Dabigatran in cardiovascular disease management: A comprehensive review

doi:10.4330/wjc.v13.i12.710

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World Journal of Cardiology

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1949-8462

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World J Cardiol. Dec 26, 2021; 13(12): 710-719
Published online Dec 26, 2021. doi: 10.4330/wjc.v13.i12.710

Dabigatran in cardiovascular disease management: A comprehensive review

Ayesha Javed, Muhammad Ajmal, Aaron Wolfson

Ayesha Javed, Department of Internal Medicine, University of Arizona, Tucson, AZ 85719, United States

Muhammad Ajmal, Department of Cardiology, University of Arizona, Tucson, AZ 85719, United States

Aaron Wolfson, Department of Cardiology, University of Southern California, Los Angeles, CA 90007, United States

Author contributions: Ajmal M came up with the idea; Javed A and Ajmal M drafted the manuscript; Wolfson A reviewed and finalized it; Javed A, Ajmal M and Wolfson A revised the manuscript.

Conflict-of-interest statement: All authors have no any conflicts of interest.

Corresponding author: Muhammad Ajmal, MD, Academic Fellow, Department of Cardiology, University of Arizona, 1625 N Campbell Ave, Tucson, AZ 85704, United States. drajmal207@gmail.com

Received: April 6, 2021
Peer-review started: April 6, 2021
First decision: September 2, 2021
Revised: September 27, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 26, 2021
Processing time: 261 Days and 2.5 Hours

Abstract

Dabigatran, a direct thrombin inhibitor, has robust data for the treatment of deep venous thrombosis and pulmonary embolism, stroke prevention in non-valvular atrial fibrillation, and the prophylaxis of venous thromboembolism (VTE) after knee and hip replacement. Recent studies have evaluated dabigatran to determine its safety and efficacy in such conditions as VTE in malignancy, coronary artery disease, mechanical and bioprosthetic valves, and antiphospholipid syndrome. This article provides a comprehensive review on the role of dabigatran in various cardiovascular diseases.

Keywords: Dabigatran; Anticoagulation; Thrombus; Bleeding; Atrial fibrillation; Deep venous thrombosis; Stroke

Core Tip: Direct oral anticoagulants (DOACs) have plethora of data for the use in medical field and particulalry in cardiovascular medicine. This review is focused on the dabigatran which is one of the DOAC and it is prudent for all the physicians to be familiar with this drug.