Almajed MR, Almajed A, Khan N, Obri MS, Ananthasubramaniam K. Systemic right ventricle complications in levo-transposition of the great arteries: A case report and review of literature. World J Cardiol 2023; 15(10): 542-552 [PMID: 37900900 DOI: 10.4330/wjc.v15.i10.542]
Corresponding Author of This Article
Karthikeyan Ananthasubramaniam, FACC, MD, Staff Physician, Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, 6777 W Maple, West Bloomfield, MI 48322, United States. kananth1@hfhs.org
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Cardiac & Cardiovascular Systems
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Oct 26, 2023 (publication date) through Mar 5, 2026
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Publication Name
World Journal of Cardiology
ISSN
1949-8462
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Almajed MR, Almajed A, Khan N, Obri MS, Ananthasubramaniam K. Systemic right ventricle complications in levo-transposition of the great arteries: A case report and review of literature. World J Cardiol 2023; 15(10): 542-552 [PMID: 37900900 DOI: 10.4330/wjc.v15.i10.542]
World J Cardiol. Oct 26, 2023; 15(10): 542-552 Published online Oct 26, 2023. doi: 10.4330/wjc.v15.i10.542
Systemic right ventricle complications in levo-transposition of the great arteries: A case report and review of literature
Karthikeyan Ananthasubramaniam, Mark S Obri, Naoshin Khan, Abdulla Almajed, Mohamed Ramzi Almajed
Mohamed Ramzi Almajed, Naoshin Khan, Mark S Obri, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, United States
Abdulla Almajed, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 00000, Bahrain
Karthikeyan Ananthasubramaniam, Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, West Bloomfield, MI 48322, United States
Author contributions: Almajed MR, Almajed A, Khan N, Obri M, Ananthasubramaniam K contributed equally to this work; All authors evaluated the case, reviewed the literature, and wrote the manuscript; All authors have read and approve of the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: Dr. Ananthasubramaniam has nothing to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Karthikeyan Ananthasubramaniam, FACC, MD, Staff Physician, Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, 6777 W Maple, West Bloomfield, MI 48322, United States. kananth1@hfhs.org
Received: June 17, 2023 Peer-review started: June 17, 2023 First decision: August 10, 2023 Revised: August 23, 2023 Accepted: September 27, 2023 Article in press: September 27, 2023 Published online: October 26, 2023 Processing time: 129 Days and 1.8 Hours
Core Tip
Core Tip: Patients with congenital heart disease such as levo-transposition of the great arteries experience progressive cardiac dysfunction and remodeling which manifests as heart failure. This predisposes patients to the formation of intracardiac thrombus (ICT). We present a case of progressive systemic right ventricle (sRV) dysfunction resulting in an apical thrombus. Review of literature identified no cases of sRV thrombus making this one of the first reports. Guidelines do not exist for anticoagulation in patients with congenital heart disease and ICT. Therefore, clinical decisions are extrapolated from anticoagulation principles in patients without congenital heart disease. Considerations for direct oral anticoagulants in this population should be individualized and involve shared decision making.
