Predictors of persistence of functional mitral regurgitation after cardiac resynchronization therapy: Review of literature

Abstract

Functional mitral regurgitation is a common finding among heart failure patients with ischemic and non-ischemic dilated cardiomyopathies. The presence of moderate or severe mitral regurgitation is associated with higher morbidity and mortality. Heart failure patients meeting electrocardiogram and left ventricle function criteria are good candidates for cardiac resynchronization therapy, which may reduce the degree of functional mitral regurgitation in the short and long term, specifically targeting myocardial dyssynchrony and inducing left ventricle reverse remodeling. In this article, we analyze data from the literature about predictors of mitral regurgitation improvement after cardiac resynchronization therapy implantation.

Keywords: Functional mitral regurgitation; Cardiac resynchronization therapy; Predictors; Mitral regurgitation improvement; Dyssynchrony

Core Tip: Functional mitral regurgitation is a common finding among heart failure patients and, if moderate or severe, is associated with higher morbidity and mortality. Cardiac resynchronization therapy, as a therapy for a subset of heart failure patients, may determine a reduction of the degree of functional mitral regurgitation specifically targeting myocardial dyssynchrony and inducing left ventricle reverse remodeling. Here, we analyze predictors of mitral regurgitation improvement after cardiac resynchronization therapy implantation.