After 15 years from its advent in the clinical field, coronary computed tomography (CCTA) is now widely considered as the best first-step test in patients with low-to-moderate pre-test probability of coronary artery disease. Technological innovation was of pivotal importance for the extensive clinical and scientific interest in CCTA. Recently, the advent of last generation wide-coverage CT scans paved the way for new clinical applications of this technique beyond coronary arteries anatomy evaluation. More precisely, both biventricular volume and systolic function quantification and myocardial fibrosis identification appeared to be feasible with last generation CT. In the present review we would focus on potential applications of cardiac computed tomography (CCT), beyond CCTA, for a comprehensive assessment patients with newly diagnosed cardiomyopathy, from technical requirements to novel clinical applications.

• cardiac computed tomographic imaging
• cardiac imaging and diagnostics
• cardiomyopathies
• multimodality imaging
• myocardial fibrosis

Computed tomography (CT) allows reproducible assessment of left ventricular (LV) function, left ventricular outflow tract area (LVOT_area) and aortic valve area (AVA). We evaluated the influence of image reconstruction parameters on these measurements.

We analyzed 45 contrast-enhanced, retrospectively ECG-gated CT datasets acquired on a third-generation dual source system. A standard filtered-back-projection data set (20 cardiac phases (5% steps, 0–95%), 0.6-mm-slice thickness, 512 × 512 matrix) and eight reconstructions with modified slice thickness (1–8 mm), number of cardiac phases (5, 10), matrix size (256×256) and an iterative reconstruction (IR) algorithm were obtained. LV parameters (ejection fraction (EF), stroke volume (SV), end-diastolic (EDV), end-systolic volumes (ESV)), LVOT_area and AVA were assessed.

Differences in LV parameters, LVOT_area and AVA, were only minimal between standard reconstructions and those with modified matrix size, IR algorithm and ≤2 mm slice thickness, while reconstructions with 8-mm slice thickness significantly overestimated SV (p < 0.001) and EDV (p = 0.016). AVA planimetry in reconstructions with ≥5 mm slice thickness was not feasible in 56% of patients. A decrease in the number of reconstructed phases (10 or 5) underestimated EF, SV, EDV, LVOT_area and AVA and overestimated ESV.

Modifications of reconstruction parameters (except a slice thickness ≤2 mm) have only a marginal effect on LV, LVOT_area and AVA assessment. However, a reduced number of reconstructions per cardiac cycle may significantly influence measurements.

Substantial modifications in number of reconstructions per cardiac cycle significantly affect the assessment of LV function, LVOT_area and AVA also in modern CT scanners.

Left ventricular ejection fraction (LVEF) is an important predictor of cardiac outcome and helps in making important diagnostic and therapeutic decisions such as the treatment of different types of congestive heart failure or implantation of devices like cardiac resynchronization therapy-defibrillator. LVEF can be measured by various techniques such as transthoracic echocardiography, contrast ventriculography, radionuclide techniques, cardiac magnetic resonance imaging and cardiac computed tomographic angiography (CTA). The development of cardiac CTA using multi-detector row CT (MDCT) has seen a very rapid improvement in the technology for identifying coronary artery stenosis and coronary artery disease in the last decade. During the acquisition, processing and analysis of data to study coronary anatomy, MDCT provides a unique opportunity to measure left ventricular volumes and LVEF simultaneously with the same data set without the need for additional contrast or radiation exposure. The development of semi-automated and automated software to measure LVEF has now added uniformity, efficiency and reproducibility of practical value in clinical practice rather than just being a research tool. This article will address the feasibility, the accuracy and the limitations of MDCT in measuring LVEF.

• Stroke volume
• Ventricular ejection fraction
• Computerized tomography
• X ray

The correlation between normal cardiac chamber linear dimensions measured during retrospective coronary computed tomographic angiography as compared to transthoracic echocardiography using the American Society of Echocardiography guidelines is not well established.

We performed a review from January 2005 to July 2011 to identify subjects with retrospective electrocardiogram-gated coronary computed tomographic angiography scans for chest pain and transthoracic echocardiography with normal cardiac structures performed within 90 days. Dimensions were manually calculated in both imaging modalities in accordance with the American Society of Echocardiography published guidelines. Left ventricular ejection fraction was calculated on echocardiography manually using the Simpson’s formula and by coronary computed tomographic angiography using the end-systolic and end-diastolic volumes.

We reviewed 532 studies, rejected 412 and had 120 cases for review with a median time between studies of 7 days (interquartile range (IQR_25,75) = 0–22 days) with no correlation between the measurements made by coronary computed tomographic angiography and transthoracic echocardiography using Bland–Altman analysis. We generated coronary computed tomographic angiography cardiac dimension reference ranges for both genders for our population.

Our findings represent a step towards generating cardiac chamber dimensions’ reference ranges for coronary computed tomographic angiography as compared to transthoracic echocardiography in patients with normal cardiac morphology and function using the American Society of Echocardiography guideline measurements that are commonly used by cardiologists.

• Coronary computed tomographic angiography
• chamber assessment
• computed tomography

To compare Magnetic Resonance (MR) and Computed Tomography (CT) for the assessment of left (LV) and right (RV) ventricular functional parameters.

Seventy nine patients underwent both Cardiac CT and Cardiac MR. Images were acquired using short axis (SAX) reconstructions for CT and 2D cine b-SSFP (balanced-steady state free precession) SAX sequence for MR, and evaluated using dedicated software.

CT and MR images showed good agreement: LV EF (Ejection Fraction) (52 ± 14% for CT vs. 52 ± 14% for MR; r = 0.73; p > 0.05); RV EF (47 ± 12% for CT vs. 47 ± 12% for MR; r = 0.74; p > 0.05); LV EDV (End Diastolic Volume) (74 ± 21 ml/m² for CT vs. 76 ± 25 ml/m² for MR; r = 0.59; p > 0.05); RV EDV (84 ± 25 ml/m² for CT vs. 80 ± 23 ml/m² for MR; r = 0.58; p > 0.05); LV ESV (End Systolic Volume)(37 ± 19 ml/m² for CT vs. 38 ± 23 ml/m² for MR; r = 0.76; p > 0.05); RV ESV (46 ± 21 ml/m² for CT vs. 43 ± 18 ml/m² for MR; r = 0.70; p > 0.05). Intra- and inter-observer variability were good, and the performance of CT was maintained for different EF subgroups.

Cardiac CT provides accurate and reproducible LV and RV volume parameters compared with MR, and can be considered as a reliable alternative for patients who are not suitable to undergo MR.

• Cardiac-CT is able to provide Left and Right Ventricular function.

• Cardiac-CT is accurate as MR for LV and RV volume assessment.

• Cardiac-CT can provide accurate evaluation of coronary arteries and LV and RV function.

The online version of this article (doi:10.1007/s00330-011-2345-6) contains supplementary material, which is available to authorized users.

• Beta-blocker
• CT coronary angiography
• Ejection fraction
• Heart rate
• Left ventricular volume
• Propranolol, 64-slice MDCT

• Aged
• Coronary Artery Disease/complications
• Coronary Artery Disease/diagnosis
• Double-Blind Method
• Echocardiography/methods
• Female
• Humans
• Male
• Reproducibility of Results
• Sensitivity and Specificity
• Stroke Volume
• Tomography, X-Ray Computed/methods
• Ventricular Dysfunction, Left/diagnosis
• Ventricular Dysfunction, Left/etiology
• Ventricular Remodeling

• Adult
• Aged
• Aged, 80 and over
• Angina Pectoris/diagnostic imaging
• Angina Pectoris/physiopathology
• Chest Pain/diagnostic imaging
• Chest Pain/physiopathology
• Coronary Angiography/methods
• Echocardiography/methods
• Female
• Humans
• Male
• Middle Aged
• Myocardial Contraction/physiology
• Myocardial Infarction/diagnostic imaging
• Myocardial Infarction/physiopathology
• Prognosis
• Radiation Dosage
• Reference Standards
• Retrospective Studies
• Sensitivity and Specificity
• Stroke Volume/physiology
• Tomography, X-Ray Computed/methods
• Ventricular Function, Left/physiology