Marzoog BA, Chomakhidze P, Gognieva D, Parunova AY, Demchuk SN, Silantyev A, Kuznetsova N, Kostikova A, Podgalo D, Nagornov E, Gadzhiakhmedova A, Kopylov P. Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry. World J Cardiol 2025; 17(2): 102851 [DOI: 10.4330/wjc.v17.i2.102851]
Corresponding Author of This Article
Basheer Abdualah Marzoog, MD, Associate Chief Physician, Department of Cardiology, Sechenov University, 8-2 Trubetskaya Street, Moscow 119991, Moskva, Russia. marzug@mail.ru
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Basheer Abdualah Marzoog, Peter Chomakhidze, Daria Gognieva, Artemiy Silantyev, Natalia Kuznetsova, Dmitrii Podgalo, Evgeny Nagornov, Aida Gadzhiakhmedova, Philipp Kopylov, Department of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia
Alena Yurievna Parunova, Undergraduate Student, National Research Ogarev Mordovia State University, Saransk 430005, Russia
Snezhana Nikolaevna Demchuk, Undergraduate Student, Omsk State Medical University, Omsk 644099, Russia
Anastasia Kostikova, Undergraduate Student, Sechenov University, Moscow 119991, Moskva, Russia
Author contributions: Marzoog BA collected and analyzed data and revised the manuscript; Chomakhidze P, Gognieva D, Parunova AY, Demchuk SN, Silantyev A, Kuznetsova N, Kostikova A, Podgalo D, Nagornov E, Gadzhiakhmedova A revised the paper; Kopylov P contributed to the concept and development of the paper. All authors have read and approved the manuscript.
Supported by the Government Assignment to Philipp Kopylov, No. 1023022600020-6; Russian Science Foundation Grant to Philipp Kopylov, No. 24-15-00549; and the Ministry of Science and Higher Education of the Russian Federation within the Framework of State Support for the Creation and Development of World-Class Research Center to Basheer Marzoog and Peter Chomakhidze, No. 075-15-2022-304.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: October 31, 2024 Revised: December 18, 2024 Accepted: January 23, 2025 Published online: February 26, 2025 Processing time: 117 Days and 16.8 Hours
Abstract
BACKGROUND
Cardiovascular disease (CVD) and associated sequalae remain the leading cause of disability worldwide. Ischemic heart disease (IHD) and heart failure are the most common etiologies of morbidity and mortality worldwide. This is due to the poor diagnostic and management methods for heart failure and IHD. Early detection of related risk factors through modern strategies is underestimated and requires further research.
AIM
To interpret data from the published literature on volatile organic compounds (VOC), including all the methods used to analyze exhaled breath in patients with IHD and heart failure.
METHODS
Searches for specific keywords were performed on Scopus and PubMed. A total of 20 studies were identified in breath analysis and IHD and heart failure. The study is registered in PROSPERO (Registration No. CRD42023470556).
RESULTS
Considering the articles found, more research is required to gain a full understanding of the role of VOCs in IHD and heart failure. However, the existing literature demonstrates that cardiac metabolic changes can be expressed in exhaled air. The number of papers found is extremely low, making interpretation extremely difficult.
CONCLUSION
Exhaled breath analysis can be a novel biomarker for the diagnosis and prevention of heart failure and IHD. Exhaled breath analysis can be used as a mirror to reflect the metabolic changes related to IHD and heart failure.
Core Tip: The breathome in heart disease diagnosis remains relatively unexplored in the medical field. Using of exhaled breath analysis to diagnose ischemic heart disease or heart failure is a promising tool for future diagnostic methods.
