Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease

doi:10.4330/wjc.v7.i7.397

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World Journal of Cardiology

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World J Cardiol. Jul 26, 2015; 7(7): 397-403
Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.397

Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease

Nileshkumar J Patel, Aashay Patel, Kanishk Agnihotri, Dhaval Pau, Samir Patel, Badal Thakkar, Nikhil Nalluri, Deepak Asti, Ritesh Kanotra, Sabeeda Kadavath, Shilpkumar Arora, Nilay Patel, Achint Patel, Azfar Sheikh, Neil Patel, Apurva O Badheka, Abhishek Deshmukh, Hakan Paydak, Juan Viles-Gonzalez

Nileshkumar J Patel, Dhaval Pau, Nikhil Nalluri, Deepak Asti, Ritesh Kanotra, Azfar Sheikh, Cardiovascular Division, Staten Island University Hospital, Staten Island, NY 10305, United States

Aashay Patel, Cardiovascular Division, Lankenau Institute of Medical Research, Wynnewood, PA 19096, United States

Kanishk Agnihotri, Nilay Patel, Cardiovascular Division, Saint Peters University Hospital, New Brunswick, NJ 08901, United States

Samir Patel, Cardiovascular Division, Western Reserve Health Education, Yougstown, OH 44504, United States

Badal Thakkar, Cardiovascular Division, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States

Sabeeda Kadavath, Cardiovascular Division, Lincoln Medical and Mental Health Center, Bronx, NY 10451, United States

Shilpkumar Arora, Cardiovascular Division, St. Lukes Roosevelt Hospital, New York, NY 10025, United States

Achint Patel, Neil Patel, Cardiovascular Division, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States

Apurva O Badheka, Cardiovascular Division, Yale School of Medicine, New Haven, CT 06519, United States

Abhishek Deshmukh, Cardiovascular Division, Mayo Clinic, Rochester, MN 55905, United States

Hakan Paydak, Cardiovascular Division, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States

Juan Viles-Gonzalez, Cardiovascular Division, University of Miami Miller School of Medicine, Miami, FL 33136, United States

Author contributions: All authors have contributed significantly to the effort of conducting this article; Patel NJ, Patel A, Agnihotri K and Pau D contributed equally to the conception of this article and to the final content of this manuscript; all other authors have contributed to drafting of the manuscript.

Conflict-of-interest statement: All authors have no disclosures or conflicts of interest.

Correspondence to: Nileshkumar J Patel, MD, Cardiovascular Division, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305, United States. dr.nilesh.j.patel@gmail.com

Telephone: +1-201-7449111 Fax: +1-610-3941787

Received: January 28, 2015
Peer-review started: January 28, 2015
First decision: March 6, 2015
Revised: April 6, 2015
Accepted: April 28, 2015
Article in press: April 30, 2015
Published online: July 26, 2015
Processing time: 188 Days and 8.2 Hours

Abstract

Atrial fibrillation (AF) is the most common type of sustained arrhythmia, which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes it a major healthcare burden. The objective of our article is to determine the prognostic impact of AF on acute coronary syndromes, heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that AF has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease.

Keywords: Atrial fibrillation; Heart failure; Chronic kidney disease; Acute coronary syndromes; Prognostic impact

Core tip: Atrial fibrillation (AF), the most common type of arrhythmia, is on course to reach epidemic proportions in the elderly. AF is a commonly encountered comorbidity in patients with acute coronary syndromes, heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that atrial fibrillation has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease.