Intravascular ULTRA sound-guided percutaneous coronary intervention in patients with STEMI: Rationale and design of the ULTRA-STEMI trial

doi:10.4330/wjc.v17.i4.106072

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Apr 26, 2025 (publication date) through Apr 21, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Cardiol. Apr 26, 2025; 17(4): 106072
Published online Apr 26, 2025. doi: 10.4330/wjc.v17.i4.106072

Intravascular ULTRA sound-guided percutaneous coronary intervention in patients with STEMI: Rationale and design of the ULTRA-STEMI trial

Efstratios Karagiannidis, Andreas S Papazoglou, Athanasios Samaras, Athina Nasoufidou, Georgios Zormpas, Georgios Tagarakis, Konstantinos C Theodoropoulos, Marios Papadakis, Apostolos Tzikas, Nikolaos Fragakis, George Kassimis

Efstratios Karagiannidis, Athanasios Samaras, Athina Nasoufidou, Georgios Zormpas, Apostolos Tzikas, Nikolaos Fragakis, George Kassimis, Second Department of Cardiology, Hippokration General Hospital of Thessaloniki, Thessaloniki 54636, Greece

Andreas S Papazoglou, Department of Cardiology, Athens Naval Hospital, Aristotle University of Thessaloniki, Thessaloniki 54636, Greece

Georgios Tagarakis, Department of Cardiothoracic Surgery, Aristotle University of Thessaloniki, Thessaloniki 55535, Greece

Konstantinos C Theodoropoulos, 1^st Cardiology Department, AHEPA General Hospital, Aristotle University of Thessaloniki, Thessaloniki 54621, Greece

Marios Papadakis, Department of Surgery II, Institution University of Witten-Herdecke, Wuppertal 42283, Germany

Co-first authors: Efstratios Karagiannidis and Andreas S Papazoglou.

Author contributions: Kassimis G and Karagiannidis E designed research; Nasoufidou A and Papazoglou AS prepared the figures; Karagiannidis E, Papazoglou AS and Samaras A wrote the paper; Tagarakis G, Fragakis N, Kassimis G supervised the manuscript preparation. All authors have read, revised and agreed to the published version of the manuscript. Karagiannidis E and Papazoglou AS contributed equally to this work as co-first authors.

Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Scientific Ethics Committee of the Hippokration General Hospital of Thessaloniki (approval code: 46/2024).

Clinical trial registration statement: This study is registered at https://clinicaltrials.gov/study/NCT05974930?cond=IVUS&rank=1. The registration identification number is ClinicalTrials.gov ID NCT05974930.

Informed consent statement: All study participants, or their legal guardian, will provide informed written consent prior to study enrollment.

Conflict-of-interest statement: The authors declare no conflict of interest.

CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.

Data sharing statement: Study data will be available upon reasonable request from the corresponding study author.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: George Kassimis, Associate Professor, Second Department of Cardiology, Aristotle University of Thessaloniki, 49 Konstantinoupoleos Road, Thessaloniki 54642, Greece. gksup@yahoo.gr

Received: February 17, 2025
Revised: March 23, 2025
Accepted: April 7, 2025
Published online: April 26, 2025
Processing time: 65 Days and 11 Hours

Core Tip

Core Tip: Intravascular ultrasound (IVUS) guidance in percutaneous coronary intervention (PCI) has shown clinical benefits, but its role in primary PCI for STEMI remains underexplored. The ULTRA-STEMI trial is a prospective, single-center study evaluating the safety, efficacy, and procedural outcomes of IVUS-guided PCI in STEMI patients. Uniquely, this study incorporates micro-computed tomography analysis of aspirated thrombi to quantify thrombus burden and correlate it with IVUS findings. The results may provide novel insights into thrombus characterization, stent optimization, and IVUS-guided PCI’s potential to improve long-term cardiovascular outcomes in STEMI patients.