Nexilin mutations, a cause of chronic heart failure: A state-of-the-art review starting from a clinical case

doi:10.4330/wjc.v17.i3.100290

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Mar 26, 2025; 17(3): 100290
Published online Mar 26, 2025. doi: 10.4330/wjc.v17.i3.100290

Nexilin mutations, a cause of chronic heart failure: A state-of-the-art review starting from a clinical case

Oana-Cornelia Năstasie, Dan-Andrei Radu, Sebastian Onciul, Marian-Bogdan Drăgoescu, Nicoleta-Monica Popa-Fotea

Oana-Cornelia Năstasie, Sebastian Onciul, Marian-Bogdan Drăgoescu, Nicoleta-Monica Popa-Fotea, Department of Cardiology, Clinical Emergency Hospital, Bucharest 014461, Romania

Dan-Andrei Radu, Laboratory of Interventional Cardiology, Carol Davila Central Military University Emergency Hospital, Bucharest 010825, Romania

Dan-Andrei Radu, Sebastian Onciul, Nicoleta-Monica Popa-Fotea, Cardio-Thoracic Department, University of Medicine and Pharmacy “Carol Davila”, Bucharest 050474, Romania

Co-first authors: Oana-Cornelia Năstasie and Dan-Andrei Radu.

Author contributions: Năstasie OC, Radu DA, Onciul S, Drăgoescu MB, and Popa-Fotea NM collected and analyzed the data; Popa-Fotea NM drafted the article; Năstasie OC, Radu DA, and Popa-Fotea NM conceived and designed the study, revised the manuscript for important intellectual content; Năstasie OC and Radu DA contributed equally as co-first authors; and all authors read and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Nicoleta-Monica Popa-Fotea, MD, PhD, Department of Cardiology, Clinical Emergency Hospital, 8 Floreasca Street, Bucharest 014461, Romania. fotea.nicoleta@yahoo.com

Received: August 12, 2024
Revised: January 12, 2025
Accepted: February 18, 2025
Published online: March 26, 2025
Processing time: 220 Days and 16.7 Hours

Core Tip

Core Tip: Cardiomyopathies are a leading cause of heart failure, a condition marked by high morbidity and mortality despite continuous advancements in diagnosis and treatment. This review provides a succinct overview of cardiomyopathies, with a particular emphasis on their genetic origins - specifically, nexilin cardiomyopathy - highlighted through the case of a patient diagnosed with this condition. Existing research provides scarce information on individuals carrying nexilin mutations, and the relationship between this gene and cardiomyopathies continues to be actively investigated.