Brugts JJ, Houtgraaf J, Hazenberg BP, Kofflard MJ. Echocardiographic features of an atypical presentation of rapidly progressive cardiac amyloidosis. World J Cardiol 2013; 5(5): 154-156 [PMID: 23710304 DOI: 10.4330/wjc.v5.i5.154]
Corresponding Author of This Article
Jasper J Brugts, MD, PhD, MSc, Department of Cardiology, Albert Schweitzer hospital, Albert Schweitzerplaats 50, 3300 AK Dordrecht, The Netherlands. j.brugts@erasmusmc.nl
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. May 26, 2013; 5(5): 154-156 Published online May 26, 2013. doi: 10.4330/wjc.v5.i5.154
Echocardiographic features of an atypical presentation of rapidly progressive cardiac amyloidosis
Jasper J Brugts, Jaco Houtgraaf, Bouke PC Hazenberg, Marcel JM Kofflard
Jasper J Brugts, Jaco Houtgraaf, Marcel JM Kofflard, Department of Cardiology, Albert Schweitzer hospital, 3300 AK Dordrecht, The Netherlands
Bouke PC Hazenberg, Department of Cardiology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
Author contributions: Brugts JJ prepared the manuscript; Houtgraaf J contributed to preparation of the manuscript, case findings and data collection; Hazenberg BPC drafted the manuscript; Kofflard MJM contributed to revision of the manuscript, case findings and data collection.
Correspondence to: Jasper J Brugts, MD, PhD, MSc, Department of Cardiology, Albert Schweitzer hospital, Albert Schweitzerplaats 50, 3300 AK Dordrecht, The Netherlands. j.brugts@erasmusmc.nl
Telephone: +31107043938 Fax: +31108003938
Received: June 9, 2012 Revised: October 13, 2012 Accepted: January 31, 2013 Published online: May 26, 2013
Abstract
We present the case of a 66 year old male who presented with dyspnea and reduced exercise tolerance. Echocardiography demonstrated impaired left ventricular (LV) function and restrictive diastolic function with pronounced concentric left ventricular hypertrophy (LVH) without a history of hypertension and no aortic valve stenosis. Differential diagnostics of concentric LVH are discussed in detail. In the current case, cardiac amyloidosis (AL) amyloidosis was diagnosed and confirmed by serum amyloid P (SAP) scintigraphy and abdominal fat aspiration biopsy. This case shows the rapid decline in clinical condition with progression of cardiac involvement of AL. As discussed in detail, cardiac involvement in AL-amyloidosis generally denotes a poor prognosis, regardless of the method of treatment.
