• Bangladesh
• Cross-sectional
• EQ-5D-5 L
• Hypertension
• Quality-of-life

• Humans
• Quality of Life/psychology
• Middle Aged
• Male
• Female
• Bangladesh/epidemiology
• Cross-Sectional Studies
• Hypertension/psychology
• Hypertension/epidemiology
• Adult
• Aged
• Aged, 80 and over
• Socioeconomic Factors
• Surveys and Questionnaires
• Adolescent
• Young Adult
• Sociodemographic Factors

• Hitotsubashi University

• Von Willebrand disease
• blood coagulation disorder
• haemophilia A
• haemophilia B
• medication adherence
• quality of life

• Humans
• Quality of Life
• von Willebrand Diseases/epidemiology
• von Willebrand Diseases/psychology
• von Willebrand Diseases/diagnosis
• von Willebrand Diseases/therapy
• Adult
• Male
• Hemophilia B/epidemiology
• Hemophilia B/psychology
• Female
• Middle Aged
• Cross-Sectional Studies
• Surveys and Questionnaires
• Denmark/epidemiology
• Hemophilia A/epidemiology
• Hemophilia A/psychology
• Hemophilia A/drug therapy
• Aged
• Young Adult
• Adolescent
• Medication Adherence

• Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Denmark
• Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Denmark

• depression
• health-related quality of life
• medication adherence
• older adults
• quality of life

• COPD
• adherence
• chronic obstructive pulmonary disease

• Aged
• Female
• Humans
• Male
• Middle Aged
• Administration, Inhalation
• Albuterol/analogs & derivatives
• Albuterol/administration & dosage
• Albuterol/therapeutic use
• Bronchodilator Agents/administration & dosage
• Bronchodilator Agents/therapeutic use
• Drug Combinations
• Fluticasone-Salmeterol Drug Combination/administration & dosage
• Fluticasone-Salmeterol Drug Combination/therapeutic use
• Health Status
• Medication Adherence/statistics & numerical data
• Pulmonary Disease, Chronic Obstructive/drug therapy
• Pulmonary Disease, Chronic Obstructive/physiopathology
• Surveys and Questionnaires
• Treatment Outcome

• Elpen Pharmaceutical Co. Inc.

• GERIATRIC MEDICINE
• NEUROLOGY
• PUBLIC HEALTH
• Parkinson-s disease
• STATISTICS & RESEARCH METHODS
• Stroke

• Humans
• Aged
• Middle Aged
• Quality of Life
• Cross-Sectional Studies
• Nervous System Diseases
• Neurology
• Surveys and Questionnaires
• Germany

• BMBF (Bundesministerium für Bildung und Forschung)

Nonadherence to antihypertensive medications is the leading cause of poor blood pressure control and thereby cardiovascular diseases and mortality worldwide.

We investigated the global epidemiology, regional differences, and trend of antihypertensive medication nonadherence via a systematic review and meta‐analyses of data from 2010 to 2020. Multiple medical databases and clinicaltrials.gov were searched for articles. Observational studies reporting the proportion of patients with anti‐hypertensive medication nonadherence were included. The proportion of nonadherence, publication year, year of first recruitment, country, and health outcomes attributable to antihypertensive medication nonadherence were extracted. Two reviewers screened abstracts and full texts, classified countries according to levels of income and locations, and extracted data. The Joanna Briggs Institute prevalence critical appraisal tool was used to rate the included studies. Prevalence meta‐analyses were conducted using a fixed‐effects model, and trends in prevalence were analyzed using meta‐regression. The certainty of evidence concerning the effect of health consequences of nonadherence was rated according to Grading of Recommendations, Assessment, Development and Evaluations. A total of 161 studies were included. Subject to different detection methods, the global prevalence of anti‐hypertensive medication nonadherence was 27% to 40%. Nonadherence was more prevalent in low‐ to middle‐income countries than in high‐income countries, and in non‐Western countries than in Western countries. No significant trend in prevalence was detected between 2010 and 2020. Patients with antihypertensive medication nonadherence had suboptimal blood pressure control, complications from hypertension, all‐cause hospitalization, and all‐cause mortality.

While high prevalence of anti‐hypertensive medication nonadherence was detected worldwide, higher prevalence was detected in low‐ to middle‐income and non‐Western countries. Interventions are urgently required, especially in these regions. Current evidence is limited by high heterogeneity.

URL: www.crd.york.ac.uk/prospero/; Unique identifier: CRD42021259860.

• adherence
• compliance
• hypertension
• meta‐analyses
• prevalence

• Adolescents
• Children
• Intervention
• Obesity
• Weight loss

• adherence
• dyslipidemia
• statin

Hypertension is a major health concern, especially in low-income countries. Nonadherence and poor or no persistence in adhering to hypertension treatment regimens result in uncontrolled high blood pressure, increasing rates of mortality and morbidity, and preventable healthcare costs. The aim of this study was to assess the level of adherence and barriers to treatment regimens among hypertensive patients living in the Gaza Strip, Palestine.

A convenience sample of 648 participants completed the Hill-Bone Compliance to High Blood Pressure Therapy Scale. The great majority of participants (n = 521, 80.4%) was highly adherent to their treatment regimen, 123 participants (18.98%) were classified as moderately nonadherent, and 4 (0.62%) participants were classified as highly nonadherent to their hypertension treatment regimen. Participants of this study showed the highest adherence rate to the domain of medication adherence (mean of 1.42 out of 4) followed by appointment keeping (mean 1.8), while they were least adherent to diet (mean of 2.18). The greatest three barriers to adherence to the recommended treatment regimen reported by participants were inability to exercise, inability to resist fast and fried food, and inability to keep themselves away from salty foods.

Overall adherence to medication in Gaza was surprisingly good in patients with a diagnosis of hypertension for at least one year. However, adherence to lifestyle advice or dietary regimes remains poor. A combination of interventions using low-cost mobile technology, combined with face-to-face interventions by healthcare professionals, can be applied to improve adherence to hypertension treatment regimens in order to reduce the consequences of uncontrolled blood pressure.

• Latin-American
• adherence
• quality of life
• schizophrenia

• the Universidad de Tarapacá through Proyecto Mayor de Investigación Científica y Tecnológica

• health services administration
• high blood pressure
• medication adherence
• primary care

• longitudinal study
• medication adherence
• patient-reported outcomes
• pulmonary tuberculosis
• quality of life

This study aims to assess the profile and predictors of Health-Related Quality of Life (HRQoL) in Type II Diabetes Mellitus (T2DM) patients in Quetta, Pakistan.

The study was designed as a questionnaire based, cross sectional analysis. 300 Type II diabetic patients attending public and private hospitals were targeted for data collection. In addition to demographic and disease related information, Euroqol Quality of Life was used to measure HRQoL. Moreover, Drug Attitude Inventory and Michigan Diabetes Knowledge Test were used to assess medication adherence and diabetes related knowledge respectively. Treatment satisfaction was assessed by patient’s experience towards health care professionals and available facilities. Descriptive statistics were used to elaborate patients’ demographic and disease related characteristics. Binary logistic regression was used to predict factors independently associated with HRQoL. SPSS v. 20 was used for data analysis and p < 0.05 was taken as significant.

Patients in the current study reported poor HRQoL with a mean score of 0.48 ± 0.36. Age, duration of disease, number of prescribed drugs, medication adherence and treatment satisfaction were significantly associated (p < 0.05) with HRQoL in the cross tabulation analysis. The significant variables were entered into the model that showed significant goodness of fit with highly significant Omnibus Test of Model Coefficient (Chi-square = 12.983, p = 0.030, df = 4). Medication adherence was reported as a significant predictor of HRQoL with an increase of one adherence score was associated with improvement of HRQoL by a factor of 1.75 provided other variables remain constant.

The study presents a model that is associated with HRQoL with patient with T2DM, where medication adherence shaped as a predictor of HRQoL. Healthcare professionals should pay special attention on patients’ medication taking behavior and should put their efforts in explaining the benefits of the medication adherence to the patients.

• HRQoL
• Pakistan
• Predictor
• Profile
• T2DM

Hypertension is a common and frequently occurring chronic disease of the cardiovascular system. Besides the pathological factors, the occurrence and exacerbation of hypertension are also associated with many factors of lifestyle and behaviors. Thus hypertensive patients’ Health-related quality of life (HRQL) is not only influenced by the disease itself but also by many subjective factors such as health literacy and self-management efficacy, especially in the deeper part of southwestern China and thus is less developed compared to the other places. The purpose of this study was to examine the association between the HRQL of hypertensive patients and health literacy and self-management efficacy as well as how they affect the HRQL, so as to provide a theoretical reference for improving the HRQL of patients with hypertension in less developed areas.

This was a cross-sectional study of baseline data from a clustered randomized controlled trial. The study design had passed a cross-national peer review and accepted grants by the China Medical Board. It was also registered in the Chinese Clinical Trial Registry (ChiCTR-OOR-14005563).

A standardized questionnaire adapted from a previous validated WHO questionnaire was used for the survey which included detailed questions about patient’s socio-demographic characteristics and self-reported information.

Patients’ HRQL was measured by the Mandarin version of the 36-item Short Form. We used the validated Mandarin version of the Self-Efficacy for Managing Chronic Disease 6-Item Scale to assess patients’ self-management efficacy. The validated three-item Brief Health Literacy Screening (BHLS) was used to measure the patients’ health literacy.

A structural equation model was constructed, and p ≤ 0.05 was taken as significant.

Demographic characteristics, health literacy and self-management efficacy have all significant effects on HRQL. Age, education level, self-management efficacy and health literacy were significantly related to the HRQL. The constructed model had a good fit for the data according to the model fit indices. Based on the model, health literacy (r = 0.604, p = 0.029) and Self-management efficacy (r = 0.714, p = 0.018) have a significant impact on HRQL. Demographic characteristics were inversely related to HRQL (r = −0.419, p = 0.007), but have a significant impact on health literacy (r = 0.675, p = 0.029) and self-management efficacy (r = 0.379, p = 0.029). At the same time, self-management efficacy was positively correlated to health literacy (r = 0.413, p < 0.01).

Age, education level, self-management efficacy and health literacy were all related to the HRQL of patient with hypertension, which means that patients who are more elderly and have lower education level, low self-management efficacy and poor health literacy get worse HRQL. This may imply the necessary to introduce routine assessment of health literacy and self-management efficacy into assessment procedures for hypertensive patients’ health management. Such assessment can help professionals to identify the population at greatest risk for poor health outcomes and low well-being in the future. In clinical practice, effective interventions such as direct guidance and education to raise the self-management efficacy and enhance health literacy might improve the HRQL of patients with hypertension.

Retrospectively registered Chinese Clinical Trial Registry (ChiCTR-OOR-14005563).

Name of registry: Effects of the integrated delivery system and payment system of community-based intervention on rural patients of chronic diseases in Qianjiang District, China

Date of registration: Retrospectively registered 23 November 2014.

Date of enrolment of the first participant to the trial: 5 July 2012

• Effect
• HRQL
• Health literacy
• Hypertension
• Self-management efficacy

• hypertension, drug therapy
• antihypertensive agents, therapeutic use
• medication adherence
• quality of life
• meta-analysis

• Antihypertensive Agents/therapeutic use
• Brazil
• Humans
• Hypertension/psychology
• Hypertension/therapy
• Medication Adherence/psychology
• Patient Compliance/psychology
• Quality of Life

Evaluate the impact of fixed-dose combination (FDC) containing emtricitabine (FTC), tenofovir (TDF), and efavirenz (EFV) versus a free-dose combination (FRC) of the same three drugs on clinical outcomes, adherence and quality of life in Malaysian outpatients with HIV.

HIV patients (n=120) on highly active antiretroviral therapy (HAART) in the infectious disease clinic of Hospital Sungai Buloh were randomized to either FDC (n=60) or FRC (n=60). Morisky scores, health-related quality of life scores and clinical outcomes such as CD4 count and viral load were assessed in both groups at baseline and six months.

Patients on FDC (108 SD=1.1) had a significantly higher CD4 count increase compared to the FRC group (746.1 SD=36.3 vs 799.8 SD=33.8) (p <0.001). The viral load profile was unchanged and remained undetectable in both groups. The quality of life EQ-5D scores showed a positive correlation with CD4 counts in the FDC group (ρ=0.301, p=0.019) at six months. On the other hand, quality of life EQ-VAS scores was significantly associated with medication adherence in the FDC group at six months (ρ=0.749, p=0.05). However, no significant changes or associations were observed in the FRC group.

Management of HAART using an FDC demonstrated a positive clinical outcome, adherence and quality of life within six months in local HIV patients.

• Anti-Retroviral Agents
• Antiretroviral Therapy
• Benzoxazines
• CD4 Lymphocyte Count
• Drug Combinations
• Emtricitabine
• Highly Active
• Malaysia
• Tenofovir
• Viral Load

• Entrepreneurship
• Ownership
• Pakistan
• Pharmacy
• Students

• Adult
• Behavior
• Culture
• Demography
• Female
• Humans
• Intention
• Male
• Ownership
• Students, Pharmacy
• Young Adult

• Greece
• adherence
• diabetes mellitus
• quality of life

• Assessing medication adherence
• Cardiovascular disease medication
• South Asia

• Treatment Satisfaction Questionnaire for Medication
• health-related quality of life
• hypertension
• quality of life
• treatment satisfaction

• Adult
• Aged
• Arabs/psychology
• Cross-Sectional Studies
• Female
• Humans
• Hypertension/therapy
• Male
• Middle Aged
• Patient Satisfaction
• Psychometrics/methods
• Quality of Life
• Surveys and Questionnaires

Non-adherence to prescribed medications represents an obstacle toward achieving treatment goals. This problem is more pronounced in patients with chronic illness.

To identify the extent of adherence in Lebanese outpatients with chronic diseases, and to suggest possible predictors of non-adherence in this population. The secondary objective was to assess if medication adherence affects patients’ quality of life.

A questionnaire was administered face-to-face to a sample of Lebanese adults visiting the external clinics at two Tertiary Care Hospitals in Beirut. The level of adherence was assessed using the 8-item Morisky Medication Adherence Scale which was first validated. The health-related quality of life (HRQoL) of patients was measured using the EQ-5D. Linear regression and logistic regression analyses examined possible predictors of adherence.

Out of the 148 patients included in this study, 42.6% were classified as adherent. In the univariate analyses, statistically significant predictors of high adherence included good physician-patient relationship (p=0.029) and counseling (p=0.037), a high level of HRQoL (p<0.001), and a high level of perceived health (p<0.001). Predictors of low adherence included a declining memory (p<0.001), anxiety/depression (p=0.002), little drug knowledge (p<0.001), and postponing physician appointments (p<0.001). The multivariate analyses revealed similar results. In the linear regression, the most powerful predictor of non-adherence was the disbelief that the drug is ameliorating the disease (beta=0.279), however, in logistic regression, patient who were willing to skip or double doses in case of amelioration/deterioration were found to be 7.35 times more likely to be non-adherent than those who were not (aOR=0.136, 95% CI: 0.037-0.503).

The findings of this study reassure the view that patients should be regarded as active decision makers. Patient education should be regarded as a cornerstone for treatment success. Additional studies as well are needed to test the practicability and effectiveness of interventions suggested to enhance adherence.

• Causality
• Lebanon
• Medication Adherence
• Multivariate Analysis
• Prevalence

To respond to growing prevalence of hypertension in Vietnam, it is critical to have an in-depth understanding about quality of life (QOL) among people living with hypertension and related factors. This study aimed to measure QOL among hypertensive people in a rural community in Vietnam, and its association with socio-demographic characteristics and factors related to treatment.

This study was conducted in a rural community located 60 km from Ho Chi Minh City. Face-to-face interviews were conducted among 275 hypertensive people aged 50 years and above using WHOQOL-BREF questionnaire. Descriptive statistics were used to examine mean scores of quality of life. Cronbach’s alpha coefficient and Pearson’s correlation coefficient were applied to estimate the internal consistency, and the level of agreement between different domains of WHOQOL-BREF, respectively. Independent T-test and ANOVA test followed by multiple linear regression analyses were used to measure the association between QOL domains and independent variables.

Both overall WHOQOL-BREF and each domain had a good internal consistency, ranging from 0.65 to 0.88. The QOL among hypertensive patients was found moderate in all domains, except for psychological domain that was fairly low (mean = 49.4). Backward multiple linear regressions revealed that being men, married, attainment of higher education, having physical activities at moderate level, and adherence to treatment were positively associated with QOL. However, older age and presence of co-morbidity were negatively associated with QOL.

WHOQOL-BREF is a reliable instrument to measure QOL among hypertensive patients. The results revealed low QOL in psychological domain and inequality in QOL across socio-demographic characteristics. Given the results, encouraging physical activities and strengthening treatment adherence should be considered to improve QOL of hypertensive people, especially for psychological aspect. Actions to improve QOL among hypertensive patients targeted towards women, lower educated and unmarried patients are needed in the setting.

• Adherence
• Forgetfulness
• Hypertension
• Palestine

• HRQoL
• adherence
• hospital pharmacist
• hypertension
• intervention
• randomized controlled trial