Said SA, Bloo R, Nooijer R, Slootweg A. Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature. World J Cardiol 2015; 7(2): 86-100 [PMID: 25717356 DOI: 10.4330/wjc.v7.i2.86]
Corresponding Author of This Article
Salah AM Said, MD, PhD, FESC, Department of Cardiology, Hospital Group Twente, Almelo-Hengelo, Geerdinksweg 141, 7555 DL Hengelo, The Netherlands. salah.said@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Retrospective Study
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Said SA, Bloo R, Nooijer R, Slootweg A. Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature. World J Cardiol 2015; 7(2): 86-100 [PMID: 25717356 DOI: 10.4330/wjc.v7.i2.86]
World J Cardiol. Feb 26, 2015; 7(2): 86-100 Published online Feb 26, 2015. doi: 10.4330/wjc.v7.i2.86
Cardiac and non-cardiac causes of T-wave inversion in the precordial leads in adult subjects: A Dutch case series and review of the literature
Salah AM Said, Rene Bloo, Ramon de Nooijer, Andries Slootweg
Salah AM Said, Rene Bloo, Ramon de Nooijer, Andries Slootweg, Department of Cardiology, Hospital Group Twente, Almelo-Hengelo, 7555 DL Hengelo, The Netherlands
Author contributions: Said SAM, Bloo R, de Nooijer R and Slootweg A treated patients and collected material and clinical data from patients; Bloo R performed the assays; de Nooijer R analysed data; Said SAM wrote the paper; all authors approved the final version of the manuscript.
Ethics approval: The study is reviewed and approved by the Hospital Group Twente, Institutional Review Board. Verbal consent was taken from the patients and ethical clearance and permission to publish the cases is obtained from the Hospital Group Twente, Institutional Review Board.
Informed consent: All study participants provided verbal informed consent.
Conflict-of-interest: The authors declare no conflict of interest.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at salah.said@gmail.com. Informed consent, neither verbal nor written, was obtained for data sharing but the presented data are anonymized and risk of identification is negligible.
Correspondence to: Salah AM Said, MD, PhD, FESC, Department of Cardiology, Hospital Group Twente, Almelo-Hengelo, Geerdinksweg 141, 7555 DL Hengelo, The Netherlands. salah.said@gmail.com
Telephone: +31-88-7085286 Fax: +31-88-7085289
Received: October 28, 2014 Peer-review started: October 28, 2014 First decision: November 27, 2014 Revised: December 14, 2014 Accepted: January 9, 2015 Article in press: January 12, 2015 Published online: February 26, 2015 Processing time: 106 Days and 10.8 Hours
Core Tip
Core tip: Myriad of clinical conditions have been described in association with T-wave inversion in the anterior precordial leads. T-wave inversion associated with or without corrected QT prolongation may be encountered in a variety of clinical conditions. In the reversible (dynamic) types such as vascular coronary, cerebral and pulmonary disorders; metabolic disturbances and acute adrenergic stress cardiomyopathy; resolution of T-wave inversion may occur after days, weeks, months or years following the index event. Tailored diagnostic approach should be conducted avoiding overuse of diagnostic methods. Specific tailored therapeutic interventions were undertaken when high index of clinical suspicion was raised towards certain disease entity.
