Wang RT, Feng YQ, Tu SQ, Yang S. Deciphering Teochew population’s genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway. World J Cardiol 2026; 18(1): 113327 [DOI: 10.4330/wjc.v18.i1.113327]
Corresponding Author of This Article
Shen Yang, MD, PhD, PsyD, Academic Fellow, Chief, Department of Neurology, The First People’s Hospital of Xiangtan City, No. 100 Shuyuan Road, Yuetang District, Xiangtan 411100, Hunan Province, China. doctoryangshen@163.com
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Cardiac & Cardiovascular Systems
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Letter to the Editor
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Jan 26, 2026 (publication date) through Jan 15, 2026
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World Journal of Cardiology
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1949-8462
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Wang RT, Feng YQ, Tu SQ, Yang S. Deciphering Teochew population’s genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway. World J Cardiol 2026; 18(1): 113327 [DOI: 10.4330/wjc.v18.i1.113327]
World J Cardiol. Jan 26, 2026; 18(1): 113327 Published online Jan 26, 2026. doi: 10.4330/wjc.v18.i1.113327
Deciphering Teochew population’s genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway
Ru-Tong Wang, Ying-Qi Feng, Si-Qi Tu, Shen Yang
Ru-Tong Wang, Ying-Qi Feng, Si-Qi Tu, Shen Yang, Department of Neurology, The First People’s Hospital of Xiangtan City, Xiangtan 411100, Hunan Province, China
Ru-Tong Wang, Ying-Qi Feng, Si-Qi Tu, Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
Co-first authors: Ru-Tong Wang and Ying-Qi Feng.
Author contributions: Wang RT and Feng YQ contributed to data organization, and they contributed equally to this manuscript as co-first authors; Wang RT, Feng YQ, and Tu SQ contributed to investigation and original draft the manuscript; Wang RT and Yang S contributed to conceptualization; Wang RT contributed to data curation, resources, and formal analysis; Yang S contributed to methodology, project administration, supervision, and revied and edited the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shen Yang, MD, PhD, PsyD, Academic Fellow, Chief, Department of Neurology, The First People’s Hospital of Xiangtan City, No. 100 Shuyuan Road, Yuetang District, Xiangtan 411100, Hunan Province, China. doctoryangshen@163.com
Received: August 22, 2025 Revised: September 16, 2025 Accepted: November 25, 2025 Published online: January 26, 2026 Processing time: 146 Days and 11.8 Hours
Abstract
Xu et al provides crucial regional data for precision cardiovascular medicine in East Asia. This study focuses on the Teochew Han population in China for the first time and reveals the synergistic protective effect of the apolipoprotein E ε2 allele and high copy numbers of kringle IV type 2. This discovery holds significant importance for optimizing regional risk assessment models.
Core Tip: This study identifies a novel synergistic cardiometabolic protective pathway in the genetically distinct Teochew (Chaozhou) Han population of southern China. We demonstrate that the co-presence of the apolipoprotein E (APOE) ε2 allele and high copy number variation of the lipoprotein(a) kringle IV type 2 gene significantly reduces coronary heart disease risk, contrasting with previous reports on APOE ε2 in Asians. This unique gene-environment interaction, potentially modulated by the local seafood-rich diet, offers a population-specific biomarker for optimized coronary heart disease risk stratification. Clinical translation emphasizes integrating APOE/lipoprotein(a) kringle IV type 2 copy number variation screening with solute carrier organic anion transporter family member 1B1 pharmacogenetics to guide precision statin therapy and personalized prevention strategies.
