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Heldeweg MLA, Lopez Matta JE, Pisani L, Slot S, Haaksma ME, Smit JM, Mousa A, Magnesa G, Massaro F, Touw HRW, Schouten V, Elzo Kraemer CV, van Westerloo DJ, Heunks LMA, Tuinman PR. The Impact of Thoracic Ultrasound on Clinical Management of Critically Ill Patients (UltraMan): An International Prospective Observational Study. Crit Care Med 2023; 51:357-364. [PMID: 36562620 DOI: 10.1097/ccm.0000000000005760] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/24/2022]
Abstract
OBJECTIVES To investigate the impact of thoracic ultrasound (TUS) examinations on clinical management in adult ICU patients. DESIGN A prospective international observational study. SETTING Four centers in The Netherlands and Italy. PATIENTS Adult ICU patients (> 18 yr) that received a clinically indicated lung ultrasound examination. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Clinicians performing TUS completed a pre- and post-examination case report form. Patient characteristics, TUS, and resulting clinical effects were recorded. First, change of management, defined as a TUS-induced change in clinical impression leading to a change in treatment plan, was reported. Second, execution of intended management changes within 8 hours was verified. Third, change in fluid balance after 8 hours was calculated. A total of 725 TUS performed by 111 operators across 534 patients (mean age 63 ± 15.0, 70% male) were included. Almost half of TUS caused a change in clinical impression, which resulted in change of management in 39% of cases. The remainder of TUS confirmed the clinical impression, while a minority (4%) did not contribute. Eighty-nine percent of management changes indicated by TUS were executed within 8 hours. TUS examinations that led to a change in fluid management also led to distinct and appropriate changes in patient's fluid balance. CONCLUSIONS In this international observational study in adult ICU patients, use of TUS had a major impact on clinical management. These results provide grounds for future randomized controlled trials to determine if TUS-induced changes in decision-making also lead to improved health outcomes.
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Affiliation(s)
- Micah L A Heldeweg
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
| | - Jorge E Lopez Matta
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
- Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands
| | - Luigi Pisani
- Department of Intensive Care Medicine, Regional General Hospital F. Miulli, Acquaviva delle Fonti, Italy
| | - Stefanie Slot
- Department of Intensive Care Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands
| | - Mark E Haaksma
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
| | - Jasper M Smit
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
| | - Amne Mousa
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
| | - Giovanna Magnesa
- Department of Intensive Care Medicine, Regional General Hospital F. Miulli, Acquaviva delle Fonti, Italy
| | - Fabrizia Massaro
- Department of Intensive Care Medicine, Regional General Hospital F. Miulli, Acquaviva delle Fonti, Italy
| | - Hugo R W Touw
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
- Department of Intensive Care Medicine, Radboud University Medical Hospital, Nijmegen, The Netherlands
| | - Viviane Schouten
- Department of Intensive Care Medicine, Noordwest Ziekenhuisgroep, Alkmaar, The Netherlands
| | - Carlos V Elzo Kraemer
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
- Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands
| | - David J van Westerloo
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
- Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, The Netherlands
| | - Leo M A Heunks
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
| | - Pieter R Tuinman
- Department of Intensive Care Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com ), Amsterdam, The Netherlands
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Maheshwarappa HM, Mishra S, Kulkarni AV, Gunaseelan V, Kanchi M. Use of Handheld Ultrasound Device with Artificial Intelligence for Evaluation of Cardiorespiratory System in COVID-19. Indian J Crit Care Med 2021; 25:524-527. [PMID: 34177171 PMCID: PMC8196368 DOI: 10.5005/jp-journals-10071-23803] [Citation(s) in RCA: 12] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/07/2023] Open
Abstract
BACKGROUND Coronavirus disease-2019 (COVID-19) causes various cardiopulmonary manifestations. Bedside ultrasound helps in the rapid diagnosis of these manifestations. Vscan Extend™ (GE, Wauwatosa, WI, USA) is a handheld ultrasound device with a dual probe and an artificial intelligence application to detect ejection fraction. It can help in reducing the time for diagnosis, duration, and the number of healthcare workers exposed to COVID-19. This is a prospective observational study comparing the cardiorespiratory parameters and time duration for assessment between Vscan Extend™ and the conventional ultrasound machine. MATERIALS AND METHODS Paired observations were made in 96 COVID-19 patients admitted to the intensive care unit by two intensivists. Intensivist A used the Vscan Extend™ device to assess the cardiac function, lung fields, diaphragm, deep veins, and abdomen. Intensivist B used clinical examination, X-ray chest, ECG, and conventional echocardiogram for assessment. The agreement between the findings and the time duration required in both the methods was compared. RESULTS The use of handheld ultrasound has significantly decreased the duration of bedside examination of patients than the conventional method. The median duration of examination using handheld ultrasound was 9 (8.0-11.0) minutes, compared to 20 (17-22) minutes with the conventional method (P < 0.001). The Cohen's kappa coefficient was 1.0 for left ventricular systolic function, most of the lung fields, and diaphragmatic movement. CONCLUSION Vscan Extend™ helps in the rapid identification and diagnosis of cardiopulmonary manifestations in COVID-19 patients. The agreement between the handheld device and the conventional method proves its efficacy and safety. CTRI NUMBER CTRI/2020/07/026701. HOW TO CITE THIS ARTICLE Maheshwarappa HM, Mishra S, Kulkarni AV, Gunaseelan V, Kanchi M. Use of Handheld Ultrasound Device with Artificial Intelligence for Evaluation of Cardiorespiratory System in COVID-19. J Crit Care Med 2021;25(5):524-527.
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Affiliation(s)
- Harish M Maheshwarappa
- Department of Critical Care Medicine, Mazumdar Shaw Medical Centre, Narayana Health City, Bengaluru, Karnataka, India
| | - Shivangi Mishra
- Department of Critical Care Medicine, Mazumdar Shaw Medical Centre, Narayana Health City, Bengaluru, Karnataka, India
| | - Anuja V Kulkarni
- Narayana Institute of Cardiac Sciences, Narayana Health City, Bengaluru, Karnataka, India
| | - Vikneswaran Gunaseelan
- Department of Clinical Research, Narayana Hrudayalaya Limited, Bengaluru, Karnataka, India
| | - Muralidhar Kanchi
- Department of Anaesthesiology and Intensive Care, Narayana Institute of Cardiac Sciences, Bengaluru, Karnataka, India
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Lichtenstein DA. An ultrasound limited test initiating medical airborne transportation (ULTIMAT-protocol): its impact in other settings in medicine. Ann Intensive Care 2020; 10:11. [PMID: 32016819 PMCID: PMC6997308 DOI: 10.1186/s13613-019-0620-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2019] [Accepted: 12/23/2019] [Indexed: 11/10/2022] Open
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Lichtenstein DA. Lung ultrasound for the cardiologist – a basic application: The B-profile of the Bedside Lung Ultrasound in Emergencies protocol for diagnosing haemodynamic pulmonary oedema. Arch Cardiovasc Dis 2020; 113:489-491. [DOI: 10.1016/j.acvd.2020.05.005] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/21/2020] [Revised: 05/12/2020] [Accepted: 05/13/2020] [Indexed: 01/07/2023]
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Hendin A, Koenig S, Millington SJ. Better With Ultrasound: Thoracic Ultrasound. Chest 2020; 158:2082-2089. [PMID: 32422131 DOI: 10.1016/j.chest.2020.04.052] [Citation(s) in RCA: 17] [Impact Index Per Article: 3.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2020] [Revised: 04/24/2020] [Accepted: 04/29/2020] [Indexed: 11/18/2022] Open
Abstract
Ultrasound examination of the thorax is superior to chest radiograph or physical examination for diagnosing common conditions such as pneumonia, pulmonary edema, pleural effusion, and pneumothorax. The basic skill set is straightforward to learn, quick to perform, repeatable, and does not involve patient transport, harmful ionizing radiation, or waiting time. This paper outlines the basic building blocks that makeup a thoracic ultrasound examination, regardless of which specific scanning protocol is performed. Narrative videos and illustrative figures demonstrating these techniques are included.
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Affiliation(s)
- Ariel Hendin
- University of Ottawa/The Ottawa Hospital, Ottawa, ON, Canada
| | - Seth Koenig
- Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY
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Bezzio C, Saibeni S. Gastrointestinal ultrasound in inflammatory bowel disease: Seeing beyond limits. Dig Liver Dis 2020; 52:19-20. [PMID: 31786084 DOI: 10.1016/j.dld.2019.11.007] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/08/2019] [Accepted: 11/12/2019] [Indexed: 12/11/2022]
Affiliation(s)
- Cristina Bezzio
- Gastroenterology Unit, Rho Hospital, ASST Rhodense, Rho, Italy
| | - Simone Saibeni
- Gastroenterology Unit, Rho Hospital, ASST Rhodense, Rho, Italy.
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Abstract
OBJECTIVES Lung ultrasound has shown increasing diagnostic value in many lung diseases and has become an efficient tool in the management of dyspnea. In the present case report, we describe a new ultrasound feature of potential interest. DATA SOURCES Clinical observation of a patient. STUDY SELECTION Case report. DATA EXTRACTION Data were extracted from medical records, after obtaining consent from the patient's family. Illustrations were extracted from the imaging software and a video device. DATA SYNTHESIS A 56-year-old man was admitted with pneumonia of adverse outcome. Lung ultrasound, a method increasingly considered as a bedside gold standard in critically ill patients due to its overwhelming advantages, was the only tool able to specify the lung injuries. We describe herein a distinctive sign unequivocally evoking a destructive process suggestive of pulmonary gangrene, a variant of the fractal sign combining a lung consolidation with an underlying heterogeneous free fluid. CONCLUSIONS Lung ultrasound may help highlight pulmonary gangrene, a poorly-known disease, with this new ultrasonographic description. The next step will be to ascertain the relation between this new ultrasound feature and pulmonary gangrene and to assess how this bedside diagnosis could impact the prognosis of the disease.
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Lichtenstein DA. Current Misconceptions in Lung Ultrasound: A Short Guide for Experts. Chest 2019; 156:21-25. [PMID: 30872018 DOI: 10.1016/j.chest.2019.02.332] [Citation(s) in RCA: 40] [Impact Index Per Article: 6.7] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2018] [Revised: 02/10/2019] [Accepted: 02/26/2019] [Indexed: 12/20/2022] Open
Affiliation(s)
- Daniel A Lichtenstein
- Medical Intensive Care Unit, Hospital Ambroise Paré, APHP, Paris-West University, Boulogne, France.
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Lichtenstein D. Novel approaches to ultrasonography of the lung and pleural space: where are we now? Breathe (Sheff) 2017; 13:100-111. [PMID: 28620429 PMCID: PMC5467658 DOI: 10.1183/20734735.004717] [Citation(s) in RCA: 51] [Impact Index Per Article: 6.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/16/2022] Open
Abstract
This review article is an update of what should be known for practicing basic lung ultrasound in the critically ill (LUCI) and is also of interest for less critical disciplines (e.g. pulmonology). It pinpoints on the necessity of a professional machine (not necessarily a sophisticated one) and probe. It lists the 10 main signs of LUCI and some of the main protocols made possible using LUCI: the BLUE protocol for a respiratory failure, the FALLS protocol for a circulatory failure, the SESAME protocol for a cardiac arrest and the investigation of a ventilated acute respiratory distress syndrome patient, etc. It shows how the field has been fully standardised to avoid confusion. KEY POINTS A simple ultrasonography unit is fully adequate, with minimal filters, and provides a unique probe for integrating the lung into a holistic, whole-body approach to the critically ill.Interstitial syndrome is strictly defined. Its clinical relevance in the critically ill is standardised for defining haemodynamic pulmonary oedema, pneumonia and pulmonary embolism.Pneumothorax is strictly and sequentially defined by the A'-profile (at the anterior wall in a supine or semirecumbent patient, abolished lung siding plus the A-line sign) and then the lung point.The BLUE protocol integrates lung and venous ultrasound findings for expediting the diagnosis of acute respiratory failure, following pathophysiology, allowing prompt diagnosis of pneumonia, haemodynamic pulmonary oedema, exacerbated chronic obstructive pulmonary disease or asthma, pulmonary embolism or pneumothorax, even in clinically challenging presentations. EDUCATIONAL AIMS To understand that the use of lung ultrasound, although long standardised, still needs educational efforts for its best use, a suitable machine, a suitable universal probe and an appropriate culture.To be able to use a terminology that has been fully standardised to avoid any confusion of useless wording.To understand the logic of the BLUE points, three points of interest enabling expedition of a lung ultrasound examination in acute respiratory failure.To be able to cite, in the correct hierarchy, the seven criteria of the B-line, then those of interstitial syndrome.To understand the sequential thinking when making ultrasound diagnosis of pneumothorax.To be able to use the BLUE protocol for building profiles of pneumonia (or acute respiratory distress syndrome) and understand their limitations.To understand that lung ultrasound can be used for the direct analysis of an acute respiratory failure (the BLUE protocol), an acute circulatory failure (the FALLS protocol) and even a cardiac arrest (SESAME protocol), following a pathophysiological approach.To understand that the first sequential target in the SESAME protocol (search first for pneumothorax in cardiac arrest) can also be used in countless more quiet settings of countless disciplines, making lung ultrasound in the critically ill cost-, time- and radiation-saving.To be able to perform a BLUE protocol in challenging patients, understanding how the best lung ultrasound can be obtained from bariatric or agitated, dyspnoeic patients.
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Lichtenstein DA. Lung Ultrasound (in the Critically Ill) Superior to CT: the Example of Lung Sliding. Korean J Crit Care Med 2017; 32:1-8. [PMID: 31723610 PMCID: PMC6786749 DOI: 10.4266/kjccm.2016.00955] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/22/2016] [Accepted: 12/27/2016] [Indexed: 11/30/2022] Open
Abstract
This review article shows the potential of lung ultrasound in the critically ill (LUCI) to study lung sliding and describes the optimal equipment for its assessment. Then, it analyses the integration of lung sliding within lung ultrasound then whole body critical ultrasound. It describes the place of lung sliding in the BLUE-protocol (bedside lung ultrasound in emergency) (lung and venous ultrasound for diagnosing acute respiratory failure), the FALLS-protocol (fluid administration limited by lung sonography) (the role of lung sliding in circulatory failure), and the SESAME-protocol (sequential assessment of sonography assessing mechanism or origin of severe shock of indistinct cause) (whole body ultrasound in cardiac arrest). In the LUCIFLR project (LUCI favoring limitation of radiations), the consideration of lung sliding allows drastic reduction in irradiation and costs. In conclusion, lung sliding is proposed as a gold standard for indicating the presence of the lung at the chest wall and its correct expansion.
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Lichtenstein DA. The FALLS-Protocol, Another Way to Assess Circulatory Status Using Lung Ultrasound. Turk J Anaesthesiol Reanim 2017; 45:176-178. [PMID: 28752012 DOI: 10.5152/tjar.2017.24041] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2017] [Accepted: 04/22/2017] [Indexed: 12/22/2022] Open
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Jorens PG, Schepens T. Ultrasound: a novel translational tool to study diaphragmatic dysfunction in critical illness. ANNALS OF TRANSLATIONAL MEDICINE 2016; 4:515. [PMID: 28149877 DOI: 10.21037/atm.2016.12.49] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/06/2022]
Affiliation(s)
- Philippe G Jorens
- Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, B-2650 Edegem, Belgium
| | - Tom Schepens
- Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, B-2650 Edegem, Belgium
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Liccardo B, Martone F, Trambaiolo P, Severino S, Cibinel GA, D’Andrea A. Incremental value of thoracic ultrasound in intensive care units: Indications, uses, and applications. World J Radiol 2016; 8:460-471. [PMID: 27247712 PMCID: PMC4882403 DOI: 10.4329/wjr.v8.i5.460] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/19/2015] [Revised: 01/25/2016] [Accepted: 02/14/2016] [Indexed: 02/06/2023] Open
Abstract
Emergency physicians are required to care for unstable patients with life-threatening conditions, and thus must make decisions that are both quick and precise about unclear clinical situations. There is increasing consensus in favor of using ultrasound as a real-time bedside clinical tool for clinicians in emergency settings alongside the irreplaceable use of historical and physical examinations. B-mode sonography is an old technology that was first proposed for medical applications more than 50 years ago. Its application in the diagnosis of thoracic diseases has always been considered limited, due to the presence of air in the lung and the presence of the bones of the thoracic cage, which prevent the progression of the ultrasound beam. However, the close relationship between air and water in the lungs causes a variety of artifacts on ultrasounds. At the bedside, thoracic ultrasound is based primarily on the analysis of these artifacts, with the aim of improving accuracy and safety in the diagnosis and therapy of the various varieties of pulmonary pathologic diseases which are predominantly "water-rich" or "air-rich". The indications, contraindications, advantages, disadvantages, and techniques of thoracic ultrasound and its related procedures are analyzed in the present review.
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Lichtenstein DA. BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill. Chest 2015; 147:1659-1670. [PMID: 26033127 DOI: 10.1378/chest.14-1313] [Citation(s) in RCA: 381] [Impact Index Per Article: 38.1] [Reference Citation Analysis] [Abstract] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022] Open
Abstract
This review article describes two protocols adapted from lung ultrasound: the bedside lung ultrasound in emergency (BLUE)-protocol for the immediate diagnosis of acute respiratory failure and the fluid administration limited by lung sonography (FALLS)-protocol for the management of acute circulatory failure. These applications require the mastery of 10 signs indicating normal lung surface (bat sign, lung sliding, A-lines), pleural effusions (quad and sinusoid sign), lung consolidations (fractal and tissue-like sign), interstitial syndrome (lung rockets), and pneumothorax (stratosphere sign and the lung point). These signs have been assessed in adults, with diagnostic accuracies ranging from 90% to 100%, allowing consideration of ultrasound as a reasonable bedside gold standard. In the BLUE-protocol, profiles have been designed for the main diseases (pneumonia, congestive heart failure, COPD, asthma, pulmonary embolism, pneumothorax), with an accuracy > 90%. In the FALLS-protocol, the change from A-lines to lung rockets appears at a threshold of 18 mm Hg of pulmonary artery occlusion pressure, providing a direct biomarker of clinical volemia. The FALLS-protocol sequentially rules out obstructive, then cardiogenic, then hypovolemic shock for expediting the diagnosis of distributive (usually septic) shock. These applications can be done using simple grayscale machines and one microconvex probe suitable for the whole body. Lung ultrasound is a multifaceted tool also useful for decreasing radiation doses (of interest in neonates where the lung signatures are similar to those in adults), from ARDS to trauma management, and from ICUs to points of care. If done in suitable centers, training is the least of the limitations for making use of this kind of visual medicine.
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Affiliation(s)
- Daniel A Lichtenstein
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, Boulogne-Billancourt, France.
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Lichtenstein D. Fluid administration limited by lung sonography: the place of lung ultrasound in assessment of acute circulatory failure (the FALLS-protocol). Expert Rev Respir Med 2014; 6:155-62. [DOI: 10.1586/ers.12.13] [Citation(s) in RCA: 63] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/16/2022]
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Lichtenstein DA. Lung ultrasound in the critically ill. Ann Intensive Care 2014; 4:1. [PMID: 24401163 PMCID: PMC3895677 DOI: 10.1186/2110-5820-4-1] [Citation(s) in RCA: 362] [Impact Index Per Article: 32.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2013] [Accepted: 11/30/2013] [Indexed: 02/08/2023] Open
Abstract
Lung ultrasound is a basic application of critical ultrasound, defined as a loop associating urgent diagnoses with immediate therapeutic decisions. It requires the mastery of ten signs: the bat sign (pleural line), lung sliding (yielding seashore sign), the A-line (horizontal artifact), the quad sign, and sinusoid sign indicating pleural effusion, the fractal, and tissue-like sign indicating lung consolidation, the B-line, and lung rockets indicating interstitial syndrome, abolished lung sliding with the stratosphere sign suggesting pneumothorax, and the lung point indicating pneumothorax. Two more signs, the lung pulse and the dynamic air bronchogram, are used to distinguish atelectasis from pneumonia. All of these disorders were assessed using CT as the “gold standard” with sensitivity and specificity ranging from 90% to 100%, allowing ultrasound to be considered as a reasonable bedside “gold standard” in the critically ill. The BLUE-protocol is a fast protocol (<3 minutes), which allows diagnosis of acute respiratory failure. It includes a venous analysis done in appropriate cases. Pulmonary edema, pulmonary embolism, pneumonia, chronic obstructive pulmonary disease, asthma, and pneumothorax yield specific profiles. Pulmonary edema, e.g., yields anterior lung rockets associated with lung sliding, making the “B-profile.” The FALLS-protocol adapts the BLUE-protocol to acute circulatory failure. It makes sequential search for obstructive, cardiogenic, hypovolemic, and distributive shock using simple real-time echocardiography (right ventricle dilatation, pericardial effusion), then lung ultrasound for assessing a direct parameter of clinical volemia: the apparition of B-lines, schematically, is considered as the endpoint for fluid therapy. Other aims of lung ultrasound are decreasing medical irradiation: the LUCIFLR program (most CTs in ARDS or trauma can be postponed), a use in traumatology, intensive care unit, neonates (the signs are the same than in adults), many disciplines (pulmonology, cardiology…), austere countries, and a help in any procedure (thoracentesis). A 1992, cost-effective gray-scale unit, without Doppler, and a microconvex probe are efficient. Lung ultrasound is a holistic discipline for many reasons (e.g., one probe, perfect for the lung, is able to scan the whole-body). Its integration can provide a new definition of priorities. The BLUE-protocol and FALLS-protocol allow simplification of expert echocardiography, a clear advantage when correct cardiac windows are missing.
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Affiliation(s)
- Daniel A Lichtenstein
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, University Paris-West, Boulogne, France.
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Lichtenstein D, Karakitsos D. Integrating lung ultrasound in the hemodynamic evaluation of acute circulatory failure (the fluid administration limited by lung sonography protocol). J Crit Care 2012; 27:533.e11-9. [DOI: 10.1016/j.jcrc.2012.03.004] [Citation(s) in RCA: 46] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/31/2011] [Revised: 03/05/2012] [Accepted: 03/12/2012] [Indexed: 01/10/2023]
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The BLUE-points: three standardized points used in the BLUE-protocol for ultrasound assessment of the lung in acute respiratory failure. Crit Ultrasound J 2011. [DOI: 10.1007/s13089-011-0066-3] [Citation(s) in RCA: 22] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/18/2022] Open
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Lichtenstein D. Should lung ultrasonography be more widely used in the assessment of acute respiratory disease? Expert Rev Respir Med 2011; 4:533-8. [PMID: 20923333 DOI: 10.1586/ers.10.51] [Citation(s) in RCA: 25] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/29/2023]
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Abstract
OBJECTIVE Lung ultrasound is increasingly used in the critically ill adult. It allows prompt management based upon reproducible data and generates fewer computed tomography (CT) examinations, therefore decreasing irradiation, delays, cost, and discomfort to the patient. The aim of this article is to describe the value of ultrasound for lung imaging in the critically ill and state our experience in neonates. METHODS Review of studies published in the peer-reviewed international literature analyzing consecutive critically ill adults admitted to intensive care units, assessing pleural effusion, alveolar consolidation, interstitial syndrome, and pneumothorax, using a standardized ultrasound approach to the lung, with CT as the reference. DATA SYNTHESIS The sensitivity and specificity of ultrasound are 92% and 93% for pleural effusion, 90% and 98% for alveolar consolidation, 93% and 93% for interstitial syndrome, 100% and 96% for complete pneumothorax, 79% and 100% for radio-occult pneumothorax. DISCUSSION This article reviews data that validate the scientific value of lung ultrasound in adult medical intensive care units. We then present observations in the critically ill neonate. The discussion points to the methodologic issues raised in lung ultrasound in the neonate, i.e. mainly the limited access to a pertinent gold standard (CT). Some CT correlations are presented, confirming the value of lung ultrasound in the neonate. CONCLUSIONS The standardized signs assessed in the adult are also found in the critically ill neonate, meaning a potential use in this field. Awaiting confirmatory CT studies, lung ultrasound can be taken into consideration as a possible bedside tool for completing bedside radiography.
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Lichtenstein D, Mezière G, Seitz J. The dynamic air bronchogram. A lung ultrasound sign of alveolar consolidation ruling out atelectasis. Chest 2009; 135:1421-1425. [PMID: 19225063 DOI: 10.1378/chest.08-2281] [Citation(s) in RCA: 235] [Impact Index Per Article: 14.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022] Open
Abstract
BACKGROUND The objective of this study was to identify the relationship between a dynamic lung artifact, the dynamic air bronchogram, within alveolar consolidation and the diagnosis of pneumonia vs resorptive atelectasis. METHODS This prospective study was undertaken within the medical ICU of a university-affiliated teaching hospital. The sample comprised 52 patients with proven pneumonia (pneumonia group) and 16 patients with proven resorptive atelectasis (atelectasis group). All patients had alveolar consolidation with air bronchograms on lung ultrasound, were mechanically ventilated, and received fibroscopy and bacteriological tests. The air bronchogram dynamic was analyzed within the ultrasound area of consolidation. RESULTS The air bronchograms in the pneumonia group yielded the dynamic air bronchogram in 32 patients and a static air bronchogram in 20. In the atelectasis group, air bronchograms yielded a dynamic air bronchogram in 1 out of 16 patients. With regard to pneumonia vs resorptive atelectasis in patients with ultrasound-visible alveolar consolidation with air bronchograms, the dynamic air bronchogram had a specificity of 94% and a positive predictive value of 97%. The sensitivity was 61%, and the negative predictive value 43%. CONCLUSIONS In patients with alveolar consolidation displaying air bronchograms on an ultrasound, the dynamic air bronchogram indicated pneumonia, distinguishing it from resorptive atelectasis. Static air bronchograms were seen in most resorptive atelectases and one third of cases of pneumonia. This finding increases the understanding of the pathophysiology of lung diseases within the clinical context and decreases the need for fibroscopy in practice.
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Affiliation(s)
- Daniel Lichtenstein
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, Boulogne (Paris-Ouest), France.
| | - Gilbert Mezière
- Service de Réanimation Polyvalente, Centre Hospitalier Général, Saint-Cloud (Paris-Ouest), France
| | - Julien Seitz
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, Boulogne (Paris-Ouest), France
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Lichtenstein DA, Mezière GA. Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol. Chest 2008; 134:117-25. [PMID: 18403664 DOI: 10.1378/chest.07-2800] [Citation(s) in RCA: 1180] [Impact Index Per Article: 69.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022] Open
Abstract
BACKGROUND This study assesses the potential of lung ultrasonography to diagnose acute respiratory failure. METHODS This observational study was conducted in university-affiliated teaching-hospital ICUs. We performed ultrasonography on consecutive patients admitted to the ICU with acute respiratory failure, comparing lung ultrasonography results on initial presentation with the final diagnosis by the ICU team. Uncertain diagnoses and rare causes (frequency<2%) were excluded. We included 260 dyspneic patients with a definite diagnosis. Three items were assessed: artifacts (horizontal A lines or vertical B lines indicating interstitial syndrome), lung sliding, and alveolar consolidation and/or pleural effusion. Combined with venous analysis, these items were grouped to assess ultrasound profiles. RESULTS Predominant A lines plus lung sliding indicated asthma (n=34) or COPD (n=49) with 89% sensitivity and 97% specificity. Multiple anterior diffuse B lines with lung sliding indicated pulmonary edema (n=64) with 97% sensitivity and 95% specificity. A normal anterior profile plus deep venous thrombosis indicated pulmonary embolism (n=21) with 81% sensitivity and 99% specificity. Anterior absent lung sliding plus A lines plus lung point indicated pneumothorax (n=9) with 81% sensitivity and 100% specificity. Anterior alveolar consolidations, anterior diffuse B lines with abolished lung sliding, anterior asymmetric interstitial patterns, posterior consolidations or effusions without anterior diffuse B lines indicated pneumonia (n=83) with 89% sensitivity and 94% specificity. The use of these profiles would have provided correct diagnoses in 90.5% of cases. CONCLUSIONS Lung ultrasound can help the clinician make a rapid diagnosis in patients with acute respiratory failure, thus meeting the priority objective of saving time.
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Affiliation(s)
- Daniel A Lichtenstein
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, F-92100 Boulogne, Faculté Paris-Ouest, France.
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Abstract
Using simple and standardized semiology, the lung appears accessible to ultrasound, despite previous opinions otherwise. Lung ultrasound allows the intensivist to quickly answer to a majority of critical situations. Not only pleural effusion but also pneumothorax, alveolar consolidation, and interstitial syndrome will have accurate ultrasound equivalents, the recognition of which practically guides management. Combined with venous, cardiac, and abdominal examination, ultrasound investigation of this vital organ provides a transparent overview of the critically ill, a kind of stethoscope for a visual medicine. It is believed that by using this tool, the intensivist may more confidently manage acute dyspnea and make emergency therapeutic decisions based on reproducible data. Further benefits include reduced requirements for computed tomographic scans, therefore decreasing delay, irradiation, cost, and above all, discomfort to the patient. Thus, ultrasound of the lung can also be added to the classic armamentarium as a clinical tool for emergency use.
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Affiliation(s)
- Daniel A Lichtenstein
- Service de Réanimation Médicale, Hôpital Ambroise-Paré, Faculté Paris-Ouest, Boulogne, France.
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Lichtenstein DA. L’échographie “ corps entier ” en réanimation, une approche visuelle du patient en état critique. BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE 2007. [DOI: 10.1016/s0001-4079(19)33041-9] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/27/2022]
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