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World J Cardiol. May 26, 2025; 17(5): 104983
Published online May 26, 2025. doi: 10.4330/wjc.v17.i5.104983
Recent advances in risk stratification and treatment of acute pulmonary embolism
George Latsios, Emmanouil Mantzouranis, Ioannis Kachrimanidis, Panagiotis Theofilis, Sotirios Dardas, Evaggelia Stroumpouli, Constantina Aggeli, Costas Tsioufis
George Latsios, Emmanouil Mantzouranis, Ioannis Kachrimanidis, Panagiotis Theofilis, Sotirios Dardas, Constantina Aggeli, Costas Tsioufis, 1st Department of Cardiology, “Hippokration” General Hospital, Athens Medical School, Athens 11527, Greece
Evaggelia Stroumpouli, Department of Radiology, “Hippokration” General Hospital, Athens Medical School, Athens 11527, Greece
Author contributions: Latsios G and Mantzouranis E were involved in the graphical abstract; Latsios G contributed to the conceptualization of this manuscript; Latsios G, Mantzouranis E, Kachrimanidis I, Theofilis P, Dardas S, and Stroumpouli E participated in the writing and review; Latsios G, Aggeli C, and Tsioufis C contributed to the review and supervision of this manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: George Latsios, MD, PhD, Chief Physician, 1st Department of Cardiology, “Hippokration” General Hospital, Athens Medical School, Alexandroupoleos 9, Athens 11527, Greece. glatsios@gmail.com
Received: January 11, 2025
Revised: March 6, 2025
Accepted: April 8, 2025
Published online: May 26, 2025
Processing time: 132 Days and 20.8 Hours
Core Tip

Core Tip: Pulmonary embolism remains a major clinical challenge with unacceptably high mortality, especially in intermediate-high risk patients. Despite major advances in risk stratification, identifying stable patients at risk of decompensation remains unsolved. Emerging catheter-based therapies prove promising and safe, but proper patient selection and optimal timing require further investigation. A multidisciplinary approach is crucial for improving outcomes, while future research should focus on validating risk tools, standardizing protocols, and evaluating hard clinical endpoints in interventional trials.