Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2025; 17(12): 114575
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.114575
Published online Dec 26, 2025. doi: 10.4330/wjc.v17.i12.114575
Complex interrelationship and therapeutic advances in diabetic patients with atrial fibrillation
Aikaterini-Eleftheria Karanikola, Dimitrios Tsiachris, Nikos Argyriou, Michail Botis, Konstantinos Pamporis, Panagiotis Xydis, Christos Fragoulis, Athanasios Kordalis, Konstantinos Tsioufis, First Department of Cardiology, National and Kapodistrian University of Athens, “Hippokration” General Hospital, Athens 11527, Greece
Author contributions: Tsiachris D contributed to conceptualization; Karanikola AE, Argyriou N, Botis M, and Pamporis K contributed to literature review; Karanikola AE wrote the original manuscript; Tsiachris D, Xydis P, and Kordalis A contributed to review and editing of the first draft; Tsiachris D and Tsioufis K did supervision. All authors have read and agreed to the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dimitrios Tsiachris, Assistant Professor, First Department of Cardiology, National and Kapodistrian University of Athens, “Hippokration” General Hospital, Vas. Sofias 114, Athens 11527, Greece. dtsiachris@yahoo.com
Received: September 24, 2025
Revised: October 8, 2025
Accepted: November 10, 2025
Published online: December 26, 2025
Processing time: 91 Days and 15.8 Hours
Revised: October 8, 2025
Accepted: November 10, 2025
Published online: December 26, 2025
Processing time: 91 Days and 15.8 Hours
Core Tip
Core Tip: Diabetes and atrial fibrillation are closely related conditions that increase cardiovascular risk through shared mechanisms of metabolic dysfunction, inflammation and atrial remodeling. Their coexistence complicates treatment decisions, yet novel strategies are reshaping care. Beyond optimized anticoagulation and rhythm control, emerging antidiabetic agents show promise in improving outcomes. This comprehensive review highlights current evidence, evolving therapies and the need for individualized management to reduce the burden of morbidity and mortality in this population.