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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Cardiol. Jun 26, 2026; 18(6): 121197
Published online Jun 26, 2026. doi: 10.4330/wjc.121197
Post-cardiac arrest care: An integrated approach to management after resuscitation
Adishwar Rao, Asna Aafreen, Akriti Agrawal, Shiavax J Rao, Saurabh Sharma, Sudhakar Sattur, Edo Kaluski
Adishwar Rao, Asna Aafreen, Akriti Agrawal, Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, PA 18840, United States
Shiavax J Rao, Saurabh Sharma, Sudhakar Sattur, Edo Kaluski, Department of Cardiology, Guthrie Robert Packer Hospital, Sayre, PA 18840, United States
Saurabh Sharma, Sudhakar Sattur, Edo Kaluski, Department of Cardiology, Geisinger Commonwealth School of Medicine, Scranton, PA 18509, United States
Author contributions: Rao A designed the research study, performed the literature review, interpreted the data, and drafted the manuscript; Aafreen A, Agrawal A, and Rao SJ contributed to literature review, data interpretation, and manuscript revision; Sharma S, Sattur S, and Kaluski E provided critical intellectual input, supervised the study, and revised the manuscript for important scientific content; and all authors reviewed and approved the final manuscript.
AI contribution statement: Authors do not declare use of artificial intelligence in the preparation of the manuscript.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Corresponding author: Adishwar Rao, MD, Department of Internal Medicine, Guthrie Robert Packer Hospital, One Guthrie Square, Sayre, PA 18840, United States. adishwar.rao@guthrie.org
Received: March 18, 2026
Revised: May 11, 2026
Accepted: May 26, 2026
Published online: June 26, 2026
Processing time: 92 Days and 16.7 Hours
Core Tip

Core Tip: Post-cardiac arrest syndrome remains associated with high mortality and poor neurological outcomes despite advances in resuscitation care. This review summarizes the current evidence on comprehensive post-resuscitation management, including hemodynamic optimization, coronary interventions, targeted temperature management, ventilation, metabolic support, sedation, and multimodal neuroprognostication. Current evidence increasingly favors strict fever prevention and individualized management strategies over uniform protocol-driven targets. Early multidisciplinary care and cautious delayed neuroprognostication remain critical to minimizing secondary neurologic injury and improving outcomes after cardiac arrest.

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