Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2023; 15(12): 633-641
Published online Dec 26, 2023. doi: 10.4330/wjc.v15.i12.633
Efficacy and prognostic impact of Pericarpium Trichosanthis injection combined with nicorandil for intractable angina pectoris in elderly patients: A retrospective study
Jun Li, Mo-Wei Kong, Yu-Yu Xie, Ze-Bi Wang, Li Xu, Guo-Xiang He
Jun Li, Mo-Wei Kong, Ze-Bi Wang, Li Xu, Guo-Xiang He, Department of Cardiology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China
Yu-Yu Xie, Department of Dermatology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China
Author contributions: Kong MW and Xie YY confirmed the authenticity of all the raw data; Kong MW wrote the manuscript; Li J, Wang ZB, and Xu L reviewed and revised the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: The GIGH Research Ethics Committee (Guiyang, China) confirmed that the study complied with ethical requirements.
Informed consent statement: This study was conducted in compliance with the requirements of the Ethics Committee and informed consent was obtained from all participating patients. The privacy and confidentiality of the patients were strictly protected, and any identifying information was removed during the process of manuscript preparation to ensure patient anonymity. In the case of specific diagnostic images or other identifiable patient-related information, previous written consent was obtained and the current consent status has been maintained.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used in this study was collected from the databases of Guiqian International General Hospital and Chengdu Fifth People’s Hospital, both of which are publicly available. The dataset includes information on demographics, medical history, and disease outcomes. The data can be accessed from the official website of Chengdu Fifth People’s Hospital (www.cd5120.com). It is important to note that the dataset contains personal and private information of patients, therefore, any use or redistribution of the data beyond the scope of this study is strictly prohibited due to privacy concerns.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mo-Wei Kong, MD, Doctor, Department of Cardiology, Guiqian International General Hospital, No. 1 Dongfeng Avenue, Wudang Distinct, Guiyang 550018, Guizhou Province, China. 1600181272@qq.com
Received: September 5, 2023
Peer-review started: September 5, 2023
First decision: October 9, 2023
Revised: October 15, 2023
Accepted: November 30, 2023
Article in press: November 30, 2023
Published online: December 26, 2023
Processing time: 110 Days and 21.7 Hours
ARTICLE HIGHLIGHTS
Research background

Coronary artery disease (CAD) is a global health concern that often leads to severe cardiovascular mortality. Refractory angina pectoris, a consequential manifestation of CAD, necessitates competent drug treatments. Two potential treatments include a traditional Chinese medicine known as Pericarpium Trichosanthis and a medication named nicorandil.

Research motivation

This research was driven by the need to investigate effective therapeutic procedures for elderly patients suffering from refractory angina pectoris due to CAD.

Research objectives

The primary objective for this research was to scrutinize the therapeutic impacts of a combined treatment, namely, Pericarpium Trichosanthis injection and nicorandil, on elderly patients with refractory angina pectoris caused by CAD.

Research methods

The study was performed as a retrospective study involving 130 patients diagnosed with refractory CAD; they were divided into control and intervention groups using digital randomization. While the control group received a routine treatment, the intervention group was subjected to the combined treatment of Pericarpium Trichosanthis injection and nicorandil.

Research results

The patients in the study group demonstrated significant enhancements in heart performance and lifestyle quality. Few patients experienced headaches, but no severe side-effects were observed. No drug-related adverse reactions were noted upon follow-up.

Research conclusions

The combined treatment of Pericarpium Trichosanthis injection and nicorandil substantially surpasses conventional treatment methods in managing symptoms and heart functionality among elderly patients suffering from refractory angina pectoris.

Research perspectives

The beneficial findings of the present study pave the way towards further exploring this combined treatment’s potential varying application for CAD and its consequent complications, ultimately improving patient wellness and prolonging life spans. Promisingly, it may add a significant contribution to personalized treatment approaches for CAD patients.