Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis

doi:10.4330/wjc.v16.i8.469

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Aug 26, 2024 (publication date) through Nov 30, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Aug 26, 2024; 16(8): 469-483
Published online Aug 26, 2024. doi: 10.4330/wjc.v16.i8.469

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Figure 1 Study selection flow diagram of preferred reporting item for systematic reviews and meta-analysis. RCTs: Randomized controlled trials.

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Figure 2 Risk of bias assessment graph. UC-MSCs: Umbilical-cord-derived mesenchymal stem cells; BM-MSCs: Bone-marrow-derived mesenchymal stem cell.

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Figure 3 Forest plot of left ventricular ejection fraction change from baseline to 6 mo of follow-up. A: Umbilical-cord-derived mesenchymal stem cells; B: Bone-marrow-derived mesenchymal stem cells. UC-MSCs: Umbilical cord-derived mesenchymal stem cells; BM-MSCs: Bone marrow-derived mesenchymal stem cell; MI: Myocardial infarction; HF: Heart failure.

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Figure 4 Forest plot of left ventricular ejection fraction change from baseline to 12 mo follow-up. A: Umbilical cord-derived mesenchymal stem cells; B: Bone marrow-derived MSCs. UC-MSCs: Umbilical-cord-derived mesenchymal stem cells; BM-MSCs: Bone-marrow-derived mesenchymal stem cell; MI: Myocardial infarction; HF: Heart failure.

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Figure 5 Forest Plot of major adverse events. A and B: Mortality in umbilical-cord-derived mesenchymal stem cells (A) and bone-marrow-derived mesenchymal stem cells (B); C and D: Major cardiac adverse events in UC-MSCs (C) and BM-MSCs (D); E and F: Rehospitalization in UC-MSCs (E) and BM-MSCs (F). UC-MSCs: Umbilical-cord-derived mesenchymal stem cells; BM-MSCs: Bone-marrow-derived mesenchymal stem cells.

Citation: Safwan M, Bourgleh MS, Aldoush M, Haider KH. Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis. World J Cardiol 2024; 16(8): 469-483
URL: https://www.wjgnet.com/1949-8462/full/v16/i8/469.htm
DOI: https://dx.doi.org/10.4330/wjc.v16.i8.469