Ischaemic heart disease (IHD) is a major cause of morbidity and mortality worldwide. While there have been major advances in this field, these patients are still a higher risk subgroup. As such, strategies to mitigate risk and tailor secondary prevention measures are of the utmost relevance. Cardiac rehabilitation (CR), encompassing several domains including exercise training, cardiovascular risk factor optimization, nutritional and psychological assessments, as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with IHD. Indeed, CR is associated with several benefits in this population, ranging from functional capacity to improvements in outcomes. Whilst this, there are still several issues concerning the optimal application of CR which are still not fully ascertained, such as lack of referral and completion, as well as questions related to programme design (particularly among patients with multiple comorbidities). In this review, we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD, while also discussing some of the caveats in the current data, as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

• Cardiac rehabilitation
• Secondary prevention
• Myocardial infarction
• Ischaemic heart disease
• Cardiovascular diseases

Exercise based cardiac rehabilitation (CR) is recognized internationally as a class 1 clinical practice recommendation for patients with select cardiovascular diseases and heart failure with reduced ejection fraction. Over the past decade, several meta-analyses have generated debate regarding the effectiveness of exercise-based CR for reducing all-cause and cardiovascular mortality. A common theme highlighted in these meta-analyses is the heterogeneity and/or lack of detail regarding exercise prescription methodology within CR programs. Currently there is no international consensus on exercise prescription for CR, and exercise intensity recommendations vary considerably between countries from light-moderate intensity to moderate intensity to moderate-vigorous intensity. As cardiorespiratory fitness [peak oxygen uptake (VO₂peak)] is a strong predictor of mortality in patients with coronary heart disease and heart failure, exercise prescription that optimizes improvement in cardiorespiratory fitness and exercise capacity is a critical consideration for the efficacy of CR programming. This review will examine the evidence for prescribing higher-intensity aerobic exercise in CR, including the role of high-intensity interval training. This discussion will highlight the beneficial physiological adaptations to pulmonary, cardiac, vascular, and skeletal muscle systems associated with moderate-vigorous exercise training in patients with coronary heart disease and heart failure. Moreover, this review will propose how varying interval exercise protocols (such as short-duration or long-duration interval training) and exercise progression models may influence central and peripheral physiological adaptations. Importantly, a key focus of this review is to provide clinically-relevant recommendations and strategies to optimize prescription of exercise intensity while maximizing safety in patients attending CR programs.

• cardiorespiratory fitness
• cardiovascular disease
• coronary artery disease
• exercise prescription
• heart failure
• interval training
• peak oxygen consumption
• progression

• coronary heart disease
• myocardial infarction
• rehabilitation medicine

• Cardiac Rehabilitation
• Cohort Studies
• Exercise Therapy
• Female
• Humans
• Male
• United Kingdom
• Walk Test

• University of Leeds
• Leeds Beckett University

• all-cause mortality
• cardiovascular mortality
• coronary artery disease
• exercise-based cardiac rehabilitation
• hospital admissions.

• Aged
• Cardiac Rehabilitation/methods
• Case-Control Studies
• Coronary Artery Disease/mortality
• Coronary Artery Disease/therapy
• Exercise Therapy/methods
• Female
• Humans
• Male
• Middle Aged
• Outcome Assessment, Health Care
• Patient Admission/statistics & numerical data
• Secondary Prevention/methods