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World J Cardiol. Jun 26, 2026; 18(6): 121185
Published online Jun 26, 2026. doi: 10.4330/wjc.121185
Identifying and treating amiodarone-induced corneal deposits: When the heart saves and the cornea speaks
Matteo Capobianco, Simonetta Gaia Nicolosi, Francesco Cappellani, Alessandro Avitabile, Ludovica Cannizaro, Federico Visalli, Fabiana D’Esposito, Irene Gattazzo, Caterina Gagliano, Marco Zeppieri
Matteo Capobianco, Eye Clinic, Policlinico G. Rodolico, University of Catania, Catania 95121, Italy
Matteo Capobianco, Simonetta Gaia Nicolosi, Federico Visalli, Faculty of Medicine, University of Catania, Catania 95123, Italy
Francesco Cappellani, Fabiana D’Esposito, Caterina Gagliano, Department of Medicine and Surgery, University of Enna “Kore”, Enna 94100, Italy
Francesco Cappellani, Caterina Gagliano, Mediterranean Foundation, “G.B. Morgagni”, Catania 95125, Italy
Alessandro Avitabile, Ludovica Cannizaro, Biomedicine, Neuroscience and Advance Diagnostic (BIND) Department, University of Palermo, Palermo 90128, Italy
Fabiana D’Esposito, Imperial College Ophthalmic Research Group Unit, Imperial College, London NW1 5QH, United Kingdom
Irene Gattazzo, Department of Ophthalmology, Ospedale Sant’Antonio, Azienda Ospedaliera, Padova 35127, Italy
Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
Marco Zeppieri, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34127, Italy
Co-corresponding authors: Caterina Gagliano and Marco Zeppieri.
Author contributions: Capobianco M, Zeppieri M, Nicolosi SG, D’Esposito F, and Gagliano C did the research and writing of the manuscript; Capobianco M, Zeppieri M, Nicolosi SG, D’Esposito F, Cannizaro L, Visalli F, Gattazzo I, Cappellani F, and Gagliano C assisted in the writing of the draft and final paper; Capobianco M, Zeppieri M, Nicolosi SG, D’Esposito F, Cappellani F, and Gagliano C were responsible for the conception and design of the study; Capobianco M, Zeppieri M, Nicolosi SG, Cannizaro L, Visalli F, D’Esposito F, Gattazzo I, and Avitabile A assisted in the writing and editing of the manuscript; Zeppieri M assisted in the editing, making critical revisions of the manuscript and viewing all versions of the manuscript; Gagliano C and Zeppieri M played important and indispensable roles in the experimental design, data interpretation and manuscript preparation and thus qualified both as the co-corresponding authors. All authors provided the final approval of the article.
AI contribution statement: ChatGPT (OpenAI, GPT-5.3) and Grammarly were used to assist with summarizing existing literature, addressing issues in the rebuttal, and enhancing the flow and English language quality. No AI-generated images were used.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Marco Zeppieri, BSc, MD, PhD, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy.
mark.zeppieri@asufc.sanita.fvg.it
Received: March 18, 2026
Revised: April 20, 2026
Accepted: May 25, 2026
Published online: June 26, 2026
Processing time: 92 Days and 20.3 Hours
