Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting

doi:10.4330/wjc.v7.i9.571

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 7, Issue 9

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10525)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-5) series.

Item

Count

PDF

572

WORD

203

HTML

3362

Figures (1-1)

964

Tables (1-5)

770

Sum=5871

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

719

Download

2519

Sum=3238

Sep 26, 2015 (publication date) through Feb 14, 2026

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Cardiology

ISSN

1949-8462

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Observational Study

World J Cardiol. Sep 26, 2015; 7(9): 571-578
Published online Sep 26, 2015. doi: 10.4330/wjc.v7.i9.571

Single vs double antiplatelet therapy in acute coronary syndrome: Predictors of bleeding after coronary artery bypass grafting

Vincenzo Tarzia, Giacomo Bortolussi, Edward Buratto, Carla Paolini, Carlo Dal Lin, Giulio Rizzoli, Tomaso Bottio, Gino Gerosa

Vincenzo Tarzia, Giacomo Bortolussi, Edward Buratto, Giulio Rizzoli, Tomaso Bottio, Gino Gerosa, Division of Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, 35128 Padua, Italy

Carla Paolini, Carlo Dal Lin, Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, 35128 Padua, Italy

Author contributions: Tarzia V, Bortolussi G, Buratto E, Paolini C, Dal Lin C, Rizzoli G, Bottio T and Gerosa G contributed to study conception and design; Tarzia V, Bortolussi G, Buratto E, Paolini C, Dal Lin C and Rizzoli G contributed to data acquisition, data analysis and interpretation, and writing of article; Tarzia V, Bortolussi G, Buratto E, Paolini C, Dal Lin C, Rizzoli G, Bottio T and Gerosa G contributed to editing, reviewing and final approval of article.

Institutional review board statement: The study was reviewed and approved by the Padua University Institutional Review Board.

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: The authors have no conflict of interest to declare.

Data sharing statement: No additional data are available.

Correspondence to: Vincenzo Tarzia, MD, Division of Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua Medical School, Via Giustiniani, 2, 35128 Padova, Italy. v.tarzia@gmail.com

Telephone: +39-049-8212410 Fax: +39-049-8212409

Received: April 3, 2015
Peer-review started: April 3, 2015
First decision: April 28, 2015
Revised: July 30, 2015
Accepted: August 20, 2015
Article in press: August 21, 2015
Published online: September 26, 2015
Processing time: 170 Days and 9.9 Hours

Core Tip

Core tip: To establish the timing of discontinuation of double antiplatelet therapy before coronary artery bypass grafting (CABG), it is crucial to identify predictors of bleeding. We analysed preoperatively classic parameters and thromboelastometry on 100 patients operated for CABG after presenting with acute coronary syndrome, to investigate the contribution of anti-platelet therapy and derangements of pre-operative coagulation status to major bleeding post-CABG. We observed that patients with a low area-under-curve (AUC) value in EXTEM were at a significantly higher risk of bleeding compared to patients with higher AUC, regardless of anti-platelet treatment. This suggests that thrombin generation potential, irrespective of the degree of platelet inhibition, correlates with surgical bleeding.