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Choi WJ, Lee P, Thomas PC, Rath TJ, Mogensen MA, Dalley RW, Wangaryattawanich P. Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification. World J Radiol 2024; 16:294-316. [PMID: 39239241 PMCID: PMC11372550 DOI: 10.4329/wjr.v16.i8.294] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/05/2024] [Revised: 08/22/2024] [Accepted: 08/27/2024] [Indexed: 08/28/2024] Open
Abstract
Jaw and maxillofacial bone lesions encompass a wide variety of both neoplastic and non-neoplastic pathologies. These lesions can arise from various tissues, including bone, cartilage, and soft tissue, each presenting distinct challenges in diagnosis and treatment. While some pathologies exhibit characteristic imaging features that aid in diagnosis, many others are nonspecific. This overlap often necessitates a multimodal imaging approach, combining techniques such as radiographs, computed tomography, and magnetic resonance imaging to achieve a diagnosis or narrow the diagnostic considerations. This article provides a comprehensive review of the imaging approach to jaw and maxillofacial bone tumors, including updates on the 2022 World Health Organization classification of these tumors. The relevant anatomy of the jaw and dental structures that is important for accurate imaging interpretation is discussed.
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Affiliation(s)
- Woongsoon John Choi
- Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, United States
- Department of Radiology, M&S Radiology Associates, San Antonio, TX 78217, United States
| | - Peggy Lee
- Division of Oral Radiology, University of Washington School of Dentistry, Seattle, WA 98195, United States
| | - Penelope C Thomas
- Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, United States
| | - Tanya J Rath
- Division of Neuroradiology, Department of Radiology, Mayo Clinic, Phoenix, AZ 85054, United States
| | - Monique A Mogensen
- Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, United States
| | - Roberta W Dalley
- Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, United States
| | - Pattana Wangaryattawanich
- Division of Neuroradiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, United States
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Yoshida S, Takeshita Y, Kawazu T, Matsumura T, Asaumi J, Nagatsuka H, Yanagi Y. A Case of Odontogenic Myxoma of the Mandible with Expansion to the Alveolar Crest – Comparison of Imaging Findings and Pathological Findings: A Case Report. Open Dent J 2022. [DOI: 10.2174/18742106-v16-2202140] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Background:
An odontogenic myxoma is an intraosseous tumor characterized by stellate and spindle-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. We herein describe an odontogenic myxoma that expanded not only to the bone marrow but also to the outside of the alveolar bone. Diagnosis of an odontogenic myxoma in a tooth-deficient region by imaging findings alone was difficult because the positional relationship between the tumor and the tooth is unknown. Furthermore, some of these odontogenic myxomas reportedly show rapid growth.
Case Report:
Here, we present the case of a patient, a 44-year-old man, who had a hard, bone-like swelling on his right mandible molar region and mild paresthesia on his right cheek. An odontogenic myxoma and ameloblastoma were suspected based on the imaging findings; however, pathological examination of the biopsy led to a diagnosis of odontogenic myxoma. Right segmental mandibulectomy was performed, and there was no recurrence observed after surgery.
Conclusion:
To improve the accuracy of imaging diagnosis, it is important to compare the imaging findings with the pathological findings of the surgical specimen. This comparison in the present case revealed differences in the magnetic resonance imaging signal intensity in regions with different types of cell components.
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Bisla S, Gupta A, Narwal A, Singh V. Odontogenic myxoma: ambiguous pathology of anterior maxilla. BMJ Case Rep 2020; 13:13/8/e234933. [PMID: 32843449 DOI: 10.1136/bcr-2020-234933] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/03/2022] Open
Abstract
Swellings in the anterior maxilla are uncommon and if present can be deemed as paradoxical conundrums presenting diagnostic and therapeutic dilemmas. Odontogenic myxoma is a rare, locally aggressive lesion that is primarily seen affecting the mandibular posterior region in association with an impacted tooth. It is found to be associated with odontogenesis. Treatment is usually surgical, with extent varying from curettage to resection. This report describes a rare case of odontogenic myxoma of the anterior maxilla in a 14-year-old boy, with an emphasis on its epidemiology, clinical presentation, histopathology, diagnosis and treatment planning.
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Affiliation(s)
- Suman Bisla
- Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, India
| | - Ambika Gupta
- Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, India
| | - Anjali Narwal
- Oral Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Rohtak, India
| | - Virendra Singh
- Oral and Maxillofacial Surgery, Post Graduate Institute of Dental Sciences, Rohtak, India
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Dotta JH, Miotto LN, Spin-Neto R, Ferrisse TM. Odontogenic Myxoma: Systematic review and bias analysis. Eur J Clin Invest 2020; 50:e13214. [PMID: 32048275 DOI: 10.1111/eci.13214] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/15/2019] [Revised: 09/24/2019] [Accepted: 02/10/2020] [Indexed: 01/29/2023]
Abstract
BACKGROUND Odontogenic myxoma (OM) is a rare neoplasm, which originates from odontogenic ectomesenchyme. There is no study in the literature that analyses the best standards for OM diagnosis and how the treatment modalities may influence the recurrence rates. OBJECTIVE To evaluate the best standards for odontogenic myxoma (OM) diagnosis and treatment, and how these may influence the recurrence rates. STUDY DESIGN Two independent researchers performed a systematic review in many databases. Fifty-two eligible studies were included for qualitative analysis. Bias analysis was conducted according to Oxford Centre for Evidence-Based Medicine. RESULTS A total of 1363 OM cases were reported on, and female gender with average age of 27 years is the most common patient profile. Conventional microscopic findings were observed in 93.43% of the reported cases. In 57.49% of the cases, multilocular radiographic appearance was present, followed by unilocular appearance (32.87%). Posterior mandible was the site with the major prevalence, while surgical resection was the most common treatment modality, followed by enucleation. Recurrence rates for both treatment modalities were approximately close (13.04% and 25.0%, respectively). CONCLUSION The correct diagnosis of OM relies on the association of clinical, radiographic and microscopic findings. About imaging examinations, panoramic radiography and computed tomography are sufficient for the evaluation of OM. Recurrence rates were closely among the two most used surgery treatments. So according to some clinical-radiological aspects, conservative surgery may be preferred than aggressive surgery modalities.
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Affiliation(s)
- Jéssica Helena Dotta
- Oral Medicine, Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil
| | - Larissa Natiele Miotto
- Oral Rehabilitation, Department of Physiology and Pathology, Araraquara Dental School, Universidade Estadual Paulista (UNESP), Araraquara, Brazil
| | - Rubens Spin-Neto
- Oral Radiology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark
| | - Túlio Morandin Ferrisse
- Oral Medicine, Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil
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The Rare Radiographic Sunburst Appearance of Odontogenic Myxomas: A Case Report and Review of the Literature. Head Neck Pathol 2020; 14:1105-1110. [PMID: 31902092 PMCID: PMC7669914 DOI: 10.1007/s12105-019-01122-1] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/04/2019] [Accepted: 12/19/2019] [Indexed: 10/25/2022]
Abstract
Odontogenic myxomas often have a distinctive radiographic presentation described as a "soap bubble", "tennis racket", or "honeycomb" pattern. Less frequently, examples of odontogenic myxomas with a "sunray" or "sunburst" pattern have been reported. Because malignant entities such as osteosarcomas more classically present with a sunray/sunburst appearance, odontogenic myxomas are rarely considered in the radiographic differential diagnosis of a sunburst lesion. The objective of this paper is to report a case of an odontogenic myxoma presenting with a sunburst appearance and to review similar reported cases in the literature. To the best of the authors' knowledge, this additional case of an odontogenic myxoma presenting with a sunburst appearance brings the total number of sunray/sunburst cases reported in the English language literature to 21.
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An atypical odontogenic myxoma. JOURNAL OF STOMATOLOGY, ORAL AND MAXILLOFACIAL SURGERY 2018; 119:154-157. [DOI: 10.1016/j.jormas.2017.12.001] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/05/2017] [Accepted: 12/05/2017] [Indexed: 11/22/2022]
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Does volumetric measurement serve as an imaging biomarker for tumor aggressiveness of ameloblastomas? Oral Oncol 2018; 78:16-24. [DOI: 10.1016/j.oraloncology.2018.01.002] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2017] [Revised: 01/01/2018] [Accepted: 01/07/2018] [Indexed: 12/18/2022]
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Kauke M, Safi AF, Kreppel M, Grandoch A, Nickenig HJ, Zöller JE, Dreiseidler T. Size distribution and clinicoradiological signs of aggressiveness in odontogenic myxoma-three-dimensional analysis and systematic review. Dentomaxillofac Radiol 2017; 47:20170262. [PMID: 29082773 DOI: 10.1259/dmfr.20170262] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
OBJECTIVES Therapeutic assessment of odontogenic myxoma (OM) is poorly standardized. Unidimensional size criteria have shown to be unreliable in therapeutic decision-making. We evaluate the size distribution of OM and scan for associated clinicoradiological signs of aggressiveness. Additionally, we evaluate three-dimensional size delineation of OM aiming to improve future therapeutic assessment of this destructive neoplasm. METHODS Primarily, we reviewed the database "PubMed" for data concerning the size of OMs as radiologically determined. Afterwards, the impact of age, sex, locularity and location on the size was investigated by χ² test, Student's t-test and regression analysis. Furthermore, we statistically evaluated the impact of size on the occurrence of clinicoradiological signs of aggressiveness. Secondly, we approximated the volume of five unpublished cases of OM by semi-automatic image segmentation of cone-beam CT images. RESULTS Multilocular OMs were significantly larger than unilocular ones (p < 0.002). Age (0.042) and multilocularity (<0.002) significantly impacted size. Size was significantly associated with cortical perforation (0.032) and multilocularity (<0.002), further regression analysis revealed tooth resorption (0.019), cortical perforation (0.005) and multilocularity (<0.002) as significant predictors of size. Employing the volume as a mean of comparison, we found that the biggest OM (38.42 ml; multilocular) was 124 times larger than the smallest (0.31 ml; unilocular). However, using the maximum diameter (cm) as a surrogate for size, the biggest lesion (6.3) was only 5.25 times larger than the smallest (1.2). CONCLUSIONS Locularity and volumetric size characterization might help in therapeutic decision-making and could help to improve our understanding of OM.
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Affiliation(s)
- Martin Kauke
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Ali-Farid Safi
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Matthias Kreppel
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Andrea Grandoch
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Hans-Joachim Nickenig
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Joachim E Zöller
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany
| | - Timo Dreiseidler
- 1 Department of Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.,2 Dreifaltigkeits-Krankenhaus Wesseling, University Teaching hospital, Wesseling, Germany
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Vasconcelos ACU, Silveira FM, Gomes APN, Tarquinio SBC, Sobral APV, de Arruda JAA, da Silva LP, da Silveira MMF, Barbosa LF, Kato CDNADO, Jaeger F, da Silva TA, Mesquita RA. Odontogenic myxoma: A 63-year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature. J Oral Pathol Med 2017; 47:71-77. [PMID: 28985009 DOI: 10.1111/jop.12647] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 10/01/2017] [Indexed: 01/02/2023]
Abstract
BACKGROUND Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS Data regarding age, gender, anatomic site, and imagiological features from 85 cases of OM were collected. Additionally, we did a review of OM studies published in three electronic databases. RESULTS Among 63 450 oral biopsies, 1178 (1.85%) were odontogenic tumors (World Health Organization - 2017), of which 85 (7.21%) met the criteria of OM. The mean age was 30.7 years (range: 10-61 years; SD: 12.22). Forty-five (52.9%) cases occurred in females and 40 (47.1%) in males (ratio: 1:1.12). Maxilla was affected in 44 cases (53%) and mandible in 39 (47%). Of the 41 informed cases (48.2%), all of them were radiolucent lesions. The literature review indicated a majority of mean ages in third decade and a predilection for females, mandible, and multilocular radiolucent lesions. CONCLUSIONS The features of OM samples have strong similarity to that reported in studies from other continents. It is possible to infer that geographic variation does not help to explain some differences observed in the clinical features of OM.
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Affiliation(s)
| | - Felipe Martins Silveira
- Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil
| | - Ana Paula Neutzling Gomes
- Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil
| | | | - Ana Paula Veras Sobral
- Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de Pernambuco, Camaragibe, Brazil
| | - José Alcides Almeida de Arruda
- Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
| | - Leorik Pereira da Silva
- Postgraduate Program in Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, Brazil
| | | | - Larissa Ferreira Barbosa
- Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil
| | | | - Filipe Jaeger
- Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
| | - Tarcília Aparecida da Silva
- Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
| | - Ricardo Alves Mesquita
- Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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10
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Mittal Y, Chugh A, Varghese KG, Dwivedi S, Goyal V. Management of Recurrent Odontogenic Myxoma of Mandible: A Clinical Case Report. J Clin Diagn Res 2016; 10:ZD30-ZD31. [PMID: 27891488 PMCID: PMC5121826 DOI: 10.7860/jcdr/2016/20917.8702] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2016] [Accepted: 07/07/2016] [Indexed: 11/24/2022]
Abstract
Odontogenic Myxoma (OM) is a slow growing painless locally aggressive tumor seen in gnathic bones and is generally asymptomatic. OM is characterized by spindle, wedge or stellate shaped cells loosely arranged in an abundant mucoid stroma. It is found incidentally on radiographs and may vary from a unilocular radiolucency to a multilocular lesion with well-defined or diffuse margins. Treatment includes surgical management that may range from simple enucleation and curettage to surgical excision including peripheral osteotomy, segmental resection, hemimandibulectomy and maxillectomy. Here we are presenting a case report on odontogenic myxoma with recurrence after conservative treatment.
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Affiliation(s)
- Yogesh Mittal
- Senior Resident, Department of Trauma and Emergency, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Ankita Chugh
- Assistant Professor, Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - K George Varghese
- Principal and Professor, Department of Oral and Maxillofacial Surgery, Government Dental College, Kottayam, Kerala, India
| | - Shailendra Dwivedi
- Senior Resident and Postdoctoral Fellow, Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Vidhi Goyal
- Postgraduate Student, Department of Prosthodontics, Crown and Bridge, Manipal College of Dental Sciences, Manipal, Karnataka, India
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11
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Del Carmen González-Galván M, Aguirre-Urizar JM, Bologna-Molina R, Farfán-Morales JE, Gainza-Cirauqui ML, Marichalar-Mendia X, Mosqueda-Taylor A. Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles. Int J Surg Pathol 2016; 24:315-319. [PMID: 26888956 DOI: 10.1177/1066896916632588] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/05/2023]
Abstract
Aim Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.
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12
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Omeje KU, Amole IO, Osunde OD, Efunkoya AA. Management of Odontogenic Fibromyxoma in Pediatric Nigerian Patients: A Review of 8 Cases. Ann Med Health Sci Res 2016; 5:461-5. [PMID: 27057387 PMCID: PMC4804660 DOI: 10.4103/2141-9248.177994] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
Odontogenic fibromyxoma (OFM) is a benign, locally invasive and aggressive nonmetastasizing neoplasm of jaw bones. They are considered relatively rare and known to be derived from embryonic mesenchymal elements of dental origin. Treatment of OFM depends on the size of the lesion and on its nature and behavior. Varying treatment modalities ranging from curettage to radical excision have been documented. Aim; This paper is a review of management of 8 pediatric patients with histologically diagnosed OFM at a Nigerian tertiary health care facility. This was a retrospective study of all patients aged 15 years and below who presented to the Oral and Maxillofacial Surgery Clinic of Aminu Kano Teaching Hospital, Kano, over a 5-year period (January 2008 to December 2012), with a histologic diagnosis of OFM. The information obtained included patients' demographics, as well as their clinical characteristics such as the anatomical site and side of lesions. Other information collated included presenting features, the onset of symptoms, type of treatment carried out, as well as treatment outcome. The data were analyzed and the results presented as frequencies and percentages. Among the 8 patients with OFM, more males (n = 5/8; 62.5%) were affected than females (n = 3/8; 37.5%). The mandible (n = 5/8; 62.5%) was the most frequent site of occurrence, and the anterior mandible was the most favored location (n = 4/8; 50%). Seven patients had excision of the lesion with peripheral ostectomy of the underlying bone while only one patient had a bone resection. These patients have been followed up for at least 1 year, and no recurrence was observed throughout the follow-up period. OFM causes gross facial disfigurement and may result in the destruction of the entire jaw bone; the impact of which may be grave for a growing child. Prompt surgical intervention and follow-up have proven to be adequate management protocol.
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Affiliation(s)
- K U Omeje
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria
| | - I O Amole
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria
| | - O D Osunde
- Department of Dental Surgery, Faculty of Medicine and Dentistry, University of Calabar, University of Calabar Teaching Hospital, Calabar, Nigeria
| | - A A Efunkoya
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bayero University, Aminu Kano Teaching Hospital, Kano, Nigeria
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Dabbaghi A, Nikkerdar N, Bayati S, Golshah A. Rare appearance of an odontogenic myxoma in cone-beam computed tomography: a case report. J Dent Res Dent Clin Dent Prospects 2016; 10:65-8. [PMID: 27092217 PMCID: PMC4831614 DOI: 10.15171/joddd.2016.010] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2014] [Accepted: 01/26/2016] [Indexed: 11/17/2022] Open
Abstract
Odontogenic myxoma (OM) is an infiltrative benign bone tumor that occurs almost exclusively in the facial skeleton. The radiographic characteristics of odontogenic myxoma may produce several patterns, making diagnosis difficult. Cone-beam computed tomography (CBCT) may prove extremely useful in clarifying the intraosseous extent of the tumor and its effects on surrounding structures. Here, we report a case of odontogenic myxoma of the mandible in a 27-year-old female. The patient exhibited a slight swelling in the left mandible. Surgical resection was performed. No recurrence was noted. In the CBCT sections, we observed perforation of the cortical plate and radiopaque line that extended from the periosteum, resembling "sunray" appearance-a rare feature of OM-which could not be assessed by panoramic radiography.
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Affiliation(s)
- Arash Dabbaghi
- Assistant Professor, Department of Oral and Maxillofacial Radiology, School of
Dentistry, Jundishapur University of Medical Sciences, Ahvaz, Iran
| | - Nafiseh Nikkerdar
- Assistant Professor, Department of Oral and Maxillofacial Radiology, School of
Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
| | - Soheyla Bayati
- Assistant Professor, Department of Oral and Maxillofacial Radiology, School of
Dentistry, Jundishapur University of Medical Sciences, Ahvaz, Iran
| | - Amin Golshah
- Assistant Professor, Department of Orthodontics, School of Dentistry, Kermanshah
University of Medical Sciences, Kermanshah, Iran
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14
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Titinchi F, Hassan BA, Morkel JA, Nortje C. Odontogenic myxoma: a clinicopathological study in a South African population. J Oral Pathol Med 2016; 45:599-604. [PMID: 26822069 DOI: 10.1111/jop.12421] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 12/15/2015] [Indexed: 11/30/2022]
Abstract
BACKGROUND Odontogenic myxoma is a benign, locally aggressive neoplasm of the jaws. Prevalence rates range between 0.5% and 17.7% of odontogenic tumours. There are few reports in the literature on this lesion in African populations, and therefore, this study aimed to report on odontogenic myxoma in a South African population over a 40-year period. METHODS The clinical records and orthopantomograms of 29 histopathologically diagnosed odontogenic myxoma were retrospectively analysed. Details of age, gender, ethnic origin and clinical, histological as well as radiological features were recorded. RESULTS The ages of patients ranged from 7 to 44 years with a mean of 21.3 years. The male-to-female ratio was 1:2.6 with the majority of patients being of mixed race and Africans. Clinically, 31% complained of pain while 58.6% had a history of swelling. The majority of odongenic myxomas (62.1%) were located in the mandible with the posterior region being most commonly affected. Multilocular lesions (69.2%) were more common and were significantly larger than unilocular lesions (P < 0.05). The outline of these tumours was mostly well-defined (84.6%) with different degrees of cortication. Only one tumour caused tooth resorption, while 20 cases (76.9%) caused tooth displacement. Six tumours expanded into the maxillary sinus, and 14 tumours caused expansion of the mandible. CONCLUSIONS Odontogenic myxomas have variable clinical, radiological and histological features. Most of these features in this population were similar to other populations. It is mandatory to use conventional radiographs along with histopathological examination to aid in arriving at an accurate diagnosis.
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Affiliation(s)
- Fadi Titinchi
- Department of Maxillo-Facial and Oral Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa
| | - Bassam A Hassan
- Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands
| | - Jean A Morkel
- Department of Maxillo-Facial and Oral Surgery, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa
| | - Christoffel Nortje
- Department of Diagnostics and Radiology, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa
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15
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Abstract
There are both odontogenic and nonodontogenic benign lesions in the maxilla and mandible. These lesions may have similar imaging features, and the key radiographic features are presented to help the clinician narrow the differential diagnosis and plan patient treatment. Both intraoral and panoramic radiographs and advanced imaging features are useful in assessing the benign lesions of the jaws. The location, margins, internal contents, and effects of the lesions on adjacent structures are important features in diagnosing the lesions.
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Affiliation(s)
- Anita Gohel
- Oral & Maxillofacial Radiology, Department of General Dentistry, Henry M. Goldman School of Dental Medicine, Boston University, 100 East Newton Street, G118, Boston, MA 02118, USA.
| | - Alessandro Villa
- Division of Oral Medicine and Dentistry, Department of Oral Medicine, Infection and Immunity, Dana Farber Cancer Institute, Brigham and Women's Hospital, Harvard School of Dental Medicine, 1620 Tremont Street, Suite BC-3-028, Boston, MA 02120, USA
| | - Osamu Sakai
- Department of Radiology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, Boston, MA 02118, USA; Department of Otolaryngology - Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, Boston, MA 02118, USA; Department of Radiation Oncology, Boston Medical Center, Boston University School of Medicine, 820 Harrison Avenue, Boston, MA 02118, USA
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Chaudhary Z, Sharma P, Gupta S, Mohanty S, Naithani M, Jain A. Odontogenic myxoma: Report of three cases and retrospective review of literature in Indian population. Contemp Clin Dent 2015; 6:522-8. [PMID: 26681859 PMCID: PMC4678552 DOI: 10.4103/0976-237x.169862] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022] Open
Abstract
Purpose: To review the clinical pattern and treatment modalities meted out to patients of odontogenic myxoma (OM) in Indian population in last 30 years and also to report 3 cases of OM. Method: A retrospective review of radiograph and histopathology of three cases of odontogenic myxoma treated between 2005 and 2011 was done. Immunohistochemical analysis was performed to examine the pattern of vimentin and NSE. Also a computerized literature search using Medline and Google scholar was conducted for published articles on OM in Indian population in last 30 years. Result: A total of 32 OM cases reviewed from 25 articles retrieved. Out of them 24 myxomas were present in maxilla, only 8 were in mandible and a single case was present in supraglottic region (larynx). Surgical procedure carried out was excision and curettage in 16 patients and resection with safe margin followed by reconstruction 13 patients. All the three reported cases were successfully treated by tumor enucleation and peripheral ostectomy with no recurrence after 3 to 7 years. Conclusion: Odontogenic myxoma is a rare odontogenic tumor with inconclusive clinical and radiographic features, hence histopathological examination is mandatory to confirm its diagnosis. Although the immunohistochemical analysis may help in diagnosis but plays no role in guiding treatment planning or predicting the rate of recurrence. Currently we lack data on number of reported OM cases in Indian population as author feels more patients must have been treated then reported.
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Affiliation(s)
- Zainab Chaudhary
- Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India
| | - Pankaj Sharma
- Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India
| | - Shalini Gupta
- Department of Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, New Delhi, India
| | - Sujata Mohanty
- Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India
| | - Manish Naithani
- Department of Anaesthesiology, Al Gharbia Hospitals, Madinat Zayed, Abu Dhabi, UAE
| | - Anshul Jain
- Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India
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17
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Klein IP, da Silva AD, Martins MAT, Rados PV, Mengatto CM, Martins MD, Carrard VC. Slow-growing mass and expansive swelling in the maxilla. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 120:284-90. [PMID: 26159086 DOI: 10.1016/j.oooo.2015.05.013] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/23/2014] [Revised: 04/20/2015] [Accepted: 05/17/2015] [Indexed: 10/23/2022]
Affiliation(s)
- Isadora Peres Klein
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
| | - Alessandra Dutra da Silva
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
| | | | - Pantelis Varvaki Rados
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
| | - Cristiane Machado Mengatto
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
| | - Manoela Domingues Martins
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
| | - Vinicius Coelho Carrard
- Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
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Abstract
Odontogenic myxomas are uncommon tumors of comprising of 3% of all the tumors of odontogenic origin. They usually occur during the second and third decades of life and are more commonly seen in females. The current case report sheds light upon the surgical treatment of a myxoma of odontogenic origin in posterior maxilla of a young female patient. Prosthodontic rehabilitation stages are also briefly described following complete healing of the lesion after surgery.
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Affiliation(s)
- Haroon Rashid
- Department of Fixed and Removable Prosthodontics, College of Dentistry, Ziauddin University, Karachi, Pakistan
| | - Atif Bashir
- Department of Oral and Maxillofacial Surgery, College of Dentistry, Ziauddin University, Karachi, Pakistan
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19
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Bruckman KC, Napoli JA, Diecidue RJ, Gold L. Facial dysmorphology and odontogenic tumor development associated with inborn errors of metabolism: a case report. J Oral Maxillofac Surg 2015; 73:274-83. [PMID: 25579010 DOI: 10.1016/j.joms.2014.08.038] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/16/2014] [Revised: 08/27/2014] [Accepted: 08/30/2014] [Indexed: 11/29/2022]
Abstract
PURPOSE Inborn errors of metabolism (IEMs) are genetic disorders that alter normal physiologic functioning. Deficiency of 3-methylcrotonyl-coenzyme A carboxylase is one such IEM that can lead to major episodes of metabolic dysfunction. Certain IEMs are associated with characteristic congenital dysmorphic facial features. This can be problematic, because these dysmorphisms can mask underlying tumor growth. Literature is lacking on a causal relation between IEM and odontogenic tumor development. MATERIALS AND METHODS This case was explained in detail and a review of the literature was undertaken. PubMed was used to search for articles involving surgical management of odontogenic myxoma (OM) and associations between odontogenic tumors and IEM. RESULTS It was determined that the development of odontogenic tumors, specifically OM, is associated with IEMs. These tumors can easily be overlooked as a common dysmorphic feature of an IEM. CONCLUSION IEMs lead to major metabolic disturbances and, thus, can alter the cellular microenvironment. Hypothetically, these alterations can lead to the development of odontogenic tumors. With the diagnosis of IEM becoming more common owing to improved newborn screening, careful attention should be given to these patients because of the possibility that dysmorphologic facial features could be masking underlying tumor growth.
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Affiliation(s)
- Karl C Bruckman
- Resident, Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA.
| | - Joseph A Napoli
- Division Chief, Department of Pediatric Plastic Surgery, Nemours/Alfred I duPont Hospital for Children, Wilmington, DE
| | - Robert J Diecidue
- Chairman and Professor, Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA
| | - Lionel Gold
- Associate Professor, Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA
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20
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Bilodeau EA, Prasad JL, Alawi F, Seethala RR. Molecular and genetic aspects of odontogenic lesions. Head Neck Pathol 2014; 8:400-10. [PMID: 25409852 PMCID: PMC4245404 DOI: 10.1007/s12105-014-0588-7] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/30/2014] [Accepted: 11/04/2014] [Indexed: 12/13/2022]
Abstract
In this article we outline the molecular findings of select odontogenic tumors. In each section, we briefly review selected the clinicoradiographic, histologic, immunologic features, focusing on the molecular findings and their applications in practice. The understanding of molecular pathobiology at various other organ sites has developed quite rapidly in recent years, however much remains unknown about the genetic profile of odontogenic tumors. Improved understanding of mutations in odontogenic tumors may clarify classification schema and elucidate targets for novel therapies. Molecular testing will no doubt improve our understanding of odontogenic tumor pathogenesis and will likely be, someday, an important component of routine clinical practice and its role will only increase in the coming years.
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Affiliation(s)
- Elizabeth A Bilodeau
- Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, 15261, USA,
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21
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Manjunath S, Gupta A, Swetha P, Moon N, Singh S, Singh A. Report of a rare case of an odontogenic myxoma of the maxilla and review of literature. Ann Med Health Sci Res 2014; 4:S45-8. [PMID: 25031907 PMCID: PMC4083722 DOI: 10.4103/2141-9248.131716] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/04/2022] Open
Abstract
Odontogenic myxoma (OM) is a mesenchymal tissue benign neoplasia, being relatively rare which is almost exclusively seen in tooth-bearing areas. OM commonly occurs in the 2(nd) and 3(rd) decade and the mandible is involved more commonly than the maxilla. The lesion often grows without symptoms and presents as a painless swelling. Radiographically, the myxoma appears as a unilocular or multilocular radiolucency. This article presents a rare case of OM occurring in the maxilla of a 28-year-old female patient with a brief review of the literature.
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Affiliation(s)
- Sm Manjunath
- Department of Oral Pathology and Microbiology, MM College of Dental Sciences, MM University, Mullana, Ambala, Haryana, India
| | - Aa Gupta
- Department of Oral Pathology and Microbiology, Peoples Dental Academy, Bhopal, Madhya Pradesh, India
| | - P Swetha
- Department of Oral Pathology and Microbiology, Vishnu Dental College and Hospital, Bhimavaram, India
| | - Nj Moon
- Department of Periodontics, RKDF Dental College, Bhopal, Madhya Pradesh, India
| | - S Singh
- BRS Institute of Medical Sciences, Dental College and Hospital, Panchkula, Haryana, India
| | - A Singh
- Department of E.C.H.S., Phagwara, Punjab, India
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22
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Chiapasco M, Montinari A, Giglio S, Tommasato G, Moneghini L, Bulfamante G. Il mixoma odontogeno: revisione della letteratura e presentazione di un caso clinico. DENTAL CADMOS 2014. [DOI: 10.1016/s0011-8524(14)70188-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
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Etemad-Moghadam S, Chookhachizadeh S, Baghaii F, Alaeddini M. Odontogenic Myxoma: a study based on biopsy material over a 40-year period. J Contemp Dent Pract 2014; 15:137-141. [PMID: 25095832 DOI: 10.5005/jp-journals-10024-1503] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/03/2023]
Abstract
AIM Odontogenic tumors, including odontogenic myxomas (OMs) are regarded as rare neoplasms in the human body. Nevertheless, they may be problematic for diagnosis and treatment planning due to possible variations between different races and countries. The aim of the current study was to present the clinicopathologic features of OM in an Iranian population over a 40-year period and compare them with those reported elsewhere. MATERIALS AND METHODS Clinical/demographic data and histologic slides of OMs and all lesions that could be considered in their differential diagnosis, reported from 1967-2008 were analyzed. Statistical analysis was performed using χ(2) and t-test and p < 0.05 was regarded significant. RESULTS Forty OMs were identified, of which 42.5% occurred in men (mean age, 27.4 years) and 57.5% in women (mean age, 28.2 years). Most tumors were observed in the posterior mandible. All cases possessed the classic World Health Organization histologic features; while 3, 15 and 6 cases showed epithelial rests, residual bone and conspicuous collagen bundles, respectively. Five patients were followed and none of their tumors recurred. CONCLUSION The clinicopathologic characteristics of the current Iranian population are similar to most other reports with a predilection for the posterior mandible, 3rd decade and female subjects; however, there were variations in microscopic features of the studied cases. Clinical significance: Clinical and histologic information on OM in different populations may be useful in clinical settings and treatment planning. Reporting more detailed histologic data can help clarify the biology of this tumor and aid in its histopathologic diagnosis. i
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Affiliation(s)
- Shahroo Etemad-Moghadam
- Assistant Professor, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
| | - Somayeh Chookhachizadeh
- Dentist, Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
| | - Fereshteh Baghaii
- Associate Professor, Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
| | - Mojgan Alaeddini
- Assistant Professor, Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
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25
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Kheir E, Stephen L, Nortje C, Janse van Rensburg L, Titinchi F. The imaging characteristics of odontogenic myxoma and a comparison of three different imaging modalities. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; 116:492-502. [DOI: 10.1016/j.oooo.2013.05.018] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/15/2013] [Revised: 04/21/2013] [Accepted: 05/25/2013] [Indexed: 10/26/2022]
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Arul ASKJ, Verma S, Arul ASSJ, Verma R. Infiltrative odontogenic myxoma of the posterior maxilla: Report of a case. J Nat Sci Biol Med 2013; 4:484-7. [PMID: 24082760 PMCID: PMC3783808 DOI: 10.4103/0976-9668.116990] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
Myxomas of the head and neck are rare tumors of uncertain histogenesis. Odontogenic myxomas in maxilla are less common but behave more aggressively, as it spreads through maxillary antrum. It therefore reaches considerable size before being detected. The current case arouses particular interest due to the rapid growth and infiltrating nature of the lesion in a 25-year-old female patient, who denied any leading symptoms, even with the lesion involving extensively. Radiographic and microscopic similarities to a number of entities make diagnostic interpretation of odontogenic myxoma challenging. Therefore sound knowledge of clinical, radiographic and histopathologic features is important to establish an appropriate treatment aimed at a good clinical course and patient cure.
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Affiliation(s)
- A Sri Kennath J Arul
- Department of Oral and Maxillofacial Pathology, Best Dental Science College, Madurai, Tamilnadu, India
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27
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Prognostic evaluation of preserving palatal mucosa after resection of maxillary myxoma: 10 years' follow-up. J Craniofac Surg 2013; 24:e361-5. [PMID: 23851870 DOI: 10.1097/scs.0b013e3182902f2a] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Abstract
OBJECTIVES This study was carried out to assess the clinical and radiological outcomes of preserving palatal mucosa after resection of odontogenic maxillary myxomas. STUDY DESIGN Fifteen patients (9 females and 6 males) with odontogenic maxillary myxomas participated in this study. Their ages ranged between 22 and 40 years. They were diagnosed as having myxomas by clinical and computed tomographic examinations as well as by performing biopsies on them. All lesions were treated by maxillary resection with preserving palatal mucosa. After surgery, the resultant surgical defects were followed up for 10 years. RESULTS No clinical or radiological evidence of recurrence was observed after 20 years' follow-up. The healing process was rapidly progressing without any serious complications. However, 6 patients complained of sore areas in their palatal mucosa because of the acrylic stents. They were successfully treated with mouthwash, anti-inflammatory drugs, and relief of the acrylic stents. After surgery, numbness of the upper lip was observed in all cases; however, it improved gradually in 5 patients over a period of 2 years. Computed tomographic scan of the surgical sites has shown incomplete filling of the resultant surgical defects. Constantly, there was empty space beneath the orbital floor in all computed tomographic images. CONCLUSIONS Maxillary resection with preserving palatal mucosa is a recommended treatment modality for odontogenic maxillary myxomas as it minimizes the unpleasant sequelae after surgery without recurrence. However, this technique should be restricted only to the cases having intact palatal bone.
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28
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Vasudevan V, Mohan Das U, Manjunath V, Manoj Bavle R, Sudhakar M, Kumar N, Srinath S. Odontogenic Myxoma of the Maxilla: A Report of Unusual Pediatric Case. Int J Clin Pediatr Dent 2011; 4:264-8. [PMID: 27678240 PMCID: PMC5034092 DOI: 10.5005/jp-journals-10005-1123] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/13/2011] [Accepted: 07/08/2011] [Indexed: 11/23/2022] Open
Abstract
Odontogenic myxoma (OM) is a rare and locally benign neoplasm of high aggressive behavior found exclusively in the jaws. OM commonly occurs in the second and third decade, its quite rare to find in maxilla that to invading the maxillary sinus completely. The lesion often grows without symptoms and presents as a painless swelling. The radiographic features are variable, and the diagnosis is therefore not easy. This article presents a case of OM of maxilla in a 13-year-old boy, which was previously diagnosed as fibrosseous lesion with the help of CT.
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Affiliation(s)
- Vijeev Vasudevan
- Professor and Head, Department of Oral Medicine and Radiodiagnosis, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
| | - Usha Mohan Das
- Former Dean, VS Dental College and Hospital, Bengaluru, Karnataka, India
| | - V Manjunath
- Senior Lecturer, Department of Oral Medicine and Radiodiagnosis, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
| | - Radhika Manoj Bavle
- Professor and Head, Department of Oral Pathology and Microbiology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
| | - M Sudhakar
- Senior Lecturer, Department of Oral Pathology and Microbiology, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
| | - Nanda Kumar
- Principal, Professor and Head, Department of Oral and Maxillofacial Surgery, Krishnadevaraya College of Dental Sciences and Hospital, Bengaluru, Karnataka, India
| | - Srinath Srinath
- Professor, Department of Oral and Maxillofacial Surgery, Krishnadevaraya College of Dental Sciences and Hospital Bengaluru, Karnataka, India
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29
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Singaraju S, Wanjari SP, Parwani RN. Odontogenic myxoma of the maxilla: A report of a rare case and review of the literature. J Oral Maxillofac Pathol 2011; 14:19-23. [PMID: 21180454 PMCID: PMC2995999 DOI: 10.4103/0973-029x.64305] [Citation(s) in RCA: 31] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022] Open
Abstract
Odontogenic myxoma represents an uncommon benign neoplasm comprising of 3–6% of all odontogenic tumors. This article presents a rare case of odontogenic myxoma occurring in the maxilla of a 7-year-old male patient with a brief review of the pathogenesis, clinical, radiological, histopathological, ultrastructural and immunohistochemical characteristics of odontogenic myxoma.
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Affiliation(s)
- Sasidhar Singaraju
- Department of Oral Pathology, Modern Dental College and Research Centre, Airport Road, Gandhi Nagar, Indore - 453 112, India
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30
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Kourda-Boujemâa J, Farah-Klibi F, Rammeh S, Adouani A, Zermani R, Ben Jilani-Baltagi S. [Odontogenic myxoma: About four cases and review of the literature]. Ann Pathol 2010; 30:168-75. [PMID: 20621593 DOI: 10.1016/j.annpat.2010.03.002] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/12/2009] [Revised: 02/15/2010] [Accepted: 03/01/2010] [Indexed: 11/26/2022]
Abstract
OBJECTIVE Odontogenic myxoma is an uncommon tumor that represent less than 0,5% of all bone tumors and only 3 to 6% of odontogenic tumors. The aim of this article was to catalogue the clinical cases diagnosed microscopically as odontogenic myxoma and to describe their clinical and radiographic characteristics, comparing these to the data found in the current literature. DESIGN Histological and immunocytochemical examinations were performed on odontogenic myxomas from four Tunisian patients in a period of 23 years. RESULTS In the present series, two were male and two female. The age at diagnosis ranged from 19 to 38 years. Three tumors involved the mandible and one occurred in the maxilla. In all cases with radiographic records, lesions presented with a multilocular and osteolytic appearance. Histologically, odontogenic myxomas were mainly composed of spindled or stellate-shaped cells in a mucoid-rich intercellular and alcian blue positive matrix. All cases were treated by tumor-enucleation. There was no evidence of recurrence after 2 to 8 years. CONCLUSION Clinical and radiological aspects of odontogenic myxomas are not conclusive; a histopathological examination of the lesion is mandatory in order to make the right diagnosis. Because of its high rate of recurrence, surgical treatment through bone resection is the most indicated treatment modality, and the patient must be followed-up closely for years.
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31
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Abstract
Odontogenic tumors represents a broad spectrum of lesions ranging from benign to malignant to dental hamartomas all arising from odontogenic residues, that is, the odontogenic epithelium, ectomesenchyme with variable amounts of dental hard tissues formed in the same sequence as in normal tooth development. We report two cases of myxoma, which were misdiagnosed initially and latter, reported as odontogenic myxoma; and were treated by conservative surgical excision in one case and radical resection with hemimandibulectomy in the other case.
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Affiliation(s)
- Sridhar P Reddy
- Department of Oral and Maxillofacial Surgery, St Joseph Dental College and Hospital, Duggirala, Eluru, Andhra Pradesh, India
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32
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Odontogenic myxoma--a case series and review of the surgical management. J Craniomaxillofac Surg 2008; 37:206-9. [PMID: 19027311 DOI: 10.1016/j.jcms.2008.10.001] [Citation(s) in RCA: 73] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/19/2008] [Revised: 08/28/2008] [Accepted: 10/06/2008] [Indexed: 11/21/2022] Open
Abstract
BACKGROUND Odontogenic myxomas (OMs) are considered to be a benign odontogenic tumour with locally aggressive behaviour. Since these neoplasms are rare in the oral cavity, the possible surgical management can be quite variable. Literature recommendation can vary from simple curettage and peripheral ostectomy up to segmental resection. CASE REPORTS In the present article, a series of three new cases are presented and discussed. The first case is a 43-year-old male presented with a relatively large OM in the left maxillary area. The second case is a 37-year-old female presented with a relatively smaller left maxillary swelling that was diagnosed as OM. The third and final case is a 52-year-old male presented with a large OM of the right mandibular molar area. The surgical management that was chosen in each case is discussed. CONCLUSION In the present manuscript, a short review of the current literature on the surgical management of OMs is presented with a review of three cases of oral OMs that were treated in our department, followed by a discussion of the treatment options in each case.
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33
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Carvalho de Melo AU, de Farias Martorelli SB, Cavalcanti PHDH, Gueiros LA, Martorelli FDO. Maxillary odontogenic myxoma involving the maxillary sinus: case report. Braz J Otorhinolaryngol 2008; 74:472-5. [PMID: 18661026 PMCID: PMC9442081 DOI: 10.1016/s1808-8694(15)30586-3] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/04/2005] [Accepted: 09/12/2005] [Indexed: 11/30/2022] Open
Abstract
The aim of this paper is to report a case of odontogenic myxoma that affected the right maxilla and maxillary sinus. We have also reviewed the literature in regards of the clinical, radiographic, histological and treatment aspects of this pathology. Odontogenic myxomas of the maxillofacial region are benign lesions, without preference for gender, race or location, with extremely varied clinical and radiographic characteristics, thus increasing the number oral and maxillofacial region tumors with which we can make the differential diagnosis.
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Jaswal A, Jana AK, Biswas M, Sikder B, Nandi TK. Recurrent odontogenic myxoma of maxilla: a diagnostic and operative dilemma. Indian J Otolaryngol Head Neck Surg 2008; 60:41-4. [PMID: 23120497 DOI: 10.1007/s12070-008-0013-1] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022] Open
Abstract
Odontogenic myxoma of maxilla is a very rare occurrence. It is a slow growing benign, locally malignant tumor notorious for recurrence. Hereby we present a case of recurrent odontogenic myxoma of the maxilla in a 32-year-old male managed surgically by partial maxillectomy. The diagnostic and operative dilemmas encountered while managing the case are discussed in detail.
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Affiliation(s)
- Abhishek Jaswal
- Department of Otorhinolaryngology, Calcutta National Medical College, 24 Gorachand Road, Kolkata, 700 014 India
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Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol 2007; 44:601-7. [PMID: 17996487 DOI: 10.1016/j.oraloncology.2007.08.009] [Citation(s) in RCA: 81] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/22/2007] [Revised: 07/25/2007] [Accepted: 08/08/2007] [Indexed: 11/20/2022]
Abstract
The aim of this study was to analyze the clinico-pathological and immunohistochemical features of 62 cases of odontogenic myxoma (OM) diagnosed in three Oral Pathology Diagnostic Services in Latin America, as well as to describe the ultrastructural features of three of these cases. OM showed a wide age range (9-71 years), with a mean of 27.97 yr (SD: 11.01) and a male to female ratio of 1:2.2. Mandible was affected in 37 cases (59.6%) and maxilla in 25 (40.4%), with 61.3% located in the posterior region. Thirty-nine cases (62.9%) were multilocular and 23 (37.1%) unilocular. Size ranged from 1 to 13 cm, (mean: 5.2 cm). Thirty-seven multilocular (54.8%) and 6 unilocular lesions (26%) were larger than 4 cm (p<0.05). Epithelial islands were identified in 5 cases (8%) on H&E stained sections, but AE1/AE3 and CK14 disclosed these structures in 15 cases each (24.2%); CK5 was positive in 8 (12.9%); CK7 in 2 (3.2%) and CK19 in only 3 cases (4.8%). All cases were negative for CKs 8 and 18, S-100 protein, NSE and CD68, and showed a low index of expression of Bcl2 and ki-67 proteins (<1%). Mast cell antibodies showed these cells in 45 cases (72.6%). Myofibroblastic differentiation evidenced by myofilaments and fibronexi was found in one case out of the three studied by TEM and 29 cases (46.7%) were positive by immunohistochemistry for alpha actin. In conclusion, only a minority of OM had epithelial islands, and only 3 cases expressed CK 19, indicating an odontogenic epithelium origin. Immunohistochemical and ultrastructural findings suggest that OM is a mesenchymal neoplasm in which several factors may contribute to its pathogenesis, including myofibroblastic differentiation and the participation of mast cell products. However, further investigations are needed to better understand the participation of these elements in this particular neoplasm.
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Araki M, Kameoka S, Matsumoto N, Mastumoto N, Komiyama K. Usefulness of cone beam computed tomography for odontogenic myxoma. Dentomaxillofac Radiol 2007; 36:423-7. [PMID: 17881604 DOI: 10.1259/dmfr/85361774] [Citation(s) in RCA: 32] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
A case of odontogenic myxoma is reported as showing a cyst-like pattern with a partially thick but vague and unclear radiopaque border between the left mandibular second premolar and first molar on rotational panoramic radiography. Internal structure of the lesion displayed radiolucency with a sparse and coarse trabecular pattern. No expansion of bucco-lingual cortical bone was apparent. The radiographic pattern of odontogenic myxoma did not resemble a tennis racket-like or straight, curved and coarse septal appearance on panoramic radiography, but characteristic findings were noted on cone beam CT. Cone beam CT may prove extremely useful in clarifying detailed internal structure and the state of margins.
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Affiliation(s)
- M Araki
- Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan.
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Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. ACTA ACUST UNITED AC 2007; 104:101-9. [PMID: 17507265 DOI: 10.1016/j.tripleo.2007.01.026] [Citation(s) in RCA: 67] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/27/2006] [Revised: 01/21/2007] [Accepted: 01/23/2007] [Indexed: 10/23/2022]
Abstract
OBJECTIVE The purpose of the study was to analyze the clinical and radiographic features of central odontogenic myxomas (OM) of the jaws diagnosed over 23 years in a black South African patient sample. STUDY DESIGN Records of 30 cases of OMs with radiographs of diagnostic quality were retrieved from 52 cases of histopathologically verified OMs from the archives of the Oral Health Center at the University of Limpopo, South Africa. The age, sex, size, location, and radiographic features were compared with the literature. RESULTS The study consisted of 21 females and 9 males. The correlation between age and size of the tumor was found to be statistically significant (P = .004). Septa were shown to be either reorientated cortical bone or sheets of dense fibrous connective tissue. Indistinct borders mimicked malignancy. The most common radiographic feature was the tennis-racket appearance. CONCLUSIONS Variations in radiographic presentation make a radiological differential interpretation of OM challenging because the radiographic features overlap with those of other benign and malignant neoplasms.
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Zhang J, Wang H, He X, Niu Y, Li X. Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol 2007; 36:160-7. [PMID: 17463101 DOI: 10.1259/dmfr/38484807] [Citation(s) in RCA: 33] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
OBJECTIVE There are some different radiographic appearances of odontogenic myxoma that have not been reported in the published literature. The purpose of this article is to offer rare views of odontogenic myxomas and analyse the characteristics of the radiographic appearances. MATERIALS AND METHODS We reviewed the radiographic appearances of 41 cases of odontogenic myxomas on conventional radiographs, recruited from patients who visited the Department of Oral Radiology, West China College of Stomatology, Sichuan University between 1964 and 2005. The diagnoses of the cases were verified by histopathology. RESULTS On conventional radiographs, odontogenic myxomas presented varying radiographic appearances, which could be divided into six types as follows: Type I-unilocular; Type II-multilocular (including honeycomb, soap bubble and tennis racquet patterns); Type III-involvement of local alveolar bone; Type IV-involvement of the maxillary sinus; Type V-osteolytic destruction and Type VI-a mix of osteolytic destruction and osteogenesis. CONCLUSION Odontogenic myxoma has variable radiographic appearances on conventional radiographs. This classification system helps us better understand the radiographic appearances of odontogenic myxoma on conventional radiographs.
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Affiliation(s)
- J Zhang
- Department of Oral Radiology, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China
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Dunfee BL, Sakai O, Pistey R, Gohel A. Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics 2006; 26:1751-68. [PMID: 17102048 DOI: 10.1148/rg.266055189] [Citation(s) in RCA: 107] [Impact Index Per Article: 5.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/12/2023]
Abstract
Mandibular lesions develop from both odontogenic and nonodontogenic origins and have varying degrees of destructive potential. Common benign cystic lesions include periapical (radicular) cysts, follicular (dentigerous) cysts, and odontogenic keratocysts. Benign solid tumors represent a broad spectrum of lesions such as ameloblastomas, odontomas, ossifying fibromas, and periapical cemental dysplasia. Malignant tumors that often involve the mandible include squamous cell carcinomas, osteosarcomas, and metastatic tumors. In addition, vascular lesions such as hemangiomas and arteriovenous malformations may develop, further expanding the differential diagnosis. Because mandibular lesions have a wide range of pathologic features but similar imaging appearances, familiarity with embryologic characteristics and secondary findings is crucial. Patient age at manifestation, prevalence, location within the mandible, cystic or solid appearance, border contour, and effect of the lesion on adjacent structures are all considerations in making the diagnosis. Despite this information, however, many lesions are impossible to differentiate without biopsy. In such cases, defining the degree of malignant potential is very helpful. Although imaging will not always provide a specific diagnosis, it should help narrow the differential diagnosis, thereby helping to guide patient treatment.
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Affiliation(s)
- Brian L Dunfee
- Department of Radiology, Boston University School of Medicine, Boston Medical Center, 715 Albany St, Boston, MA 02118, USA.
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Li TJ, Sun LS, Luo HY. Odontogenic Myxoma: A Clinicopathologic Study of 25 Cases. Arch Pathol Lab Med 2006; 130:1799-806. [PMID: 17149953 DOI: 10.5858/2006-130-1799-omacso] [Citation(s) in RCA: 85] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 05/04/2006] [Indexed: 11/06/2022]
Abstract
Abstract
Context.—Odontogenic myxoma is an uncommon tumor that has the potential for extensive destruction of the jaws.
Objective.—To document the clinical, pathologic, and behavioral features of odontogenic myxomas.
Design.—Histologic and immunocytochemical examinations were performed on odontogenic myxomas from 25 Chinese patients. Clinical and available follow-up data were analyzed.
Results.—In the present series, 13 were male and 12 female. The age at diagnosis ranged from 6 to 66 years, with a mean age of 28.8 years. Twelve tumors involved the mandible and 13 occurred in the maxilla, with a predilection for posterior areas. The posterior maxillary tumors frequently (9/10) involved the maxillary sinus. Of the 23 cases with radiographic records, 22 lesions presented with a multilocular appearance. Although 80% of the mandibular lesions showed a well-defined border, only 33.3% of the maxillary tumors were well-defined. Histologically, odontogenic myxomas were mainly composed of spindled or stellate-shaped cells in a mucoid-rich intercellular matrix. Tumors containing noticeable fibrous components were evident in 13 cases. Apart from 5 cases treated conservatively by enucleation, the remaining 20 cases were treated by relatively radical procedures, including block/segmental resection and partial or total maxillectomy or mandibulectomy. Follow-up data were available on 22 patients and only 1 patient initially treated by enucleation had a recurrence.
Conclusions.—Odontogenic myxomas have a very bland histologic appearance that lacks atypia and may easily lead to misdiagnosis. The tumors are infiltrative with no capsulation and may recur after inadequate surgery.
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Affiliation(s)
- Tie-Jun Li
- Department of Oral Pathology, School and Hospital of Stomatology, Peking University, 22 S Zhongguancun Ave, Haidian District, Beijing, PR China 100081.
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Aquilino RN, Tuji FM, Eid NL, Molina OF, Joo HY, Neto FH. Odontogenic myxoma in the maxilla: A case report and characteristics on CT and MR. ACTA ACUST UNITED AC 2006. [DOI: 10.1016/j.ooe.2005.10.002] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/25/2022]
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Said-Al-Naief N. Odontogenic Tumors for General Pathologists. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 2005; 563:148-64. [PMID: 16433130 DOI: 10.1007/0-387-32025-3_14] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/11/2023]
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Simon ENM, Merkx MAW, Vuhahula E, Ngassapa D, Stoelinga PJW. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg 2004; 33:333-7. [PMID: 15145033 DOI: 10.1016/j.ijom.2003.12.004] [Citation(s) in RCA: 146] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 12/09/2003] [Indexed: 11/29/2022]
Abstract
Odontogenic myxoma, a rare tumour that occurs in the jaws, has been reported to be the second commonest odontogenic tumour in many countries. Few studies, however, provide detailed clinicopathological findings of a large series of cases and no study so far has attempted to calculate the incidence of this condition. Retrospective and prospective studies were carried out in Tanzania from 1982 to 1998 (16 years) and 1999 to 2002 (4 years), respectively. A total of 33 cases of myxomas were found with a male:female ratio of 1:1.83. Most of the tumours were located in the mandible compared to the maxilla and were predominantly multilocular. Pain, diasthesia, ulceration, invasion of the soft tissues and tooth mobility were among the symptoms that patients presented with although the majority had no clinical signs or symptoms. Based on the prospective study only, an annual incidence of 0.07 per million can be ascertained. Late reporting was a common feature in this group of patients. Radical surgery with resection of the tumour with a safe margin is advocated.
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Affiliation(s)
- Elison N M Simon
- Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Muhimbili University College of Health Sciences, Dar Es Salaam, Tanzania.
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Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor. Oral Maxillofac Surg Clin North Am 2004; 16:359-74. [DOI: 10.1016/j.coms.2004.03.004] [Citation(s) in RCA: 56] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022]
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MacDonald-Jankowski DS, Yeung RWK, Li T, Lee KM. Computed tomography of odontogenic myxoma. Clin Radiol 2004; 59:281-7. [PMID: 15037142 DOI: 10.1016/j.crad.2003.09.024] [Citation(s) in RCA: 32] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/29/2003] [Revised: 09/25/2003] [Accepted: 09/30/2003] [Indexed: 11/22/2022]
Abstract
AIM The aim of this study was to determine the computed tomography (CT) presentation of odontogenic myxoma (OM) in a Chinese population and to compare them with those observed on the accompanying conventional radiographs (CR). MATERIALS AND METHODS The files of the Department of Oral and Maxillofacial Surgery of the University of Hong Kong between 1989 and 2000 were reviewed for myxoma cases. RESULTS Ten cases of OM were found of which eight had been investigated by CT. The formatted hard copy was found in seven cases, four in the maxilla and three in the mandible. Most of the OMs had a round shape but one was fusiform. CT was more likely to display a cortex and its perforation. All OMs had perforated cortices on CT with soft tissue appearing outside the bony contour in two cases. Contrast enhancement was apparent in six cases. Both CR and CT displayed septae, but the latter method revealed that most septae were situated at the periphery, presenting as "sunray" type spicules in one case. Tooth displacement and root resorption were more reliably observed on CR. CONCLUSION The likelihood of perforation and pattern of septa of OM is better displayed by CT. CR should also allow a better assessment of the degree of definition of the lesion's margins with adjacent normal bone. Therefore, both CT and CR should be used in an investigation of an OM.
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Abstract
Benign odontogenic tumors are characterized by imaging findings of expansile growth and well-defined margins with smooth borders, and their appearance is very similar to that of odontogenic and nonodontogenic cysts. From the viewpoint of diagnostic imaging of odontogenic tumors, teeth are designed differently according to their origin from the apex or crown. Therefore, for differential diagnosis, it is necessary to select diagnostic methods that make it possible to evaluate these findings in detail. Intraoral and panoramic radiography are highly effective in examining the relationship between teeth and lesions, especially the vertical relationship. When a lesion is suspected in the mandible or maxilla on CT, MR imaging, or nuclear medicine, these procedures must be performed as supplementary imaging techniques. CT demonstrates well the degree of bone resorption, osteosclerosis, cortical bone swelling, destruction, and calcification. MR imaging is effective in differentiating between tumors and cysts, evaluating the infiltration of malignant tumors in the jawbone and surrounding soft tissue, and detecting bone marrow changes of the jaw. Differentiation between tumors and cysts must be achieved by contrast-enhanced studies. Combining plain radiography with advanced imaging techniques, including CT and MR imaging, can improve the accuracy of diagnosing odontogenic tumors.
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Affiliation(s)
- Takashi Kaneda
- Department of Radiology, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-Nishi, Matsudo, Chiba 271-8587, Japan.
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Koseki T, Kobayashi K, Hashimoto K, Ariji Y, Tsuchimochi M, Toyama M, Araki M, Igarashi C, Koseki Y, Ariji E. Computed tomography of odontogenic myxoma. Dentomaxillofac Radiol 2003; 32:160-5. [PMID: 12917281 DOI: 10.1259/dmfr/16752462] [Citation(s) in RCA: 24] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open
Abstract
OBJECTIVES The purpose of this study was to clarify the CT features of odontogenic myxoma. METHODS CT appearances were analysed in 17 patients with histologically verified odontogenic myxoma collected from five dental hospitals in Japan. RESULTS On the CT images, tumour borders were generally well defined with a smooth margin both for bony and soft tissue structures in all patients. Cortical status was clearly evaluated using CT and the continuity was interrupted in nine patients. Intralesional trabeculations were observed in 13 patients. Of these 13, 6 patients showed the characteristic appearance of angular or straight trabeculations within the tumour. The trabeculations were frequently observed at the peripheral portion of the tumour. In three maxillary tumours, soft tissue margins were observed beyond the cortical margin and/or intralesional trabeculations. In 10 of the 13 lesions evaluated, the majority of the whole tumour area showed relatively lower density compared with surrounding muscles. CONCLUSION CT clearly demonstrated characteristic features of odontogenic myxoma. CT analysis may contribute to establishing a consensus regarding the interpretation of conventional radiographic appearances in odontogenic myxoma.
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Affiliation(s)
- T Koseki
- Department of Oral Radiology, Osaka Dental University, Osaka, Japan
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White DK, Street CC, Jenkins WS, Clark AR, Ford JE. Panoramic radiograph in pathology. Atlas Oral Maxillofac Surg Clin North Am 2003; 11:1-53. [PMID: 12725098 DOI: 10.1016/s1061-3315(02)00012-4] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
Affiliation(s)
- Dean K White
- Division of Oral and Maxillofacial Pathology, College of Dentistry, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USA.
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Yoshida M, Kumamoto H, Ooya K, Mayanagi H. Immunohistochemical Analysis of Benign Mixed and Mesenchymal Odontogenic Tumors. ACTA ACUST UNITED AC 2003. [DOI: 10.3353/omp.8.125] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
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Ochsenius G, Ortega A, Godoy L, Peñafiel C, Escobar E. Odontogenic tumors in Chile: a study of 362 cases. J Oral Pathol Med 2002; 31:415-20. [PMID: 12165060 DOI: 10.1034/j.1600-0714.2002.00073.x] [Citation(s) in RCA: 115] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]
Abstract
BACKGROUND Odontogenic tumors are infrequent lesions. Thus, the review of a large number of cases becomes a necessity for both the pathologist and the clinician. Studies on odontogenic tumors have been published in many parts of the world, but there is little information available in the English language literature on the relative frequency of odontogenic tumors in Latin America. The aim of this study was to determine the relative frequency of this heterogeneous group of lesions in a Chilean population, and to compare these data with previous reports. METHODS We reviewed the records of 28,041 specimens from 1975 to 2000 in the Oral Pathology Referral Institute (IREPO), and using the criteria for histological typification published by the World Health Organization in 1992, we reclassified the odontogenic tumors. RESULTS We confirmed a total of 362 odontogenic tumors. The frequency of odontogenic tumors as a percentage of all pathological specimens in our institute was 1.29%. The most frequent histological type was odontomas (44.7%), followed by ameloblastomas (20.4%) and myxomas (8.8%). CONCLUSIONS Odontogenic tumors are uncommon lesions in the Chilean population and malignant odontogenic tumors are very rare. The relative frequency of various types of odontogenic tumors, as well as the age and gender distribution are similar to those reported in the North American series and different from those found in recently published Asian and African series.
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Affiliation(s)
- Germán Ochsenius
- Oral Pathology Referral Institute, Faculty of Odontology, University of Chile, Santiago, Chile
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