifest through recognizable phenotypes and clinical presentations, others exhibit unexpected radiosensitivity which nevertheless has an underlying genetic cause. Currently, functional assays for cellular radiosensitivity represent a strategy to identify patients with potential radiosensitivity before radiotherapy begins, without needing to discover or evaluate the impact of the precise genetic determinants. Yet, some of the genes responsible for extreme radiosensitivity would also be expected to confer susceptibility to radiation-induced cancer, which can be considered another late adverse event associated with radiotherapy. Here, the utility of functional assays of radiosensitivity for identifying individuals susceptible to radiotherapy-induced second cancer is discussed, considering both the common mechanisms and important differences between stochastic radiation carcinogenesis and the range of deterministic acute and late toxic effects of radiotherapy.
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Affiliation(s)
- Mohammad Habash
- Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
- Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
| | - Luis C Bohorquez
- Physical Sciences, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
| | - Elizabeth Kyriakou
- Physical Sciences, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
| | - Tomas Kron
- Physical Sciences, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
| | - Olga A Martin
- Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
- Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
- The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.
| | - Benjamin J Blyth
- Cancer Research Division, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
- Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, 305 Grattan Street, Parkville, VIC 3000, Australia.
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Marcu LG. Photons – Radiobiological issues related to the risk of second malignancies. Phys Med 2017; 42:213-220. [DOI: 10.1016/j.ejmp.2017.02.013] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/05/2016] [Revised: 01/21/2017] [Accepted: 02/14/2017] [Indexed: 12/23/2022] Open
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McLean AR, Adlen EK, Cardis E, Elliott A, Goodhead DT, Harms-Ringdahl M, Hendry JH, Hoskin P, Jeggo PA, Mackay DJC, Muirhead CR, Shepherd J, Shore RE, Thomas GA, Wakeford R, Godfray HCJ. A restatement of the natural science evidence base concerning the health effects of low-level ionizing radiation. Proc Biol Sci 2017; 284:20171070. [PMID: 28904138 PMCID: PMC5597830 DOI: 10.1098/rspb.2017.1070] [Citation(s) in RCA: 53] [Impact Index Per Article: 6.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2017] [Accepted: 07/13/2017] [Indexed: 11/12/2022] Open
Abstract
Exposure to ionizing radiation is ubiquitous, and it is well established that moderate and high doses cause ill-health and can be lethal. The health effects of low doses or low dose-rates of ionizing radiation are not so clear. This paper describes a project which sets out to summarize, as a restatement, the natural science evidence base concerning the human health effects of exposure to low-level ionizing radiation. A novel feature, compared to other reviews, is that a series of statements are listed and categorized according to the nature and strength of the evidence that underpins them. The purpose of this restatement is to provide a concise entrée into this vibrant field, pointing the interested reader deeper into the literature when more detail is needed. It is not our purpose to reach conclusions on whether the legal limits on radiation exposures are too high, too low or just right. Our aim is to provide an introduction so that non-specialist individuals in this area (be they policy-makers, disputers of policy, health professionals or students) have a straightforward place to start. The summary restatement of the evidence and an extensively annotated bibliography are provided as appendices in the electronic supplementary material.
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Affiliation(s)
- Angela R McLean
- Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
- Oxford Martin School, University of Oxford, 34 Broad Street, Oxford OX1 3BD, UK
| | - Ella K Adlen
- Oxford Martin School, University of Oxford, 34 Broad Street, Oxford OX1 3BD, UK
| | - Elisabeth Cardis
- Barcelona Institute for Global Health (ISGlobal), Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
| | - Alex Elliott
- College of Medical, Veterinary and Life Sciences, Wellcome Surgical Institute, University of Glasgow, Garscube Estate, Glasgow G61 1QH, UK
| | | | - Mats Harms-Ringdahl
- Center for Radiation Protection Research, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
| | - Jolyon H Hendry
- Christie Medical Physics and Engineering, Christie Hospital and University of Manchester, Manchester, UK
| | - Peter Hoskin
- Mount Vernon Cancer Centre, Northwood HA6 2RN, UK
| | - Penny A Jeggo
- Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
| | - David J C Mackay
- Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK
| | - Colin R Muirhead
- Institute of Health and Society, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
| | - John Shepherd
- Ocean and Earth Science, University of Southampton, Southampton SO14 3ZH, UK
| | - Roy E Shore
- Radiation Effects Research Foundation, Hiroshima, Japan
| | - Geraldine A Thomas
- Department of Surgery and Cancer, Imperial College London, Room 11L04, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
| | - Richard Wakeford
- Centre for Occupational and Environmental Health, Institute of Population Health, Faculty of Medical and Human Sciences, University of Manchester, Ellen Wilkinson Building, Oxford Road, Manchester M13 9PL, UK
| | - H Charles J Godfray
- Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
- Oxford Martin School, University of Oxford, 34 Broad Street, Oxford OX1 3BD, UK
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Radiation dose associated with CT-guided drain placement for pediatric patients. Pediatr Radiol 2017; 47:718-723. [PMID: 28283724 DOI: 10.1007/s00247-017-3814-0] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/25/2016] [Revised: 01/27/2017] [Accepted: 02/15/2017] [Indexed: 10/20/2022]
Abstract
BACKGROUND To date, there are limited radiation dose data on CT-guided procedures in pediatric patients. OBJECTIVE Our goal was to quantify the radiation dose associated with pediatric CT-guided drain placement and follow-up drain evaluations in order to estimate effective dose. MATERIALS AND METHODS We searched the electronic medical record and picture archiving and communication system (PACS) to identify all pediatric (<18 years old) CT-guided drain placements performed between January 2008 and December 2013 at our institution. We compiled patient data and radiation dose information from CT-guided drain placements as well as pre-procedural diagnostic CTs and post-procedural follow-up fluoroscopic abscess catheter injections (sinograms). Then we converted dose-length product, fluoroscopy time and number of acquisitions to effective doses using Monte Carlo simulations and age-appropriate conversion factors based on annual quality-control testing. RESULTS Fifty-two drainages were identified with mean patient age of 11.0 years (5 weeks to 17 years). Most children had diagnoses of appendicitis (n=23) or inflammatory bowel disease (n=11). Forty-seven patients had diagnostic CTs, with a mean effective dose of 7.3 mSv (range 1.1-25.5 mSv). Drains remained in place for an average of 16.9 days (range 0-75 days), with an average of 0.9 (0-5) sinograms per patient in follow-up. The mean effective dose for all drainages and follow-up exams was 5.3 mSv (0.7-17.1) and 62% (32/52) of the children had effective doses less than 5 mSv. CONCLUSION The majority of pediatric patients who have undergone CT-guided drain placements at our institution have received total radiation doses on par with diagnostic ranges. This information could be useful when describing the dose of radiation to parents and providers when CT-guided drain placement is necessary.
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Affiliation(s)
- Savvas Andronikou
- Department of Paediatric Radiology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol, BS2 8BJ, UK.
- University of Bristol, CRICBristol, 60 St. Michaels Hill, Bristol, BS2 8DX, UK.
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Risk Communication Strategies: Lessons Learned from Previous Disasters with a Focus on the Fukushima Radiation Accident. Curr Environ Health Rep 2016; 3:348-359. [PMID: 27796965 DOI: 10.1007/s40572-016-0111-2] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
Abstract
PURPOSE OF THE REVIEW It has been difficult to both mitigate the health consequences and effectively provide health risk information to the public affected by the Fukushima radiological disaster. Often, there are contrasting public health ethics within these activities which complicate risk communication. Although no risk communication strategy is perfect in such disasters, the ethical principles of risk communication provide good practical guidance. FINDINGS These discussions will be made in the context of similar lessons learned after radiation exposures in Goiania, Brazil, in 1987; the Chernobyl nuclear power plant accident, Ukraine, in 1986; and the attack at the World Trade Center, New York, USA, in 2001. Neither of the two strategies is perfect nor fatally flawed. Yet, this discussion and lessons from prior events should assist decision makers with navigating difficult risk communication strategies in similar environmental health disasters.
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Armao D, Hartman T, Shea CM, Sams C, Fordham LA, Smith JK. Working Face-to-Face for Pediatric CT Dose Reduction: A Community Toolkit. DIAGNOSTIC IMAGING EUROPE 2016; 32:10-13. [PMID: 27942250 PMCID: PMC5146988] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Subscribe] [Scholar Register] [Indexed: 06/06/2023]
Abstract
Although children are especially vulnerable to the health risks of ionizing radiation, approximately 8 million CTs are performed on children in the USA. Widespread dose variation is common, particularly in non-pediatric focused facilities. In this article we present our rationale and hands-on approach in developing and refining a toolkit aimed at helping a community hospital with pediatric CT dose reduction.
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Affiliation(s)
- Diane Armao
- Department of Radiology, UNC School of Medicine, Chapel Hill, NC, USA
- Department of Pathology and Laboratory Medicine, Chapel Hill, NC, USA
- Department of Physician Assistant Studies, Elon University, Elon, NC, USA
| | - Terry Hartman
- Sanford School of Public Policy, Duke University, Durham, NC, USA
| | - Christopher M. Shea
- Department of Health Policy and Management, UNC Gillings School of Global Public Health, Chapel Hill, NC, USA
| | - Cassandra Sams
- Department of Radiology, UNC School of Medicine, Chapel Hill, NC, USA
| | | | - J. Keith Smith
- Department of Radiology, UNC School of Medicine, Chapel Hill, NC, USA
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Armao D, Hartman T, Shea CM, Sams C, Ivanovic M, Fordham LA, Smith JK. A Toolkit for Pediatric CT Dose Reduction in Community Hospitals. J Am Coll Radiol 2016; 13:1337-1342.e11. [PMID: 27289341 DOI: 10.1016/j.jacr.2016.04.032] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/09/2016] [Revised: 04/29/2016] [Accepted: 04/30/2016] [Indexed: 10/21/2022]
Abstract
Pediatric CT radiation dose optimization is a challenging process for pediatric-focused facilities and community hospitals alike. Ongoing experience and trial-and-error approaches to dose reduction in the large academic hospital setting may position these centers to help community hospitals that strive for CT quality improvement. We describe our hands-on approach in a pilot project to create a partnership between an academic medical center and a community hospital to develop a toolkit for implementing CT dose reduction. Our aims were to (1) assess the acceptability of an interactive educational program and electronic toolkit booklet, (2) conduct a limited test of the efficacy of the toolkit in promoting knowledge and readiness to change, and (3) assess the acceptability and practicality of a collaborative approach to implementing dose reduction protocols in community hospitals. In partnering with the community hospital, we found that they had size-specific radiation doses two to three times higher than those at our center. Survey results after a site visit with interactive educational presentations revealed an increase in knowledge, stronger opinions about the health risks of radiation from CT scans, and willingness and perceived ability to reduce pediatric CT doses.
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Affiliation(s)
- Diane Armao
- Department of Radiology, UNC School of Medicine, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, UNC School of Medicine, Chapel Hill, North Carolina; Department of Physician Assistant Studies, Elon University, Elon, North Carolina.
| | - Terry Hartman
- Sanford School of Public Policy, Duke University, Durham, North Carolina
| | - Christopher M Shea
- Department of Health Policy and Management, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina
| | - Cassandra Sams
- Department of Radiology, UNC School of Medicine, Chapel Hill, North Carolina
| | - Marija Ivanovic
- Department of Radiology, UNC School of Medicine, Chapel Hill, North Carolina
| | - Lynn Ansley Fordham
- Department of Radiology, UNC School of Medicine, Chapel Hill, North Carolina
| | - J Keith Smith
- Department of Radiology, UNC School of Medicine, Chapel Hill, North Carolina
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Laiakis EC, Pannkuk EL, Diaz-Rubio ME, Wang YW, Mak TD, Simbulan-Rosenthal CM, Brenner DJ, Fornace AJ. Implications of genotypic differences in the generation of a urinary metabolomics radiation signature. Mutat Res 2016; 788:41-9. [PMID: 27040378 PMCID: PMC4887295 DOI: 10.1016/j.mrfmmm.2016.03.003] [Citation(s) in RCA: 19] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/10/2015] [Revised: 03/04/2016] [Accepted: 03/24/2016] [Indexed: 02/04/2023]
Abstract
The increased threat of radiological terrorism and accidental nuclear exposures, together with increased usage of radiation-based medical procedures, has made necessary the development of minimally invasive methods for rapid identification of exposed individuals. Genetically predisposed radiosensitive individuals comprise a significant number of the population and require specialized attention and treatments after such events. Metabolomics, the assessment of the collective small molecule content in a given biofluid or tissue, has proven effective in the rapid identification of radiation biomarkers and metabolic perturbations. To investigate how the genotypic background may alter the ionizing radiation (IR) signature, we analyzed urine from Parp1(-/-) mice, as a model radiosensitive genotype, exposed to IR by utilizing the analytical power of liquid chromatography coupled with mass spectrometry (LC-MS), as urine has been thoroughly investigated in wild type (WT) mice in previous studies from our laboratory. Samples were collected at days one and three after irradiation, time points that are important for the early and efficient triage of exposed individuals. Time-dependent perturbations in metabolites were observed in the tricarboxylic acid pathway (TCA). Other differentially excreted metabolites included amino acids and metabolites associated with dysregulation of energy metabolism pathways. Time-dependent apoptotic pathway activation between WT and mutant mice following IR exposure may explain the altered excretion patterns, although the origin of the metabolites remains to be determined. This first metabolomics study in urine from radiation exposed genetic mutant animal models provides evidence that this technology can be used to dissect the effects of genotoxic agents on metabolism by assessing easily accessible biofluids and identify biomarkers of radiation exposure. Applications of metabolomics could be incorporated in the future to further elucidate the effects of IR on the metabolism of Parp1(-/-) genotype by assessing individual tissues.
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Affiliation(s)
- Evagelia C Laiakis
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, USA.
| | - Evan L Pannkuk
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, USA
| | - Maria Elena Diaz-Rubio
- Pediatrics, Division of Developmental Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR, USA
| | - Yi-Wen Wang
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, USA
| | - Tytus D Mak
- Mass Spectrometry Data Center, National Institute of Standards and Technology (NIST), Gaithersburg MD, USA
| | | | | | - Albert J Fornace
- Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington DC, USA; Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA; Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah 22254, Saudi Arabia
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Cohen A, Hughes K, Fahey N, Caldwell B, Wang CH, Park S. Wide Variation in Radiation Exposure During Computerized Tomography. Urology 2016; 95:47-53. [PMID: 27233928 DOI: 10.1016/j.urology.2016.05.036] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2016] [Revised: 05/17/2016] [Accepted: 05/18/2016] [Indexed: 11/17/2022]
Abstract
OBJECTIVE To determine the variance in computeed tomography (CT) radiation measured via dose-length product (DLP) and effective dose (ED) during stone protocol CT scans. METHODS We retrospectively examined consecutive records of patients receiving stone protocol diagnostic CT scans (n = 1793) in 2010 and 2014 in our health system. Patient age, body mass index (BMI), and gender were recorded, along with the hospital, machine model, year, DLP, and ED of each scan. Multivariate regression was performed to identify predictive factors for increased DLP. We also collected data on head (n = 837) CT scans to serve as a comparison. RESULTS For stone CT scans, mean patient age was 55.1 ± 18.4 years with no significant difference in age (P=.2557) or BMI (P=.1794) between 2010 and 2014. Gender, BMI, and machine model were independent predictors of radiation dosage (P < .0001). Within each BMI class, there was an inexplicable 6-fold variation in the ED for the same imaging test when comparing the lowest and highest CT dose patients. There was no significant change in DLP over time for stone CT scans, but head scan patients in 2014 received lower radiation doses than those in 2010 (P < .0001). Low-dose scans for renal colic (defined as <4 mSv) were underutilized. Substantial variation exists for head scan radiation doses. CONCLUSION Our data demonstrate large variations in diagnostic CT radiation dosage. Such differences within a single institution suggest similar trends elsewhere, warranting more stringent dosage guidelines and regulations for diagnostic CT scans within institutions.
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Affiliation(s)
- Andrew Cohen
- Section of Urology, University of Chicago, Chicago, IL
| | - Katie Hughes
- Division of Urology, NorthShore University HealthSystem, Evanston, IL
| | - Natalie Fahey
- Division of Urology, NorthShore University HealthSystem, Evanston, IL
| | - Brandon Caldwell
- Division of Urology, NorthShore University HealthSystem, Evanston, IL
| | - Chi Hsiung Wang
- Division of Urology, NorthShore University HealthSystem, Evanston, IL
| | - Sangtae Park
- Division of Urology, NorthShore University HealthSystem, Evanston, IL.
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Incidence of actionable findings on contrast enhanced magnetic resonance angiography ordered for pulmonary embolism evaluation. Eur J Radiol 2016; 85:1383-9. [PMID: 27423676 DOI: 10.1016/j.ejrad.2016.05.008] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/28/2016] [Revised: 04/27/2016] [Accepted: 05/19/2016] [Indexed: 12/31/2022]
Abstract
PURPOSE To determine the incidence of actionable findings on contrast-enhanced magnetic resonance angiography (MRA) scans performed for the primary diagnosis of pulmonary embolism (PE). MATERIALS AND METHODS This was a HIPAA-compliant and IRB-approved single center, retrospective study of consecutive series of patients evaluated with contrast-enhanced MRA for PE. The final radiology report of each MRA was reviewed. All technically adequate negative exams were included in the analysis. The findings were divided into three types: those requiring further action (actionable-Type 1) those not requiring follow-up (non-actionable-Type 2) and normal exams. We compared our results with the literature regarding the use of computed tomographic angiography (CTA) in this scenario using Fisher's exact test. RESULTS 580 MRA scans for PE were performed. There were 561/580 (97%) technically adequate exams. Of these, 514/580 (89%) were negative and 47/580 (8%) were positive for PE. In the PE negative group of 514 exams, Type 1 findings were identified in 85/514 (17%), 188/514 (36%) cases were Type 2 and 241/514 (47.0%) were Type 3. There was no significant difference between the incidence of Type 1 and the combination of Type 2 and Type 3 findings on MRA and the reported incidence of actionable findings derived from CTA negative exams for PE (p<0.5). CONCLUSION MRA as a first-line test for PE can identify actionable findings in those patients without PE, with an incidence similar to that reported in the literature for CTA.
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Muhogora W, Ngoye W, Byorushengo E, Lwakatare F, Kalambo C. Paediatric doses during some common X-ray procedures at selected referral hospitals in Tanzania. RADIATION PROTECTION DOSIMETRY 2016; 168:253-260. [PMID: 25790826 PMCID: PMC4884876 DOI: 10.1093/rpd/ncv021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/14/2014] [Revised: 02/19/2015] [Accepted: 02/20/2015] [Indexed: 06/04/2023]
Abstract
The aim of this study was to determine the radiation doses to paediatric patients of different age groups at three large hospitals for optimisation purposes. The entrance surface air kerma (ESAK) values were determined from the measured X-ray output values using calibrated ionisation chamber, TW 233612 and clinical patient parameters. The air kerma-area product (KAP) values were measured using a calibrated Diamentor E2 system. The volume computed tomography dose index (CTDIvol) and dose length product (DLP) values were obtained from the computed tomography (CT) equipment verified by a calibrated CT chamber, Unifors Xi CT. Irrespective of age groups, the results show that the median ESAK values ranged from 62.6 to 248.1 µGy. The median KAP values ranged from 135.6 to 1612 µGy cm(2), while the median DLP values ranged from 119.1 to 600 mGy cm. Analysis of the results indicates that optimisation can be achieved through good practice awareness and patient dose and image quality evaluations.
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Affiliation(s)
- W Muhogora
- Tanzania Atomic Energy Commission, Block J, Njiro, Arusha, Tanzania
| | - W Ngoye
- Tanzania Atomic Energy Commission, Block J, Njiro, Arusha, Tanzania
| | - E Byorushengo
- Tanzania Atomic Energy Commission, Block J, Njiro, Arusha, Tanzania
| | - F Lwakatare
- Muhimbili National Hospital, Mariki Road, Dar es Salaam, Tanzania
| | - C Kalambo
- Kilimanjaro Christian Medical Centre, Off Sokoine Road, Moshi, Tanzania
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Shuryak I. Mechanistic Modeling of Dose and Dose Rate Dependences of Radiation-Induced DNA Double Strand Break Rejoining Kinetics in Saccharomyces cerevisiae. PLoS One 2016; 11:e0146407. [PMID: 26741137 PMCID: PMC4711806 DOI: 10.1371/journal.pone.0146407] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2015] [Accepted: 12/16/2015] [Indexed: 11/19/2022] Open
Abstract
Mechanistic modeling of DNA double strand break (DSB) rejoining is important for quantifying and medically exploiting radiation-induced cytotoxicity (e.g. in cancer radiotherapy). Most radiation-induced DSBs are quickly-rejoinable and are rejoined within the first 1–2 hours after irradiation. Others are slowly-rejoinable (persist for several hours), and yet others are essentially unrejoinable (persist for >24 hours). The dependences of DSB rejoining kinetics on radiation dose and dose rate remain incompletely understood. We hypothesize that the fraction of slowly-rejoinable and/or unrejoinable DSBs increases with increasing dose/dose rate. This radiation-dependent (RD) model was implemented using differential equations for three DSB classes: quickly-rejoinable, slowly-rejoinable and unrejoinable. Radiation converts quickly-rejoinable to slowly-rejoinable, and slowly-rejoinable to unrejoinable DSBs. We used large published data sets on DSB rejoining in yeast exposed to sparsely-ionizing (electrons and γ-rays, single or split-doses, high or low dose rates) and densely-ionizing (α-particles) radiation to compare the performances of the proposed RD formalism and the established two-lesion kinetic (TLK) model. These yeast DSB rejoining data were measured within the radiation dose range relevant for clonogenic cell survival, whereas in mammalian cells DSB rejoining is usually measured only at supra-lethal doses for technical reasons. The RD model described both sparsely-ionizing and densely-ionizing radiation data much better than the TLK model: by 217 and 14 sample-size-adjusted Akaike information criterion units, respectively. This occurred because: the RD (but not the TLK) model reproduced the observed upwardly-curving dose responses for slowly-rejoinable/unrejoinable DSBs at long times after irradiation; the RD model adequately described DSB yields at both high and low dose rates using one parameter set, whereas the TLK model overestimated low dose rate data. These results support the hypothesis that DSB rejoining is progressively impeded at increasing radiation doses/dose rates.
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Affiliation(s)
- Igor Shuryak
- Center for Radiological Research, Columbia University, New York, NY, United States of America
- * E-mail:
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Slovis TL, Strouse PJ, Strauss KJ. Radiation Exposure in Imaging of Suspected Child Abuse: Benefits versus Risks. J Pediatr 2015; 167:963-8. [PMID: 26354874 DOI: 10.1016/j.jpeds.2015.07.064] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/28/2015] [Revised: 05/29/2015] [Accepted: 07/30/2015] [Indexed: 11/30/2022]
Affiliation(s)
- Thomas L Slovis
- Department of Radiology, Wayne State University School of Medicine, Children's Hospital of Michigan, Detroit, MI
| | - Peter J Strouse
- Section of Pediatric Radiology, C. S. Mott Children's Hospital, Department of Radiology, University of Michigan Health System, Ann Arbor, MI.
| | - Keith J Strauss
- Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
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Brenner DJ. Should we worry about inherited radiation risks? Lancet Oncol 2015; 16:1275-6. [PMID: 26384239 DOI: 10.1016/s1470-2045(15)00270-3] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2015] [Accepted: 08/20/2015] [Indexed: 11/25/2022]
Affiliation(s)
- David J Brenner
- Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA.
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Armao DM, Smith JK, Semelka RC. Debriefing the Brief: It is Time for the Provision of Informed Consent before Pediatric CT. Radiology 2015; 275:326-30. [DOI: 10.1148/radiol.2015142860] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/12/2023]
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Cohen MD. ALARA, image gently and CT-induced cancer. Pediatr Radiol 2015; 45:465-70. [PMID: 25680877 DOI: 10.1007/s00247-014-3198-3] [Citation(s) in RCA: 58] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/09/2014] [Accepted: 09/28/2014] [Indexed: 12/20/2022]
Affiliation(s)
- Mervyn D Cohen
- Department of Radiology, Indiana University School of Medicine,Riley Hospital for Children, 520 W. Cedar St, Zionsville, IN, 46077, USA,
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Doss M. COUNTERPOINT: Should Radiation Dose From CT Scans Be a Factor in Patient Care? No. Chest 2015; 147:874-877. [DOI: 10.1378/chest.14-3022] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022] Open
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Levy A. Communication is key. Clin Med (Lond) 2015; 15:107-8. [PMID: 25650219 PMCID: PMC4954509 DOI: 10.7861/clinmedicine.15-1-106b] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Affiliation(s)
- Andy Levy
- University of Bristol, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
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Gordic S, Alkadhi H, Hodel S, Simmen HP, Brueesch M, Frauenfelder T, Wanner G, Sprengel K. Whole-body CT-based imaging algorithm for multiple trauma patients: radiation dose and time to diagnosis. Br J Radiol 2015; 88:20140616. [PMID: 25594105 DOI: 10.1259/bjr.20140616] [Citation(s) in RCA: 46] [Impact Index Per Article: 4.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
OBJECTIVE To determine the number of imaging examinations, radiation dose and the time to complete trauma-related imaging in multiple trauma patients before and after introduction of whole-body CT (WBCT) into early trauma care. METHODS 120 consecutive patients before and 120 patients after introduction of WBCT into the trauma algorithm of the University Hospital Zurich were compared regarding the number and type of CT, radiography, focused assessment with sonography for trauma (FAST), additional CT examinations (defined as CT of the same body regions after radiography and/or FAST) and the time to complete trauma-related imaging. RESULTS In the WBCT cohort, significantly more patients underwent CT of the head, neck, chest and abdomen (p < 0.001) than in the non-WBCT cohort, whereas the number of radiographic examinations of the cervical spine, chest and pelvis and of FAST examinations were significantly lower (p < 0.001). There were no significant differences between cohorts regarding the number of radiographic examinations of the upper (p = 0.56) and lower extremities (p = 0.30). We found significantly higher effective doses in the WBCT (29.5 mSv) than in the non-WBCT cohort (15.9 mSv; p < 0.001), but fewer additional CT examinations for completing the work-up were needed in the WBCT cohort (p < 0.001). The time to complete trauma-related imaging was significantly shorter in the WBCT (12 min) than in the non-WBCT cohort (75 min; p < 0.001). CONCLUSION Including WBCT in the initial work-up of trauma patients results in higher radiation doses, but fewer additional CT examinations are needed, and the time for completing trauma-related imaging is shorter. ADVANCES IN KNOWLEDGE WBCT in trauma patients is associated with a high radiation dose of 29.5 mSv.
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Affiliation(s)
- S Gordic
- 1 Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland
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Abstract
Several radiation-related professional societies have concluded that carcinogenic risks associated with doses below 50-100 mSv are either too small to be detected, or are nonexistent. This is especially important in the context of doses from medical imaging. Radiation exposure to the public from medical imaging procedures is rising around the world, primarily due to increased utilization of computed tomography. Professional societies and advisory bodies consistently recommend against multiplying small doses by large populations to predict excess radiation-induced cancers, in large part because of the potential for sensational claims of health impacts which do not adequately take the associated uncertainties into account. Nonetheless, numerous articles have predicted thousands of future cancers as a result of CT scanning, and this has generated considerable concern among patients and parents. In addition, some authors claim that we now have direct epidemiological evidence of carcinogenic risks from medical imaging. This paper critically examines such claims, and concludes that the evidence cited does not provide direct evidence of low-dose carcinogenicity. These claims themselves have adverse public health impacts by frightening the public away from medically justified exams. It is time for the medical and scientific communities to be more assertive in responding to sensational claims of health risks.
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Affiliation(s)
- Brant A. Ulsh
- Principal Health Physicist, M.H. Chew & Associates, Livermore, CA
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47
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Westra SJ. The communication of the radiation risk from CT in relation to its clinical benefit in the era of personalized medicine: part 1: the radiation risk from CT. Pediatr Radiol 2014; 44 Suppl 3:515-8. [PMID: 25304714 DOI: 10.1007/s00247-014-3139-1] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/04/2014] [Revised: 04/29/2014] [Accepted: 07/18/2014] [Indexed: 11/25/2022]
Abstract
The theory of radiation carcinogenesis has been debated for decades. Most estimates of the radiation risks from CT have been based on extrapolations from the lifespan follow-up study of atomic bomb survivors and on follow-up studies after therapeutic radiation, using the linear no-threshold theory. Based on this, many population-based projections of induction of future cancers by CT have been published that should not be used to estimate the risk to an individual because of their large margin of error. This has changed recently with the publication of three large international cohort follow-up studies, which link observed cancers to CT scans received in childhood. A fourth ongoing multi-country study in Europe is expected to have enough statistical power to address the limitations of the prior studies. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) report released in 2013 specifically addresses variability in response of the pediatric population exposed to ionizing radiation. Most authorities now conclude that there is enough evidence to link future cancers to the radiation exposure from a single CT scan in childhood but that cancer risk estimates for individuals must be based on the specifics of exposure, age at exposure and absorbed dose to certain tissues. Generalizations are not appropriate, and the communication of the CT risk to individuals should be conducted within the framework of personalized medicine.
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Affiliation(s)
- Sjirk J Westra
- Division of Pediatric Radiology, Massachusetts General Hospital, 34 Fruit St., White 246A, Boston, MA, 02114, USA,
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Doss M. Radiation Dose Justification and Optimization Should Not Be Applied to Medical Imaging in Emergency Medicine. Ann Emerg Med 2014; 64:332-3. [DOI: 10.1016/j.annemergmed.2014.03.032] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/10/2014] [Revised: 03/13/2014] [Accepted: 03/13/2014] [Indexed: 11/29/2022]
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Doss M. Radiation doses from radiological imaging do not increase the risk of cancer. Br J Radiol 2014; 87:20140085. [PMID: 24641172 PMCID: PMC4067027 DOI: 10.1259/bjr.20140085] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2014] [Accepted: 02/17/2014] [Indexed: 12/14/2022] Open
Affiliation(s)
- M Doss
- Diagnostic Imaging, Fox Chase Cancer Center, Philadelphia, PA, USA
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50
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Affiliation(s)
- K M Prise
- Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK
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