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World J Cardiol. May 26, 2026; 18(5): 120519
Published online May 26, 2026. doi: 10.4330/wjc.v18.i5.120519
Published online May 26, 2026. doi: 10.4330/wjc.v18.i5.120519
S1PR1 knockdown protects endothelial cells from oxidized low-density lipoprotein-induced injury via reducing interleukin-1β and tumor necrosis factor-α expression
Fu-Ying Chu, Le-Ming Gu, Ya-Nan Li, Xiang Chen, Department of Laboratory Medicine, Nantong First People’s Hospital, Southeast University, Nantong 226000, Jiangsu Province, China
Meng-Han Yao, Medical School, Nantong University, Nantong 226000, Jiangsu Province, China
Hua Cai, Xin-Xin Xu, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu Province, China
Co-first authors: Fu-Ying Chu and Meng-Han Yao.
Author contributions: Chu FY and Yao MH contributed equally to this manuscript as co-first authors; Xu XX conceived and designed this research; Yao MH and Gu LM performed the experiments; Cai H collected important background information; Li YN and Chen X performed the statistical analysis. Chu FY and Xu XX edited the manuscript. All authors read and approved the final manuscript.
Supported by Wu Jieping Medical Foundation, No. 320.6750.2024-03-70.
Institutional review board statement: Approved by Nantong First People’s Hospital's Medical Ethics Committee (approval No. 2024-KT228-01).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The author stated that the data of this study can be obtained by contacting the corresponding author under reasonable circumstances.
Corresponding author: Xin-Xin Xu, Department of Laboratory Medicine, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Chongchuan District, Nantong 226000, Jiangsu Province, China. xxxin891119@163.com
Received: March 9, 2026
Revised: April 1, 2026
Accepted: April 24, 2026
Published online: May 26, 2026
Processing time: 73 Days and 0 Hours
Revised: April 1, 2026
Accepted: April 24, 2026
Published online: May 26, 2026
Processing time: 73 Days and 0 Hours
Core Tip
Core Tip: In this study, sphingosine-1-phosphate receptor 1 (S1PR1) is upregulated in coronary atherosclerotic heart disease and positively correlates with interleukin-1β and tumor necrosis factor-α. It serves as a promising diagnostic biomarker, and combined detection with inflammatory cytokines enhances diagnostic performance. S1PR1 knockdown alleviates oxidized low-density lipoprotein-induced endothelial cell injury via modulating inflammatory responses, highlighting S1PR1 as a potential target for coronary atherosclerotic heart disease diagnosis and intervention.