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NeoHexa stent at five years: Sirolimus power meets real-world endurance
Ji-Xin Zhong, Department of Rheumatology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Ji-Xin Zhong, Fujian Institute of Clinical Immunology, Fuzhou 350001, Fujian Province, China
Ji-Xin Zhong, Key Laboratory of Vascular Aging (HUST), Ministry of Education, Wuhan 430030, Hubei Province, China
Xiao-Quan Rao, Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Co-corresponding authors: Ji-Xin Zhong and Xiao-Quan Rao.
Author contributions: Zhong JX drafted the manuscript; Zhong JX and Rao XQ conceived the idea and edited the manuscript as co-corresponding authors; all of the authors read and approved the final version of the manuscript to be published.
AI contribution statement: ChatGPT is only used for language polishing and optimization. This AI tool is not employed for the conception of core ideas or the interpretation of research results.
Supported by the National Key Research and Development Program of China, No. 2023YFC2507902 and No. 2022YFA1105303; National Natural Science Foundation of China, No. 82572075, No. 82270903, and No. 82370465; and Hubei Key R and D Project, No. 2023BCB013.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: Ji-Xin Zhong, MD, PhD, Chief Physician, Director, Principal Investigator, Professor, Department of Rheumatology, Fujian Medical University Union Hospital, No. 29 Xinquan Road, Fuzhou 350001, Fujian Province, China.
Received: December 18, 2025
Revised: February 3, 2026
Accepted: April 21, 2026
Published online: July 26, 2026
Processing time: 211 Days and 21.1 Hours
Revised: February 3, 2026
Accepted: April 21, 2026
Published online: July 26, 2026
Processing time: 211 Days and 21.1 Hours
Core Tip
Core Tip: The retrospective study by Trehan et al provides critical five-year real-world evidence for the NeoHexa sirolimus-eluting stent, demonstrating exceptional long-term durability in a complex, all-comer patient population. With a remarkably low rate of major adverse cardiac events and target lesion revascularization, the findings underscore the stent's sustained safety and efficacy.