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Prognostic value of glomerular-filtration-rate estimated by common and modified Asian/Chinese equations for cardiovascular outcomes in elderly Chinese individuals
Atawula Aili, Department of Cardiology, The First People’s Hospital of Kashgar District, Kashgar 844000, Xinjiang Uygur Autonomous Region, China
Atawula Aili, Ayman A Mohammed, Song Zhao, Mo-Ran Li, Hao-Nan Li, Ya-Wei Xu, Yi Zhang, Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
Rui-Yuan Li, Department of Cardiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101199, China
Co-first authors: Atawula Aili and Rui-Yuan Li.
Co-corresponding authors: Ayman A Mohammed and Yi Zhang.
Author contributions: Aili A and Li RY made equal contributions to this work as co-first authors; Mohammed AA, Aili A, Li RY, Zhao S, and Li MR designed and conducted the study and wrote the paper; Mohammed AA, Li RY, and Zhang Y contributed to data analysis; Li HN, Li MR, and Xu YW provided clinical advice; and Mohammed AA, Xu YW, and Zhang Y supervised the study. Mohammed AA and Zhang Y contributed equally to this work as co-corresponding authors. All authors approved the final version to be published.
Supported by National Nature Science Foundation of China, No. 82570350.
Institutional review board statement: This study was approved by the Institutional Review Board of Shanghai Tenth People’s Hospital.
Informed consent statement: All participants provided informed consent before enrollment in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The corresponding author will provide the dataset generated and analyzed in this study upon reasonable request.
Corresponding author: Yi Zhang, MD, PhD, Professor, Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, No. 301 Yanchang Road, Shanghai 200072, China. yizshcn@gmail.com
Received: January 26, 2026
Revised: February 16, 2026
Accepted: May 9, 2026
Published online: June 26, 2026
Processing time: 143 Days and 21.5 Hours
Revised: February 16, 2026
Accepted: May 9, 2026
Published online: June 26, 2026
Processing time: 143 Days and 21.5 Hours
Core Tip
Core Tip: For risk stratification in elderly Chinese adults, the choice of estimated glomerular filtration rate equation is crucial. This study finds that while the modified Chinese-abbreviated Modification of Diet in Renal Disease equation specifically predicts major adverse cardiovascular events and cardiovascular death, the newer Chronic Kidney Disease Epidemiology Collaboration and its Chinese-adjusted versions are superior overall, offering the best predictive power for all-cause mortality.