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Ralston MR, McCreath G, Lees ZJ, Salt IP, Sim MA, Watson MJ, Freeman DJ. Beyond body mass index: exploring the role of visceral adipose tissue in intensive care unit outcomes. BJA OPEN 2025; 14:100391. [PMID: 40223920 PMCID: PMC11986990 DOI: 10.1016/j.bjao.2025.100391] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 06/20/2024] [Accepted: 02/11/2025] [Indexed: 04/15/2025]
Abstract
Obesity is a worldwide health crisis and poses significant challenges in critical care. Many studies suggest an 'obesity paradox', in which obesity, defined by body mass index (BMI), is associated with better outcomes. However, the inability of BMI to discriminate between fat and muscle or between visceral adipose tissue and subcutaneous adipose tissue, limits its prediction of metabolic ill health. We suggest that the 'obesity paradox' may be more reflective of the limitations of BMI than the protective effect of obesity. We explore the biological processes leading to visceral fat accumulation, and the evidence linking it to outcomes in critical illness. In the 'spillover' hypothesis of adipose tissue expansion, caloric excess and impaired expansion of storage capacity in the subcutaneous adipose tissue lead to accumulation of visceral adipose tissue. This is associated with a chronic inflammatory state, which is integral to the link between visceral adiposity, type 2 diabetes mellitus, and ischaemic heart disease. We review the current evidence on visceral adiposity and critical illness outcomes. In COVID-19, increased visceral adipose tissue, irrespective of BMI, is associated with more severe disease. This is mirrored in acute pancreatitis, suggesting visceral adiposity is linked to poorer outcomes in some hyperinflammatory conditions. We suggest that visceral adiposity's chronic inflammatory state may potentiate acute inflammation in conditions such as COVID-19 and acute pancreatitis. Further work is required to investigate other critical illnesses, especially sepsis and acute respiratory distress syndrome, in which current evidence is scarce. This may give further insights into pathophysiology and inform tailored treatment and nutrition strategies based on body fat distribution.
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Affiliation(s)
- Maximilian R. Ralston
- School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
- Academic Unit of Anaesthesia, Critical Care & Perioperative Medicine, University of Glasgow, Glasgow, UK
| | - Gordan McCreath
- Academic Unit of Anaesthesia, Critical Care & Perioperative Medicine, University of Glasgow, Glasgow, UK
| | - Zoe J. Lees
- School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
| | - Ian P. Salt
- School of Molecular Biosciences, University of Glasgow, Glasgow, UK
| | - Malcolm A.B. Sim
- Academic Unit of Anaesthesia, Critical Care & Perioperative Medicine, University of Glasgow, Glasgow, UK
- Department of Critical Care, Queen Elizabeth University Hospital, Glasgow, UK
| | - Malcolm J. Watson
- School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, UK
- Department of Anaesthesia, Queen Elizabeth University Hospital, Glasgow, UK
| | - Dilys J. Freeman
- School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK
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Drenjančević I, Prošić I, Firi L, Stupin A, Jukić I. Dietary Habits, Anthropometric Values, and Microvascular Reactivity in Older Persons of Both Sexes Living at Retirement Home in Osijek, Croatia. Clin Interv Aging 2025; 20:625-638. [PMID: 40417052 PMCID: PMC12101452 DOI: 10.2147/cia.s514573] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/20/2025] [Accepted: 05/14/2025] [Indexed: 05/27/2025] Open
Abstract
Purpose To examine the correlation between dietary habits, anthropometric measurements, and microvascular reactivity with respect to sex in older adults (aged > 65 years) residing in organized accommodation within retirement homes. Patients and Methods Sixty-nine older persons who live in a retirement home in Osijek, Croatia volunteered to participate (34 men and 35 women) in this observational cross-sectional study. Study was performed in the period from May 1, 2024 to July 1, 2024. Subjects weight, height, waist circumference, hip circumference, blood pressure and heart rate were measured, and body mass index (BMI) and waist to hip ratio (WHR) were calculated. To assess microvascular endothelium-dependent vasodilation, skin microvascular post-occlusion reactive hyperemia (PORH) was assessed by Laser Doppler Flowmetry. Long-term dietary patterns and dietary habits were evaluated with validated EPIC-Norfolk food frequency questionnaire, in Croatian language. Study was approved by Ethical Committee of Faculty of Medicine Osijek (Class: 641-01/24-01/04, No: 2158-61-46-24-86). Results Mean age (standard deviation, SD) of 34 older men was 83.8 (5.4) years, and of 34 older women 83.6 (5.5) years. The mean BMI of all subjects was 27.1 kg/m2 classifying them as overweight. Both men (WHR 0.99 (0.07)) and women (WHR 0.90 (0.06) had significantly higher than normal WHR (normal WHR, men <0.90, women <0.80), suggesting the visceral type of obesity. The mean intake of NaCl was higher (NaCl g/day men 6.91 (1.43), women 6.93 (2.51)), and intake of vitamin D lower (vitamin D µg/day men 3.64 (1.35), women 3.47 (2.61)) than recommended values (NaCl g/day <5 g/day, vitamin D 15 µg/day). Men consumed significantly more alcohol (alcohol g/day men 1.48 (3.36) vs women 0.17 (0.39), P = 0.03), while women had higher carotene intake (β-carotene, µg/day men 2603 (1020) vs women 3478 (1580), P = 0.009). Microvascular reactivity was similar in women and men (PORH, R-O% men 85.2 (30.6) vs women 76.2 (31.5), P > 0.05). However, women had a significant negative correlation of waist circumference (R = -0.350, P =0.04) and WHR (R = -0.406, P = 0.02) to PORH. Conclusion Dietary habits were similar between older men and women, except for higher alcohol intake in men and higher carotene intake in women. In older women, microvascular reactivity was negatively associated with waist circumference and WHR, underscoring central obesity as a key cardiovascular risk factor in this population. Given the increased cardiometabolic vulnerability in postmenopausal women, measures of central adiposity should be routinely monitored in geriatric care.
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Affiliation(s)
- Ines Drenjančević
- Department of Physiology and Immunology, Faculty of Medicine Osijek, Osijek, Croatia
| | - Ivan Prošić
- Department of Physiology and Immunology, Faculty of Medicine Osijek, Osijek, Croatia
| | - Lucija Firi
- Department of Physiology and Immunology, Faculty of Medicine Osijek, Osijek, Croatia
| | - Ana Stupin
- Department of Physiology and Immunology, Faculty of Medicine Osijek, Osijek, Croatia
| | - Ivana Jukić
- Department of Physiology and Immunology, Faculty of Medicine Osijek, Osijek, Croatia
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Lang L, Zuo L, Dou K, Fan J, Li D, Tang Y, Ji W, Yu D. The optimal slice to quantify the volumes of subcutaneous adipose tissue and skeletal muscle on chest computed tomography as imaging marker for body composition estimation. Postgrad Med J 2025:qgaf076. [PMID: 40366758 DOI: 10.1093/postmj/qgaf076] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2024] [Revised: 04/10/2025] [Accepted: 04/29/2025] [Indexed: 05/16/2025]
Abstract
BACKGROUND/OBJECTIVES This study aims to identify the optimal anatomical site that best predicts the total thoracic subcutaneous adipose tissue (SAT) and skeletal muscle (SM) volumes on chest computed tomography (CT), and to evaluate the relationships between SAT and SM areas at optimal slice and lung function. SUBJECTS/METHODS Healthy participants and chronic obstructive pulmonary disease (COPD) patients undergoing chest CT between January 2022 and April 2023 were retrospectively included. On chest CT, cross-sectional areas of SAT and SM at 14 specific anatomical levels, and thoracic SAT and SM volumes were measured using 3D Slicer software. Correlations were calculated by Spearman's correlation coefficients. RESULTS About 58 healthy participants and 68 COPD patients were included. In healthy participants, the T4 SAT area correlated most strongly with thoracic SAT volume (r = 0.888, P < 0.01), and the aortic arch SM area with SM volume (r = 0.941, P < 0.01). The combined Spearman's correlation coefficients reached their highest sum (1.816) at the aortic arch level. In COPD patients, correlations were identified between SAT area at the aortic arch slice with forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC) (r = 0.472, P < 0.001), while SM area with both FEV1(r = 0.431, P < 0.001) and FVC (r = 0.522, P < 0.001). CONCLUSION Considering measurement simplicity and accuracy, the aortic arch slice was identified as the optimal single slice for predicting total thoracic SAT and SM volumes. Additionally, the clinical significance of SAT and SM area at this slice was verified with lung function in COPD patients. Key messages What is already known on this topic: Specific abdominal slices have been shown to estimate abdominal volumes accurately, while the optimal slice to predict thoracic volumes is uncertain. What this study adds: To identify the optimal slice for simultaneously predicting both thoracic SAT and SM volumes. How this study might affect research, practice or policy: The optimal slice in the chest for measurement is crucial for advancing research on thoracic SAT and SM.
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Affiliation(s)
- Linlin Lang
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Liping Zuo
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Kai Dou
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Jinlei Fan
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Donglai Li
- Department of Emergency Medicine, Qilu Hospital of Shandong University, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, No. 107, Wenhua West Road, Jinan, Shandong, 250014, China
| | - Yuqing Tang
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Weiwei Ji
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
| | - Dexin Yu
- Department of Radiology, Qilu Hospital of Shandong University, No. 107, Wenhua West Road, Jinan, Shandong, 250012, China
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Lubogo D, Wamani H, Mayega RW, Orach CG. Optimal waist circumference cut-off points for predicting metabolic syndrome among females of reproductive age in Wakiso district, central Uganda. PLOS GLOBAL PUBLIC HEALTH 2025; 5:e0003059. [PMID: 40202967 PMCID: PMC11981207 DOI: 10.1371/journal.pgph.0003059] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/08/2024] [Accepted: 03/04/2025] [Indexed: 04/11/2025]
Abstract
Metabolic syndrome (MetS) poses a significant challenge to global public health, due to its strong association with Type 2 diabetes and cardiovascular disease. Waist circumference (WC) is a convenient metric for diagnosing MetS. Our study sought to establish waist circumference cut-off points that predict MetS among females of reproductive age in Wakiso district, central Uganda.The data collected were from a cross-sectional study conducted in Wakiso district, central Uganda, involving 697 randomly selected females aged 15 to 49, between 9th June 2021 and 17th August 2021. Data included MetS components: WC, High-Density Lipoprotein (HDL) Cholesterol, triglycerides, blood pressure, and fasting blood glucose. MetS status was identified based on two or more MetS components excluding WC. ROC analysis established the average optimal WC. The accuracy and performance of the cut-off points were evaluated through sensitivity, specificity, positive likelihood ratio, and the Youden Index. Of the 634 participants who were aged 18-49 years, 51.4% had two or more MetS risk factors. Their average optimal WC threshold was 80.3 cm. Variations in optimal WC thresholds were observed across different age groups: 80.4 cm (18-24 years), 79.9 cm (25-34 years), 85.6 cm (35-44 years), and 91.1 cm (45-49 years) respectively. The area under the ROC curve at the cut point for these age groups ranged from 0.78 to 0.86, indicating good discriminatory capability. The sensitivity ranged from 85% to 97%, specificity from 58% to 88%, and the Youden Index from 0.557 to 0.729. A waist circumference of 80.3 cm was the optimal threshold for identifying metabolic syndrome in females between the ages of 18 and 49 years in the setting. This finding concurs with the guidance set forth by the International Diabetes Federation. Additionally, study participants' WC cut-offs varied, ranging from 79.9 cm to 91.1 cm, depending on their age.
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Affiliation(s)
- David Lubogo
- Department of Community Health and Behavioural Sciences, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda
| | - Henry Wamani
- Department of Community Health and Behavioural Sciences, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda
| | - Roy William Mayega
- Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda
| | - Christopher Garimoi Orach
- Department of Community Health and Behavioural Sciences, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda
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Ma X, Jiang X, Gao G, Ban B, Sheng J, Shi S, Zhao H, Ji B. Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes 2025; 18:1025-1034. [PMID: 40201233 PMCID: PMC11977559 DOI: 10.2147/dmso.s506490] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/14/2024] [Accepted: 03/24/2025] [Indexed: 04/10/2025] Open
Abstract
Background Several lipid metabolism-related profiles have been explored for their association with obesity, but no consensus has been reached. Therefore, this study aimed to comprehensively analyze the correlation between conventional and unconventional lipid profiles and visceral fat area (VFA) in overweight/obese patients with type 2 diabetes mellitus (T2DM). Emphasizing the overall relationship between lipid metabolism and visceral fat accumulation. Methods This cross-sectional study included 1288 overweight/obese T2DM patients, with VFA measured using bioelectrical impedance analysis and visceral fat obesity (VFO) was defined as VFA ≥ 100 cm². Both conventional lipid profiles include total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and lipoprotein(a), and unconventional lipid profiles include lipid composite index (LCI), platelet/ HDL-c ratio (PHR), remnant cholesterol (RC), TG/HDL-c, Castelli Risk Index I (CRI-I), Castelli Risk Index II (CRI-II), Non-HDL-c, atherogenic index of plasma (AIP) and atherogenic coefficient (AC) were analyzed. The study population was divided into non-VFO and VFO groups, The relationship between conventional and unconventional lipid profiles and VFO was evaluated. Results Compared to the non-VFO group, the VFO group exhibited significantly higher levels of TG, lipoprotein(a), LCI, RC, TG/HDL-c, CRI-I, CRI-II, AIP, and AC (all P < 0.05). Univariate analysis revealed that RC, TG, LCI, TG/HDL-c, CRI-I, CRI-II, AIP, and AC were positively correlated with VFA and VFO, while HDL-c and lipoprotein(a) were negatively correlated (all P < 0.05). Logistic regression identified RC as an independent risk factor for VFO (OR: 1.667, 95% CI: 1.216-2.285, P = 0.001). Conclusion Among lipid profiles, RC is independently and significantly associated with VFO, underscoring its role in lipid metabolism and abdominal obesity management, especially in overweight/obese T2DM patients.
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Affiliation(s)
- Xuan Ma
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
| | - Xinghe Jiang
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China
| | - Guanqi Gao
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
| | - Bo Ban
- Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China
| | - Jie Sheng
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
| | - Shuwei Shi
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
| | - Hongyan Zhao
- School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
| | - Baolan Ji
- Department of Endocrinology, Linyi People’s Hospital Affiliated to Shandong Second Medical University, Linyi, Shandong, 276034, People’s Republic of China
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Bibi S, Naeem M, Schipf S, Bahls M, Dörr M, Friedrich N, Nauck M, Bülow R, Völzke H, Markus MRP, Ittermann T. Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers-Results from the study of health in Pomerania. Eur J Clin Invest 2025; 55:e70005. [PMID: 39921528 PMCID: PMC11891827 DOI: 10.1111/eci.70005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/14/2024] [Accepted: 01/27/2025] [Indexed: 02/10/2025]
Abstract
BACKGROUND AND AIMS Evidence links body composition and inflammatory markers with type 2 diabetes (T2D). However, the comparative analysis of body composition markers derived from different modalities and inflammatory markers in relation to T2D remains unexplored. This study aims to evaluate and compare the association of body composition and inflammatory markers with T2D. METHODS We included 4043 participants (2081 female, 51.4%) aged 20-84 enrolled in the population-based Study of Health in Pomerania. Multivariable logistic regression models adjusted for confounding were used to analyse associations of standardized body composition markers derived from classic anthropometry, bioelectrical impedance analysis, magnetic resonance imaging as well as inflammatory markers C-reactive protein, white blood cell count, fibrinogen, ferritin and CRP-to-albumin ratio with prevalent T2D. RESULTS Body composition markers were more strongly associated with T2D than inflammatory markers. Waist circumference exhibited the strongest association with T2D (female: odds ratio (OR) = 2.55; 95% confidence interval [CI]: 2.17-3.00; male: OR = 2.20; 95% CI: 1.86-2.60). Similarly, body weight (female: 2.07; 1.78-2.41; male: OR = 1.99; 95% CI = 1.71-2.31), waist-to-height ratio (female: OR = 2.39; 95% CI = 2.05-2.77; male: 2.28; 1.92-2.70) and visceral adipose tissue (female: 3.02; 95% CI = 2.11-4.32; male: 1.50; 1.19-1.89) showed strong associations with T2D. Among inflammatory markers, white blood cell count in male and CRP-to-albumin ratio in female exhibit the strongest association with T2D. CONCLUSIONS Body composition markers seem to be more tightly associated with prevalent T2D compared to inflammatory markers.
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Affiliation(s)
- Saima Bibi
- Institute for Community Medicine – Department SHIP/ Clinical‐Epidemiological ResearchUniversity Medicine GreifswaldGreifswaldGermany
| | - Muhammad Naeem
- Institute for Community Medicine – Department SHIP/ Clinical‐Epidemiological ResearchUniversity Medicine GreifswaldGreifswaldGermany
- Department of ZoologyUniversity of MalakandChakdara Dir (L)Pakistan
| | - Sabine Schipf
- Institute for Community Medicine – Department SHIP/ Clinical‐Epidemiological ResearchUniversity Medicine GreifswaldGreifswaldGermany
- German Center for Diabetes Research (DZD) Partner Site GreifswaldGreifswaldGermany
| | - Martin Bahls
- Department of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious DiseasesUniversity Medicine GreifswaldGreifswaldGermany
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
| | - Marcus Dörr
- Department of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious DiseasesUniversity Medicine GreifswaldGreifswaldGermany
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
| | - Nele Friedrich
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
- Institute of Clinical Chemistry and Laboratory MedicineUniversity Medicine GreifswaldGreifswaldGermany
| | - Matthias Nauck
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
- Institute of Clinical Chemistry and Laboratory MedicineUniversity Medicine GreifswaldGreifswaldGermany
| | - Robin Bülow
- Institute for Radiology and NeuroradiologyUniversity Medicine GreifswaldGreifswaldGermany
| | - Henry Völzke
- Institute for Community Medicine – Department SHIP/ Clinical‐Epidemiological ResearchUniversity Medicine GreifswaldGreifswaldGermany
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
| | - Marcello Ricardo Paulista Markus
- German Center for Diabetes Research (DZD) Partner Site GreifswaldGreifswaldGermany
- Department of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious DiseasesUniversity Medicine GreifswaldGreifswaldGermany
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
| | - Till Ittermann
- Institute for Community Medicine – Department SHIP/ Clinical‐Epidemiological ResearchUniversity Medicine GreifswaldGreifswaldGermany
- German Centre for Cardiovascular Research (DZHK), Partner Site GreifswaldGreifswaldGermany
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Huang L, Liao J, Lu C, Yin Y, Ma Y, Wen Y. The non-linear relationship between the visceral adiposity index and the risk of prediabetes and diabetes. Front Endocrinol (Lausanne) 2025; 16:1407873. [PMID: 40190401 PMCID: PMC11968367 DOI: 10.3389/fendo.2025.1407873] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/27/2024] [Accepted: 02/28/2025] [Indexed: 04/09/2025] Open
Abstract
Background The visceral adiposity index is a valuable tool for assessing visceral fat accumulation. However, its non-linear association with prediabetes and diabetes requires further elucidation. Therefore, we aim to clarify the intricate interplay between the visceral adiposity index and these dysglycemic conditions. Methods The National Health and Nutrition Examination Survey database from 1999 to 2018 was utilized to analyze health data from 24,072 participants. A multivariate logistic regression model was employed to evaluate the independent association between the visceral adiposity index and prediabetes and diabetes while considering potential confounding factors. Generalized additive models were used to identify any non-linear relationships by fitting smooth curves. Additionally, a stratified analysis based on different baseline characteristics was conducted, along with an interactive analysis. Results After accounting for all relevant variables, individuals in the lowest quartile of the visceral adiposity index had a notably diminished likelihood of progressing to prediabetes and diabetes when compared with those in the other three quartiles. The odds ratios and 95% confidence intervals were as follows: 1.37 (1.23, 1.53), 1.87 (1.65, 2.12), and 2.80 (2.33, 3.37). More importantly, a non-linear association was observed between the visceral adiposity index and prediabetes and diabetes, with a threshold identified at 2.10. Conclusions There exists a notable and positive association between the visceral adiposity index and prediabetes and diabetes, displaying non-linear attributes in this evaluation of the relationship. Risk assessment and early prevention strategies targeting the maintenance of low levels of visceral adiposity index may substantially diminish the likelihood of developing prediabetes and diabetes.
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Affiliation(s)
| | | | | | | | | | - Yue Wen
- Division of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China
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Liu MJ, Pei JY, Zeng C, Xing Y, Zhang YF, Tang PQ, Deng SM, Hu XQ. Triglyceride-glucose related indices as predictors for major adverse cardiovascular events and overall mortality in type-2 diabetes mellitus patients. World J Diabetes 2025; 16:101488. [PMID: 40093282 PMCID: PMC11885977 DOI: 10.4239/wjd.v16.i3.101488] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Revised: 11/05/2024] [Accepted: 12/26/2024] [Indexed: 01/21/2025] Open
Abstract
BACKGROUND Recent studies have indicated that triglyceride glucose (TyG)-waist height ratio (WHtR) and TyG-waist circumference (TyG-WC) are effective indicators for evaluating insulin resistance. However, research on the association in TyG-WHtR, TyG-WC, and the risk and prognosis of major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus (T2DM) cases are limited. AIM To clarify the relation in TyG-WHtR, TyG-WC, and the risk of MACEs and overall mortality in T2DM patients. METHODS Information for this investigation was obtained from Action to Control Cardiovascular Risk in Diabetes (ACCORD)/ACCORD Follow-On (ACCORDION) study database. The Cox regression model was applied to assess the relation among TyG-WHtR, TyG-WC and future MACEs risk and overall mortality in T2DM cases. The RCS analysis was utilized to explore the nonlinear correlation. Subgroup and interaction analyses were conducted to prove the robustness. The receiver operating characteristic curves were applied to analysis the additional predicting value of TyG-WHtR and TyG-WC. RESULTS After full adjustment for confounding variables, the highest baseline TyG-WHtR cohort respectively exhibited a 1.353-fold and 1.420-fold higher risk for MACEs and overall mortality, than the lowest quartile group. Similarly, the highest baseline TyG-WC cohort showed a 1.314-fold and 1.480-fold higher risk for MACEs and overall mortality, respectively. Each 1 SD increase in TyG-WHtR was significantly related to an 11.7% increase in MACEs and a 14.9% enhance in overall mortality. Each 1 SD increase in TyG-WC corresponded to an 11.5% in MACEs and a 16.6% increase in overall mortality. Including these two indexes in conventional models significantly improved the predictive power for MACEs and overall mortality. CONCLUSION TyG-WHtR and TyG-WC were promising predictors of MACEs and overall mortality risk in T2DM cases.
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Affiliation(s)
- Mao-Jun Liu
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Jun-Yu Pei
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Cheng Zeng
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Ying Xing
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Yi-Feng Zhang
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Pei-Qi Tang
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Si-Min Deng
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
| | - Xin-Qun Hu
- Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
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Ruano GR, Nogueira GA, Dadson P, Ferreira SRG, Sapienza MT, Velloso LA, Monfort-Pires M. Abdominal obesity and cardiometabolic risk markers: A comparative analysis of waist circumference, dual-energy X-ray absorptiometry, and magnetic resonance imaging techniques. Nutr Metab Cardiovasc Dis 2025; 35:103801. [PMID: 39826997 DOI: 10.1016/j.numecd.2024.103801] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/05/2024] [Revised: 11/07/2024] [Accepted: 11/19/2024] [Indexed: 01/22/2025]
Abstract
BACKGROUND AND AIMS This study compares three methods to determine central adiposity (waist circumference -WC - and visceral adipose tissue - VAT - estimated by dual-energy x-ray absorptiometry - DXA, and by magnetic resonance imaging - MRI) in their ability to predict increases in cardiometabolic risk (CMR) markers in young individuals. We examined their associations with CMR in 47 men and women aged 25-40. METHODS AND RESULTS VAT mass was assessed using DXA and MRI. Blood samples were analyzed for CMR markers. Associations between central adiposity measurements and CMR factors were analyzed using Spearman's correlation coefficient, and the ability of these three central adiposity measurements to detect increased CMR was compared using receiver operating characteristic (ROC) curves. Similar to what was observed for the MRI-DXA and VAT-DXA, WC showed strong correlations with LDL-c and triglycerides (TG) and an inverse correlation with HDL-c (rho = -0.657 MRI, rho = -0.628 DXA, and rho = -0.604 WC, p < 0.01). On the other hand, only MRI-VAT and WC were associated with insulin and HOMA-IR (rho = 0.341 MRI and rho = 0.421 WC, p < 0.01). Central adiposity measurements were negatively associated with cold-induced 18F-FDG uptake in subcutaneous adipose tissue and positively associated with VAT TG content. No significant differences were observed when comparing the three central adiposity measurements in ROC curve analysis, and all measurements could predict increases in CMR markers and the combined CMR index. CONCLUSIONS This study reinforces the importance of using WC to assess increases in CMR markers among young adults. Given its practicality and efficacy, WC should be recommended in health centers to assess CMR risk.
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Affiliation(s)
- Giulianna Regeni Ruano
- Department of Nutrition, School of Public Health - University of São Paulo, São Paulo, SP, Brazil
| | - Guilherme Augusto Nogueira
- Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
| | - Prince Dadson
- Turku PET Centre, University of Turku, Turku, Finland
| | - Sandra R G Ferreira
- Department of Epidemiology, School of Public Health - University of São Paulo, São Paulo, SP, Brazil
| | - Marcelo Tatit Sapienza
- Division of Nuclear Medicine, Department of Radiology and Oncology, Medical School of University of São Paulo (FMUSP), São Paulo, Brazil
| | - Licio A Velloso
- Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
| | - Milena Monfort-Pires
- Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Turku PET Centre, University of Turku, Turku, Finland.
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Ütebey AR, Aslan HS, Arslan M, Alver KH, Peker H, Tekinhatun M, Yağcı AB, Sabir N. Predictive factors for spontaneous dislodgement of percutaneous nephrostomies for malignant ureteral obstruction. Abdom Radiol (NY) 2025:10.1007/s00261-025-04855-6. [PMID: 40009157 DOI: 10.1007/s00261-025-04855-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/01/2025] [Revised: 01/26/2025] [Accepted: 02/16/2025] [Indexed: 02/27/2025]
Abstract
PURPOSE To investigate the etiology of spontaneous percutaneous nephrostomy (PCN) catheter dislodgements and evaluate factors potentially associated with these dislodgements, including muscle-to-fat composition and tissue characteristics of catheter traces. MATERIALS AND METHODS Data from 92 patients (63 males, 29 females; mean age 63.9 ± 11.4 years, range 28-88) undergoing 151 PCN catheter replacements between January 2016 and June 2021 were analyzed. Patients were divided into Group 1 (prophylactic replacements every 3 months, n = 41) and Group 2 (at least one spontaneous dislodgement, n = 51). Associations were evaluated for factors including intraabdominal visceral adipose tissue index (IAVATI), subcutaneous adipose tissue index (SATI), and abdominal perimeter. Other variables assessed were Eastern Cooperative Oncology Group (ECOG) performance status scores, psoas muscle index (PMI), renal size, renal parenchymal thickness, renal cortex-to-skin distance, posterolateral abdominal wall muscle thickness, and PCN replacement frequency. RESULTS No significant differences were identified between Group 1 and Group 2 in IAVATI, SATI, or abdominal perimeter values (p = 0.210-0.412). A significant difference in ECOG performance status scores (p = 0.0001), PMI (p = 0.04) and lower renal size, renal parenchymal thickness, renal cortex-to-skin distance, and posterolateral abdominal muscle thickness (p = 0.0001-0.039) were observed in Group 2. PCN replacements were significantly more frequent in Group 2 (p = 0.0001). Multivariate regression identified renal parenchymal thickness and abdominal wall muscle thickness as significant independent predictors (p = 0.0001, p = 0.02). ROC analysis yielded an AUC of 0.843 (95% CI: 0.769-0.917) for renal parenchymal thickness and 0.694 (95% CI: 0.610-0.778) for abdominal wall muscle thickness. Sensitivity and specificity rates were 73.1% and 96.4% for a 16 mm cutoff in renal parenchymal thickness, and 50.7% and 79.8% for an 8 mm cutoff in abdominal wall muscle thickness. CONCLUSION A significant association was identified between spontaneous PCN catheter dislodgement and both the psoas muscle index and ECOG performance status scores, while no notable relationship was observed with abdominal visceral or subcutaneous fat tissue volumes or abdominal perimeter. The risk of dislodgement was found to increase with reduced renal parenchymal and abdominal wall muscle thickness, as well as with more frequent nephrostomy replacements, suggesting these parameters may serve as useful markers for identifying patients at higher risk.
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11
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Marquardt JP, Tonnesen PE, Mercaldo ND, Graur A, Allaire B, Bouxsein ML, Samelson EJ, Kiel DP, Fintelmann FJ. Subcutaneous and Visceral Adipose Tissue Reference Values From the Framingham Heart Study Thoracic and Abdominal CT. Invest Radiol 2025; 60:95-104. [PMID: 39047288 DOI: 10.1097/rli.0000000000001104] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/27/2024]
Abstract
BACKGROUND Computed tomography (CT) captures the quantity, density, and distribution of subcutaneous and visceral (SAT and VAT) adipose tissue compartments. These metrics may change with age and sex. OBJECTIVE The study aims to provide age-, sex-, and vertebral level-specific reference values for SAT on chest CT and for SAT and VAT on abdomen CT. MATERIALS AND METHODS This secondary analysis of an observational study describes SAT and VAT measurements in participants of the Framingham Heart Study without known cancer diagnosis who underwent at least 1 of 2 CT examinations between 2002 and 2011. We used a previously validated machine learning-assisted pipeline and rigorous quality assurance to segment SAT at the fifth, eighth, and tenth thoracic vertebra (T5, T8, T10) and SAT and VAT at the third lumbar vertebra (L3). For each metric, we measured cross-sectional area (cm 2 ) and mean attenuation (Hounsfield units [HU]) and calculated index (area/height 2 ) (cm 2 /m 2 ) and gauge (attenuation × index) (HU × cm 2 /m 2 ). We summarized body composition metrics by age and sex and modeled sex-, age-, and vertebral level-specific reference curves. RESULTS We included 14,898 single-level measurements from up to 4 vertebral levels of 3797 scans of 3730 Framingham Heart Study participants (1889 [51%] male with a mean [standard deviation] age of 55.6 ± 10.6 years; range, 38-81 years). The mean VAT index increased with age from 65 (cm 2 /m 2 ) in males and 29 (cm 2 /m 2 ) in females in the <45-year-old age group to 99 (cm 2 /m 2 ) in males and 60 (cm 2 /m 2 ) in females in >75-year-old age group. The increase of SAT with age was less pronounced, resulting in the VAT/SAT ratio increasing with age. A free R package and online interactive visual web interface allow access to reference values. CONCLUSIONS This study establishes age-, sex-, and vertebral level-specific reference values for CT-assessed SAT at vertebral levels T5, T8, T10, and L3 and VAT at vertebral level L3.
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Affiliation(s)
- J Peter Marquardt
- From the Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA (J.P.M., P.E.T., A.G., F.J.F.); Harvard Medical School, Boston, MA (J.P.M., N.D.M., E.J.S., D.P.K., F.J.F.); Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (J.P.M.); Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany (P.E.T.); Department of Radiology, Massachusetts General Hospital, Boston, MA (N.D.M.); Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA (B.A., M.L.B.); Department of Orthopedic Surgery, Harvard Medical School, Boston, MA (M.L.B.); Endocrine Division, Massachusetts General Hospital, Boston, MA (M.L.B.); Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA (E.J.S., D.P.K.); and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.J.S., D.P.K.)
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12
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Wang Y, Chen F, Zhang B, Song Z. Association of the body roundness index with chronic diarrhea and chronic constipation: findings based on the National Health and Nutrition Examination Survey 2005-2010 data. Lipids Health Dis 2025; 24:33. [PMID: 39891178 PMCID: PMC11783814 DOI: 10.1186/s12944-025-02451-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Accepted: 01/23/2025] [Indexed: 02/03/2025] Open
Abstract
AIM The study aimed to explore potential links between long-term digestive issues (specifically diarrhea and constipation) and body roundness index (BRI) in a representative U.S. population sample. METHODS This study adopted a design that is cross sectional, drawing on data from the NHANES, gathered from 2005 to 2010 with health information from a total of 11,235 individuals. Persistent bowel movement patterns were categorized based on the BSFS-Bristol Stool Form Scale, while stool types 1 and 2 were designated as indicators of long-term constipation and types 6 and 7 were identified as markers of persistent diarrhea. To assess the relationship between digestive health and the BRI, this study employed weighted logistic regression analysis. To capture and visualize the nuanced interplay between BRI and gastrointestinal patterns, we utilized advanced nonlinear regression methods, specifically restricted cubic spline (RCS) analyses. Additionally, the research compared the efficacy of various physical measurements-including BRI, WC, BMI (body roundness index, waist circumference, and body mass index, respectively)-to determine their respective diagnostic power for chronic diarrhea and constipation through comparative analysis of receiver operating characteristic (ROC) curves. RESULTS After comprehensive adjustment in the final statistical model (Model 3), the BRI demonstrated the statistically significant associations with diarrhea and persistent constipation. RCS analysis further uncovered statistically significant nonlinear positive associations of BRI and with diarrhea (P = 0.005) and constipation (P = 0.037). Further stratified analyses revealed that the relationship between BRI and persistent diarrhea was particularly evident among individuals with diabetes. In contrast, the association between BRI and constipation was stronger in individuals under 60 years of age. ROC analysis indicated that BRI outperformed conventional anthropometric measures (AUC, area under the curve: 0.601). Specifically, BMI resulted in an AUC of 0.569, while WC produced an AUC of 0.572. However, the AUC value of BRI (0.537) was less effective than BMI (0.551) and WC (0.570) in diagnosing constipation. CONCLUSIONS BRI is strongly associated with changes in the individual's bowel habits, particularly in diagnosing chronic diarrhea. This study highlighted the potential significance of maintaining moderate BRI levels to improve bowel health and prevent diarrhea.
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Affiliation(s)
- Yinda Wang
- Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, Jiaxing, Zhejiang, 314000, P.R. China
| | - Fei Chen
- Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, Jiaxing, Zhejiang, 314000, P.R. China.
| | - Binzhong Zhang
- Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, Jiaxing, Zhejiang, 314000, P.R. China
| | - Zhengwei Song
- Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, Jiaxing, Zhejiang, 314000, P.R. China
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13
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Oliveira TMD, Moreira PDA, Anjos MSD, Assumpção DD, Corona LP. [Clinical phenotype of abdominal obesity and dynapenia: Brazilian Longitudinal Study of Aging (ELSI-Brazil)]. CAD SAUDE PUBLICA 2025; 41:e00233323. [PMID: 39879401 PMCID: PMC11774333 DOI: 10.1590/0102-311xpt233323] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/28/2023] [Revised: 08/05/2024] [Accepted: 08/16/2024] [Indexed: 01/31/2025] Open
Abstract
This study aims to examine the prevalence of abdominal obesity-dynapenia phenotype, identified by the presence of abdominal obesity and dynapenia, and understand its associated factors with a representative sample of the Brazilian population. Data were collected from the baseline of the Brazilian Longitudinal Study of Aging (ELSI-Brasil) 2015-2016. Abdominal obesity was determined by a waist-to-height ratio ≥ 0.55cm, while dynapenia was identified by evidence of low handgrip strength assessed via dynamometry, according to cutoff points proposed for the Brazilian population. The dependent variable was the coexistence of both conditions (abdominal obesity and dynapenia), and its association with independent variables (sociodemographic characteristics, behavior and health conditions, chronic diseases, and place of residence by Brazilian region) was analyzed using Poisson regression to obtain crude and adjusted prevalence ratios by sex, age, and education level. The prevalence of isolated abdominal obesity was 57.8%, isolated dynapenia was 5.7%, and abdominal obesity-dynapenia was 12.3%. In the adjusted model, significant associations were found with smoking (0.7; 95%CI: 0.5-0.9), alcohol consumption (0.7; 95%CI: 0.5-0.9), physical activity (0.6; 95%CI: 0.5-0.8), poor self-rated health (1.7; 95%CI: 1.4-2.2), multimorbidity (1.3; 95%CI: 1.1-1.6), and regions of residence. These factors indicate key points for the development of prevention and treatment strategies for abdominal obesity associated with low muscle strength, and we suggest that methodologies discussed here for abdominal obesity diagnosis be used as a reliable and practical means to identify this condition in older adults.
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Zhang W, Su X, Liu S, Yue T, Tu Z, Zhang H, Li C, Yao H, Wang J, Zheng X, Luo S, Ding Y. Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk. Acta Diabetol 2025:10.1007/s00592-025-02447-w. [PMID: 39792170 DOI: 10.1007/s00592-025-02447-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/07/2024] [Accepted: 12/31/2024] [Indexed: 01/12/2025]
Abstract
BACKGROUND Visceral adipose tissue (VAT) is known to play a role in the development of metabolic and cardiovascular disease (CVD). However, the age- and sex-specific associations between VAT and these diseases remain unclear. METHODS In this cross-sectional study, 1,150 participants (39.5% women; mean age 61.5 years) underwent VAT measurement using dual abdominal bioelectrical impedance analysis (BIA). The four age groups that the participants were divided into were 18-44, 45-59, 60-74, and ≥ 75 years. The relationships between VAT and cardiometabolic outcomes were analyzed by age and sex using multivariable logistic regression. RESULTS Significant associations between VAT and metabolic health status were observed in middle-aged (45-59 years; OR = 1.41, 95% CI: 1.04-1.92) and elderly adults (60-74 years; OR = 1.45, 95% CI: 1.10-1.92). VAT demonstrated age-dependent relationships with cardiovascular risk factors, with the strongest associations found in the 60-74 years group for hypertension (OR: 1.55, 95% CI: 1.22-1.98) and low high-density lipoprotein cholesterol (OR: 1.66, 95% CI: 1.33-2.08). Notably, the VAT-CVD association was most pronounced in elderly women (60-74 years; OR: 1.86, 95% CI: 1.14-3.11), while no significant associations were observed in men across all age groups. CONCLUSIONS The impact of VAT on metabolic and cardiovascular disease risk varies by age and sex, with particularly strong associations observed in elderly women. This highlights the need for tailored prevention and treatment strategies.
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Affiliation(s)
- Wenhao Zhang
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Xiaoyu Su
- Graduate School, Bengbu Medical College, Bengbu, Anhui, China
| | - SiHua Liu
- Pan-Vascular Management Center, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
| | - Tong Yue
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Zhixin Tu
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Hongqiang Zhang
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Chenghua Li
- Pan-Vascular Management Center, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
| | - Haifeng Yao
- Information Center, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China
| | - Jumei Wang
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Xueying Zheng
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China
| | - Sihui Luo
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China.
| | - Yu Ding
- Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China.
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15
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Tárraga Marcos PJ, López-González ÁA, Martínez-Almoyna Rifá E, Paublini Oliveira H, Martorell Sánchez C, Tárraga López PJ, Ramírez-Manent JI. The Prevalence of Metabolic Syndrome and Hypertriglyceridemic Waist Based on Sociodemographic Variables and Healthy Habits in Healthcare Workers: A Retrospective Study. Life (Basel) 2025; 15:81. [PMID: 39860021 PMCID: PMC11766689 DOI: 10.3390/life15010081] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Revised: 01/01/2025] [Accepted: 01/08/2025] [Indexed: 01/27/2025] Open
Abstract
Introduction: Metabolic syndrome (MetS) and hypertriglyceridemic waist (HTW) are two multifactorial pathological conditions that have been increasing in prevalence worldwide. The objective of this study was to evaluate how various sociodemographic variables and healthy habits are associated with the presence or absence of MetS and HTW. Methodology: This study employed a mixed-methods approach, consisting of a retrospective longitudinal study and a cross-sectional descriptive study, analyzing 44,939 healthcare workers with MS and HTW across four professional categories to evaluate the relationship between age, sex, smoking, physical activity, and adherence to the Mediterranean diet using three diagnostic criteria. Descriptive analysis included categorical and quantitative variables, which were assessed through frequencies, Student's t-test, chi-square, and binary logistic regression models. Logistic regression and Cohen's kappa were used to evaluate associations and concordances. Age, sex, and lack of physical activity showed the strongest associations with MetS (OR: 2.65-2.84). The results highlight the importance of physical activity and other factors in metabolic prevention. Results: Age, sex, and physical activity were the variables most strongly associated with MetS and HTW across the three evaluated diagnostic criteria. The odds ratios revealed significant values: age (9.07-13.71 for MetS and 13.42 for HTW), sex (2.82-3.31 for MetS and 3.72 for HTW), and physical activity (2.65-2.84 for MetS and 2.40 for HTW). Conclusions: The risk of developing MetS and HTW among healthcare personnel is influenced by lifestyle habits, sex, and age, with the highest ORs observed in nursing assistants and orderlies. Future research that delves deeper into the causal relationship between lifestyle factors and the severity of MetS and HTW in healthcare personnel will improve understanding and facilitate the development of preventive activities to reduce their incidence.
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Affiliation(s)
| | - Ángel Arturo López-González
- ADEMA-Health Group, University Institute of Health Sciences (IUNICS), 07009 Palma, Balearic Islands, Spain; (Á.A.L.-G.); (E.M.-A.R.); (H.P.O.); (C.M.S.); (J.I.R.-M.)
- Faculty of Odontology, University School ADEMA-UIB, 07009 Palma, Balearic Islands, Spain
- Health Service of the Balearic Islands, 07010 Palma, Balearic Islands, Spain
| | - Emilio Martínez-Almoyna Rifá
- ADEMA-Health Group, University Institute of Health Sciences (IUNICS), 07009 Palma, Balearic Islands, Spain; (Á.A.L.-G.); (E.M.-A.R.); (H.P.O.); (C.M.S.); (J.I.R.-M.)
- Faculty of Odontology, University School ADEMA-UIB, 07009 Palma, Balearic Islands, Spain
| | - Hernán Paublini Oliveira
- ADEMA-Health Group, University Institute of Health Sciences (IUNICS), 07009 Palma, Balearic Islands, Spain; (Á.A.L.-G.); (E.M.-A.R.); (H.P.O.); (C.M.S.); (J.I.R.-M.)
- Faculty of Odontology, University School ADEMA-UIB, 07009 Palma, Balearic Islands, Spain
| | - Cristina Martorell Sánchez
- ADEMA-Health Group, University Institute of Health Sciences (IUNICS), 07009 Palma, Balearic Islands, Spain; (Á.A.L.-G.); (E.M.-A.R.); (H.P.O.); (C.M.S.); (J.I.R.-M.)
- Faculty of Odontology, University School ADEMA-UIB, 07009 Palma, Balearic Islands, Spain
| | | | - José Ignacio Ramírez-Manent
- ADEMA-Health Group, University Institute of Health Sciences (IUNICS), 07009 Palma, Balearic Islands, Spain; (Á.A.L.-G.); (E.M.-A.R.); (H.P.O.); (C.M.S.); (J.I.R.-M.)
- Health Service of the Balearic Islands, 07010 Palma, Balearic Islands, Spain
- Faculty of Medicine, Balearic Islands University, 07010 Palma, Balearic Islands, Spain
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16
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Liu M, Pei J, Zeng C, Xin Y, Zhang Y, Tang P, Deng S, Hu X. Association of non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio with cardiovascular outcomes in patients with type 2 diabetes mellitus: Evidence from the ACCORD cohort. Diabetes Obes Metab 2025; 27:300-311. [PMID: 39415313 PMCID: PMC11618286 DOI: 10.1111/dom.16018] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/12/2024] [Revised: 09/23/2024] [Accepted: 10/02/2024] [Indexed: 10/18/2024]
Abstract
AIM To explore the association between the non-high-density lipoprotein cholesterol (HDL-C)/HDL-C ratio (NHHR) and the risk of major adverse cardiovascular events (MACEs) and overall mortality in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS NHHR, calculated as (total cholesterol - HDL-C)/HDL-C, was evaluated in 10,188 participants. Cox proportional hazard regression models were employed to assess the association of NHHR with future risk of MACEs and overall mortality. Restricted cubic spline analysis, smooth curve fitting and piecewise regression models were utilized to explore the non-linear correlation and establish the threshold. Subgroup and interaction analyses verified the robustness of the findings. The area under the receiver operating characteristic area under the curve assessed the additional predictive value of NHHR beyond conventional risk factors. RESULTS After adjusting for confounding factors, each 1-unit increase in NHHR was associated with a 12% increased risk of MACEs (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.07-1.16; p < 0.0001), a 5% increase in overall mortality (HR: 1.05, 95% CI: 1.01-1.10; p = 0.0256), a 10% increase in cardiovascular disease mortality (HR 1.10, 95% CI: 1.03-1.18; p = 0.0074), an 12% increase in non-fatal myocardial infarction (HR: 1.12, 95% CI: 1.05-1.18; p = 0.0002), and an 11% increase in non-fatal stroke (HR: 1.11, 95% CI: 1.02-1.20; p = 0.0123). Analyses showed a non-linear relationship between NHHR and MACEs in patients with T2DM (non-linearity p < 0.001). A two-stage linear regression model identified a threshold for MACEs at 6.28. Integration NHHR into the conventional model significantly enhanced predictive accuracy for MACEs. CONCLUSIONS NHHR is a predictor of the risk of developing MACEs and overall mortality in patients with T2DM, with higher NHHR values independently associated with increased future MACE risks after full adjustment for confounders.
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Affiliation(s)
- Maojun Liu
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Junyu Pei
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Cheng Zeng
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Ying Xin
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Yifeng Zhang
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Peiqi Tang
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Simin Deng
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
| | - Xinqun Hu
- Department of Cardiovascular Medicine, The Second Xiangya HospitalCentral South UniversityChangshaChina
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Jeon M, Yoon J, Yun HJ. Deep Learning-Based Body Shape Clustering Analysis Using 3D Body Scanner: Application of Transformer Algorithm. IRANIAN JOURNAL OF PUBLIC HEALTH 2025; 54:133-143. [PMID: 39902372 PMCID: PMC11787839 DOI: 10.18502/ijph.v54i1.17583] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 03/09/2024] [Accepted: 05/16/2024] [Indexed: 02/05/2025]
Abstract
Background This study was conducted to perform deep learning-based body shape cluster analysis using 3D Body Scanner. Methods For this study, 54 variables were measured using 3D Body Scanner on 366 adult men and women at Korea National Sport University in 2022. Transformer learning and dimensionality reduction models were used to perform cluster analysis on the measured data. Mann-Whitney test and Kruskal-Wallis test were applied to compare the principal component differences of new scale characteristics, and all statistical significance levels were set at .05. Results First, among the two methods for classifying body types, the transformer algorithm had a higher performance in body type classification. Second, in the classification of body type clusters, two clusters, endomorphic body type and ectomorphic body type, were divided into six clusters, two for cluster 1 and four for cluster 2. Conclusion The six clusters provide more granular information than previous body type classifications, and we believe that they can be used as basic information for predicting health and disease.
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Affiliation(s)
- Minsoo Jeon
- Department of International Sport, Dankook University, Chungcheongnam-do, Republic of Korea
| | - Jiwun Yoon
- Center for Sports Performance Analytics, Korea National Sport University, Seoul, Republic of Korea
| | - Hyo Jun Yun
- Center for Sports Performance Analytics, Korea National Sport University, Seoul, Republic of Korea
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Ma G, Xu B, Wang Z, Duan W, Chen X, Zhu L, Yang B, Zhang D, Qin X, Yin H, Wei X. Non-linear association of sleep duration with osteoarthritis among U.S. middle-aged and older adults. BMC Public Health 2024; 24:3565. [PMID: 39716177 DOI: 10.1186/s12889-024-21140-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/07/2024] [Accepted: 12/18/2024] [Indexed: 12/25/2024] Open
Abstract
BACKGROUND The duration of sleep is linked to a range of disorders. Osteoarthritis (OA) stands as one of the most prevalent forms of arthritis and serves as a leading cause of disability. The correlation between the duration of sleep and OA remains ambiguous. Research indicates that waist circumference correlates with sleep duration and OA, respectively. This study aimed to investigate the association of sleep duration with OA and the mediated effect of waist circumference. METHODS The study sample comprised adults who were participants in the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2018. Insufficient sleep is characterized by a duration of less than seven hours, whereas 7-8 h is considered appropriate, and 9 h or more is categorized as a long sleep duration. Three models were employed in this study. Model 1 was not adjusted for any covariates, while Model 2 was adjusted for sex, age, and race. Model 3 has been adjusted to account for all covariates. Utilizing multivariable logistic regression, subgroup analysis, interaction tests and smoothing curve fitting, the correlation between sleep duration and OA was explored. The mediating effect of waist circumference on the association between sleep duration and OA was investigated through mediation analysis. RESULTS In this study, 9380 did not have OA, while 2424 were diagnosed with the ailment. After multivariable adjustment, the odds ratios (OR) for OA were 1.19 (95% CI 1.06, 1.34; P = 0.0026) for people with insufficient sleep duration and 1.18 (95% CI 1.03, 1.35 P = 0.0142) for participants with long sleep duration. Sleep duration and the incidence of OA were found to be related in a U-shaped manner. Additionally, 12.1% of the correlation between sleep duration and OA appeared to be mediated by waist circumference. CONCLUSIONS Increased OA was found to be correlated in a U-shaped manner with sleep duration in the middle-aged and elderly cohorts. Both insufficient and long sleep duration contribute to an elevated risk of developing OA. A potential mediating factor in the association between OA and sleep duration is waist circumference. Focus on sleep health and visceral obesity in middle-aged and older adults is necessary.
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Affiliation(s)
- Guoliang Ma
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Bo Xu
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Zhizhuang Wang
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Weili Duan
- Nanyang Hospital of Traditional Chinese Medicine (Dushan Campus), Henan , 473003, China
| | - Xin Chen
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Liguo Zhu
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
- Beijing Key Laboratory of Bone Setting Technology of Traditional Chinese Medicine, Beijing, 100700, China
| | - Bowen Yang
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Dian Zhang
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - Xiaokuan Qin
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China
| | - He Yin
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China.
| | - Xu Wei
- Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Zhonghuan South Road, Chaoyang District, Beijing, 100102, China.
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Liu H, Liu Q, Chen M, Lu C, Feng P. Construction and validation of a nomogram model for predicting diabetic peripheral neuropathy. Front Endocrinol (Lausanne) 2024; 15:1419115. [PMID: 39736870 PMCID: PMC11682957 DOI: 10.3389/fendo.2024.1419115] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/17/2024] [Accepted: 12/02/2024] [Indexed: 01/01/2025] Open
Abstract
Objective Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes that can potentially escalate into ulceration, amputation and other severe consequences. The aim of this study was to construct and validate a predictive nomogram model for assessing the risk of DPN development among diabetic patients, thereby facilitating the early identification of high-risk DPN individuals and mitigating the incidence of severe outcomes. Methods 1185 patients were included in this study from June 2020 to June 2023. All patients underwent peripheral nerve function assessments, of which 801 were diagnosed with DPN. Patients were randomly divided into a training set (n =711) and a validation set (n = 474) with a ratio of 6:4. The least absolute shrinkage and selection operator (LASSO) logistic regression analysis was performed to identify independent risk factors and develop a simple nomogram. Subsequently, the discrimination and clinical value of the nomogram was extensively validated using receiver operating characteristic (ROC) curves, calibration curves and clinical decision curve analyses (DCA). Results Following LASSO regression analysis, a nomogram model for predicting the risk of DPN was eventually established based on 7 factors: age (OR = 1.02, 95%CI: 1.01 - 1.03), hip circumference (HC, OR = 0.94, 95%CI: 0.92 - 0.97), fasting plasma glucose (FPG, OR = 1.06, 95%CI: 1.01 - 1.11), fasting C-peptide (FCP, OR = 0.66, 95%CI: 0.56 - 0.77), 2 hour postprandial C-peptide (PCP, OR = 0.78, 95%CI: 0.72 - 0.84), albumin (ALB, OR = 0.90, 95%CI: 0.87 - 0.94) and blood urea nitrogen (BUN, OR = 1.08, 95%CI: 1.01 - 1.17). The areas under the curves (AUC) of the nomogram were 0.703 (95% CI 0.664-0.743) and 0.704 (95% CI 0.652-0.756) in the training and validation sets, respectively. The Hosmer-Lemeshow test and calibration curves revealed high consistency between the predicted and actual results of the nomogram. DCA demonstrated that the nomogram was valuable in clinical practice. Conclusions The DPN nomogram prediction model, containing 7 significant variables, has exhibited excellent performance. Its generalization to clinical practice could potentially help in the early detection and prompt intervention for high-risk DPN patients.
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Affiliation(s)
| | | | | | | | - Ping Feng
- Department of Endocrinology, Taizhou Central Hospital (Taizhou University
Hospital), Taizhou, China
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20
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Wang Y, Shen F, Zhang P, Xu M, Qiu D, Wang H, Li L. Cross-sectional and prospective associations between children's eating behavior and visceral fat area and trunk fat mass. Front Pediatr 2024; 12:1514535. [PMID: 39726532 PMCID: PMC11669656 DOI: 10.3389/fped.2024.1514535] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Accepted: 11/29/2024] [Indexed: 12/28/2024] Open
Abstract
Background Understanding children's eating behaviors is crucial for elucidating the etiology of childhood obesity. However, the relationship between these behaviors and abdominal fat accumulation remains poorly understood. This study aims to investigate this association in primary school children. Methods This study included 1,475 children aged 8-10 years in Ningbo, China. Body composition was measured both at baseline (September 2022) and after 9 months of follow-up (June 2023). Primary caregivers completed the Children's Eating Behavior Questionnaire (CEBQ). A mixed-effects linear model was applied to analyze the relationships between children's eating behaviors and body composition. Results Greater visceral fat area (VFA) was associated with greater slowness in eating [β = 0.25 (0.02, 0.49)], greater food responsiveness [β = 0.29 (0.14, 0.43)], increased emotional undereating [β = 0.35 (0.17, 0.54)], and more emotional overeating [β = 0.21 (0.02, 0.39)]. Children with greater trunk fat mass (TrFM) tended to have greater food responsiveness [β = 0.02 (0.01, 0.03)] and greater enjoyment of food [β = 0.01 (0.00, 0.03)], increased emotional undereating [β = 0.02 (0.01, 0.03)] and emotional overeating [β = 0.02 (0.00, 0.03)]. Prospectively, positive correlations were observed between VFA and food responsiveness [β = 0.18 (0.02, 0.35)], as were emotional undereating [β = 0.31 (0.10, 0.52)] and emotional overeating [β = 0.24 (0.03, 0.46)]. Similarly, TrFM was positively correlated with food responsiveness [β = 0.02 (0.00, 0.03)], enjoyment of food [β = 0.02 (0.00, 0.04)], emotional undereating [β = 0.02 (0.01, 0.04)] and emotional overeating [β = 0.02 (0.01, 0.04)]. Conclusions Our findings suggest that eating behaviors are significantly associated with abdominal fat accumulation in primary school children. Addressing specific eating behaviors may be crucial in mitigating abdominal fat and its related health risks.
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Affiliation(s)
- Youxin Wang
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
- Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China
| | - Fangjing Shen
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
| | - Pingping Zhang
- Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
| | - Miao Xu
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
| | - Danqi Qiu
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
| | - Hui Wang
- Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China
| | - Li Li
- Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
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21
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Sartori G, Bertoldo F, Gretter A, Lovati FM, Caprino R, Viterale G, Crisafulli E. Impact of the visceral adipose tissue on bone quality in patients with untreated mild-to-severe obstructive sleep apnea. J Sleep Res 2024:e14397. [PMID: 39658313 DOI: 10.1111/jsr.14397] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Revised: 10/09/2024] [Accepted: 10/22/2024] [Indexed: 12/12/2024]
Abstract
Obstructive sleep apnea (OSA) predominantly affects patients who are obese and causes systemic organ damage. Little is known about the relationship between fat distribution and bone impairment in these patients. We aimed to evaluate the impact of the visceral adipose tissue (VAT) on the bone quality of patients with OSA. In our prospective study, 49 untreated patients with mild-to-severe OSA underwent dual-energy X-ray absorptiometry. Polygraphy data were also collected. According to the recent reference values for European adults, patients were divided by the sex-related threshold of the VAT index into two categories: VAT index within limits (normal VAT [nVAT]) and increased VAT (iVAT). In all, 63% of the patients were in the iVAT category. Compared to patients with nVAT, those with iVAT had a higher prevalence of arterial hypertension (52% versus 22%) and diabetes (32% versus 6%), and higher values of mean nocturnal desaturation. Patients with iVAT had, in comparison to those with nVAT, lower values of the lumbar spine trabecular bone score (TBS; mean 1.24 versus 1.39; p < 0.001), TBS T-score (mean -1.82 versus -0.52; p < 0.001) and TBS Z-score (mean -0.35 versus 0.75; p = 0.002). Moreover, a close association was present between the VAT index and TBS lumbar spine L1-L4 (r2 linear 0.573; p < 0.001), and altered values of the TBS Z-score were associated with the severity of vertebral fractures. Finally, in a linear regression-adjusted model, the VAT index predicted TBS lumbar spine L1-L4 (β -0.323; p < 0.001). In patients with OSA VAT impacts bone quality. In these patients, the role of VAT as a metabolically active tissue should be considered.
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Affiliation(s)
- Giulia Sartori
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Francesco Bertoldo
- Emergency Medicine Unit, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Andrea Gretter
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Federica Margherita Lovati
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Rosaria Caprino
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Giovanni Viterale
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
| | - Ernesto Crisafulli
- Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
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Ramírez-Gallegos I, Marina-Arroyo M, López-González ÁA, Vallejos D, Martínez-Almoyna-Rifá E, Tárraga López PJ, Ramírez-Manent JI. Associations Between Metabolic Age, Sociodemographic Variables, and Lifestyle Factors in Spanish Workers. Nutrients 2024; 16:4207. [PMID: 39683600 DOI: 10.3390/nu16234207] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/19/2024] [Revised: 12/01/2024] [Accepted: 12/04/2024] [Indexed: 12/18/2024] Open
Abstract
BACKGROUND Metabolic age is defined as an estimation of a person's age based on their basal metabolic rate (BMR) and other physiological health indicators. Unlike chronological age, which simply measures the number of years lived since birth, metabolic age is based on various health and fitness markers that estimate the body's "true" biological age and can be assessed using various methodologies, including bioimpedance. The aim of this study was to evaluate how age, sex, social class, smoking habits, physical activity, and adherence to the Mediterranean diet influence metabolic age. METHODS A cross-sectional, descriptive study was conducted on 8590 Spanish workers in the Balearic Islands. A series of sociodemographic variables and health-related habits were assessed, while metabolic age was measured using bioimpedance. A metabolic age exceeding chronological age by 12 years or more was considered high. A descriptive analysis of categorical variables was performed by calculating their frequency and distribution. By applying multivariate models, specifically multinomial logistic regression, we observe that all independent variables (sex, age, social class, physical activity, mediterranean diet, and smoking) show varying levels of association with the occurrence of high metabolic age values. Among these independent variables, those showing the highest degree of association, represented by odds ratios, are physical activity, adherence to the Mediterranean diet, and social class. In all cases, the observed differences demonstrate a high level of statistical significance (p < 0.001). RESULTS The factors with the greatest influence were physical inactivity, with an OR of 5.07; and low adherence to the Mediterranean diet, with an OR of 2.8; followed by social class, with an OR of 2.51. Metabolic age increased with chronological age and was higher in males, with an OR of 1.38. Smoking also had a negative impact on metabolic age, with an OR of 1.19. CONCLUSIONS Mediterranean diet is associated with a higher metabolic age. The most influential factors on metabolic age are physical activity and adherence to the Mediterranean diet, followed by the individual's socioeconomic class. Smoking also contributes to increased metabolic age, albeit to a lesser extent.
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Affiliation(s)
- Ignacio Ramírez-Gallegos
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
| | - Marta Marina-Arroyo
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
| | - Ángel Arturo López-González
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
- Faculty of Dentistry, University School ADEMA, 07009 Palma, Balearic Islands, Spain
- Balearic Islands Institute of Health Research (IDISBA), Balearic Islands Health Research Institute Foundation, 07010 Palma, Balearic Islands, Spain
- Balearic Islands Health Service, 07010 Palma, Balearic Islands, Spain
| | - Daniela Vallejos
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
| | - Emilio Martínez-Almoyna-Rifá
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
| | - Pedro Juan Tárraga López
- Faculty of Medicine, University of Castilla la Mancha, 02008 Albacete, Castilla-La Mancha, Spain
- SESCAM (Servicio Salud Castilla La Mancha), 45071 Toledo, Castilla-La Mancha, Spain
| | - José Ignacio Ramírez-Manent
- ADEMA-Health Group University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain
- Balearic Islands Institute of Health Research (IDISBA), Balearic Islands Health Research Institute Foundation, 07010 Palma, Balearic Islands, Spain
- Balearic Islands Health Service, 07010 Palma, Balearic Islands, Spain
- Faculty of Medicine, University of the Balearic Islands, 07010 Palma, Balearic Islands, Spain
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23
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Zhang Y, Shi M, Dong Z, Li T, Gong Y, Ge W. Impact of Chinese visceral adiposity index on all-cause mortality risk in community-dwelling older adults: a prospective cohort study. Aging Clin Exp Res 2024; 36:230. [PMID: 39625579 PMCID: PMC11614971 DOI: 10.1007/s40520-024-02891-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2024] [Accepted: 11/14/2024] [Indexed: 12/06/2024]
Abstract
BACKGROUNDS Whether excess visceral fat tissue increases the risk of death in older individuals remains controversial. AIMS To investigate the association between the Chinese Visceral Adiposity Index (CVAI) and all-cause mortality risk in older Chinese individuals. METHODS This cohort study utilized data of individuals aged ≥ 65 years in 2014 to 2018 wave from the Chinese Longitudinal Healthy Longevity Survey database. Older individuals in the 2014 wave were included and followed up in 2018. CVAI was calculated based on age, body size, and blood lipid parameters, with higher values indicating increased visceral fat. Survival status was determined from official death certificates, local primary healthcare providers, or the family members of participants. Kaplan-Meier survival curve and log-rank test were employed to analyze cumulative mortality risk through CVAI tertiles (tertile 1: CVAI index < 97.34; tertile 2: 97.43 ≤ CVAI index < 132.21; and tertile 3: CVAI index ≥ 132.21). A Cox proportional hazards regression model was used to assess the relationship between the CVAI groups and all-cause mortality risk. Additionally, a sensitivity analysis was performed by excluding participants who died within the first year of follow-up. A subgroup analysis was performed based on age and sex, and a restricted cubic spline plot was created to analyze the dose-response relationship between CVAI and mortality risk. RESULTS A total of 1414 individuals were included, and the mean age of the participants was 84.6 (standard deviation: 10.9) years, of which 46.4% were women and 32.8% were died during a median follow-up time of 36.4 months. In the multivariable adjusted Cox regression model, we observed a significantly lower risk of mortality in the CVAI tertile 2 and 3 groups than in the tertile 1 group. The hazard ratios (HR) of the tertile 2 and 3 groups were 0.68 (95% CI, approximately 0.52-0.89) and 0.63 (95% CI, approximately 0.48-0.82), respectively. Subgroup analysis revealed that the protective effect of higher CVAI levels on mortality was more pronounced in participants aged 65-79 years and in women. CONCLUSION Our study established a linear relationship between CVAI and mortality risk among community-dwelling older adults, with higher CVAI levels associated with a lower risk of all-cause mortality. These findings highlight the potential importance of visceral adiposity in predicting mortality risk in community-dwelling older adults.
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Affiliation(s)
- Yuyu Zhang
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China
| | - Mingyue Shi
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China
| | - Zhao Dong
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China
| | - Tingting Li
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China
| | - Yangfan Gong
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China
| | - Wei Ge
- Department of General Practice, Xijing Hospital, Fourth Military Medical University, Changle West Road #127, Xi'an, Shaanxi Province, 710032, P.R. China.
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24
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Liu Y, He H, Qian K, Huang Y, Ao X, Shi X, Ruan B, Xue R, Fu X, Wang S. Evaluation of Health Associations With Height-Normalised Abdominal Body Composition Indices: A Single-Centre Cross-Sectional Study. J Cachexia Sarcopenia Muscle 2024; 15:2651-2659. [PMID: 39375152 PMCID: PMC11634505 DOI: 10.1002/jcsm.13609] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/20/2023] [Revised: 08/03/2024] [Accepted: 09/11/2024] [Indexed: 10/09/2024] Open
Abstract
BACKGROUND Traditional metrics such as body mass index (BMI) and waist circumference (WC) fail to accurately assess the health outcomes associated with abdominal adiposity, because they neglect the intricacies of adipose tissue distribution. Notably, the variability in body composition scaled to height remains underexplored in Chinese demographics. This study introduces height-normalised indices of abdominal adiposity using computed tomography (CT) scans and further assesses their associations with various health outcomes. METHODS In a large, diverse Chinese population (n = 1054 healthy individuals; n = 1159 with dyslipidemia; n = 803 with diabetes; n = 1289 with cardio-cerebrovascular diseases; n = 1108 with cancers; and n = 509 with abnormal bone mas), abdominal CT scans were performed and allometric growth model analyses were used to derive height-normalised indices (body composition/heightβ). Logistic regression models assessed the associations between these indices and health outcomes. RESULTS Distinct scaling powers were observed for visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total abdominal adipose tissue (TAT), as well as for sagittal diameter (SAD), with marked sex differences. Powers for VAT were 1.786 ± 1.270 for males and 1.274 ± 0.692 for females. Powers for SAT were 2.266 ± 0.856 for males and 1.656 ± 0.497 for females. Powers for TAT were 2.141 ± 0.967 for males and 1.438 ± 0.489 for females. Powers for SAD were 0.646 ± 0.217 for males and 0.678 ± 0.141 for females. After controlling for age, BMI and WC, VAT/heightβ, TAT/heightβ and SAD/heightβ retained their significantly positive associations with the odds of health outcomes, whereas SAT/heightβ did not. CONCLUSIONS Our findings endorse the clinical utility of height-normalised indices, particularly VAT/heightβ, TAT/heightβ and SAD/heightβ, in health outcomes assessment. These indices, grounded in robust empirical data, underscore the necessity of a nuanced approach in obesity-related health evaluations, advocating for a departure from conventional methods like BMI.
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Affiliation(s)
- Yupeng Liu
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Hangqian He
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Keyu Qian
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Yufeng Huang
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Xuemei Ao
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Xudong Shi
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Binye Ruan
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Ru Xue
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Xiaoyi Fu
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
| | - Shuran Wang
- Department of Preventive Medicine, School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina
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25
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Ran CQ, Su Y, Li J, Wu K, Liu ZL, Yang Y, Zhang MX, Yuan G, Yu XF, He WT. Epicardial adipose tissue volume highly correlates with left ventricular diastolic dysfunction in endogenous Cushing's syndrome. Ann Med 2024; 56:2387302. [PMID: 39101236 DOI: 10.1080/07853890.2024.2387302] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/30/2024] [Revised: 06/30/2024] [Accepted: 07/05/2024] [Indexed: 08/06/2024] Open
Abstract
BACKGROUND Cushing's syndrome (CS) is associated with increased risk for heart failure, which often initially manifests as left ventricular diastolic dysfunction (LVDD). In this study, we aimed to explore the potential risk factors of LVDD in CS by incorporating body composition parameters. METHODS A retrospective study was conducted on patients diagnosed with endogenous CS no less than 18 years old. The control group consisted of healthy individuals who were matched to CS patients in terms of gender, age, and BMI. LIFEx software (version 7.3) was applied to measure epicardial adipose tissue volume (EATV) on non-contrast chest CT, as well as abdominal adipose tissue and skeletal muscle mass at the first lumbar vertebral level. Echocardiography was used to evaluate left ventricular (LV) diastolic function. Body compositions and clinical data were examined in relation to early LVDD. RESULTS A total of 86 CS patients and 86 healthy controls were enrolled. EATV was significantly higher in CS patients compared to control subjects (150.33 cm3 [125.67, 189.41] vs 90.55 cm3 [66.80, 119.84], p < 0.001). CS patients had noticeably increased visceral fat but decreased skeletal muscle in comparison to their healthy counterparts. Higher prevalence of LVDD was found in CS patients based on LV diastolic function evaluated by E/A ratio (p < 0.001). EATV was proved to be an independent risk factor for LVDD in CS patients (OR = 1.015, 95%CI 1.003-1.026, p = 0.011). If the cut-point of EATV was set as 139.252 cm3 in CS patients, the diagnostic sensitivity and specificity of LVDD were 84.00% and 55.60%, respectively. CONCLUSION CS was associated with marked accumulation of EAT and visceral fat, reduced skeletal muscle mass, and increased prevalence of LVDD. EATV was an independent risk factor for LVDD, suggesting the potential role of EAT in the development of LVDD in CS.
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Affiliation(s)
- Chun-Qiong Ran
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Ying Su
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Department of Endocrinology, The First People's Hospital of Jiangxia District Wuhan City & Union Jiangnan Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
| | - Jin Li
- Computer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
| | - Kun Wu
- Computer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
| | - Zhe-Long Liu
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Yan Yang
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Mu-Xun Zhang
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Gang Yuan
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Xue-Feng Yu
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
| | - Wen-Tao He
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, Hubei Province, China
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Wu RL, Chen N, Chen Y, Wu X, Ko CY, Chen XY. Visceral Adiposity as an Independent Risk Factor for Diabetic Peripheral Neuropathy in Type 2 Diabetes Mellitus: A Retrospective Study. J Diabetes Res 2024; 2024:9912907. [PMID: 39559714 PMCID: PMC11573447 DOI: 10.1155/2024/9912907] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/27/2024] [Accepted: 10/14/2024] [Indexed: 11/20/2024] Open
Abstract
Background: Diabetic peripheral neuropathy (DPN) impacts approximately 50% of individuals with Type 2 diabetes mellitus (T2DM), leading to severe complications such as foot ulcers and amputations. Notably, visceral adiposity is increasingly recognized as a pivotal factor in augmenting the risk of DPN. We aim to evaluate the correlation between obesity-related body composition, particularly visceral fat, and DPN to facilitate early identification of high-risk patients with T2DM. Methods: This cross-sectional analysis encompassed 113 T2DM patients from the Department of Endocrinology and Metabolism at the Second Affiliated Hospital of Fujian Medical University, conducted between September 2020 and January 2021. Patients were categorized into two cohorts: those with DPN (DPN group) and those without (NDPN group). We utilized bioelectrical impedance analysis (BIA) to determine body measurements, such as weight and visceral fat area, in addition to collecting clinical and biochemical data. Logistic regression was employed to analyze the data. Results: The study uncovered a statistically significant difference in the visceral fat area between the DPN and NDPN groups (p = 0.048). Through multivariate logistic regression analysis, the visceral fat area was identified as an independent risk factor for DPN among T2DM patients (OR 1.027; 95% CI 1.004-1.051, p = 0.022). Other significant risk factors included the duration of diabetes and the presence of diabetic retinopathy. Conclusion: The visceral fat area serves as an independent risk factor for DPN in individuals with T2DM. Implementing measures to assess and manage visceral obesity could be vital in the prevention and management of DPN. This underscores the value of technologies such as BIA in clinical and community settings for early intervention.
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Affiliation(s)
- Rui-Ling Wu
- Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
| | - Niyao Chen
- Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
| | - Yanni Chen
- Department of Endocrinology, Shishi General Hospital, Quanzhou, China
| | - Xiaohong Wu
- Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
| | - Chih-Yuan Ko
- Department of Clinical Nutrition, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
| | - Xiao-Yu Chen
- Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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Chen J, Liu X, Lu S, Man S, Zhang L, Xu X, Deng W, Jiang X. Linear associations of Chinese visceral adiposity index and its change with hyperuricemia: A prospective cohort study. Nutr Metab Cardiovasc Dis 2024; 34:2472-2479. [PMID: 39079837 DOI: 10.1016/j.numecd.2024.06.021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/10/2024] [Revised: 06/15/2024] [Accepted: 06/24/2024] [Indexed: 09/15/2024]
Abstract
BACKGROUND AND AIMS This study aims to investigate the association of Chinese visceral adiposity index (CVAI) with incident hyperuricemia (HUA). METHODS AND RESULTS We included 5186 adults aged ≥45 years from China Health and Retirement Longitudinal Study. Modified Poisson regression model was used to estimate the relative risks (RRs) of incident HUA associated with baseline CVAI, and logistic model was used to estimate the odds ratios (ORs) of HUA for CVAI change. Restricted cubic splines analysis was adopted to model the dose-response associations. The area under the receiver operating characteristic curve (AUC) analysis was used to evaluate the predictive value of CVAI. During 4-year follow-up, a total of 510 (9.8%) HUA cases were identified. The RRs (95%CIs) of incident HUA were 3.75 (2.85-4.93) for quartile 4 versus quartile 1 and 1.56 (1.45-1.69) for per-standard deviation increase in baseline CVAI. For the analyses of CVAI change, compared with stable group, participants in decreased group had 34% lower risk (OR 0.66, 95%CI 0.49-0.87) and those in increased group had 35% (1.35, 1.03-1.78) higher risk of HUA. Linear associations of baseline CVAI and its change with HUA were observed (Pnonlinear >0.05). Besides, the AUC value for HUA was 0.654 (0.629-0.679), which was higher than other five obesity indices. CONCLUSIONS Our study found linear associations between baseline CVAI and its change and risk of HUA. CVAI had the best predictive performance in predicting incident HUA. These findings suggest CVAI as a reliable obesity index to identify individuals with higher HUA risk.
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Affiliation(s)
- Jia Chen
- Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Xuejiao Liu
- Department of Medical Record Management and Statistics, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Shuai Lu
- Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Siliang Man
- Department of Rheumatology, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Liang Zhang
- Department of Orthopedic Surgery, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Xiaojie Xu
- Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China
| | - Wei Deng
- Department of Endocrinology, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China.
| | - Xieyuan Jiang
- Department of Orthopedic Trauma, Beijing Jishuitan Hospital, Capital Medical University, 100035 Beijing, China.
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Huang JC, Huang YC, Lu CH, Chuang YS, Chien HH, Lin CI, Chao MF, Chuang HY, Ho CK, Wang CL, Dai CY. Exploring the Relationship Between Visceral Fat and Coronary Artery Calcification Risk Using Metabolic Score for Visceral Fat (METS-VF). Life (Basel) 2024; 14:1399. [PMID: 39598197 PMCID: PMC11595436 DOI: 10.3390/life14111399] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/18/2024] [Revised: 10/27/2024] [Accepted: 10/29/2024] [Indexed: 11/29/2024] Open
Abstract
BACKGROUND Metabolic Score for Visceral Fat (METS-VF) is a novel indicator for estimating intra-abdominal fat, yet its connection with coronary artery calcification (CAC) remains uncharted. Our research aims to explore the novel METS-VF indicator's link to CAC while comparing its performance against relevant anthropometric indices. METHODS This study enrolled participants who underwent health checkups and computed tomography scans for categorizing severity of CAC using the coronary artery calcium score. The METS-VF was calculated and compared with anthropometric indices in estimating the presence of CAC and different CAC severity using receiver operating characteristic curves. RESULTS Overall, 1217 participants (mean age 50.7 ± 9.9, 53.8% male) were included. METS-VF (odds ratio [OR], 1.506; 95% confidence interval [CI], 1.181-1.921; p = 0.001) was positively associated with the presence of CAC, even after accounting for cardiometabolic factors. Notably, METS-VF was positively associated with mild (OR, 1.450; 95% CI, 1.115-1.886; p = 0.006), moderate (OR, 1.865; 95% CI, 1.137-3.062; p = 0.014), and severe (OR, 2.316; 95% CI, 1.090-4.923; p = 0.029) CAC. Moreover, METS-VF yielded the highest area under curve (AUC) value in the estimation of the CAC presence (AUC = 0.710), mild (AUC = 0.682), moderate (AUC = 0.757), and severe (AUC = 0.807) CAC when compared with body mass index, waist circumference, visceral adiposity index, triglyceride-glucose index, and metabolic score for insulin resistance. The optimal METS-VF cut-off value was 6.4 for predicting CAC. CONCLUSIONS METS-VF emerged as a strong independent marker for detecting CAC presence across mild, moderate, and severe CAC categories, outperforming major anthropometric indices in accurately estimating the presence of CAC and different severity of CAC.
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Affiliation(s)
- Jiun-Chi Huang
- Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan;
- Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
- Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
| | - Ya-Chin Huang
- Department of Preventive Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan; (Y.-C.H.); (H.-H.C.); (C.-I.L.)
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
| | - Chia-Hsin Lu
- Department of Medical Imaging, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan;
| | - Yun-Shiuan Chuang
- Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan;
| | - Hsu-Han Chien
- Department of Preventive Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan; (Y.-C.H.); (H.-H.C.); (C.-I.L.)
| | - Chia-I Lin
- Department of Preventive Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan; (Y.-C.H.); (H.-H.C.); (C.-I.L.)
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
| | - Ming-Fang Chao
- Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan;
| | - Hung-Yi Chuang
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
| | - Chi-Kung Ho
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
| | - Chao-Ling Wang
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
| | - Chia-Yen Dai
- Department of Occupational & Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-Y.C.); (C.-K.H.)
- Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
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Cao H, Huang X, Luo B, Shi W, Li H, Shi R. Gender Differences of Visceral Fat Area to Hip Circumference Ratio for Insulin Resistance. Diabetes Metab Syndr Obes 2024; 17:3935-3942. [PMID: 39465126 PMCID: PMC11512554 DOI: 10.2147/dmso.s482820] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/25/2024] [Accepted: 10/16/2024] [Indexed: 10/29/2024] Open
Abstract
Introduction Not all type 2 diabetes mellitus (T2DM) patients exhibit insulin resistance (IR). Our objective is to identify the most effective sex-specific index for predicting IR in T2DM. This will be achieved through a comparative analysis of the sex-specific attributes of waist to hip circumference ratio (WHR), visceral fat area to hip circumference ratio (VHR), and visceral fat area to subcutaneous fat area ratio (VSR). Methods Receiver operating characteristic curve analysis was conducted to estimate the area under the curve for WHR, VHR, and VSR. Subsequently, logistic regression was employed to analyze the relationship between VHR and IR. Results There were significant differences between males and females in anthropometric measurements, biochemical data, and obesity prevalence. ROC analysis revealed that the area under the curve (AUC) for predicting male IR was 0.67, 0.71, and 0.62 for WHR, VHR, and VSR, respectively. For females, the AUC values were 0.63, 0.69, and 0.60, respectively. In multivariate logistic regression analysis, adjusting for confounding factors, compared to the lowest tertile of VHR, the odds ratio (OR) of the highest tertile was 2.2 (95% CI: 1.47-3.3, P<0.001) for males and 2.1 (95% CI: 1.24-3.57, P=0.005) for females. Conclusion VHR emerges as the most reliable predictor of IR risk in individuals with T2DM.
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Affiliation(s)
- Huiying Cao
- Clinical Laboratory, The First People’s Hospital of Honghe State, Honghe State, Yunnan Province, People’s Republic of China
| | - Xuan Huang
- Clinical Laboratory, The First People’s Hospital of Honghe State, Honghe State, Yunnan Province, People’s Republic of China
| | - Beibei Luo
- Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, People’s Republic of China
| | - Wei Shi
- Clinical Laboratory, The First People’s Hospital of Honghe State, Honghe State, Yunnan Province, People’s Republic of China
| | - Huan Li
- Clinical Laboratory, The First People’s Hospital of Honghe State, Honghe State, Yunnan Province, People’s Republic of China
| | - Rui Shi
- Clinical Laboratory, People’s Hospital of Yuxi City, the Sixth Affiliated Hospital of Kunming Medical University, Yuxi City, Yunnan Province, People’s Republic of China
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30
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Ergün U, Aktepe E, Koca YB. Detection of body shape changes in obesity monitoring using image processing techniques. Sci Rep 2024; 14:24178. [PMID: 39406756 PMCID: PMC11480043 DOI: 10.1038/s41598-024-73270-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/23/2024] [Accepted: 09/16/2024] [Indexed: 10/19/2024] Open
Abstract
Body measurements are primarily made with a tape measure. In measurements taken with a tape measure, the inability to take measurements from the same part of the body each time, incorrect positioning of the tape measure, the occurrence of incorrect measurements, and the need for a person to take the measurements are significant problems in the traditional measurement method. Due to the social distancing rule that must be followed during the Covid-19 pandemic, the close contact between the person to be measured and the person taking the measurement became the starting point of this study. This study focuses on the detecting body shape changes using image processing techniques with 2D imaging. The novelty of the work is that non-contact body measurements are taken more accurately and reliably using the cosine theorem. Regular monitoring of obese patients is important in combating obesity, which is also the source of many health problems. In the monitoring of obese patients, it is necessary to determine the rate of slimming in areas where fat accumulation is intense. The error margin between the real measurements of human models and the calculated measurements was calculated as an average of ± 5.16% for waistline and an average of ± 4.58% for hip size. The cosine theorem was used instead of the ellipse formula used in the literature, and it was observed that the cosine theorem obtained results closer to reality. It is also thought that the developed system will be beneficial not only for extracting body measurements but also for extracting body measurements contactless in the textile sector. The study demonstrates the feasibility of image processing for non-contact body anthropometry and shape tracking.
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Affiliation(s)
- Uçman Ergün
- Engineering Faculty, Biomedical Engineering Department , Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey
| | - Elif Aktepe
- Afyon Vocational School, Electronics and Automation Department , Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey
| | - Yavuz Bahadır Koca
- Engineering Faculty, Electrical Engineering Department, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey.
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31
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Wu J, Lu D, Chen X. Association of body roundness index with abdominal aortic calcification among middle aged and elderly population: findings from NHANES. Front Cardiovasc Med 2024; 11:1475579. [PMID: 39450238 PMCID: PMC11499151 DOI: 10.3389/fcvm.2024.1475579] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2024] [Accepted: 09/23/2024] [Indexed: 10/26/2024] Open
Abstract
Aim We aim to investigate the association between body roundness index (BRI) and abdominal aortic calcification (AAC) among middle aged and elderly US residents. Methods This cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 cycle, including 3,079 middle-aged and elderly participants aged 40 and above. AAC scores for these participants were assessed using dual-energy x-ray absorptiometry (DXA). BRI was calculated from participants' height and waist circumference, with all measurements conducted by trained surveyors using standardized methods. The relationship between BRI and AAC was analyzed using weighted multivariate logistic regression, adjusting for confounding variable. Additionally, restricted cubic splines (RCS) analysis was also employed. Results We found that those with AAC were significantly older and had a higher prevalence of smoking and chronic kidney disease (CKD) prevalence compared to those without AAC. Using weighted multivariable logistic regression, we determined that an increase of one unit in BRI was associated with a 22% higher risk of AAC. Additionally, higher BRI quartiles (Q2, Q3, Q4) showed significantly increased risks of AAC compared to the lowest quartile. Visualization using RCS indicated a gradual increase in AAC risk with higher BRI, which plateaued beyond a BRI of 7.2. This relationship was significant across different age and gender group. Conclusion There is a positive association between abdominal obesity (as measured by BRI) and AAC in the middle-aged and elderly population. This suggests the impact of abdominal obesity on vascular health and that this factor should be considered in public health strategies.
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Affiliation(s)
- Ji Wu
- Department of Thyroid Breast Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, China
- Department of Hand and Foot Surgery, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, Wuxi, China
| | - Daojun Lu
- Department of Hand and Foot Surgery, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, Wuxi, China
| | - Xiang Chen
- Department of Thyroid Breast Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, China
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32
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Júnior AC, França AK, dos Santos E, Silveira V, dos Santos A. Artificial Neural Networks to Predict Metabolic Syndrome without Invasive Methods in Adolescents. J Clin Med 2024; 13:5914. [PMID: 39407974 PMCID: PMC11477488 DOI: 10.3390/jcm13195914] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/04/2024] [Revised: 09/07/2024] [Accepted: 09/11/2024] [Indexed: 10/20/2024] Open
Abstract
Background/Objectives: The prevalence of metabolic syndrome (MetS) is increasing worldwide, and an increasing number of cases are diagnosed in younger age groups. This study aimed to propose predictive models based on demographic, anthropometric, and non-invasive clinical variables to predict MetS in adolescents. Methods: A total of 2064 adolescents aged 18-19 from São Luís-Maranhão, Brazil were enrolled. Demographic, anthropometric, and clinical variables were considered, and three criteria for diagnosing MetS were employed: Cook et al., De Ferranti et al. and the International Diabetes Federation (IDF). A feed-forward artificial neural network (ANN) was trained to predict MetS. Accuracy, sensitivity, and specificity were calculated to assess the ANN's performance. The ROC curve was constructed, and the area under the curve was analyzed to assess the discriminatory power of the networks. Results: The prevalence of MetS in adolescents ranged from 5.7% to 12.3%. The ANN that used the Cook et al. criterion performed best in predicting MetS. ANN 5, which included age, sex, waist circumference, weight, and systolic and diastolic blood pressure, showed the best performance and discriminatory power (sensitivity, 89.8%; accuracy, 86.8%). ANN 3 considered the same variables, except for weight, and exhibited good sensitivity (89.0%) and accuracy (87.0%). Conclusions: Using non-invasive measures allows for predicting MetS in adolescents, thereby guiding the flow of care in primary healthcare and optimizing the management of public resources.
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Affiliation(s)
- Antonio Costa Júnior
- Coordenação do Curso de Medicina, Centro de Ciências de Pinheiro, Universidade Federal do Maranhão, São Luís 65200-000, Brazil
- Programa de Pós-Graduação em Saúde Coletiva, Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís 65020-070, Brazil; (A.K.F.); (V.S.); (A.d.S.)
| | - Ana Karina França
- Programa de Pós-Graduação em Saúde Coletiva, Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís 65020-070, Brazil; (A.K.F.); (V.S.); (A.d.S.)
| | - Elisângela dos Santos
- Departamento de Enfermagem, Universidade Federal do Maranhão, São Luís 65080-805, Brazil;
| | - Victor Silveira
- Programa de Pós-Graduação em Saúde Coletiva, Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís 65020-070, Brazil; (A.K.F.); (V.S.); (A.d.S.)
| | - Alcione dos Santos
- Programa de Pós-Graduação em Saúde Coletiva, Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís 65020-070, Brazil; (A.K.F.); (V.S.); (A.d.S.)
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Roden-Foreman JS, Foreman ML, Monday K, Lingle K, Blough B, Safa MM, Schwartz G. Body mass index is not associated with time on veno-venous extracorporeal membrane oxygenation or in-hospital mortality. Perfusion 2024; 39:1356-1362. [PMID: 37501258 DOI: 10.1177/02676591231193269] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/29/2023]
Abstract
Morbid obesity, as characterized by BMI, is often utilized as an exclusion criterion for VV-ECMO because of presumed poor prognosis and technically complex cannulation. However, the "obesity paradox" suggests obesity may be protective during critical illness, and BMI does not capture variations in body type, adiposity, or fluid balance. This study examines relationships between BMI and patient outcomes. Adult VV-ECMO patients with BMI ≥ 35 kg/m2 admitted January 2012 to June 2021 were identified from an institutional registry. BMI and outcomes were analyzed with Mann-Whitney U tests and Pearson correlations with Bayesian post-hoc analyses. 116 of 960 ECMO patients met inclusion criteria. Median (Q1, Q3) BMI was 42.3 (37.3, 50.8) and min, max of 35.0, 87.8 with 9.0 (5.0, 15.5) ECMO days. BMI was not significantly correlated with ECMO days (r = -0.102; p = .279). Bayesian analyses showed moderate evidence against BMI correlating with ECMO days. In-hospital mortality (27%) was significantly associated with ECMO days (p = .014) but not BMI (p = .485). In this cohort of high-BMI patients, BMI was not associated with survival or time on ECMO. BMI itself should not be used as an exclusion criterion for VV-ECMO.
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Affiliation(s)
- Jordin S Roden-Foreman
- Baylor University Medical Center at Dallas, Dallas, TX, USA
- University of North Texas Health Science Center, Fort Worth, TX, USA
| | | | - Kara Monday
- Baylor University Medical Center at Dallas, Dallas, TX, USA
| | - Kaitlyn Lingle
- Baylor University Medical Center at Dallas, Dallas, TX, USA
| | - Britton Blough
- Baylor University Medical Center at Dallas, Dallas, TX, USA
| | - Mohamad M Safa
- Baylor University Medical Center at Dallas, Dallas, TX, USA
| | - Gary Schwartz
- Baylor University Medical Center at Dallas, Dallas, TX, USA
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Barus NRV, Tahapary DL, Kurniawan F, Sinto R, Wafa S, Wisnu W, Mansjoer A, Wijaya CN, Felix I, Tarigan TJE, Harbuwono DS, Soewondo P. Obesity Parameters as Predictor of Poor Outcomes in Hospitalized Patients with Confirmed Mild-to-Moderate COVID-19. Infect Dis Rep 2024; 16:894-905. [PMID: 39311212 PMCID: PMC11417886 DOI: 10.3390/idr16050071] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/01/2024] [Revised: 08/19/2024] [Accepted: 08/19/2024] [Indexed: 09/26/2024] Open
Abstract
(1) Background: This study aims to assess visceral fat values, waist circumference (WC), body mass index (BMI), and body fat percentage for their ability to predict poor outcomes during COVID-19 patients' hospitalization; (2) Methods: This study was a prospective cohort of mild-moderate COVID-19 patients hospitalized at Dr. Cipto Mangunkusumo National General Hospital from December 2020 to March 2021. This study includes hospitalized patients over 18 diagnosed with COVID-19 using RT-PCR. Patients who do not have chest radiography, waist circumference, a bioimpedance analyzer (BIA) error, or are unable to stand or mobilize during the examination are excluded from this study. Cox regression was used for multivariate analysis; (3) Results: The study included two hundred sixty-one patients. The median visceral fat value was 10 (equivalent to 100 cm2), the WC was 93.4 cm, the BMI was 26.1 kg/m2, and the body fat percentage was 31.5%. Based on multivariate Cox regression, WC was statistically significant as an independent factor influencing poor outcomes in COVID-19 patients (RR 1.037 [95% CI 1.011-1.064]) along with COVID-19 degree of severity (RR 3.063 [95% CI 1.537-6.104]) and comorbidities (RR 2.123 [95% CI 1.017-4.435]); (4) Conclusions: Waist circumference can influence poor outcomes in confirmed COVID-19 patients during hospitalization.
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Affiliation(s)
- Nadya R. V. Barus
- Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia;
| | - Dicky Levenus Tahapary
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
- Clinical Research Unit, Dr. Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia
| | - Farid Kurniawan
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Robert Sinto
- Division of Tropical Disease and Infection, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia;
| | - Syahidatul Wafa
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Wismandari Wisnu
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Arif Mansjoer
- Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia;
| | - Calysta Nadya Wijaya
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Immanuel Felix
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Tri Juli Edi Tarigan
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Dante Saksono Harbuwono
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
| | - Pradana Soewondo
- Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta 10430, Indonesia; (F.K.); (S.W.); (W.W.); (T.J.E.T.); (D.S.H.); (P.S.)
- Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; (C.N.W.); (I.F.)
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Jia S, Huo X, Sun L, Yao Y, Chen X. The association between the weight-adjusted-waist index and frailty in US older adults: a cross-sectional study of NHANES 2007-2018. Front Endocrinol (Lausanne) 2024; 15:1362194. [PMID: 39319256 PMCID: PMC11420920 DOI: 10.3389/fendo.2024.1362194] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/27/2023] [Accepted: 03/15/2024] [Indexed: 09/26/2024] Open
Abstract
Objective This study aimed to evaluate the relationship between the weight-adjusted waist circumference index (WWI) and the frailty in American adults aged over 60 years. Methods We utilized data from the National Health and Nutrition Examination Surveys (NHANES) spanning from 2007 to 2018. WWI was calculated using the square root of waist circumference (cm) divided by body weight (kg). The frailty index ≥ 0.25 was employed to assess frailty. Weighted multivariate logistic regression was conducted to explore the association between WWI and frailty. Generalized Additive Modeling (GAM) was used to explore potential non-linear relationships. Receiver operating characteristic curve (ROC) analysis was used to assess the predictive ability of WWI for frailty. Results The study encompassed 7765 participants. Higher WWI was significantly associated with higher odds of frailty. In the fully adjusted model, each unit increase of WWI was associated with an 82% increased odds of frailty (OR: 1.82, 95% CI: 1.61 - 2.06; P < 0.001). GAM found significant nonlinear relationships and threshold effects. Conclusion The study presented a robust correlation between elevated WWI and increased odds of frailty among American older adults. However, these findings require further validation in large-scale, prospective studies.
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Affiliation(s)
- Shanshan Jia
- Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China
| | - Xingwei Huo
- Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China
| | - Lirong Sun
- Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China
- Affiliated Hospital of Xizang Minzu University, Xianyang, Shaanxi, China
| | - Yuanyuan Yao
- Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China
| | - Xiaoping Chen
- Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Vaccarino R, Wachtmeister M, Karelis A, Marinko E, Sun J, Resch T, Sonesson B, Dias NV. The role of CT-assessed sarcopenia and visceral adipose tissue in predicting long-term survival in patients undergoing elective endovascular infrarenal aortic repair. Br J Radiol 2024; 97:1461-1466. [PMID: 38848475 PMCID: PMC11256935 DOI: 10.1093/bjr/tqae114] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2024] [Revised: 05/22/2024] [Accepted: 05/31/2024] [Indexed: 06/09/2024] Open
Abstract
OBJECTIVES To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT. Primary endpoint was all-cause mortality. Values are presented as median and interquartile range or absolute number and percentage. Cox regression analyses were performed to assess the associations with mortality. RESULTS Two hundred and eighty-four patients could be included in the study. During a median follow-up of 8 (4-11) years, 223 (79.9%) patients died. Age (P ≤ .001), cardiovascular (P = .041), cerebrovascular (P = .009), renal diseases (P = .002), and chronic obstructive pulmonary disease (P ≤ .001) were independently associated with mortality. TPA was associated with mortality in a univariate (P = .040), but not in a multivariate regression model (P = .764). No significant association was found between mortality and TPA index (P = .103) or any of the adiposity measurements with the exception of SAT (P = .040). However, SAT area loss in a multivariate analysis (P = .875). CONCLUSIONS Assessment of core muscle size and VAT did not contribute to improving the prediction of long-term survival after EVAR. ADVANCES IN KNOWLEDGE The finding of this study contradicts the previously claimed utility of core muscle size and VAT in predicting long-term survival after EVAR.
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Affiliation(s)
- Roberta Vaccarino
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
| | | | - Angelos Karelis
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
- Department of Thoracic Surgery and Vascular Diseases, Vascular Center, Skane University Hospital, Malmö 21428, Sweden
| | - Elisabet Marinko
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
| | - Jianming Sun
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
| | - Timothy Resch
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
- Department of Vascular Surgery, Rigshospitalet, Copenhagen 2100, Denmark
- Department of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark
| | - Björn Sonesson
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
- Department of Thoracic Surgery and Vascular Diseases, Vascular Center, Skane University Hospital, Malmö 21428, Sweden
| | - Nuno V Dias
- Department of Clinical Sciences Malmö, Lund University, Malmö 21428, Sweden
- Department of Thoracic Surgery and Vascular Diseases, Vascular Center, Skane University Hospital, Malmö 21428, Sweden
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Li X, Zhao D, Wang H. Association between weight-adjusted waist index and risk of diabetes mellitus type 2 in United States adults and the predictive value of obesity indicators. BMC Public Health 2024; 24:2025. [PMID: 39075353 PMCID: PMC11285432 DOI: 10.1186/s12889-024-19576-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2023] [Accepted: 07/24/2024] [Indexed: 07/31/2024] Open
Abstract
BACKGROUND The weight-adjusted waist index (WWI) is a quantitative anthropometric index that can be applied to evaluate obesity. This study examined the relationship between adult United States (US) residents' risk of diabetes mellitus type 2 (T2DM) and WWI. METHODS The NHANES (National Health and Nutrition Examination Survey) 2001-2018 provided the data for this investigation. This study used multifactorial logistic regression analysis, smoothed curve fitting, subgroup analysis, and interaction tests to assess the association between WWI and T2DM. Additionally, threshold effects were calculated using a two-stage linear regression model. The receiver operating characteristic(ROC) curves evaluated the diagnostic ability of the WWI and commonly used obesity indicators. RESULTS 20,477 participants were enrolled in the analysis, and patients with greater levels of WWI had a higher prevalence of T2DM. WWI and T2DM have a non-linear relationship, with a positive association found on the left side of the breakpoint (WWI = 12.35) (OR = 1.82, 95%CI:1.64-2.02), whereas, on the right side, no such relationship was found (OR = 0.9, 95%CI:0.61-1.34). For every unit rise in WWI, the probability of having T2DM increased by 67% after controlling for all other variables (OR:1.67,95%CI:1.53-1.83). Based on subgroup analyses, individuals under 40 had a higher correlation between WWI and T2DM (P < 0.001).ROC analyses showed that WWI had the best discrimination and accuracy in predicting T2DM compared to other obesity indicators (WC, BMI, and Weight). CONCLUSION Higher WWI values had a higher prevalence of T2DM in US individuals, especially in adults under 40. WWI has the strongest ability to predict T2DM. Therefore, the importance of WWI in the early identification of T2DM in US adults should be emphasized.
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Affiliation(s)
- XinMeng Li
- Department of Rehabilitation Medicine, Binzhou Medical University Hospital, Binzhou, Shandong Province, 256600, China
| | - Dan Zhao
- Department of Anesthesiology, Binzhou Medical University Hospital, Binzhou, Shandong Province, 256600, China
| | - Hongkun Wang
- Department of Rehabilitation Medicine, Binzhou Medical University Hospital, Binzhou, Shandong Province, 256600, China.
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Xu T, Jin F, Yu Y, He J, Yang R, Lv T, Yan Z. Association between waist circumference and chronic pain: insights from observational study and two-sample Mendelian randomization. Front Nutr 2024; 11:1415208. [PMID: 39131735 PMCID: PMC11310123 DOI: 10.3389/fnut.2024.1415208] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2024] [Accepted: 07/16/2024] [Indexed: 08/13/2024] Open
Abstract
Background Current research offers limited clarity on the correlation between waist circumference and chronic pain prevalence. Objective This investigation seeks to elucidate the potential relationship between waist circumference and chronic pain and their causal association. Methods An observational study was conducted, leveraging data from the National Health and Nutrition Examination Survey (NHANES) collected between 2001 and 2004. The multivariable logistic regression was used to assess the relationship between waist circumference and chronic pain. Furthermore, a meta-analysis of Mendelian Randomization (MR) was applied to explore a causal relationship between waist circumference and pain. Results The observational study, post multivariable adjustment, indicated that an increase in waist circumference by 1 dm (decimeter) correlates with a 14% elevation in chronic pain risk (Odds Ratio [OR] = 1.14, 95% Confidence Interval [CI]: 1.04-1.24, p = 0.01). Moreover, the meta-analysis of MR demonstrated that an increased waist circumference was associated with a genetic predisposition to pain risk (OR = 1.14, 95%CI: 1.06-1.23, p = 0.0007). Conclusion Observational analysis confirmed a significant relationship between increased waist circumference and the incidence of chronic pain, and results based on MR Study identified increased waist circumference as potentially causal for pain.
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Affiliation(s)
- Ting Xu
- Department of Anesthesiology, Traditional Chinese Medical Hospital of Zhuji, Zhuji, China
| | - Fan Jin
- Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China
| | - Yeting Yu
- Department of Anesthesiology, Traditional Chinese Medical Hospital of Zhuji, Zhuji, China
| | - Jie He
- Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China
| | - Ren Yang
- Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China
| | - Tian Lv
- Department of Neurology, Zhuji People's Hospital, Shaoxing University, Zhuji, China
| | - Zhangjun Yan
- Department of Anesthesiology, Zhuji People's Hospital, Shaoxing University, Zhuji, China
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Abdulghani MF, Al-Fayyadh S. The effect of a nurse-led low carbohydrate regimen on anthropometric and laboratory parameters of patients with metabolic syndrome: a quasi-experimental study. Front Public Health 2024; 12:1415916. [PMID: 39086815 PMCID: PMC11288854 DOI: 10.3389/fpubh.2024.1415916] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2024] [Accepted: 06/27/2024] [Indexed: 08/02/2024] Open
Abstract
Introduction Metabolic syndrome is a global health concern. It is a condition that includes a cluster of various risk factors for type 2 diabetes and cardiovascular disease. This quasi-experimental study investigates the effect of a nurse-led low-carbohydrate regimen on anthropometric and laboratory parameters in metabolic syndrome patients. Methods The study used a quasi-experimental design conducted at the University of Mosul; 128 participants meeting the metabolic syndrome criteria were recruited and divided into the intervention and control groups. The intervention group received personalized counseling and support in implementing a low-carb regime, while the control group received standard advice. The study participants were assessed by anthropometry, and laboratory parameters were evaluated pre- and post-intervention. Statistical data analysis was conducted using IBM-SPSS 27, including chi-square, Fisher's exact test, t-tests, and the Mcnemar test, which were performed to compare the changes within and between groups. Results The mean age of the participants in the intervention and control groups was 50.72 ± 6.43 years and 49.14 ± 6.89 years, respectively. Compared to the control group, the intervention group experienced a significant positive reduction in anthropometric measures and laboratory parameters, including weight, body mass index (BMI), waist circumference, lipid profiles, and HbA1c. Conclusion A tangible effect of nurse-led interventions based on low-carbohydrate regimens in managing metabolic syndrome was empirically authenticated. Positive changes were observed in the intervention group regarding anthropometric measures and laboratory parameters. However, future research may require a larger sample size and a longer follow-up to confirm these effects and evaluate long-term metabolic impacts.
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Gordito Soler M, López-González ÁA, Vallejos D, Martínez-Almoyna Rifá E, Vicente-Herrero MT, Ramírez-Manent JI. Usefulness of Body Fat and Visceral Fat Determined by Bioimpedanciometry versus Body Mass Index and Waist Circumference in Predicting Elevated Values of Different Risk Scales for Non-Alcoholic Fatty Liver Disease. Nutrients 2024; 16:2160. [PMID: 38999907 PMCID: PMC11243258 DOI: 10.3390/nu16132160] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2024] [Revised: 06/28/2024] [Accepted: 07/05/2024] [Indexed: 07/14/2024] Open
Abstract
BACKGROUND Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of liver disease in developed countries, which progresses to liver cirrhosis and liver cancer. MAFLD is associated with obesity and can be evaluated by validated formulas to assess MAFLD risk using different parameters such as the body mass index (BMI) and waist circumference (WC). However, these parameters do not accurately measure body fat. As MAFLD is strongly associated with obesity, we hypothesize that measuring body and visceral fat by electrical bioimpedance is an efficient method to predict the risk of MAFLD. The objective of our work was to demonstrate that electrical bioimpedance is a more efficient method than the BMI or WC to predict an elevated risk of MAFLD. METHODS A cross-sectional, descriptive study involving 8590 Spanish workers in the Balearic Islands was carried out. The study's sample of employees was drawn from those who underwent occupational medicine examinations between January 2019 and December 2020. Five MAFLD risk scales were determined for evaluating very high levels of body fat and visceral fat. The determination of body and visceral fat was performed using bioimpedanciometry. Student's t-test was employed to ascertain the mean and standard deviation of quantitative data. The chi-square test was used to find prevalences for qualitative variables, while ROC curves were used to define the cut-off points for body and visceral fat. The calculations included the area under the curve (AUC), the cut-off points along with their Youden index, sensitivity, and specificity. Correlation and concordance between the various scales were determined using Pearson's correlation index and Cohen's kappa, respectively. RESULTS As both total body fat and visceral fat increase, the risk of MAFLD increases with a statistically significant result (p < 0.001), presenting a higher risk in men. The areas under the curve (AUC) of the five scales that assess overweight and obesity to determine the occurrence of high values of the different MAFLD risk scales were very high, most of them exceeding 0.9. These AUC values were higher for visceral and body fat than for the BMI or waist circumference. FLD-high presented the best results in men and women with the AUC at around 0.97, both for visceral fat and total body fat, with a high Youden index in all cases (women body fat = 0.830, visceral fat = 0.892; men body fat = 0.780, visceral fat = 0.881). CONCLUSIONS In our study, all the overweight and obesity scales show a very good association with the scales assessing the risk of MAFLD. These values are higher for visceral and body fat than for waist circumference and the BMI. Both visceral fat and body fat are better associated than the BMI and waist circumference with MAFLD risk scales.
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Affiliation(s)
| | - Ángel Arturo López-González
- Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain
- Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain
| | - Daniela Vallejos
- Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain
- Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain
| | - Emilio Martínez-Almoyna Rifá
- Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain
- Faculty of Dentistry, University School ADEMA, 07010 Palma, Balearic Islands, Spain
| | - María Teófila Vicente-Herrero
- Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain
| | - José Ignacio Ramírez-Manent
- Investigation Group ADEMA SALUD, University Institute for Research in Health Sciences (IUNICS), 07010 Palma, Balearic Islands, Spain
- Institut d'Investigació Sanitària de les Illes Balears (IDISBA), Balearic Islands Health Research Institute Foundation, 07010 Palma, Balearic Islands, Spain
- Balearic Islands Health Service, 07010 Palma, Balearic Islands, Spain
- Faculty of Medicine, University of the Balearic Islands, 07010 Palma, Balearic Islands, Spain
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Chen Y, Yang J, Wan Y, Li Q, Yang D, Wang Y, Gong J, Bai L, Liu Y, Li X, Wang J. DEAR model in overweight endometrial cancer patients undergoing fertility-sparing treatment: A randomized controlled trial. Gynecol Oncol 2024; 185:148-155. [PMID: 38422947 DOI: 10.1016/j.ygyno.2024.02.017] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2023] [Revised: 01/13/2024] [Accepted: 02/12/2024] [Indexed: 03/02/2024]
Abstract
OBJECTIVE To evaluate the effects of DEAR weight management in overweight patients undergoing fertility-sparing treatment for endometrial cancer or atypical hyperplasia. METHODS Women with endometrial cancer or atypical hyperplasia who received fertility-sparing treatment and had a body mass index of >25 kg/m2 were randomly allocated to the DEAR (DEAR weight management) and control (self weight management) groups. Body morphology and composition, glycolipid metabolism, and tumor outcomes were assessed in both groups before and at 3 and 6 months after intervention. RESULTS Overall, 72 subjects were included (36 in each group). Following intervention, the DEAR group showed significantly lower median body weight (69.45 vs. 78.05), body mass index (26.19 vs. 29.15), lipid accumulation index (29.21 vs. 57.86), body fat mass (24.00 vs. 29.30), visceral fat area (112.5 vs. 133.3), and glycolipid metabolic indices (except high density lipoprotein) than the control group (P < 0.05) and showed a decreasing trend. The test group achieved significantly higher complete remission (88.46% vs. 57.14%; P < 0.05); the time to complete remission did not differ significantly (P > 0.05). CONCLUSIONS DEAR weight management can improve the studied parameters and complete remission rates in this population. REGISTRATION NCT06169449.
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Affiliation(s)
- YiQian Chen
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China; Beijing Health Vocational College, Beijing, China
| | - JingYing Yang
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China; Peking University School of Nursing, Beijing, China
| | - Yu Wan
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - QingRan Li
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - DanDan Yang
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - YongLi Wang
- Department of Pediatrics, Peking University People's Hospital, Beijing, China
| | - JingJing Gong
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - LianHua Bai
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - YuanYuan Liu
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
| | - XiaoDan Li
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
| | - JianLiu Wang
- Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China
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Xiao T, Huang Z, Zheng C, Quach B, Zhu Y, Li F, Liang W, Baker J, Reichetzeder C, Hocher B, Yang Y. Associations of bisphenol A exposure with metabolic syndrome and its components: A systematic review and meta-analysis. Obes Rev 2024; 25:e13738. [PMID: 38491337 DOI: 10.1111/obr.13738] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/20/2023] [Revised: 01/21/2024] [Accepted: 02/13/2024] [Indexed: 03/18/2024]
Abstract
Mounting evidence shows that bisphenol A (BPA) is associated with metabolic risk factors. The aim of this study was to review related epidemiologic studies and conduct a meta-analysis to quantitatively estimate the association between BPA and metabolic syndrome. Four electronic databases were systematically searched to identify suitable articles. A total of 47 published studies were finally included. Two studies involved metabolic syndrome. Of the 17, 17, 14, and 13 studies on the relationship between BPA with abdominal obesity, blood pressure, fasting plasma glucose, and dyslipidemia, 10, 6, 3, and 4 studies were included in the meta-analysis, respectively. The results showed that the risk of abdominal obesity increased with the increase of BPA exposure, especially in the group with higher BPA exposure levels (Quartile 2 vs. Quartile 1, pooled OR = 1.16, 95%CI: 1.01, 1.33; Q3 vs. Q1, pooled OR = 1.31, 95%CI: 1.13, 1.51; Q4 vs. Q1, pooled OR = 1.40, 95%CI: 1.21, 1.61). However, there was no significant correlation between BPA exposure and metabolic syndrome components including hypertension, abnormal fasting plasma glucose, and dyslipidemia. The present study found that BPA exposure is significantly associated with a higher risk of abdominal obesity. However, the relationship between BPA with metabolic syndrome and its other components needs further longitudinal studies to verify.
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Affiliation(s)
- Tianli Xiao
- Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
- The Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, China
| | - Zehua Huang
- Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
- The Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, China
| | - Chanjuan Zheng
- Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
- The Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, China
| | - Binh Quach
- Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong, China
| | - Yulian Zhu
- Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha, China
| | - Feifei Li
- Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong, China
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China
| | - Wei Liang
- School of Physical Education, Shenzhen University, Shenzhen, China
| | - Julien Baker
- Centre for Health and Exercise Science Research, Hong Kong Baptist University, Hong Kong, China
- Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China
| | - Christoph Reichetzeder
- Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
- HMU - Health and Medical University, Potsdam, Germany
| | - Berthold Hocher
- Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
- Institute of Medical Diagnostics, IMD, Berlin, Germany
- Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China
| | - Yide Yang
- Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
- The Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, China
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Su Y, Sun J, Zhou Y, Sun W. The Relationship of Waist Circumference with the Morbidity of Cardiovascular Diseases and All-Cause Mortality in Metabolically Healthy Individuals: A Population-Based Cohort Study. Rev Cardiovasc Med 2024; 25:212. [PMID: 39076338 PMCID: PMC11270058 DOI: 10.31083/j.rcm2506212] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/15/2023] [Revised: 01/16/2024] [Accepted: 01/24/2024] [Indexed: 07/31/2024] Open
Abstract
Background This study explores the relationship between waist circumference and morbidity of cardiovascular diseases (CVD) and all-cause mortality in metabolically healthy individuals. Methods A cohort of 5775 metabolically healthy participants from the 2001-2014 US National Health and Nutrition Examination Survey and National Death Index database was tracked over a median period of 81 months. These participants were divided into quartiles (Q1, Q2, Q3, Q4) based on increasing waist circumference. To compensate for missing covariates, multivariate multiple imputation methods were used. Adjusted logistic regression models were employed to examine the correlation between waist circumference and cardiovascular disease prevalence. Furthermore, Kaplan-Meier curves and multivariable Cox regression analysis were utilized to evaluate the association between waist circumference and all-cause mortality, both qualitatively and quantitatively. Results The adjusted logistic regression model indicated that a 10 cm increase in waist circumference was associated with a 1.45 times higher prevalence of CVD. As a categorical variable, there was a significant upward trend in CVD incidence across quartiles of waist circumference. The adjusted odds ratios (95% confidence intervals) were 2.41 (1.13-5.53) for Q2, 2.65 (1.18-6.39) for Q3, and 2.53 (0.9-7.44) for Q4, compared to Q1. Notably, individuals with high waist circumference showed significantly poorer survival compared to those with low waist circumference (p = 0.008). The Cox regression analysis revealed that each 10 cm increase in waist circumference contributed to an ~8% increase in all-cause mortality. Conclusions This study underscores a positive correlation between waist circumference and both CVD morbidity and all-cause mortality in metabolically healthy individuals. The findings highlight the significance of routinely monitoring waist circumference for effective CVD risk management, regardless of metabolic health status.
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Affiliation(s)
- Yue Su
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
| | - Jinyu Sun
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
| | - Ying Zhou
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
| | - Wei Sun
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, Jiangsu, China
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Mousa MFM, Naeem M, Bibi S, Bülow R, Bahls M, Siewert-Markus U, Töpfer P, Aghdassi A, Khattak MNK, Völzke H, Markus MRP, Ittermann T. Central obesity and fat-free mass are associated with a larger spleen volume in the general population. Ups J Med Sci 2024; 129:10465. [PMID: 38863728 PMCID: PMC11165247 DOI: 10.48101/ujms.v129.10465] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/22/2023] [Revised: 03/28/2024] [Accepted: 03/28/2024] [Indexed: 06/13/2024] Open
Abstract
Background and aim As the spleen plays a significant role in immunity, the aim was to investigate the associations of different body composition markers derived from various sources with spleen volume in a general population sample. Materials and methods Cross-sectional data of 1095 individuals (570 women; 52%) aged between 30 and 90 years were collected in the Study of Health in Pomerania (SHIP-START-2). We measured spleen volume by magnetic resonance imaging (MRI).Body composition markers were derived from classic anthropometry, bioelectrical impedance analysis, including absolute fat mass (FM) and fat-free mass (FFM), as well as from MRI, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content. Sex-stratified-adjusted linear regression models were used to analyze the associations of body composition markers with spleen volumes. Results We observed positive associations of body mass index, body weight, waist circumference, hip circumference, waist-to-height ratio, absolute FM, absolute FFM, and VAT and SAT with spleen volume in men and women. An 8.12 kg higher absolute FFM was associated with a 38.4 mL (95% confidence interval [CI]: 26.7-50.1) higher spleen volume in men and a 5.21 kg higher absolute FFM with a 42.6 mL (95% CI: 26.2-59.0) higher spleen volume in women. Conclusion Our findings indicate that obesity-related body composition markers and FFM are associated with a higher spleen volume. Particularly, higher absolute FFM showed a strong association with a larger spleen volume in both men and women. Further studies are warranted to understand the clinical significance of body composition markers on large spleen volume.
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Affiliation(s)
- Mohammed Farah Mahmoud Mousa
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
| | - Muhammad Naeem
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
- Department of Zoology, University of Malakand, Chakdara Dir (L), Pakistan
| | - Saima Bibi
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
| | - Robin Bülow
- Department for Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany
| | - Martin Bahls
- Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
- German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
| | - Ulrike Siewert-Markus
- Clinic and Polyclinic for Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
| | - Philipp Töpfer
- Department of Medical Psychology, University Medicine Greifswald, Germany
| | - Ali Aghdassi
- Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
| | - Muhammad Nasir Khan Khattak
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
| | - Henry Völzke
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
| | - Marcello RP Markus
- Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
- German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
| | - Till Ittermann
- Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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45
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Zhang X, Wang Y, Yang X, Li Y, Gui J, Mei Y, Liu H, Guo LL, Li J, Lei Y, Li X, Sun L, Yang L, Yuan T, Wang C, Zhang D, Li J, Liu M, Hua Y, Zhang L. Obesity and lipid indices as predictors of depressive symptoms in middle-aged and elderly Chinese: insights from a nationwide cohort study. BMC Psychiatry 2024; 24:351. [PMID: 38730360 PMCID: PMC11088055 DOI: 10.1186/s12888-024-05806-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/30/2023] [Accepted: 05/02/2024] [Indexed: 05/12/2024] Open
Abstract
BACKGROUND Depressive symptoms are one of the most common psychiatric disorders, with a high lifetime prevalence rate among middle-aged and elderly Chinese. Obesity may be one of the risk factors for depressive symptoms, but there is currently no consensus on this view. Therefore, we investigate the relationship and predictive ability of 13 obesity- and lipid-related indices with depressive symptoms among middle-aged and elderly Chinese. METHODS The data were obtained from The China Health and Retirement Longitudinal Study (CHARLS). Our analysis includes individuals who did not have depressive symptoms at the baseline of the CHARLS Wave 2011 study and were successfully follow-up in 2013 and 2015. Finally, 3790 participants were included in the short-term (from 2011 to 2013), and 3660 participants were included in the long-term (from 2011 to 2015). The average age of participants in short-term and long-term was 58.47 years and 57.88 years. The anthropometric indicators used in this analysis included non-invasive [e.g. waist circumference (WC), body mass index (BMI), and a body mass index (ABSI)], and invasive anthropometric indicators [e.g. lipid accumulation product (LAP), triglyceride glucose index (TyG index), and its-related indices (e.g. TyG-BMI, and TyG-WC)]. Receiver operating characteristic (ROC) analysis was used to examine the predictive ability of various indicators for depressive symptoms. The association of depressive symptoms with various indicators was calculated using binary logistic regression. RESULTS The overall incidence of depressive symptoms was 20.79% in the short-term and 27.43% in the long-term. In males, WC [AUC = 0.452], LAP [AUC = 0.450], and TyG-WC [AUC = 0.451] were weak predictors of depressive symptoms during the short-term (P < 0.05). In females, BMI [AUC = 0.468], LAP [AUC = 0.468], and TyG index [AUC = 0.466] were weak predictors of depressive symptoms during the long-term (P < 0.05). However, ABSI cannot predict depressive symptoms in males and females during both periods (P > 0.05). CONCLUSION The research indicates that in the middle-aged and elderly Chinese, most obesity- and lipid-related indices have statistical significance in predicting depressive symptoms, but the accuracy of these indicators in prediction is relatively low and may not be practical predictors.
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Affiliation(s)
- Xiaoyun Zhang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ying Wang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Xue Yang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Yuqing Li
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Jiaofeng Gui
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Yujin Mei
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Haiyang Liu
- Student Health Center, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lei-Lei Guo
- Department of Surgical Nursing, School of Nursing, Jinzhou Medical University, No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province, People's Republic of China
| | - Jinlong Li
- Department of Occupational and Environmental Health, Key Laboratory of Occupational Health and Safety for Coal Industry in Hebei Province, School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, People's Republic of China
| | - Yunxiao Lei
- Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Xiaoping Li
- Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lu Sun
- Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Liu Yang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ting Yuan
- Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Congzhi Wang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Dongmei Zhang
- Department of Pediatric Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Jing Li
- Department of Surgical Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Mingming Liu
- Department of Surgical Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ying Hua
- Rehabilitation Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lin Zhang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China.
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Li L, Gao J, Rao X, Liu X. Relationship between atherosclerotic cardiovascular disease and diabetic retinopathy in patients with type 2 diabetes mellitus. Medicine (Baltimore) 2024; 103:e38051. [PMID: 38728488 PMCID: PMC11081578 DOI: 10.1097/md.0000000000038051] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/15/2023] [Accepted: 04/05/2024] [Indexed: 05/12/2024] Open
Abstract
This study aimed to explore the potential correlation between atherosclerotic cardiovascular disease (ASCVD) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). We enrolled 6540 patients with T2DM who were receiving chronic disease management for hypertension, hyperglycemia, and hyperlipidemia in Chengyang District of Qingdao. Among them, 730 had ASCVD (ASCVD group), which 5810 did not (N-ASCVD group). The results showed significantly higher levels of age, blood glucose, glycosylated hemoglobin (HbA1c), systolic blood pressure, ASCVD family history, female proportion, and DR incidence in the N-ASCVD group. Additionally, the glomerular filtration rate was significantly lower in the ASCVD group. Logistic regression analysis revealed a positive correlation between DR and ASCVD risk. DR was further categorized into 2 subtypes, nonproliferative DR (NPDR) and proliferative DR (PDR), based on e lesion severity. Interestingly, only the PDR was associated with ASCVD. Even after accounting for traditional ASCVD risk factors such as age, sex, and family history, PDR remained associated with ASCVD, with a staggering 718% increase in the risk for patients with PDR. Therefore, there is a strong association between ASCVD and DR in individuals with T2DM, with PDR particularly exhibiting an independent and positive correlation with increased ASCVD risk.
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Affiliation(s)
- Li Li
- Endocrinology and Metabolism Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
| | - Jiyun Gao
- Department of Ophthalmology, Qingdao West Coast New Area District Hospital, Qingdao, Shandong, China
| | - Xiaopang Rao
- Qingdao Chengyang District People’s Hospital, Qingdao, Shandong, China
| | - Xiaoling Liu
- Pingdu City People Hospital, Qingdao, Shandong, China
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47
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Zhang X, Wang Y, Li Y, Gui J, Mei Y, Yang X, Liu H, Guo LL, Li J, Lei Y, Li X, Sun L, Yang L, Yuan T, Wang C, Zhang D, Li J, Liu M, Hua Y, Zhang L. Four-years change of BMI and waist circumference are associated with metabolic syndrome in middle-aged and elderly Chinese. Sci Rep 2024; 14:10220. [PMID: 38702424 PMCID: PMC11068757 DOI: 10.1038/s41598-024-60172-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/19/2023] [Accepted: 04/19/2024] [Indexed: 05/06/2024] Open
Abstract
The purpose of the study was to determine whether changes in body mass index (BMI) and waist circumference (WC) in middle-aged and elderly Chinese are associated with metabolic syndrome. In this cohort investigation, 3697 middle-aged and elderly people aged 45 or over were recruited from the China Health and Retirement Longitudinal Study (CHARLS). The National Cholesterol Education Program Adult Treatment Panel III (2005) defined metabolic syndrome (MetS). With Cox regression analysis, we calculated hazard ratio (HR) and 95% confidence intervals (CIs) for MetS based on BMI-WC change categories. To assess the prevalence of MetS, the changes in BMI and WC levels were classified into four quartiles based on their relative and absolute changes. In subjects whose BMI and WC decreased (HR = 0.338; 95% CIs 0.264, 0.433) as well as those whose BMI increased and their WC decreased (HR = 0.375; 95% CIs 0.228, 0.499), metabolic syndrome risk was significantly lower compared with those with increases in both BMI and WC. Regarding the absolute changes in BMI, the lowest percentile of BMI was significantly lower in both males (HR = 0.302; 95% CIs 0.204, 0.448) and females (HR = 0.486; 95% CIs 0.354, 0.667) for the risk of metabolic syndrome. Similar results were observed in the absolute changes in WC, with the lowest quantile of WC having a significant impact on MetS risk in males (HR = 0.170; 95% CIs 0.107, 0.270) and females (HR = 0.303; 95% CIs 0.217, 0.424). The risk of metabolic syndrome was significantly associated with changes in BMI and WC in middle-aged and elderly Chinese. A reduced BMI and WC are associated with lower metabolic syndrome risks in middle-aged and elderly people.
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Affiliation(s)
- Xiaoyun Zhang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ying Wang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Yuqing Li
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Jiaofeng Gui
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Yujin Mei
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Xue Yang
- Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Haiyang Liu
- Student Health Center, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lei-Lei Guo
- Department of Surgical Nursing, School of Nursing, Jinzhou Medical University, No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province, People's Republic of China
| | - Jinlong Li
- Department of Occupational and Environmental Health, Key Laboratory of Occupational Health and Safety for Coal Industry in Hebei Province, School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, People's Republic of China
| | - Yunxiao Lei
- Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Xiaoping Li
- Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lu Sun
- Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Liu Yang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ting Yuan
- Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Congzhi Wang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Dongmei Zhang
- Department of Pediatric Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Jing Li
- Department of Surgical Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Mingming Liu
- Department of Surgical Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Ying Hua
- Rehabilitation Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China
| | - Lin Zhang
- Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China.
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Lau Y, Wong SH, Chee DGH, Ng BSP, Ang WW, Han CY, Cheng LJ. Technology-delivered personalized nutrition intervention on dietary outcomes among adults with overweight and obesity: A systematic review, meta-analysis, and meta-regression. Obes Rev 2024; 25:e13699. [PMID: 38296771 DOI: 10.1111/obr.13699] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/08/2023] [Revised: 01/01/2024] [Accepted: 01/02/2024] [Indexed: 02/02/2024]
Abstract
The prevalence of overweight and obesity has continued to increase globally, and one-size-fits-all dietary recommendations may not be suitable for different individual characteristics. A personalized nutrition intervention may be a potential solution. This review aims to evaluate the effects of the technology-delivered personalized nutrition intervention on energy, fat, vegetable, and fruit intakes among adults with overweight and obesity. A three-step comprehensive search strategy was performed from 10 databases and seven clinical registries in published and unpublished trials. A total of 46 randomized controlled trials (RCTs) involving 19,670 adults with overweight and obesity from 14 countries are included. Subgroup and meta-regression analyses were conducted. Meta-analyses showed a reduction of energy intake (-128.05, 95% CI: -197.08, -59.01) and fat intake (-1.81% energy/days, 95% CI: -3.38, -0.24, and -0.19 scores, 95% CI: -0.40, 0.02) in the intervention compared with the comparator. Significant improvements in vegetable and fruit intakes with 0.12-0.15 servings/day were observed in the intervention. Combined one- and two-way interactions had a greater effect on energy intake reduction compared with their counterparts. Meta-regression analyses revealed that no significant covariates were found. Given that the certainty of the evidence was rated as low or very low, further well-designed RCTs with long-term follow-up are warranted.
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Affiliation(s)
- Ying Lau
- The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
| | | | | | - Brenda Sok Peng Ng
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
| | - Wen Wei Ang
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
| | - Chad Yixian Han
- Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia
| | - Ling Jie Cheng
- Health Systems and Behavioural Science Domain, Saw Swee Hock School of Public Health, National University of Singapore, Singapore
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49
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Pereira LMC, de Souza MFC, Aidar FJ, Getirana-Mota M, dos Santos-Junior AM, Filho MFDDS, Almeida-Santos MA, Rocha RMS, de Almeida RR, Baumworcel L, Costa LHSDM, Mendes RR, Sousa ACS. Wrist Circumference Cutoff Points for Determining Excess Weight Levels and Predicting Cardiometabolic Risk in Adults. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2024; 21:549. [PMID: 38791764 PMCID: PMC11120788 DOI: 10.3390/ijerph21050549] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/02/2024] [Revised: 04/04/2024] [Accepted: 04/15/2024] [Indexed: 05/26/2024]
Abstract
(1) Background: An elevated wrist circumference may indicate excess weight and cardiometabolic risk. The present study aims to identify wrist circumference cutoff points (WrC) to determine excess weight levels and predict cardiometabolic risk in adults. (2) Methods: A cross-sectional study was conducted with adults aged 20 to 59 years old, attending the outpatient clinic at University Hospital/Federal University of Sergipe HU/UFS-EBSERH. Demographic, anthropometric, biochemical, and blood pressure (BP) data were collected. Cardiometabolic risk was assessed, according to the global risk score (ERG) and Framingham score criteria. The descriptive analysis included calculating medians and frequencies of anthropometric, demographic, biochemical, and blood pressure variables. The gender and age of adult groups were compared using the Mann-Whitney test. Spearman's correlation coefficient and multiple regression analysis were used to assess the association between wrist circumference (WrC) and the variables mentioned above. The predictive validity of WrC in identifying excess weight levels and cardiometabolic risk was analyzed using the ROC curve. The sample consisted of 1487 adults aged 20 to 59 years, 55.7% of whom were female; (3) Results: WrC correlated positively with other adiposity indicators such as waist circumference and Body Mass Index. WrC was the anthropometric indicator most significantly associated with cardiometabolic risk factors. WrC cutoff points identified by the study for determining excess weight were categorized by gender and age group. For males aged 20 to 40 years and >40 years, respectively, the cutoff points for overweight were 17.1 cm and 17.3 cm, and for obesity, 17.9 cm and 17.5 cm. For females aged 20 to 40 years and >40 years, respectively, the cutoff points for overweight were 15.6 cm and 15.4 cm, and for obesity, 16.1 cm and 16 cm (4). Conclusions: Wrist circumference showed a significant correlation with other adiposity indicators and can be used to identify adults with excess weight and predict cardiometabolic risk.
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Affiliation(s)
- Larissa Monteiro Costa Pereira
- Graduate Program in Health Sciences, Federal University of Sergipe (UFS), Aracaju 49100-676, Brazil; (L.M.C.P.); (R.M.S.R.); (R.R.d.A.); (A.C.S.S.)
| | - Márcia Ferreira Cândido de Souza
- Graduate Program in Nutritional Sciences, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil; (M.F.C.d.S.); (A.M.d.S.-J.); (M.F.D.d.S.F.)
| | - Felipe J. Aidar
- Graduate Program in Physiological Sciences, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil;
- Graduate Program in Physical Education, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil
| | - Márcio Getirana-Mota
- Graduate Program in Physiological Sciences, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil;
- Graduate Program in Physical Education, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil
| | - Alex Menezes dos Santos-Junior
- Graduate Program in Nutritional Sciences, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil; (M.F.C.d.S.); (A.M.d.S.-J.); (M.F.D.d.S.F.)
| | | | | | - Raysa Manuelle Santos Rocha
- Graduate Program in Health Sciences, Federal University of Sergipe (UFS), Aracaju 49100-676, Brazil; (L.M.C.P.); (R.M.S.R.); (R.R.d.A.); (A.C.S.S.)
| | - Rebeca Rocha de Almeida
- Graduate Program in Health Sciences, Federal University of Sergipe (UFS), Aracaju 49100-676, Brazil; (L.M.C.P.); (R.M.S.R.); (R.R.d.A.); (A.C.S.S.)
| | - Leonardo Baumworcel
- Division of Cardiology, University Hospital of Federal University of Sergipe (UFS), Aracaju 49100-000, Brazil;
- Clinic and Hospital São Lucas/Rede D’Or São Luiz, Aracaju 49060-676, Brazil;
| | | | - Renata Rebello Mendes
- Department of Nutrition, Federal University of Sergipe (UFS), São Cristóvão 49100-000, Brazil;
| | - Antônio Carlos Sobral Sousa
- Graduate Program in Health Sciences, Federal University of Sergipe (UFS), Aracaju 49100-676, Brazil; (L.M.C.P.); (R.M.S.R.); (R.R.d.A.); (A.C.S.S.)
- Clinic and Hospital São Lucas/Rede D’Or São Luiz, Aracaju 49060-676, Brazil;
- Department of Medicine, Federal University of Sergipe (UFS), Aracaju 49100-000, Brazil
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Liu X, He M, Li Y. Adult obesity diagnostic tool: A narrative review. Medicine (Baltimore) 2024; 103:e37946. [PMID: 38669386 PMCID: PMC11049696 DOI: 10.1097/md.0000000000037946] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/21/2024] [Accepted: 03/29/2024] [Indexed: 04/28/2024] Open
Abstract
Obesity is a complex chronic metabolic disorder characterized by abnormalities in lipid metabolism. Obesity is not only associated with various chronic diseases but also has negative effects on physiological functions such as the cardiovascular, endocrine and immune systems. As a global health problem, the incidence and prevalence of obesity have increased significantly in recent years. Therefore, understanding assessment methods and measurement indicators for obesity is critical for early screening and effective disease control. Current methods for measuring obesity in adult include density calculation, anthropometric measurements, bioelectrical impedance analysis, dual-energy X-ray absorptiometry, computerized imaging, etc. Measurement indicators mainly include weight, hip circumference, waist circumference, neck circumference, skinfold thickness, etc. This paper provides a comprehensive review of the literature to date, summarizes and analyzes various assessment methods and measurement indicators for adult obesity, and provides insights and guidance for the innovation of obesity assessment indicators.
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Affiliation(s)
- Xiaolong Liu
- School of Life & Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi, China
- School of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin, Guangxi, China
- Rehabilitation College, Guilin Life and Health Career Technical College, Guilin, Guangxi, China
| | - Mengxiao He
- School of Physical Education and Health, Guilin University, Guilin, Guangxi, China
| | - Yi Li
- School of Physical Education and Health, Guilin University, Guilin, Guangxi, China
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