Yang X, Su XH, Zeng Z, Fan Y, Wu Y, Guo LL, Xu XY. Integrated analysis of comorbidity, pregnant outcomes, and amniotic fluid cytogenetics of fetuses with persistent left superior vena cava. World J Cardiol 2023; 15(10): 500-507 [PMID: 37900905 DOI: 10.4330/wjc.v15.i10.500]
Corresponding Author of This Article
Xiao-Yan Xu, PhD, Doctor, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xuxiaoyan@tjh.tjmu.edu.cn
Research Domain of This Article
Obstetrics & Gynecology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Oct 26, 2023; 15(10): 500-507 Published online Oct 26, 2023. doi: 10.4330/wjc.v15.i10.500
Integrated analysis of comorbidity, pregnant outcomes, and amniotic fluid cytogenetics of fetuses with persistent left superior vena cava
Xin Yang, Xin-Hui Su, Zhen Zeng, Yao Fan, Yuan Wu, Li-Li Guo, Xiao-Yan Xu
Xin Yang, Xin-Hui Su, Zhen Zeng, Yao Fan, Yuan Wu, Li-Li Guo, Xiao-Yan Xu, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Yang X and Su XH performed the conception and design; Zeng Z and Guo LL performed the development of methodology; Fan Y and Wu Y contributed to the analysis and interpretation of data; Yang X and Su XH contributed to the writing and review of the manuscript; Xu XY performed the study supervision; Yang X and Su XH contributed equally to this work; all authors had final approval of the submitted versions.
Supported byKey Research and Development Plan Projects in Hubei Province, No. 2022BCA041; and National Natural Science Foundation of China, No. 82101277.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (No. TJ-IRB20230736).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Xu, PhD, Doctor, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. xuxiaoyan@tjh.tjmu.edu.cn
Received: July 9, 2023 Peer-review started: July 9, 2023 First decision: August 17, 2023 Revised: August 29, 2023 Accepted: September 28, 2023 Article in press: September 28, 2023 Published online: October 26, 2023 Processing time: 106 Days and 15.6 Hours
ARTICLE HIGHLIGHTS
Research background
Persistent left superior vena cava (PLSVC) is the most common venous system variant. Previous research has shown that the probability of adverse pregnancy outcomes in isolated PLSVC is lower, and the risk of adverse pregnancy outcomes is significantly increased when combined with other malformations. In recent years, some studies have reported that the proportion of fetal chromosomal abnormalities among PLSVC fetuses has significantly increased, which is different from the classic opinion on this disease. There is a lack of comprehensive studies that provide reliable conclusions for patients and clinicians.
Research motivation
In recent years, the advancement of prenatal diagnostic technology has overturned traditional concepts of some diseases.
Research objectives
We integrated clinical information, imaging features, and molecular-level results to provide reliable advice to patients and clinicians in multiple dimensions.
Research methods
We retrospectively collected cases of PLSVC diagnosed using prenatal ultrasonography between September 2019 and November 2022. The clinical characteristics of the pregnant women, ultrasonic imaging information, gestational age at diagnosis, pregnancy outcomes, and amniocentesis results were summarized and analyzed.
Research results
The differences in pregnancy outcomes and amniocentesis conditions between the two groups were statistically significant (P < 0.05). According to the results of the classification statistics, the most common intracardiac abnormality was a ventricular septal defect and the most common extracardiac abnormality was a single umbilical artery. Additionally, all abnormal cytogenetic findings on amniocentesis were observed in the comorbidity group.
Research conclusions
PLSVC is associated with a certain percentage of other combined structural abnormalities. Examination for other structural abnormalities is strongly recommended when PLSVC is diagnosed. Poorer pregnancy outcomes and increased amniocentesis were observed in PLSVC cases with other structural abnormalities. Integrated analysis of multiple levels could provide more information.
Research perspectives
In future studies, researchers should collect more amniotic fluid cytological data and follow-up prognosis of related fetuses.
