Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction: A review of clinical evidence and guidelines

doi:10.4330/wjc.v7.i12.889

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Dec 26, 2015; 7(12): 889-894
Published online Dec 26, 2015. doi: 10.4330/wjc.v7.i12.889

Thrombus aspiration during primary percutaneous coronary intervention for acute myocardial infarction: A review of clinical evidence and guidelines

Muhammad Muzaffar Mahmood, Jonathan Watt, Javed M Ahmed

Muhammad Muzaffar Mahmood, Jonathan Watt, Javed M Ahmed, Cardiology Department, Freeman Hospital, Newcastle-upon-Tyne NE7 7DN, United Kingdom

Author contributions: Mahmood MM performed the search and wrote the initial draft; Watt J and Ahmed JM reviewed the article and Ahmed JM is the guarantor of the content.

Conflict-of-interest statement: The authors have no conflict of interest to declare.

Correspondence to: Dr. Javed M Ahmed, Consultant Cardiologist, Cardiology Department, Freeman Hospital, Freeman Road, Newcastle-upon-Tyne NE7 7DN, United Kingdom. javed.ahmed@nuth.nhs.uk

Telephone: +44-191-2137145 Fax: +44-191-2231175

Received: May 28, 2015
Peer-review started: June 1, 2015
First decision: June 18, 2015
Revised: October 4, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: December 26, 2015
Processing time: 210 Days and 10.7 Hours

Core Tip

Core tip: The role of manual thrombus aspiration during primary percutaneous coronary intervention (PPCI) for acute ST segment elevation myocardial infarction (STEMI) has been a matter of significant research and intense debate recently. The rationale for manual thrombus aspiration during PPCI is the removal of intracoronary thrombus, thus avoiding the complication of downstream embolization leading to impaired myocardial perfusion. In this review article, we present the data from early clinical trials and meta-analyses of thrombus aspiration during PPCI, and the more recent evidence from larger multi-center randomized controlled trials that have had a major influence on clinical practice. We highlight the relevant major society guidelines for thrombus aspiration during PPCI and provide the reader with an overview of this technology and its role in contemporary management of STEMI.