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Lin YF, Hsieh CH, Tien HJ, Lee YH, Chen YC, Lai LH, Hsu SM, Shueng PW. Evaluation of cutout factors with small and narrow fields using various dosimetry detectors in electron beam keloid radiotherapy. JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY 2024; 32:1177-1184. [PMID: 38905079 DOI: 10.3233/xst-240059] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/23/2024]
Abstract
BACKGROUND The inherent problems in the existence of electron equilibrium and steep dose fall-off pose difficulties for small- and narrow-field dosimetry. OBJECTIVE To investigate the cutout factors for keloid electron radiotherapy using various dosimetry detectors for small and narrow fields. METHOD The measurements were performed in a solid water phantom with nine different cutout shapes. Five dosimetry detectors were used in the study: pinpoint 3D ionization chamber, Farmer chamber, semiflex chamber, Classic Markus parallel plate chamber, and EBT3 film. RESULTS The results demonstrated good agreement between the semiflex and pinpoint chambers. Furthermore, there was no difference between the Farmer and pinpoint chambers for large cutouts. For the EBT3 film, half of the cases had differences greater than 1%, and the maximum discrepancy compared with the reference chamber was greater than 2% for the narrow field. CONCLUSION The parallel plate, semiflex chamber and EBT3 film are suitable dosimeters that are comparable with pinpoint 3D chambers in small and narrow electron fields. Notably, a semiflex chamber could be an alternative option to a pinpoint 3D chamber for cutout widths≥3 cm. It is very important to perform patient-specific cutout factor calibration with an appropriate dosimeter for keloid radiotherapy.
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Affiliation(s)
- Yu-Fang Lin
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Chen-Hsi Hsieh
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- School of Nursing, Yuan Ze University, Taoyuan, Taiwan
| | - Hui-Ju Tien
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Yi-Huan Lee
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
| | - Yi-Chun Chen
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
| | - Lu-Han Lai
- Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan
| | - Shih-Ming Hsu
- Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Pei-Wei Shueng
- Department of Radiology, Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
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Ma CMC, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, Seuntjens J, Siebers JV, Traneus E. Beam modeling and beam model commissioning for Monte Carlo dose calculation-based radiation therapy treatment planning: Report of AAPM Task Group 157. Med Phys 2019; 47:e1-e18. [PMID: 31679157 DOI: 10.1002/mp.13898] [Citation(s) in RCA: 25] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/14/2019] [Revised: 10/01/2019] [Accepted: 10/18/2019] [Indexed: 11/07/2022] Open
Abstract
Dose calculation plays an important role in the accuracy of radiotherapy treatment planning and beam delivery. The Monte Carlo (MC) method is capable of achieving the highest accuracy in radiotherapy dose calculation and has been implemented in many commercial systems for radiotherapy treatment planning. The objective of this task group was to assist clinical physicists with the potentially complex task of acceptance testing and commissioning MC-based treatment planning systems (TPS) for photon and electron beam dose calculations. This report provides an overview on the general approach of clinical implementation and testing of MC-based TPS with a specific focus on models of clinical photon and electron beams. Different types of beam models are described including those that utilize MC simulation of the treatment head and those that rely on analytical methods and measurements. The trade-off between accuracy and efficiency in the various source-modeling approaches is discussed together with guidelines for acceptance testing of MC-based TPS from the clinical standpoint. Specific recommendations are given on methods and practical procedures to commission clinical beam models for MC-based TPS.
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Affiliation(s)
- Chang Ming Charlie Ma
- Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA
| | - Indrin J Chetty
- Radiation Oncology Department, Henry Ford Health System, Detroit, MI, 48188, USA
| | - Jun Deng
- Department of Therapeutic Radiology, Yale University, New Haven, CT, 06032, USA
| | - Bruce Faddegon
- Department of Radiation Oncology, UCSF, San Francisco, CA, 94143, USA
| | - Steve B Jiang
- Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA
| | | | - Jan Seuntjens
- Medical Physics Unit, McGill University, Montreal, QC, H4A 3J1, Canada
| | - Jeffrey V Siebers
- Department of Radiation Oncology, University of Virginia, Charlottesville, VA, 22908, USA
| | - Erik Traneus
- RaySearch Laboratories AB, SE-103 65, Stockholm, Sweden
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Park JI, Ha SW, Kim JI, Lee H, Lee J, Kim IH, Ye SJ. Design and evaluation of electron beam energy degraders for breast boost irradiation. Radiat Oncol 2016; 11:112. [PMID: 27580698 PMCID: PMC5007734 DOI: 10.1186/s13014-016-0686-7] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2016] [Accepted: 08/19/2016] [Indexed: 11/25/2022] Open
Abstract
Background For breast cancer patients who require electron boost energies between 6 and 9 MeV, an energy degraders (ED) in the 9 MeV beamline was specially designed and manufactured to increase the skin dose of 6 MeV and to reduce the penetration depth of 9 MeV beams. Methods We used Monte Carlo (MC) techniques as a guide in the design of ED for use with linear accelerators. In order to satisfy percent depth dose (PDD) characteristics and dose profile uniformity in water, the shape and thickness of Lucite® ED in the 9 MeV beamline was iteratively optimized and then manufactured. The ED geometry consists of a truncated cone attached on top of a plane plate, with total central thickness of 1.0 cm. The ED was placed on the lower most scraper of the electron applicator. The PDDs, profiles, and output factors were measured in water to validate the MC-based design. Results Skin doses with the EDs increased by 8–9 %, compared to those of the 9 MeV beam. The outputs with the EDs were 0.882 and 0.972 for 10 × 10 and 15 × 15 cm2 cones, respectively, as compared to that of a conventional 9 MeV beam for a 10 × 10 cm2 cone. The X-ray contamination remained less than 1.5 %. In-vivo measurements were also performed for three breast boost patients and showed close agreement with expected values. Conclusions The optimally designed ED in the 9 MeV beamline provides breast conserving patients with a new energy option of 7 MeV for boost of the shallow tumor bed. It would be an alternative to bolus and thus eliminate inconvenience and concern about the daily variation of bolus setup.
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Affiliation(s)
- Jong In Park
- Department of Transdisciplinary Studies, Program in Biomedical Radiation Sciences, Seoul National University Graduate School of Convergence Science and Technology, Seoul, 151-742, Korea.,Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea.,Interdisciplinary Program in Radiation Applied Life Science, Seoul National University College of Medicine, Seoul, Korea
| | - Sung Whan Ha
- Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea.,Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea
| | - Jung-In Kim
- Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.,Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Korea
| | - Hyunseok Lee
- Department of Transdisciplinary Studies, Program in Biomedical Radiation Sciences, Seoul National University Graduate School of Convergence Science and Technology, Seoul, 151-742, Korea.,Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
| | - Jaegi Lee
- Department of Transdisciplinary Studies, Program in Biomedical Radiation Sciences, Seoul National University Graduate School of Convergence Science and Technology, Seoul, 151-742, Korea.,Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
| | - Il Han Kim
- Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.,Interdisciplinary Program in Radiation Applied Life Science, Seoul National University College of Medicine, Seoul, Korea
| | - Sung-Joon Ye
- Department of Transdisciplinary Studies, Program in Biomedical Radiation Sciences, Seoul National University Graduate School of Convergence Science and Technology, Seoul, 151-742, Korea. .,Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea. .,Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea. .,Interdisciplinary Program in Radiation Applied Life Science, Seoul National University College of Medicine, Seoul, Korea. .,Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Korea.
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Chow JCL. Some computer graphical user interfaces in radiation therapy. World J Radiol 2016; 8:255-267. [PMID: 27027225 PMCID: PMC4807334 DOI: 10.4329/wjr.v8.i3.255] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/02/2015] [Revised: 11/06/2015] [Accepted: 01/07/2016] [Indexed: 02/06/2023] Open
Abstract
In this review, five graphical user interfaces (GUIs) used in radiation therapy practices and researches are introduced. They are: (1) the treatment time calculator, superficial X-ray treatment time calculator (SUPCALC) used in the superficial X-ray radiation therapy; (2) the monitor unit calculator, electron monitor unit calculator (EMUC) used in the electron radiation therapy; (3) the multileaf collimator machine file creator, sliding window intensity modulated radiotherapy (SWIMRT) used in generating fluence map for research and quality assurance in intensity modulated radiation therapy; (4) the treatment planning system, DOSCTP used in the calculation of 3D dose distribution using Monte Carlo simulation; and (5) the monitor unit calculator, photon beam monitor unit calculator (PMUC) used in photon beam radiation therapy. One common issue of these GUIs is that all user-friendly interfaces are linked to complex formulas and algorithms based on various theories, which do not have to be understood and noted by the user. In that case, user only needs to input the required information with help from graphical elements in order to produce desired results. SUPCALC is a superficial radiation treatment time calculator using the GUI technique to provide a convenient way for radiation therapist to calculate the treatment time, and keep a record for the skin cancer patient. EMUC is an electron monitor unit calculator for electron radiation therapy. Instead of doing hand calculation according to pre-determined dosimetric tables, clinical user needs only to input the required drawing of electron field in computer graphical file format, prescription dose, and beam parameters to EMUC to calculate the required monitor unit for the electron beam treatment. EMUC is based on a semi-experimental theory of sector-integration algorithm. SWIMRT is a multileaf collimator machine file creator to generate a fluence map produced by a medical linear accelerator. This machine file controls the multileaf collimator to deliver intensity modulated beams for a specific fluence map used in quality assurance or research. DOSCTP is a treatment planning system using the computed tomography images. Radiation beams (photon or electron) with different energies and field sizes produced by a linear accelerator can be placed in different positions to irradiate the tumour in the patient. DOSCTP is linked to a Monte Carlo simulation engine using the EGSnrc-based code, so that 3D dose distribution can be determined accurately for radiation therapy. Moreover, DOSCTP can be used for treatment planning of patient or small animal. PMUC is a GUI for calculation of the monitor unit based on the prescription dose of patient in photon beam radiation therapy. The calculation is based on dose corrections in changes of photon beam energy, treatment depth, field size, jaw position, beam axis, treatment distance and beam modifiers. All GUIs mentioned in this review were written either by the Microsoft Visual Basic.net or a MATLAB GUI development tool called GUIDE. In addition, all GUIs were verified and tested using measurements to ensure their accuracies were up to clinical acceptable levels for implementations.
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Parameterization of electron beam output factor. Phys Med 2015; 31:420-4. [PMID: 25726475 DOI: 10.1016/j.ejmp.2015.02.006] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/09/2014] [Revised: 02/03/2015] [Accepted: 02/06/2015] [Indexed: 11/22/2022] Open
Abstract
Electron beam dose distribution is dependent on the beam energy and complicated trajectory of particles. Recent treatment planning systems using Monte Carlo calculation algorithm provide accurate dose calculation. However, double check of monitor units (MUs) based on an independent algorithm is still required. In this study, we have demonstrated single equation that reproduces the measured relative output factor (ROF) that can be used for MU calculation for electron radiotherapy. Electron beams generated by an iX (Varian Medical Systems) and a PRIMUS (Siemens) accelerator were investigated. For various energies of electron beams, the ROF at respective dmax were measured using diode detector in a water phantom at SSD of 100 cm. Curve fitting was performed with an exponential generalized equation ROF = α(β - e(-γR)) including three variables (α, β, γ) as a function of field radius and electron energy. The correlation coefficients between the ROF measured and that calculated by the equation were greater than 0.998. For ROF of Varian electron beams, the average values of all fitting formulas were applied for two of the constants; α and β. The parameter γ showed good agreement with the quadratic approximation as a function of mean energy at surface (E0). The differences between measured and calculated ROF values were within ± 3% for beams with cutout radius of ≥ 1.5 cm for electron beams with energies from 6 MeV to 15 MeV. The proposed formula will be helpful for double-check of MUs, as it requires minimal efforts for MU calculation.
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Gajewski R. An enhanced sector integration model for output and dose distribution calculation of irregular concave shaped electron beams. Med Phys 2009; 36:2966-75. [PMID: 19673195 DOI: 10.1118/1.3148583] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/07/2023] Open
Abstract
A comprehensive method of output factor and dose distribution calculation for electron beams has been developed. It allows one to calculate the output factors and isodose distributions in water of arbitrary shaped electron fields with excellent accuracy even for the cases of concaved, small, elongated beams, and extended source to surface distances (SSDs). The method requires two sets of data: Depth dose distribution per monitor unit for circular cutouts and depth dose distributions per monitor unit for circular blocks (plugs), both for two SSDs, one reference of 100 cm and second extended one. The method has been extensively tested using a combination of different irregular cutouts and various SSDs for the 6 and 9 MeV electron beams. The calculated values agreed with the measured data well within 1% for output factors and below 1 for gamma (gamma test) for isodose distributions. The computer program has been developed to facilitate the method for practical application. The method has been used for almost 8 years considerably cutting workload in the department.
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Affiliation(s)
- Romuald Gajewski
- Department of Medical Physics, Sydney West Cancer Network, Westmead, New South Wales 2145, Australia.
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Chen J, Irion J, Faddegon BA. Validation of the final aperture superposition technique to calculate electron output factors and depth dose curves. Med Phys 2009; 36:3397-405. [DOI: 10.1118/1.3157104] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022] Open
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Dosimetric changes induced by positional uncertainty of cutout in electron radiotherapy. JOURNAL OF RADIOTHERAPY IN PRACTICE 2008. [DOI: 10.1017/s1460396908006353] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022]
Abstract
AbstractDosimetric changes caused by the positional uncertainty of centring a small electron cutout to the machine central beam axis (CAX) of the linear accelerator (linac) were investigated. First, six circular cutouts with 4 cm diameter were made with their centres shifted off from the machine CAX for 0, 2, 4, 6, 8 and 10 mm using the 6 × 6 cm2 applicator. Then, the percentage depth doses (PDDs) at the machine CAX and cutout centre were measured using the 4, 9 and 16 MeV clinical electron beams produced by a Varian 21 EX linac. The cross- and in-line axis beam profiles were measured at depth of maximum dose (dm) and source-to-surface distance equal to 100 cm using a scanning water tank system and diode detector. When the cutout centre was shifted away from machine CAX for the electron beam with low energy of 4 MeV, the dm, depths of the 80 (R80) and 90% (R90) depth dose at the machine CAX had no significant change (<0.1 mm). For higher energies of 9 and 16 MeV beams, the dm were reduced with 0.45 and 1.63 mm per mm off-axis shift between the cutout centre and the machine CAX, respectively. The R80 and R90 were reduced with 0.7 mm per mm off-axis shift for both energies. When there was a 4 mm off-axis shift, the relative output factors for the 4, 9 and 16 MeV beams were reduced with 0.8, 1.6 and 0.5%, respectively. The isodose coverage of the in-line axis beam profile was reduced when the cutout centre was shifted away from machine CAX. It is important for radiation oncologists, dosimetrists, therapists and physicists to note such dosimetric changes in the electron radiotherapy to the patient, because such positional uncertainty is unavoidable in fabricating an electron cutout in the mould room.
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Chow JCL, Grigorov GN. Electron radiotherapy: a study on dosimetric uncertainty using small cutouts. Phys Med Biol 2006; 52:N1-11. [PMID: 17183121 DOI: 10.1088/0031-9155/52/1/n01] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/11/2022]
Abstract
This note investigated the dosimetric uncertainties due to the positional error when centring a small cutout to the machine central beam axis (CAX) in electron radiotherapy. A group of six circular cutouts with 4 cm diameter were made with their centres shifting 0, 2, 4, 6, 8 and 10 mm from the machine CAX for the 6 x 6 cm(2) applicator. The per cent depth doses, beam profiles and output factors were measured using the 4, 9 and 16 MeV clinical electron beams produced by a Varian 21 EX linear accelerator. The 2D isodose distributions in the z-x (or cross-line) and z-y (or in-line) plane were calculated by Monte Carlo simulation using the EGSnrc system. When the cutout centre was shifted away from the machine CAX for the 4 MeV beam, the d(m), R(80) and R(90) at the machine CAX had no significant change (<0.1 mm). For higher energies of 9 and 16 MeV beams, the d(m) was reduced by 0.45 and 1.63 mm per mm, between the cutout centre and the machine CAX with off-axis shift <6 mm respectively. R(80) and R(90) were reduced by more than 0.3 mm per mm off-axis shift for both energies. The isodose coverage of the in-line axis beam profile was reduced when the cutout centre was shifted away from machine CAX. It is important for oncology staff to note such dosimetric changes in the clinical electron radiotherapy, particularly when a high energy electron beam is used for small cutout. Such positional uncertainty is unavoidable in fabricating an electron cutout in the mould room.
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Affiliation(s)
- James C L Chow
- Department of Radiation Oncology, University of Toronto and Radiation Medicine Program, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
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Chow JCL, Grigorov GN, MacGregor C. A graphical user interface for an electron monitor unit calculator using a sector-integration algorithm and exponential curve-fitting method. J Appl Clin Med Phys 2006. [PMID: 16518317 DOI: 10.1120/jacmp.2027.25371] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022] Open
Abstract
A new electron monitor unit (MU) calculator program called "eMUc" was developed to provide a convenient electron MU calculation platform for the physics and radiotherapy staff in electron radiotherapy. The program was written using the Microsoft Visual Basic.net framework and has a user-friendly front-end window with the following features: (1) Apart from using the well-known polynomial curvefitting method for the interpolation and extrapolation of relative output factors (ROFs), an exponential curve-fitting method was used to obtain better results. (2) A new algorithm was used to acquire the radius in each angular segment in the irregular electron field during the sector integration. (3) A comprehensive graphical user interface running on the Microsoft Windows operating system was used. (4) Importing irregular electron cutout field images to the calculator program was simplified by using only a commercial optical scanner. (5) Interlocks were provided when the input patient treatment parameters could not be handled by the calculator database accurately. (6) A patient treatment record could be printed out as an electronic file or hard copy and transferred to the patient database. The data acquisition mainly required ROF measurements using various circular cutouts for all the available electron energies and applicators for our Varian 21 EX linear accelerator. To verify and implement the calculator, the measured results using our specific designed irregular and clinical cutouts were compared to those predicted by the calculator. Both agreed well with an error of +/-2%.
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Affiliation(s)
- James C L Chow
- Medical Physics Department, Grand River Regional Cancer Center, Grand River Hospital, Kitchener, Ontario, Canada.
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Chow JCL, Grigorov GN, MacGregor C. A graphical user interface for an electron monitor unit calculator using a sector-integration algorithm and exponential curve-fitting method. J Appl Clin Med Phys 2006; 7:52-64. [PMID: 16518317 PMCID: PMC5722481 DOI: 10.1120/jacmp.v7i1.2183] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/28/2022] Open
Abstract
A new electron monitor unit (MU) calculator program called “eMUc” was developed to provide a convenient electron MU calculation platform for the physics and radiotherapy staff in electron radiotherapy. The program was written using the Microsoft Visual Basic.net framework and has a user‐friendly front‐end window with the following features: (1) Apart from using the well‐known polynomial curve‐fitting method for the interpolation and extrapolation of relative output factors (ROFs), an exponential curve‐fitting method was used to obtain better results. (2) A new algorithm was used to acquire the radius in each angular segment in the irregular electron field during the sector integration. (3) A comprehensive graphical user interface running on the Microsoft Windows operating system was used. (4) Importing irregular electron cutout field images to the calculator program was simplified by using only a commercial optical scanner. (5) Interlocks were provided when the input patient treatment parameters could not be handled by the calculator database accurately. (6) A patient treatment record could be printed out as an electronic file or hard copy and transferred to the patient database. The data acquisition mainly required ROF measurements using various circular cutouts for all the available electron energies and applicators for our Varian 21 EX linear accelerator. To verify and implement the calculator, the measured results using our specific designed irregular and clinical cutouts were compared to those predicted by the calculator. Both agreed well with an error of ±2%. PACS number(s): 87.53.Fs; 87.53.Hv; 87.66.‐a
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Affiliation(s)
- James C L Chow
- Medical Physics Department, Grand River Regional Cancer Center, Grand River Hospital, Kitchener, Ontario, Canada.
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Faddegon BA, Villarreal-Barajas JE. Final Aperture Superposition Technique applied to fast calculation of electron output factors and depth dose curves. Med Phys 2005; 32:3286-94. [PMID: 16370417 DOI: 10.1118/1.2068947] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022] Open
Abstract
The Final Aperture Superposition Technique (FAST) is described and applied to accurate, near instantaneous calculation of the relative output factor (ROF) and central axis percentage depth dose curve (PDD) for clinical electron beams used in radiotherapy. FAST is based on precalculation of dose at select points for the two extreme situations of a fully open final aperture and a final aperture with no opening (fully shielded). This technique is different than conventional superposition of dose deposition kernels: The precalculated dose is differential in position of the electron or photon at the downstream surface of the insert. The calculation for a particular aperture (x-ray jaws or MLC, insert in electron applicator) is done with superposition of the precalculated dose data, using the open field data over the open part of the aperture and the fully shielded data over the remainder. The calculation takes explicit account of all interactions in the shielded region of the aperture except the collimator effect: Particles that pass from the open part into the shielded part, or visa versa. For the clinical demonstration, FAST was compared to full Monte Carlo simulation of 10 x 10, 2.5 x 2.5, and 2 x 8 cm2 inserts. Dose was calculated to 0.5% precision in 0.4 x 0.4 x 0.2 cm3 voxels, spaced at 0.2 cm depth intervals along the central axis, using detailed Monte Carlo simulation of the treatment head of a commercial linear accelerator for six different electron beams with energies of 6-21 MeV. Each simulation took several hours on a personal computer with a 1.7 Mhz processor. The calculation for the individual inserts, done with superposition, was completed in under a second on the same PC. Since simulations for the pre calculation are only performed once, higher precision and resolution can be obtained without increasing the calculation time for individual inserts. Fully shielded contributions were largest for small fields and high beam energy, at the surface, reaching a maximum of 5.6% at 21 MeV. Contributions from the collimator effect were largest for the large field size, high beam energy, and shallow depths, reaching a maximum of 4.7% at 21 MeV. Both shielding contributions and the collimator effect need to be taken into account to achieve an accuracy of 2%. FAST takes explicit account of the shielding contributions. With the collimator effect set to that of the largest field in the FAST calculation, the difference in dose on the central axis (product of ROF and PDD) between FAST and full simulation was generally under 2%. The maximum difference of 2.5% exceeded the statistical precision of the calculation by four standard deviations. This occurred at 18 MeV for the 2.5 x 2.5 cm2 field. The differences are due to the method used to account for the collimator effect.
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Affiliation(s)
- B A Faddegon
- Department of Radiation Oncology, UCSF, San Francisco, California 94143-1708, USA.
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Björk P, Knöös T, Nilsson P. Measurements of output factors with different detector types and Monte Carlo calculations of stopping-power ratios for degraded electron beams. Phys Med Biol 2004; 49:4493-506. [PMID: 15552413 DOI: 10.1088/0031-9155/49/19/004] [Citation(s) in RCA: 25] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/11/2022]
Abstract
The aim of the present study was to investigate three different detector types (a parallel-plate ionization chamber, a p-type silicon diode and a diamond detector) with regard to output factor measurements in degraded electron beams, such as those encountered in small-electron-field radiotherapy and intraoperative radiation therapy (IORT). The Monte Carlo method was used to calculate mass collision stopping-power ratios between water and the different detector materials for these complex electron beams (nominal energies of 6, 12 and 20 MeV). The diamond detector was shown to exhibit excellent properties for output factor measurements in degraded beams and was therefore used as a reference. The diode detector was found to be well suited for practical measurements of output factors, although the water-to-silicon stopping-power ratio was shown to vary slightly with treatment set-up and irradiation depth (especially for lower electron energies). Application of ionization-chamber-based dosimetry, according to international dosimetry protocols, will introduce uncertainties smaller than 0.3% into the output factor determination for conventional IORT beams if the variation of the water-to-air stopping-power ratio is not taken into account. The IORT system at our department includes a 0.3 cm thin plastic scatterer inside the therapeutic beam, which furthermore increases the energy degradation of the electrons. By ignoring the change in the water-to-air stopping-power ratio due to this scatterer, the output factor could be underestimated by up to 1.3%. This was verified by the measurements. In small-electron-beam dosimetry, the water-to-air stopping-power ratio variation with field size could mostly be ignored. For fields with flat lateral dose profiles (>3 x 3 cm2), output factors determined with the ionization chamber were found to be in close agreement with the results of the diamond detector. For smaller field sizes the lateral extension of the ionization chamber hampers its use. We therefore recommend that the readily available silicon diode detector should be used for output factor measurements in complex electron fields.
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Affiliation(s)
- Peter Björk
- Department of Radiation Physics, Lund University Hospital, Lund, Sweden.
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Turian JV, Smith BD, Bernard DA, Griem KL, Chu JC. Monte Carlo calculations of output factors for clinically shaped electron fields. J Appl Clin Med Phys 2004; 5:42-63. [PMID: 15738912 PMCID: PMC5723462 DOI: 10.1120/jacmp.v5i2.1976] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022] Open
Abstract
We report on the use of the EGS4/BEAM Monte Carlo technique to predict the output factors for clinically relevant, irregularly shaped inserts as they intercept a linear accelerator's electron beams. The output factor for a particular combination—energy, cone, insert, and source‐to‐surface distance (SSD)—is defined in accordance with AAPM TG‐25 as the product of cone correction factor and insert correction factor, evaluated at the depth of maximum dose. Since cone correction factors are easily obtained, we focus our investigation on the insert correction factors (ICFs). An analysis of the inserts used in routine clinical practice resulted in the identification of a set of seven “idealized” shapes characterized by specific parameters. The ICFs for these shapes were calculated using a Monte Carlo method (EGS4/BEAM) and measured for a subset of them using an ion chamber and well‐established measurement methods. Analytical models were developed to predict the Monte Carlo–calculated ICF values for various electron energies, cone sizes, shapes, and SSDs. The goodness‐of‐fit between predicted and Monte Carlo–calculated ICF values was tested using the Kolmogorov–Smirnoff statistical test. Results show that Monte Carlo–calculated ICFs match the measured values within 2.0% for most of the shapes considered, except for few highly elongated fields, where deviations up to 4.0% were recorded. Predicted values based on analytical modeling agree with measured ICF values within 2% to 3% for all configurations. We conclude that the predicted ICF values based on modeling of Monte Carlo–calculated values could be introduced in clinical use. PACS numbers: 87.53.Wz, 87.53.Hv
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Affiliation(s)
- Julius V Turian
- Department of Radiation Oncology, University of Illinois Medical Center, OCC C-400, 1801 W. Taylor Street, Chicago, Illinois 60612, USA.
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Chow JCL, Wong E, Chen JZ, Van Dyk J. Comparison of dose calculation algorithms with Monte Carlo methods for photon arcs. Med Phys 2003; 30:2686-94. [PMID: 14596305 DOI: 10.1118/1.1601331] [Citation(s) in RCA: 29] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022] Open
Abstract
The objective of this study is to seek an accurate and efficient method to calculate the dose distribution of a photon arc. The algorithms tested include Monte Carlo, pencil beam kernel (PK), and collapsed cone convolution (CCC). For the Monte Carlo dose calculation, EGS4/DOSXYZ was used. The SRCXYZ source code associated with the DOSXYZ was modified so that the gantry angle of a photon beam would be sampled uniformly within the arc range about an isocenter to simulate a photon arc. Specifically, photon beams (6/18 MV, 4 x 4 and 10 x 10 cm2) described by a phase space file generated by BEAM (MCPHS), or by two point sources with different photon energy spectra (MCDIV) were used. These methods were used to calculate three-dimensional (3-D) distributions in a PMMA phantom, a cylindrical water phantom, and a phantom with lung inhomogeneity. A commercial treatment planning system was also used to calculate dose distributions in these phantoms using equivalent tissue air ratio (ETAR), PK and CCC algorithms for inhomogeneity corrections. Dose distributions for a photon arc in these phantoms were measured using a RK ion chamber and radiographic films. For homogeneous phantoms, the measured results agreed well (approximately 2% error) with predictions by the Monte Carlo simulations (MCPHS and MCDIV) and the treatment planning system for the 180 degrees and 360 degrees photon arcs. For the dose distribution in the phantom with lung inhomogeneity with a 90 degrees photon arc, the Monte Carlo calculations agreed with the measurements within 2%, while the treatment planning system using ETAR, PK and CCC underestimated or overestimated the dose inside the lung inhomogeneity from 6% to 12%.
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Affiliation(s)
- James C L Chow
- Department of Physics, London Regional Cancer Center, 790 Commissioners Road East, London, ON N6A 4L6, Canada.
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16
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van Battum LJ, van der Zee W, Huizenga H. Scattered radiation from applicators in clinical electron beams. Phys Med Biol 2003; 48:2493-507. [PMID: 12953911 DOI: 10.1088/0031-9155/48/15/316] [Citation(s) in RCA: 21] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/07/2023]
Abstract
In radiotherapy with high-energy (4-25 MeV) electron beams, scattered radiation from the electron applicator influences the dose distribution in the patient. In most currently available treatment planning systems for radiotherapy this component is not explicitly included and handled only by a slight change of the intensity of the primary beam. The scattered radiation from an applicator changes with the field size and distance from the applicator. The amount of scattered radiation is dependent on the applicator design and on the formation of the electron beam in the treatment head. Electron applicators currently applied in most treatment machines are essentially a set of diaphragms, but still do produce scattered radiation. This paper investigates the present level of scattered dose from electron applicators, and as such provides an extensive set of measured data. The data provided could for instance serve as example input data or benchmark data for advanced treatment planning algorithms which employ a parametrized initial phase space to characterize the clinical electron beam. Central axis depth dose curves of the electron beams have been measured with and without applicators in place, for various applicator sizes and energies, for a Siemens Primus, a Varian 2300 C/D and an Elekta SLi accelerator. Scattered radiation generated by the applicator has been found by subtraction of the central axis depth dose curves, obtained with and without applicator. Scattered radiation from Siemens, Varian and Elekta electron applicators is still significant and cannot be neglected in advanced treatment planning. Scattered radiation at the surface of a water phantom can be as high as 12%. Scattered radiation decreases almost linearly with depth. Scattered radiation from Varian applicators shows clear dependence on beam energy. The Elekta applicators produce less scattered radiation than those of Varian and Siemens, but feature a higher effective angular variance. The scattered radiation decreases somewhat with increasing field size and is spread uniformly over the aperture. Experimental results comply with the results of simulations of the treatment head and electron applicator, using the BEAM Monte Carlo code, and Siemens, but feature a higher effective angular variance. The scattered radiation decreases somewhat with increasing field size and is spread uniformly over the aperture. Experimental results comply with the results of simulations of the treatment head and electron applicator, using the BEAM Monte Carlo code.
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Affiliation(s)
- L J van Battum
- Erasmus MC-Daniel den Hoed Cancer Center, Department of Radiotherapy, Subdivision Clinical Physics, PO Box 5201, 3008 AE Rotterdam, The Netherlands.
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Choi DR, Mobit PN, Breitman KE. The clinical implementation of a method for calculating the output factor and per cent depth dose for an electron beam. Phys Med Biol 2003; 48:899-908. [PMID: 12701894 DOI: 10.1088/0031-9155/48/7/307] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/11/2022]
Abstract
A modified sector-integration method has been developed that predicts electron beam output factor at any point on the beam central axis, for a given source to surface distance (SSD), as a function of the geometry of the irradiated field. The main concept of this method is that with the arbitrary field shape divided into small sectors, the individual contributions from each sector can be calculated based on the sector radius, using a dataset consisting of circular inserts of standard radii. A computer program was developed based on this algorithm. The program interfaces to a digital camera that is used to capture the shape of the electron insert. We compared the calculated and the measured output factors and per cent depth doses (PDDs) at different SSDs for various rectangular inserts and a typical irregularly shaped insert used in our clinic. To determine the geometric limitations of this algorithm, a series of rectangular inserts were designed with the long-to-short axis ratio between 1:1 and 7:1. The agreement between calculation and measurement for the electron output and PDD was generally within 2% (or 2 mm) for energies from 6 to 20 MeV.
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Affiliation(s)
- David R Choi
- Department of Oncology, University of Calgary, Alberta, Canada T2N 4N2.
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Chengjun G, Zhangwen W, Zhengming L, Jette D. Three-dimensional electron dose calculation using an improved hybrid pencil beam model. Med Phys 2003; 30:415-23. [PMID: 12674242 DOI: 10.1118/1.1538234] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022] Open
Abstract
An improved hybrid-pencil beam model (HPBM) for electron-beam three-dimensional dose calculation has been studied. The model is based on the fact that away from the edges of a large field, the electron distribution function exactly equals that for an infinitely wide electron beam. In the present model, we use the bipartition model to calculate the longitudinal part of the pencil-beam distribution function, and Fermi-Eyges multiple-scattering theory to calculate its transverse part. In order to describe the electron beam characteristics accurately, we introduce a new parameter, which is extracted from measured profile data near the surface of a water phantom, to correct the transverse distribution determined by the Fermi-Eyges theory. Furthermore, we introduce an effective energy spectrum to describe the effect on the collimated electron beam of the accelerator head. The dose distributions calculated with the improved HPBM were compared with the experimental data, and the agreement was within 1% in most of cases. This preliminary study has demonstrated the potential for use of the model in the clinical therapy.
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Affiliation(s)
- Gou Chengjun
- Key Lab for Radiation Physics & Technology of the Education Ministry of China, Institute of Nuclear and Technology, Sichuan University, Chengdu, 610065, People's Republic of China
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Ravindran BP, Singh IRR, Brindha S, Sathyan S. Manual multi-leaf collimator for electron beam shaping--a feasibility study. Phys Med Biol 2002; 47:4389-96. [PMID: 12539979 DOI: 10.1088/0031-9155/47/24/306] [Citation(s) in RCA: 27] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/28/2022]
Abstract
In electron beam therapy, lead or low melting point alloy (LMA) sheet cutouts of sufficient thickness are commonly used to shape the beam. In order to avoid making cutouts for each patient, an attempt has been made to develop a manual multi-leaf collimator for electron beams (eMLC). The eMLC has been developed using LMA for a 15 x 15 cm2 applicator. Electron beam characteristics such as depth dose, beam profiles, surface dose, output factors and virtual source position with the eMLC have been studied and compared with those of an applicator electron beam. The interleaf leakage radiation has also been measured with film dosimetry. Depth dose values obtained using the eMLC were found to be identical to those with the applicator for depths larger than Dmax. However, a decrease in the size of the beam penumbra with the eMLC and increase in the values of surface dose, output factors and virtual source position with eMLC were observed. The leakage between the leaves was less than 5% and the leakage between the opposing leaves was 15%, which could be minimized further by careful positioning of the leaves. It is observed that it is feasible to use such a manual eMLC for patients and eliminate the fabrication of cutouts for each patient.
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Affiliation(s)
- B Paul Ravindran
- Department of Radiation Oncology, CMC Hospital, Vellore 632 004, India.
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