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Oct 26, 2022 (publication date) through Feb 24, 2026
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World Journal of Cardiology
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1949-8462
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2022; 14(10): 557-560
Published online Oct 26, 2022. doi: 10.4330/wjc.v14.i10.557
Is Takotsubo cardiomyopathy still looking for its own nosological identity?
Riccardo Scagliola, Gian Marco Rosa
Riccardo Scagliola, Gian Marco Rosa, Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy
Author contributions: Scagliola R and Rosa GM contributed to the conception and design of the manuscript; Scagliola R drafted the manuscript; all authors contributed equally to the critical revision, editing and approval of the final version of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Corresponding author: Riccardo Scagliola, MD, Doctor, Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi n. 10, Genoa 16132, Italy. risca88@live.it
Received: May 7, 2022
Peer-review started: May 7, 2022
First decision: May 31, 2022
Revised: May 31, 2022
Accepted: October 5, 2022
Article in press: October 5, 2022
Published online: October 26, 2022
Processing time: 165 Days and 8.5 Hours
Abstract

Despite several efforts to provide a proper nosological framework for Takotsubo cardiomyopathy (TCM), this remains an unresolved matter in clinical practice. Several clinical, pathophysiologic and histologic findings support the conceivable hypothesis that TCM could be defined as a unique pathologic entity, rather than a distinct subset of myocardial infarction with non-obstructive coronary arteries. Further investigations are needed in order to define TCM with the most appropriate disease taxonomy.

Keywords: Takotsubo cardiomyopathy; Myocardial infarction with non-obstructive coronary arteries; Disease classification

Core Tip: Despite several efforts to provide a proper nosological framework for Takotsubo cardiomyopathy (TCM), this remains an unresolved matter in clinical practice. Several clinical, pathophysiologic and histologic findings support the conceivable hypothesis that TCM could be defined as a unique pathologic entity, rather than a distinct subset of myocardial infarction with non-obstructive coronary arteries. These issues need to be confirmed by further investigations, in order to define TCM with the most appropriate disease taxonomy.
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