Bhandari M, Pradhan A, Behera S, Singh AK. Coronary drug-coated balloons: Current evidence and emerging trends. World J Cardiol 2025; 17(12): 111468 [PMID: 41479994 DOI: 10.4330/wjc.v17.i12.111468]
Corresponding Author of This Article
Akshyaya Pradhan, FACC, FCCP, FESC, Professor, Department of Cardiology, King George’s Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. akshyaya33@gmail.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
review-article
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Bhandari M, Pradhan A, Behera S, Singh AK. Coronary drug-coated balloons: Current evidence and emerging trends. World J Cardiol 2025; 17(12): 111468 [PMID: 41479994 DOI: 10.4330/wjc.v17.i12.111468]
Co-first authors: Monika Bhandari and Akshyaya Pradhan.
Author contributions: Pradhan A and Bhandari M conceived the project, prepared the first draft, performed the bibliography, and submitted the final manuscript; and they contributed equally to this manuscript and are co-first authors; Behera S and Singh AK performed the literature search and critically reviewed it.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Akshyaya Pradhan, FACC, FCCP, FESC, Professor, Department of Cardiology, King George’s Medical University, Shahmina Road, Chowk, Lucknow 226003, Uttar Pradesh, India. akshyaya33@gmail.com
Received: July 1, 2025 Revised: July 21, 2025 Accepted: November 4, 2025 Published online: December 26, 2025 Processing time: 177 Days and 9.3 Hours
Core Tip
Core Tip: Percutaneous coronary intervention has advanced rapidly over the past four decades. Despite significant progress in stent technology, there is still risk of late stent thrombosis and in-stent restenosis in long-term. Further improvement in percutaneous coronary intervention techniques/devices is imperative to achieve better outcomes. In recent years, drug-coated balloons have emerged as a viable alternative designed to overcome the limitations associated with drug-eluting stents. Drug-coated balloon leaves no residual metal inside coronary arteries and consequently suitable for an abridged antiplatelet regimen. They have demonstrated efficacy in the treatment of in-stent restenosis and can be useful in as small-vessel disease and diffuse lesions.
