©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2015; 7(9): 504-510
Published online Sep 26, 2015. doi: 10.4330/wjc.v7.i9.504
Published online Sep 26, 2015. doi: 10.4330/wjc.v7.i9.504
Central and peripheral testosterone effects in men with heart failure: An approach for cardiovascular research
Viktor Čulić, Department of Cardiology, University Hospital Center Split, 21000 Split, Croatia
Željko Bušić, Viktor Čulić, University of Split School of Medicine, 21000 Split, Croatia
Author contributions: Bušić Ž reviewed the literature, wrote the manuscript; Čulić V critically revised the article and finally approved the version of the article to be published.
Conflict-of-interest statement: There is no conflict of interest.
Correspondence to: Viktor Čulić, MD, PhD, Professor, University Hospital Center Split, Šoltanska 1, 21000 Split, Croatia. viktor.culic@st.t-com.hr
Telephone: +385-21-557531 Fax: +385-21-557385
Received: November 17, 2014
Peer-review started: November 17, 2014
First decision: December 12, 2014
Revised: June 10, 2015
Accepted: July 21, 2015
Article in press: July 23, 2015
Published online: September 26, 2015
Processing time: 101 Days and 23.9 Hours
Peer-review started: November 17, 2014
First decision: December 12, 2014
Revised: June 10, 2015
Accepted: July 21, 2015
Article in press: July 23, 2015
Published online: September 26, 2015
Processing time: 101 Days and 23.9 Hours
Core Tip
Core tip: Patients with heart failure often have a lower endogenous testosterone level. Testosterone has a number of effects on cardiac and extracardiac structures via genomic and non-genomic mechanisms. We summarize current knowledge about the involvement of testosterone in heart failure syndrome.