Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Oct 26, 2022; 14(10): 557-560
Published online Oct 26, 2022. doi: 10.4330/wjc.v14.i10.557
Is Takotsubo cardiomyopathy still looking for its own nosological identity?
Riccardo Scagliola, Gian Marco Rosa
Riccardo Scagliola, Gian Marco Rosa, Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy
Author contributions: Scagliola R and Rosa GM contributed to the conception and design of the manuscript; Scagliola R drafted the manuscript; all authors contributed equally to the critical revision, editing and approval of the final version of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Riccardo Scagliola, MD, Doctor, Cardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi n. 10, Genoa 16132, Italy. risca88@live.it
Received: May 7, 2022
Peer-review started: May 7, 2022
First decision: May 31, 2022
Revised: May 31, 2022
Accepted: October 5, 2022
Article in press: October 5, 2022
Published online: October 26, 2022
Processing time: 165 Days and 8.5 Hours
Abstract

Despite several efforts to provide a proper nosological framework for Takotsubo cardiomyopathy (TCM), this remains an unresolved matter in clinical practice. Several clinical, pathophysiologic and histologic findings support the conceivable hypothesis that TCM could be defined as a unique pathologic entity, rather than a distinct subset of myocardial infarction with non-obstructive coronary arteries. Further investigations are needed in order to define TCM with the most appropriate disease taxonomy.

Keywords: Takotsubo cardiomyopathy; Myocardial infarction with non-obstructive coronary arteries; Disease classification

Core Tip: Despite several efforts to provide a proper nosological framework for Takotsubo cardiomyopathy (TCM), this remains an unresolved matter in clinical practice. Several clinical, pathophysiologic and histologic findings support the conceivable hypothesis that TCM could be defined as a unique pathologic entity, rather than a distinct subset of myocardial infarction with non-obstructive coronary arteries. These issues need to be confirmed by further investigations, in order to define TCM with the most appropriate disease taxonomy.