Erol N, Karaagac AT, Kounis NG. Dangerous triplet: Polycystic ovary syndrome, oral contraceptives and Kounis syndrome. World J Cardiol 2014; 6(12): 1285-1289 [PMID: 25548619 DOI: 10.4330/wjc.v6.i12.1285]
Corresponding Author of This Article
Nurdan Erol, MD, Pediatric Cardiologist, Siyami Ersek Thorax and Cardiovascular Surgery Training and Research Hospital, Pediatric Cardiology Clinic, Tıbbiye Caddesi No:13, 34668 Uskudar, Istanbul, Turkey. drnurdanerol@superonline.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Case Report
Open-Access Policy of This Article
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World J Cardiol. Dec 26, 2014; 6(12): 1285-1289 Published online Dec 26, 2014. doi: 10.4330/wjc.v6.i12.1285
Dangerous triplet: Polycystic ovary syndrome, oral contraceptives and Kounis syndrome
Nurdan Erol, Aysu Turkmen Karaagac, Nicholas G Kounis
Nurdan Erol, Siyami Ersek Thorax and Cardiovascular Surgery Training and Research Hospital, Pediatric Cardiology Clinic, 34668 Uskudar, Istanbul, Turkey
Aysu Turkmen Karaagac, Kartal Kosuyolu Research and Training Hospital Pediatri, 34846 Kartal, Istanbul, Turkey
Nicholas G Kounis, Department of Medical Sciences, Northwestern Greece Highest Institute of Education and Technology, 26221 Achaia, Greece
Author contributions: Erol N carried out acqustion of data, interpreted the results and wrote the article; Kounis NG contributed to analysis and interpretation of data and revising the paper; Karaagac AT contributed to write the article.
Correspondence to: Nurdan Erol, MD, Pediatric Cardiologist, Siyami Ersek Thorax and Cardiovascular Surgery Training and Research Hospital, Pediatric Cardiology Clinic, Tıbbiye Caddesi No:13, 34668 Uskudar, Istanbul, Turkey. drnurdanerol@superonline.com
Telephone: +90-505-7588787 Fax: +90-216-5424444
Received: August 9, 2014 Revised: September 20, 2014 Accepted: October 23, 2014 Published online: December 26, 2014 Processing time: 141 Days and 12.8 Hours
Core Tip
Core tip: The young lady in our case has had suffered from hyperandrogenism, oligomenorrhea, polycystic ovaries and while was receiving oral contraceptives she developed intermittent angina attacks not strictly related to her medication. The angina attacks associated with increased cardiac enzymes increased high sensitivity cardiac troponin, skin itching and electrocardiographic changes suggesting of myocardial ischemia. Eosinophils were raised but the coronary arteries were normal. The angina attacks disappeared with discontinuation of contraceptives. Such angina attacks associated with such clinical setting are attributed to disease itself, to oral contraceptives and/or to Kounis hypersensitivity coronary syndrome, namely a dangerous triplet.
