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Molossi S, Sachdeva S. Advice to Young Athletes With Anomalous Aortic Origin of a Coronary Artery With and Without Surgery. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2025; 28:83-93. [PMID: 40382130 DOI: 10.1053/j.pcsu.2025.01.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/03/2024] [Revised: 01/13/2025] [Accepted: 01/18/2025] [Indexed: 05/20/2025]
Abstract
Congenital coronary artery anomalies remain a leading cause of sudden cardiac death in the young. Within these, anomalous aortic origin of a coronary artery represents the largest group, with anomalies of the left coronary artery carrying higher risk for sudden cardiac arrest and clinical manifestations of myocardial ischemia. In contrast, anomalies of origin of the right coronary artery are more common and generally have a more benign clinical course, though rarely also associated with sudden events and myocardial ischemia. Risk stratification to guide management decisions remains to be well defined, though substantial advances have occurred in the last few years, with assessment of myocardial perfusion under provocative stress being an integral part of the evaluation in the young. Discussion and counseling on exercise behavior is essential to foster healthy lifestyle for these patients, acknowledging shared decision-making should be practiced in lieu of many unanswered questions as to outcomes long-term.
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Affiliation(s)
- Silvana Molossi
- Coronary Artery Anomalies Program, Texas Children's Hospital, Houston, Texas; The Lillie Frank Abercrombie Division of Cardiology, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
| | - Shagun Sachdeva
- Coronary Artery Anomalies Program, Texas Children's Hospital, Houston, Texas; The Lillie Frank Abercrombie Division of Cardiology, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, Texas
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Magalhães TA, Carneiro ACDC, Moreira VDM, Trad HS, Lopes MMU, Cerci RJ, Nacif MS, Schvartzman PR, Chagas ACP, Costa IBSDS, Schmidt A, Shiozaki AA, Montenegro ST, Piegas LS, Zapparoli M, Nicolau JC, Fernandes F, Hadlich MS, Ghorayeb N, Mesquita ET, Gonçalves LFG, Ramires FJA, Fernandes JDL, Schwartzmann PV, Rassi S, Torreão JA, Mateos JCP, Beck-da-Silva L, Silva MC, Liberato G, Oliveira GMMD, Feitosa Filho GS, Carvalho HDSMD, Markman Filho B, Rocha RPDS, Azevedo Filho CFD, Taratsoutchi F, Coelho-Filho OR, Kalil Filho R, Hajjar LA, Ishikawa WY, Melo CA, Jatene IB, Albuquerque ASD, Rimkus CDM, Silva PSDD, Vieira TDR, Jatene FB, Azevedo GSAAD, Santos RD, Monte GU, Ramires JAF, Bittencourt MS, Avezum A, Silva LSD, Abizaid A, Gottlieb I, Precoma DB, Szarf G, Sousa ACS, Pinto IMF, Medeiros FDM, Caramelli B, Parga Filho JR, Santos TSGD, Prazeres CEED, Lopes MACQ, Avila LFRD, Scanavacca MI, Gowdak LHW, Barberato SH, Nomura CH, Rochitte CE. Cardiovascular Computed Tomography and Magnetic Resonance Imaging Guideline of the Brazilian Society of Cardiology and the Brazilian College of Radiology - 2024. Arq Bras Cardiol 2024; 121:e20240608. [PMID: 39475988 DOI: 10.36660/abc.20240608] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/23/2025] Open
Affiliation(s)
- Tiago Augusto Magalhães
- Complexo Hospital de Clínicas da Universidade Federal do Paraná (CHC-UFPR), Curitiba, PR - Brasil
- Hospital do Coração (HCOR), São Paulo, SP - Brasil
- Hospital Sírio Libanês, SP, São Paulo, SP - Brasil
| | | | - Valéria de Melo Moreira
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | - Marly Maria Uellendahl Lopes
- Universidade Federal de São Paulo (UNIFESP), São Paulo, SP - Brasil
- DASA - Diagnósticos da América S/A, São Paulo, SP - Brasil
| | | | - Marcelo Souto Nacif
- Universidade Federal Fluminense, Niterói, RJ - Brasil
- Hospital Universitário Antonio Pedro, Niterói, RJ - Brasil
| | | | - Antônio Carlos Palandrini Chagas
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
- Faculdade de Medicina do ABC, Santo André, SP - Brasil
| | | | - André Schmidt
- Universidade de São Paulo (USP), Ribeirão Preto, SP - Brasil
| | - Afonso Akio Shiozaki
- ND Núcleo Diagnóstico, Maringá, PR - Brasil
- Ômega Diagnóstico, Maringá, PR - Brasil
- Hospital Paraná, Maringá, PR - Brasil
| | | | | | - Marcelo Zapparoli
- Quanta Diagnóstico por Imagem, Curitiba, PR - Brasil
- DAPI, Curitiba, PR - Brasil
| | - José Carlos Nicolau
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Fabio Fernandes
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Marcelo Souza Hadlich
- Fleury Medicina e Saúde, Rio de Janeiro, RJ - Brasil
- Rede D'Or RJ, Rio de Janeiro, RJ - Brasil
- Unimed, Rio de Janeiro, RJ - Brasil
- Instituto Nacional de Cardiologia (INC), Rio de Janeiro, RJ - Brasil
| | - Nabil Ghorayeb
- Instituto Dante Pazzanese de Cardiologia, São Paulo, SP - Brasil
- Inspirali Educação, São Paulo, SP - Brasil
- Anhanguera Educacional, São Paulo, SP - Brasil
| | | | - Luiz Flávio Galvão Gonçalves
- Hospital São Lucas, Rede D'Or SE, Aracaju, SE - Brasil
- Hospital Universitário da Universidade Federal de Sergipe, Aracaju, SE - Brasil
- Clínica Climedi, Aracaju, SE - Brasil
| | - Felix José Alvarez Ramires
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | - Pedro Vellosa Schwartzmann
- Hospital Unimed Ribeirão Preto, Ribeirão Preto, SP - Brasil
- Centro Avançado de Pesquisa, Ensino e Diagnóstico (CAPED), Ribeirão Preto, SP - Brasil
| | | | | | - José Carlos Pachón Mateos
- Hospital do Coração (HCOR), São Paulo, SP - Brasil
- Hospital Sírio Libanês, SP, São Paulo, SP - Brasil
| | - Luiz Beck-da-Silva
- Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS - Brasil
| | | | - Gabriela Liberato
- Hospital Sírio Libanês, SP, São Paulo, SP - Brasil
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | | | - Hilka Dos Santos Moraes de Carvalho
- PROCAPE - Universidade de Pernambuco, Recife, PE - Brasil
- Hospital das Clínicas de Pernambuco da Universidade Federal de Pernambuco (UFPE), Recife, PE - Brasil
- Real Hospital Português de Pernambuco, Recife, PE - Brasil
| | - Brivaldo Markman Filho
- Hospital das Clínicas de Pernambuco da Universidade Federal de Pernambuco (UFPE), Recife, PE - Brasil
| | | | | | - Flávio Taratsoutchi
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | - Roberto Kalil Filho
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | - Walther Yoshiharu Ishikawa
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Cíntia Acosta Melo
- Hospital Beneficência Portuguesa de São Paulo, São Paulo, SP - Brasil
- Hospital Infantil Sabará, São Paulo, SP - Brasil
| | | | | | - Carolina de Medeiros Rimkus
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
- Instituto D'Or de Pesquisa e Ensino (IDOR), São Paulo SP - Brasil
| | - Paulo Savoia Dias da Silva
- Fleury Medicina e Saúde, Rio de Janeiro, RJ - Brasil
- University of Iowa Hospitals and Clinics, Iowa City - EUA
| | - Thiago Dieb Ristum Vieira
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Fabio Biscegli Jatene
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Guilherme Sant Anna Antunes de Azevedo
- ECOMAX, Blumenau, SC - Brasil
- Hospital Unimed Blumenau, Blumenau, SC - Brasil
- Hospital São José de Jaraguá do Sul, Blumenau, SC - Brasil
- Cliniimagem Criciúma, Blumenau, SC - Brasil
| | - Raul D Santos
- Hospital Sírio Libanês, SP, São Paulo, SP - Brasil
- Universidade de São Paulo (USP), Ribeirão Preto, SP - Brasil
| | | | - José Antonio Franchini Ramires
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | - Alvaro Avezum
- Hospital Alemão Oswaldo Cruz, São Paulo, SP - Brasil
| | | | | | - Ilan Gottlieb
- Fonte Imagem Medicina Diagnostica, Rio de Janeiro, RJ - Brasil
| | | | - Gilberto Szarf
- Universidade Federal de São Paulo (UNIFESP), São Paulo, SP - Brasil
| | - Antônio Carlos Sobral Sousa
- Universidade Federal de Sergipe, Aracaju, SE - Brasil
- Hospital São Lucas, Aracaju, SE - Brasil
- Rede D'Or de Aracaju, Aracaju, SE - Brasil
| | | | | | - Bruno Caramelli
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - José Rodrigues Parga Filho
- Hospital Sírio Libanês, SP, São Paulo, SP - Brasil
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | | | | | | | | | - Mauricio Ibrahim Scanavacca
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
| | - Luis Henrique Wolff Gowdak
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
- Universidade de São Paulo (USP), Ribeirão Preto, SP - Brasil
| | - Silvio Henrique Barberato
- Quanta Diagnóstico por Imagem, Curitiba, PR - Brasil
- Cardioeco, Centro de Diagnóstico Cardiovascular, Curitiba, PR - Brasil
| | | | - Carlos Eduardo Rochitte
- Hospital do Coração (HCOR), São Paulo, SP - Brasil
- Instituto do Coração (Incor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo SP - Brasil
- DASA - Diagnósticos da América S/A, São Paulo, SP - Brasil
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Heins J, Salatzki J, Köhrer A, Ochs A, Weberling LD, Hund H, Giannitsis E, Frey N, Loßnitzer D, André F, Steen H. Safety of dobutamine stress cardiovascular magnetic resonance in patients with prior coronary artery bypass grafting. J Cardiovasc Magn Reson 2024; 26:101119. [PMID: 39471913 DOI: 10.1016/j.jocmr.2024.101119] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Revised: 10/07/2024] [Accepted: 10/22/2024] [Indexed: 11/01/2024] Open
Abstract
BACKGROUND Patients with coronary artery bypass grafts (CABG) face an elevated risk of major adverse cardiac events. High-dose dobutamine stress cardiovascular magnetic resonance (DCMR) imaging is a well-established technique to detect hemodynamically significant coronary artery disease. However, there is a lack of data regarding the safety of DCMR in patients with CABG. This study aims to evaluate the safety of DCMR in patients with CABG. METHODS We retrospectively studied patients after CABG who subsequently underwent DCMR between November 2008 and July 2018. Side effects, defined as adverse events and minor symptoms, during DCMR were analyzed and compared to 200 individuals matched for age, sex, and body mass index without prior CABG undergoing DCMR. RESULTS Three hundred and thirty-six patients (70 ± 9 years, 85% men (284/336)) were identified. Adverse events occurred in 35 CABG patients (10% (35/336)) and 18 controls (9% (18/200), p = 0.595). A drop of systolic blood pressure (SBP) >40 mmHg (12 patients), non-sustained ventricular tachycardia (6 patients), increase in SBP >200 mmHg (5 patients), monomorphic premature ventricular contractions (PVC) (2 patients), bigeminy (2 patients), left bundle-branch block (2 patients), as well as tachycardiac paroxysmal atrial fibrillation, bradycardia, supraventricular tachycardia, couplets/triplets, and sinus arrhythmia in 1 patient each occurred in the study group. In addition, one patient was hospitalized due to tachycardiac paroxysmal atrial fibrillation and transient ischemic attack. Twenty-nine (8.7% (29/336)) examinations in the study group were aborted because of either chest pain, dyspnea, nausea, dizziness, a drop of SBP, arrhythmias, tachycardiac paroxysmal atrial fibrillation, monomorphic PVCs, or non-sustained ventricular tachycardia. The rate of aborted examination was comparable to the control group (7.5% (15/(200), p = 0.631). Univariable logistic regression analysis revealed that female sex (odds ratio [OR] 2.21, 95% confidence intervals [CI] 1.2-4.3, p = 0.017) and inducible ischemia (OR 3.50, 95% CI 2.0-6.0, p < 0.001) were associated with an increased risk of side effects during DCMR. CONCLUSION Dobutamine stress CMR did not show a relevant increase in adverse events in patients with prior CABG compared to patients without prior CABG. Female sex and dobutamine-induced myocardial ischemia are associated with side effects during DCMR.
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Affiliation(s)
- Jannick Heins
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.
| | - Janek Salatzki
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Anne Köhrer
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Andreas Ochs
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Lukas D Weberling
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Hauke Hund
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany; GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany
| | - Evangelos Giannitsis
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Norbert Frey
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Dirk Loßnitzer
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Florian André
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Henning Steen
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany; MEDNEO, Hamburg, Germany
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Beattie M, Beroukhim R, Annese D, Dionne A, Baker A, Powell AJ. Coronary Events Following Dobutamine Stress Cardiac Magnetic Resonance Imaging in Pediatric Patients. Pediatr Cardiol 2024:10.1007/s00246-024-03632-4. [PMID: 39172254 DOI: 10.1007/s00246-024-03632-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/08/2024] [Accepted: 08/14/2024] [Indexed: 08/23/2024]
Abstract
Dobutamine stress cardiac magnetic resonance (dsCMR) has demonstrated value in identifying patients at risk for adverse cardiovascular events in adults with coronary artery disease, but its prognostic value in younger patients is unknown. This study sought to evaluate the relationship between dsCMR results and the risk of subsequent cardiovascular events in children. Patients age < 23 years who underwent dsCMR at Boston Children's Hospital were eligible for inclusion. Patients were excluded if no follow-up data were available after dsCMR or the dsCMR protocol was not completed. Data regarding the presence of inducible regional wall motion abnormalities and subsequent cardiovascular events during follow-up were analyzed. Cardiovascular events included myocardial infarction, surgical or catheter-based coronary artery intervention, and ischemic symptoms. Among 80 dsCMR studies in 64 patients with median age 5.3 years (range 0.5-22.4 years), 3 patients had a positive dsCMR with inducible regional wall motion abnormalities. Over a median follow-up of 7.4 years (IQR 4.0-11.2), 2 of these patients underwent surgical intervention (coronary artery bypass grafting and unroofing of a myocardial bridge) and the third remained asymptomatic with no interventions. Among 61 patients with a negative dsCMR, none experienced myocardial infarction, death, or aborted sudden death. Four underwent cardiac interventions (cardiac transplantation, coronary artery bypass grafting, and unroofing) due to symptoms or catheterization findings. In pediatric patients undergoing dsCMR, wall motion abnormalities indicating inducible ischemia were uncommon. Those with a negative dsCMR were unlikely to experience an adverse cardiac event or undergo a cardiac intervention on medium-term follow-up.
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Affiliation(s)
- Meaghan Beattie
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
- Division of Cardiology, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA, USA.
| | - Rebecca Beroukhim
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA
| | - David Annese
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA
| | - Audrey Dionne
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA
| | - Annette Baker
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA
| | - Andrew J Powell
- Department of Cardiology, Boston Children's Hospital, Boston, MA, USA
- Department of Pediatrics, Harvard Medical School, Boston, MA, USA
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Molossi S, Doan T, Sachdeva S. Anomalous Coronary Arteries: A State-of-the-Art Approach. Card Electrophysiol Clin 2024; 16:51-69. [PMID: 38280814 DOI: 10.1016/j.ccep.2023.09.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/29/2024]
Abstract
Congenital coronary anomalies are not an infrequent occurrence and their clinical presentation typically occurs during early years, though may be manifested only in adulthood. In the setting of anomalous aortic origin of a coronary artery, this is particularly concerning as it inflicts sudden loss of healthy young lives. Risk stratification remains a challenge and so does the best management decision-making in these patients, particularly if asymptomatic. Standardized approach to evaluation and management, with careful data collection and collaboration among centers, will likely impact future outcomes in this patient population, thus allowing for exercise participation and healthier lives.
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Affiliation(s)
- Silvana Molossi
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA.
| | - Tam Doan
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Shagun Sachdeva
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
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Weberling LD, Seitz S, Salatzki J, Ochs A, Heins J, Haney AC, Siry D, Frey N, André F, Steen H. Safety of dobutamine or adenosine stress cardiac magnetic resonance imaging in patients with left ventricular thrombus. Clin Res Cardiol 2024; 113:446-455. [PMID: 37843560 PMCID: PMC10881726 DOI: 10.1007/s00392-023-02317-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/21/2023] [Accepted: 09/28/2023] [Indexed: 10/17/2023]
Abstract
BACKGROUND Left ventricular (LV) thrombus formation is a common but potentially serious complication, typically occurring after myocardial infarction. Due to perceived high thromboembolic risk and lack of safety data, stress cardiac magnetic resonance (CMR) imaging especially with dobutamine is usually avoided despite its high diagnostic yield. This study aimed to investigate the characteristics, safety and outcome of patients with LV thrombus undergoing dobutamine or vasodilator stress CMR. METHODS Patients undergoing stress CMR with concomitant LV thrombus were retrospectively included. Risk factors, comorbidities, and previous embolic events were recorded. Periprocedural safety was assessed for up to 48 h following the examination. Major adverse cardiac events (MACE) 12 months before the diagnosis were compared to 12 months after the exam and between patients and a matched control group. Additionally, patients were followed up for all-cause mortality. RESULTS 95 patients (78 male, 65 ± 10.7 years) were included. Among them, 43 patients underwent dobutamine (36 high-dose, 7 low-dose) and 52 vasodilator stress CMR. Periprocedural safety was excellent with no adverse events. During a period of 24 months, 27 MACE (14.7%) occurred in patients and controls with no statistical difference between groups. During a median follow-up of 33.7 months (IQR 37.6 months), 6 deaths (6.3%) occurred. Type of stress agent, thrombus mobility, or protrusion were not correlated to embolic events or death. CONCLUSION The addition of a stress test to a CMR exam is safe and does increase the generally high cardioembolic event rate in LV thrombus patients. Therefore, it is useful to support reperfusion decision-making.
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Affiliation(s)
- Lukas D Weberling
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany.
| | | | - Janek Salatzki
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Andreas Ochs
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Jannick Heins
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
| | - Ailís C Haney
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
| | - Deborah Siry
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
| | - Norbert Frey
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Florian André
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany
| | - Henning Steen
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
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Molossi S, Doan T, Sachdeva S. Anomalous Coronary Arteries: A State-of-the-Art Approach. Interv Cardiol Clin 2024; 13:51-70. [PMID: 37980067 DOI: 10.1016/j.iccl.2023.09.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/20/2023]
Abstract
Congenital coronary anomalies are not an infrequent occurrence and their clinical presentation typically occurs during early years, though may be manifested only in adulthood. In the setting of anomalous aortic origin of a coronary artery, this is particularly concerning as it inflicts sudden loss of healthy young lives. Risk stratification remains a challenge and so does the best management decision-making in these patients, particularly if asymptomatic. Standardized approach to evaluation and management, with careful data collection and collaboration among centers, will likely impact future outcomes in this patient population, thus allowing for exercise participation and healthier lives.
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Affiliation(s)
- Silvana Molossi
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA.
| | - Tam Doan
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Shagun Sachdeva
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
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Gräni C, Bigler MR, Kwong RY. Noninvasive Multimodality Imaging for the Assessment of Anomalous Coronary Artery. Curr Cardiol Rep 2023; 25:1233-1246. [PMID: 37851270 DOI: 10.1007/s11886-023-01948-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 08/19/2023] [Indexed: 10/19/2023]
Abstract
PURPOSE OF REVIEW Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital coronary anomaly with the potential to cause myocardial ischemia and adverse cardiac events. The presence of AAOCA anatomy itself does not necessarily implicate a need for revascularization. Therefore, the purpose of this review is to assess how noninvasive comprehensive anatomic- and physiologic evaluation may guide patient management. RECENT FINDINGS The assessment of AAOCA includes an accurate description of the anomalous origin/vessel course including anatomical high-risk features such as a slit-like ostium, proximal narrowing, elliptic vessel shape, acute take-off angle, intramural course, and possible concomitant coronary atherosclerosis and hemodynamics. Various cardiac imaging modalities offer unique advantages and capabilities in visualizing these anatomical and functional aspects of AAOCA. This review explored the role of noninvasive multimodality imaging in the characterization of AAOCA by highlighting the strengths, limitations, and potential applications of the current different cardiac imaging methods, with a focus on the pathophysiology of myocardial ischemia and stress testing protocols.
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Affiliation(s)
- Christoph Gräni
- Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
| | - Marius R Bigler
- Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
| | - Raymond Y Kwong
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
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Weberling LD, Seitz S, Salatzki J, Ochs A, Haney AC, Siry D, Heins J, Steen H, Frey N, André F. Safety, accuracy, and prediction of prognosis in patients with end-stage chronic kidney disease undergoing dobutamine stress cardiac magnetic resonance imaging. Front Cardiovasc Med 2023; 10:1228691. [PMID: 37711564 PMCID: PMC10498284 DOI: 10.3389/fcvm.2023.1228691] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2023] [Accepted: 08/10/2023] [Indexed: 09/16/2023] Open
Abstract
Introduction Advanced chronic kidney disease (CKD) is an independent risk factor for coronary artery disease (CAD). Due to its unique uremia-derived pathophysiology of atherosclerosis and the limitations of using potentially harmful contrast agents, the best non-invasive approach to assess CAD in these patients remains unclear. We sought to investigate the accuracy, safety, and prognosis of patients with severe CKD undergoing dobutamine stress cardiac magnetic resonance imaging (CMR). Materials and methods In this retrospective, single-center study, patients on dialysis or with a glomerular filtration rate of <15 ml/min/1.73 m2 who underwent dobutamine stress CMR were included. A rest and stress wall motion analysis was performed using dobutamine/atropine as stressor. The target heart rate was 85% of the maximum heart rate. Periprocedural adverse events and 1-year follow-up data were obtained. Results A total of 176 patients (127 men, 49 women) with a mean age of 60.9 ± 14.7 years were included, of which 156 patients were on permanent dialysis. Short-term symptoms such as angina or shortness of breath during stress CMR were frequent (22.1%), but major complications were rare (one patient with myocardial infarction, 0.6%). The 1-year event rate was high (16.4%) with a significant independent correlation to reduced ejection fraction at rest (p = 0.037) and failure to achieve the target heart rate (p = 0.029). The overall accuracy for predicting significant CAD was good (sensitivity of 71.4%, specificity of 98.4%) and excellent if the target heart rate was achieved (83.3%, 97.9%). A negative stress CMR was highly predictive for the absence of major adverse cardiac event or any coronary revascularization during the 1-year follow-up (negative predictive value of 95.0%). Discussion Dobutamine stress CMR is a safe and accurate diagnostic imaging technique in patients at advanced stages of chronic kidney disease. A reduced ejection fraction and the inability to reach the target heart rate are independent predictors of a poor outcome.
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Affiliation(s)
- Lukas D. Weberling
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany
| | - Sebastian Seitz
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- MVZ-DRZ Heidelberg, Heidelberg, Germany
| | - Janek Salatzki
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany
| | - Andreas Ochs
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany
| | - Ailís C. Haney
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Deborah Siry
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Jannick Heins
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Henning Steen
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- Medneo, Hamburg, Germany
| | - Norbert Frey
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany
| | - Florian André
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Germany
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Molossi S, Doan T, Sachdeva S. Anomalous Coronary Arteries. Cardiol Clin 2023; 41:51-69. [DOI: 10.1016/j.ccl.2022.08.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/10/2022]
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11
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Adenosine triphosphate (ATP): a safe and effective vasodilator for stress perfusion cardiac magnetic resonance imaging. Clin Radiol 2023; 78:e71-e76. [PMID: 36351853 DOI: 10.1016/j.crad.2022.08.133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2022] [Revised: 06/16/2022] [Accepted: 08/17/2022] [Indexed: 11/08/2022]
Abstract
AIM To evaluate the efficiency and safety of adenosine triphosphate (ATP) as a stress agent in a cohort of patients undergoing stress perfusion cardiac magnetic resonance imaging (CMRI). MATERIALS AND METHODS This retrospective study was conducted between December 2019 and October 2021. The study recruited patients who underwent stress perfusion CMRI using ATP as a vasodilator. Adverse events, such as chest pain, flushing, dyspnoea, headache, and splenic switch-off (SSO) phenomenon, were evaluated in the patients who underwent stress perfusion CMRI. RESULTS The study included 107 patients (age range: 53 ± 11 years; male:female, 62%:38%). The haemodynamic response (heart rate increased by ≥ 10 beats/min) was quick and observed within 2 minutes of ATP infusion. Scanning was stopped in three patients because of atrioventricular block. CMRI images of seven out of 104 patients were excluded from the final analysis because of inferior quality. During ATP infusion, 37/107 patients (35%) experienced mild adverse events, such as chest pain, flushing, dyspnoea, headache, and atrioventricular block. Myocardial infarction and bronchospasms were not observed during ATP infusion. SSO, a marker of adequate stress, was observed in 91% (94/103) of the patients who underwent stress perfusion CMRI. CONCLUSIONS As a coronary vasodilator, ATP was safe for stress perfusion CMRI. In addition, the adverse events during ATP infusion were mild, which were relieved within 2 minutes of ATP injection cessation. SSO could serve as an indicator of stress success in ATP stress perfusion CMRI.
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Salatzki J, Ochs A, Kirchgäßner N, Heins J, Seitz S, Hund H, Mereles D, Friedrich MG, Katus HA, Frey N, André F, Ochs MM. Safety of Stress Cardiac Magnetic Resonance in Patients With Moderate to Severe Aortic Valve Stenosis. J Cardiovasc Imaging 2023; 31:26-38. [PMID: 36693342 PMCID: PMC9880345 DOI: 10.4250/jcvi.2022.0063] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/22/2022] [Revised: 08/20/2022] [Accepted: 08/22/2022] [Indexed: 01/26/2023] Open
Abstract
BACKGROUND Dobutamine and adenosine stress cardiac magnetic resonance (CMR) imaging is relatively contraindicated in patients with moderate to severe aortic valve stenosis (AS). We aimed to determine the safety of dobutamine and adenosine stress CMR in patients with moderate to severe AS. METHODS In this retrospective study patients with AS who underwent either dobutamine or adenosine stress CMR for exclusion of obstructive coronary artery disease were enrolled. We recorded clinical data, CMR and echocardiography findings, and complications as well as minor symptoms. Patients with AS were compared to matched individuals without AS. RESULTS A total of 187 patients with AS were identified and compared to age-, gender- and body mass index-matched 187 patients without AS. No severe complications were reported in the study nor the control group. The reported frequency of non-severe complications and minor symptoms were similar between the study and the control groups. Nineteen patients with AS experienced non-severe complications or minor symptoms during dobutamine stress CMR compared to eighteen patients without AS (p = 0.855). One patient with AS and two patients without AS undergoing adenosine stress CMR experienced minor symptoms (p = 0.562). Four examinations were aborted because of chest pain, paroxysmal atrial fibrillation and third-degree atrioventricular block. Inducible ischaemia, prior coronary artery bypass grafting, prior stroke and age were associated with a higher incidence of complications and minor symptoms. CONCLUSIONS Moderate to severe AS was not associated with complications during CMR stress test. The incidence of non-severe complications and minor symptoms was greater with dobutamine.
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Affiliation(s)
- Janek Salatzki
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
| | - Andreas Ochs
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
| | - Nadja Kirchgäßner
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Jannick Heins
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Sebastian Seitz
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Hauke Hund
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,GECKO Institute, Heilbronn University of Applied Sciences, Heilbronn, Germany
| | - Derliz Mereles
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
| | - Matthias G. Friedrich
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,Division of Cardiology, Departments of Medicine and Diagnostic Radiology, Mc-Gill University Health Centre, Montreal, Canada
| | - Hugo A. Katus
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
| | - Norbert Frey
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
| | - Florian André
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
| | - Marco M. Ochs
- Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research), Partner Site, Heidelberg, Germany
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Raj V, Gowda S, Kothari R. Myocardial tissue characterization by cardiac magnetic resonance: A primer for the clinician. JOURNAL OF THE INDIAN ACADEMY OF ECHOCARDIOGRAPHY & CARDIOVASCULAR IMAGING 2023. [DOI: 10.4103/jiae.jiae_44_22] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/05/2023] Open
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14
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Weberling LD, Lossnitzer D, Frey N, André F. Coronary Computed Tomography vs. Cardiac Magnetic Resonance Imaging in the Evaluation of Coronary Artery Disease. Diagnostics (Basel) 2022; 13:diagnostics13010125. [PMID: 36611417 PMCID: PMC9818886 DOI: 10.3390/diagnostics13010125] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2022] [Revised: 12/23/2022] [Accepted: 12/28/2022] [Indexed: 01/04/2023] Open
Abstract
Coronary artery disease (CAD) represents a widespread burden to both individual and public health, steadily rising across the globe. The current guidelines recommend non-invasive anatomical or functional testing prior to invasive procedures. Both coronary computed tomography angiography (cCTA) and stress cardiac magnetic resonance imaging (CMR) are appropriate imaging modalities, which are increasingly used in these patients. Both exhibit excellent safety profiles and high diagnostic accuracy. In the last decade, cCTA image quality has improved, radiation exposure has decreased and functional information such as CT-derived fractional flow reserve or perfusion can complement anatomic evaluation. CMR has become more robust and faster, and advances have been made in functional assessment and tissue characterization allowing for earlier and better risk stratification. This review compares both imaging modalities regarding their strengths and weaknesses in the assessment of CAD and aims to give physicians rationales to select the most appropriate modality for individual patients.
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Affiliation(s)
- Lukas D. Weberling
- Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany
- Correspondence: ; Tel.: +49-6221-8676
| | - Dirk Lossnitzer
- Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
| | - Norbert Frey
- Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany
| | - Florian André
- Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
- DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120 Heidelberg, Germany
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15
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Ostroumova OD, Chernyaeva MS, Kochetkov AI, Vorobieva AE, Bakhteeva DI, Korchagina SP, Bondarets OV, Boyko ND, Sychev DA. Drug-Induced Atrial Fibrillation / Atrial Flutter. RATIONAL PHARMACOTHERAPY IN CARDIOLOGY 2022. [DOI: 10.20996/1819-6446-2021-12-11] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Drug-induced atrial fibrillation / flutter (DIAF) is a serious and potentially life-threatening complication of pharmacotherapy. Purpose of the work: systematization and analysis of scientific literature data on drugs, the use of which can cause the development of DIAF, as well as on epidemiology, pathophysiological mechanisms, risk factors, clinical picture, diagnosis and differential diagnosis, treatment and prevention of DIAF. Analysis of the literature has shown that many groups of drugs can cause the development of DIAF, with a greater frequency while taking anticancer drugs, drugs for the treatment of the cardiovascular, bronchopulmonary and central nervous systems. The mechanisms and main risk factors for the development of DIAF have not been finally established and are known only for certain drugs, therefore, this section requires further study. The main symptoms of DIAF are due to the severity of tachycardia and their influence on the parameters of central hemodynamics. For diagnosis, it is necessary to conduct an electrocardiogram (ECG) and Holter monitoring of an ECG and echocardiography. Differential diagnosis should be made with AF, which may be caused by other causes, as well as other rhythm and conduction disturbances. Successful treatment of DIAF is based on the principle of rapid recognition and immediate discontinuation of drugs (if possible), the use of which potentially caused the development of adverse drug reactions (ADR). The choice of management strategy: heart rate control or rhythm control, as well as the method of achievement (medication or non-medication), depends on the specific clinical situation. For the prevention of DIAF, it is necessary to instruct patients about possible symptoms and recommend self-monitoring of the pulse. It is important for practitioners to be wary of the risk of DIAF due to the variety of drugs that can potentially cause this ADR.
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Affiliation(s)
- O. D Ostroumova
- Russian Medical Academy of Continuing Professional Education
| | - M. S. Chernyaeva
- Central State Medical Academy of the Administrative Department of the President; Hospital for War Veterans No. 2
| | - A. I. Kochetkov
- Russian Medical Academy of Continuing Professional Education
| | - A. E. Vorobieva
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimova
| | | | | | - O. V. Bondarets
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimova
| | | | - D. A. Sychev
- Russian Medical Academy of Continuing Professional Education
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16
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Ochs A, Nippes M, Salatzki J, Weberling LD, Riffel J, Müller-Hennessen M, Giannitsis E, Osman N, Stehning C, André F, Katus HA, Frey N, Friedrich MG, Ochs MM. Dynamic Handgrip Exercise: Feasibility and Physiologic Stress Response of a Potential Needle-Free Cardiac Magnetic Resonance Stress Test. Front Cardiovasc Med 2021; 8:755759. [PMID: 34912862 PMCID: PMC8666587 DOI: 10.3389/fcvm.2021.755759] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2021] [Accepted: 10/25/2021] [Indexed: 11/15/2022] Open
Abstract
Background: Cardiac magnetic resonance (CMR) pharmacological stress-testing is a well-established technique for detecting myocardial ischemia. Although stressors and contrast agents seem relatively safe, contraindications and side effects must be considered. Substantial costs are further limiting its applicability. Dynamic handgrip exercise (DHE) may have the potential to address these shortcomings as a physiological stressor. We therefore evaluated the feasibility and physiologic stress response of DHE in relation to pharmacological dobutamine-stimulation within the context of CMR examinations. Methods: Two groups were prospectively enrolled: (I) volunteers without relevant disease and (II) patients with known CAD referred for stress-testing. A both-handed, metronome-guided DHE was performed over 2 min continuously with 80 contractions/minute by all participants, whereas dobutamine stress-testing was only performed in group (II). Short axis strain by fast-Strain-ENCoded imaging was acquired at rest, immediately after DHE and during dobutamine infusion. Results: Eighty middle-aged individuals (age 56 ± 17 years, 48 men) were enrolled. DHE triggered significant positive chronotropic (HRrest: 68 ± 10 bpm, HRDHE: 91 ± 13 bpm, p < 0.001) and inotropic stress response (GLSrest: −19.4 ± 1.9%, GLSDHE: −20.6 ± 2.1%, p < 0.001). Exercise-induced increase of longitudinal strain was present in healthy volunteers and patients with CAD to the same extent, but in general more pronounced in the midventricular and apical layers (p < 0.01). DHE was aborted by a minor portion (7%) due to peripheral fatigue. The inotropic effect of DHE appears to be non-inferior to intermediate dobutamine-stimulation (GLSDHE= −19.5 ± 2.3%, GLSDob= −19.1 ± 3.1%, p = n.s.), whereas its chronotropic effect was superior (HRDHE= 89 ± 14 bpm, HRDob= 78 ± 15 bpm, p < 0.001). Conclusions: DHE causes positive ino- and chronotropic effects superior to intermediate dobutamine-stimulation, suggesting a relevant increase of myocardial oxygen demand. DHE appears to be safe and timesaving with broad applicability. The data encourages further studies to determine its potential to detect obstructive CAD.
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Affiliation(s)
- Andreas Ochs
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany
| | - Michael Nippes
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany
| | - Janek Salatzki
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany
| | - Lukas D Weberling
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Johannes Riffel
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Matthias Müller-Hennessen
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Evangelos Giannitsis
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Nael Osman
- Department of Radiology and Radiological Science, School of Medicine, John Hopkins University, Baltimore, MD, United States.,Myocardial Solutions, Inc., Morrisville, NC, United States
| | | | - Florian André
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Hugo A Katus
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Norbert Frey
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
| | - Matthias G Friedrich
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,Departments of Medicine and Diagnostic Radiology, McGill University, Montreal, QC, Canada
| | - Marco M Ochs
- Department of Cardiology, University of Heidelberg, Heidelberg, Germany.,DZHK (German Centre for Cardiovascular Research) Partner Site, Heidelberg, Germany
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Monmeneu Menadas JV, García Gonzalez MP, Lopez-Lereu MP, Higueras Ortega L, Maceira Gonzalez AM. Safety and tolerability of regadenoson in comparison with adenosine stress cardiovascular magnetic resonance: Data from a multicentre prospective registry. Int J Cardiovasc Imaging 2021; 38:195-209. [PMID: 34331614 DOI: 10.1007/s10554-021-02363-4] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/03/2021] [Accepted: 07/20/2021] [Indexed: 11/29/2022]
Abstract
To assess the feasibility and incidence of immediate complications of stress cardiovascular magnetic resonance (CMR) with regadenoson in comparison with adenosine in a large referral population. This is a large, multicenter, prospective registry of vasodilator stress-CMR in a referral population. We recorded the clinical and demographic data, quality of test, CMR findings, hemodynamic data, and complications. Between January 2016 and July 2019, 2908 patients underwent stress-CMR, 2253 with regadenoson and 655 with adenosine. 25.1% of patients had previously known coronary artery disease (CAD). In 305 patients regadenoson was used due to presence of chronic obstructive pulmonary disease (COPD) or asthma, while in 1948 subjects regadenoson was used as first-line vasodilator. Quality was optimal in 90.0%, suboptimal in 9.5%, and poor in 0.5%. Images were diagnostic in 98.9%. After stress with regadenoson, aminophylline 200 mg was administered intravenously in all patients. No patient died or had severe immediate complications with regadenoson as opposed to 2 severe bronchospasm with adenosine (p = 0.05). 11 patients (0.5%) had non-severe complications with regadenoson and five patients (0.8%) with adenosine (p = n.s.). Only two patients (0.088%) had non-severe bronchospasm after regadenoson administration. All complications were solved in the CMR unit, with no need for further specific care. Factors significantly associated with presence of complications were history of COPD or asthma and detection of inducible ischaemia. Patients had significantly more minor symptoms when adenosine was used (66.0% vs. 18.4%, p < 0.0001). Stress-CMR with regadenoson is feasible, providing diagnostic information in a referral population. Regadenoson had an excellent safety profile and better tolerability than adenosine, with no serious immediate complications and low incidence of non-severe complications. Only inducible ischaemia and previous history of COPD or asthma were associated with complications after regadenoson-CMR. The incidence of minor symptoms was low.
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Affiliation(s)
- Jose V Monmeneu Menadas
- Cardiovascular Unit, ASCIRES Biomedical Group, C/Marqués de San Juan, 6, 46015, Valencia, Spain.
| | - Maria P García Gonzalez
- Cardiovascular Unit, ASCIRES Biomedical Group, C/Marqués de San Juan, 6, 46015, Valencia, Spain
| | - Maria P Lopez-Lereu
- Cardiovascular Unit, ASCIRES Biomedical Group, C/Marqués de San Juan, 6, 46015, Valencia, Spain
| | - Laura Higueras Ortega
- Cardiovascular Unit, ASCIRES Biomedical Group, C/Marqués de San Juan, 6, 46015, Valencia, Spain
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18
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Pezel T, Garot P, Hovasse T, Unterseeh T, Champagne S, Kinnel M, Toupin S, Louvard Y, Morice MC, Sanguineti F, Garot J. Vasodilatation stress cardiovascular magnetic resonance imaging: Feasibility, workflow and safety in a large prospective registry of more than 35,000 patients. Arch Cardiovasc Dis 2021; 114:490-503. [PMID: 34274252 DOI: 10.1016/j.acvd.2021.06.004] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/12/2021] [Revised: 03/14/2021] [Accepted: 06/02/2021] [Indexed: 01/24/2023]
Abstract
BACKGROUND Cardiovascular magnetic resonance imaging (CMR) is an accurate technique for assessing ventricular function, myocardial perfusion and viability; its development remains limited mainly because of logistical and time constraints. Data regarding optimization of a dedicated stress CMR workflow are needed. AIMS This study aimed to describe the optimization of a dedicated workflow, and to assess the feasibility and safety of stress CMR in a large registry of>35,000 patients. METHODS A large single-centre French registry of vasodilator stress CMR included consecutive patients referred between 2008 and 2019 for the detection of inducible ischaemia. Stress CMR was performed at 1.5 Tesla using dipyridamole. Clinical and demographic data, test quality, CMR findings, haemodynamic data and complications were recorded prospectively. A locally optimized workflow was described and evaluated. RESULTS Among the 35,862 patients referred for vasodilator stress CMR (mean age 68.9±11.8 years; 64.1% male), the stress CMR protocol was completed in 35,013 (97.6%) patients; 144 (0.3%) patients with missing baseline data were excluded. The mean examination duration was 27±5min, with image quality optimal in 90.8%, suboptimal in 7.1% and poor in 0.5% of cases. Images were diagnostic in 97.9% of patients. No patients died during or immediately after CMR. Fifty-six (0.16%) patients had severe complications. The incidence of non-severe complications was low (1.5%), whereas minor symptoms occurred frequently (35.5%). The presence of ischaemia was associated with a higher incidence of severe complications, non-severe complications and minor symptoms (all P<0.001). CONCLUSIONS This single-centre prospective registry of>35,000 referral patients with known or suspected CAD showed that stress CMR was feasible in clinical routine practice, with high diagnostic image quality and an excellent safety profile. Inducible ischaemia was associated with severe complications, non-severe complications and minor symptoms.
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Affiliation(s)
- Théo Pezel
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France; Division of Cardiology, Johns Hopkins University, Baltimore, MD, 21287-0409 USA
| | - Philippe Garot
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Thomas Hovasse
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Thierry Unterseeh
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Stéphane Champagne
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Marine Kinnel
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Solenn Toupin
- Siemens Healthcare France, 93200 Saint-Denis, France
| | - Yves Louvard
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Marie Claude Morice
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Francesca Sanguineti
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France
| | - Jérôme Garot
- Hôpital Privé Jacques Cartier, Institut Cardiovasculaire Paris Sud, Cardiovascular Magnetic Resonance Laboratory, Ramsay Santé, 6, Avenue du Noyer Lambert, 91300 Massy, France.
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19
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Doan TT, Molossi S, Sachdeva S, Wilkinson JC, Loar RW, Weigand JD, Schlingmann TR, Reaves-O'Neal DL, Pednekar AS, Masand P, Noel CV. Dobutamine stress cardiac MRI is safe and feasible in pediatric patients with anomalous aortic origin of a coronary artery (AAOCA). Int J Cardiol 2021; 334:42-48. [PMID: 33892043 DOI: 10.1016/j.ijcard.2021.04.031] [Citation(s) in RCA: 33] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/08/2021] [Revised: 04/09/2021] [Accepted: 04/16/2021] [Indexed: 11/17/2022]
Abstract
BACKGROUND Risk stratification in anomalous aortic origin of a coronary artery (AAOCA) is challenged by the lack of a reliable method to detect myocardial ischemia. We prospectively studied the safety and feasibility of Dobutamine stress-cardiac magnetic resonance (DSCMR), a test with excellent performance in adults, in pediatric patients with AAOCA. METHODS Consecutive DSCMR from 06/2014-12/2019 in patients≤20 years old with AAOCA were included. Hemodynamic response and major/minor events were recorded. Image quality and spatial/temporal resolution were evaluated. Rest and stress first-pass perfusion and wall motion abnormalities (WMA) were assessed. Inter-observer agreement was assessed using kappa coefficient. RESULTS A total of 224 DSCMR were performed in 182 patients with AAOCA at a median age of 14 years (IQR 12, 16) and median weight of 58.0 kg (IQR 43.3, 73.0). Examinations were completed in 221/224 (98.9%), all studies were diagnostic. Heart rate and blood pressure increased significantly from baseline (p < 0.001). No patient had major events and 28 (12.5%) had minor events. Inducible hypoperfusion was noted in 31/221 (14%), associated with WMA in 13/31 (42%). Inter-observer agreement for inducible hypoperfusion was very good (Κ = 0.87). Asymptomatic patients with inducible hypoperfusion are considered high-risk and those with a negative test are of standard risk. CONCLUSIONS DSCMR is feasible in pediatric patients with AAOCA to assess for inducible hypoperfusion and WMA. It can be performed safely with low incidence of major/minor events. Thus, DSCMR is potentially a valuable test for detection of myocardial ischemia and helpful in the management of this patient population.
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Affiliation(s)
- Tam T Doan
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA.
| | - Silvana Molossi
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA.
| | - Shagun Sachdeva
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - James C Wilkinson
- The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Robert W Loar
- Pediatric Cardiology, Cook Children's Medical Center, 1500 Cooper St, Fort Worth, TX 76104, USA
| | - Justin D Weigand
- The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Tobias R Schlingmann
- The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Dana L Reaves-O'Neal
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; The Lillie Frank Abercrombie Section of Cardiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Amol S Pednekar
- Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
| | - Prakash Masand
- Coronary Artery Anomalies Program, Texas Children's Hospital, 6651 Main Street, MC E1920, Houston, TX 77030, USA; EB Singleton Department of Pediatric Radiology, Texas Children's Hospital, Baylor College of Medicine, 6651 Main Street, MC E1920, Houston, TX 77030, USA
| | - Cory V Noel
- Pediatric Cardiology of Alaska, Seattle Children's Hospital, 3841 Piper St, Suite T345, Anchorage, AK 99508, USA
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20
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Fares M, Critser PJ, Arruda MJ, Wilhelm CM, Rattan MS, Lang SM, Alsaied T. Pharmacologic stress cardiovascular magnetic resonance in the pediatric population: A review of the literature, proposed protocol, and two examples in patients with Kawasaki disease. CONGENIT HEART DIS 2019; 14:1166-1175. [PMID: 31498562 DOI: 10.1111/chd.12840] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/05/2019] [Revised: 08/13/2019] [Accepted: 08/29/2019] [Indexed: 12/01/2022]
Abstract
Pharmacologic stress cardiovascular magnetic resonance (PSCMR) is a well-established and reliable diagnostic tool for evaluation of coronary artery disease in the adult population. Stress imaging overall and PSCMR in particular is less utilized in the pediatric population with limited reported data. In this review, we highlight the potential use of PSCMR in specific pediatric cohorts with congenital and acquired heart disease, and we review the reported experience. A suggested protocol is presented in addition to two case examples of patients with Kawasaki disease where PSCMR aided decision making.
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Affiliation(s)
- Munes Fares
- Division of Pediatric Cardiology, UH Rainbow Babies & Children's Hospital, Cleveland, Ohio
| | - Paul J Critser
- Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
| | - Maria J Arruda
- Division of Pediatric Cardiology, UH Rainbow Babies & Children's Hospital, Cleveland, Ohio
| | - Carolyn M Wilhelm
- Division of Pediatric Cardiology, UH Rainbow Babies & Children's Hospital, Cleveland, Ohio
| | - Mantosh S Rattan
- Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
| | - Sean M Lang
- Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.,Faculty of Medicine, Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
| | - Tarek Alsaied
- Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.,Faculty of Medicine, Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
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21
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Runte K, Brosien K, Salcher-Konrad M, Schubert C, Goubergrits L, Kelle S, Schubert S, Berger F, Kuehne T, Kelm M. Hemodynamic Changes During Physiological and Pharmacological Stress Testing in Healthy Subjects, Aortic Stenosis and Aortic Coarctation Patients-A Systematic Review and Meta-Analysis. Front Cardiovasc Med 2019; 6:43. [PMID: 31024935 PMCID: PMC6467940 DOI: 10.3389/fcvm.2019.00043] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/13/2018] [Accepted: 03/22/2019] [Indexed: 12/20/2022] Open
Abstract
Introduction: Exercise testing has become a diagnostic standard in the evaluation and management of heart disease. While different methods of exercise and pharmacological stress testing exist, only little is known about their comparability. We aimed to assess hemodynamic changes during dynamic exercise, isometric exercise, and dobutamine stress testing at different stress intensities in healthy subjects and patients with aortic stenosis (AS) and aortic coarctation (CoA). Methods: A systematic literature search (PROSPERO 2017:CRD42017078608) in MEDLINE of interventional trials was conducted to identify eligible studies providing evidence of changes in hemodynamic parameters under different stress conditions acquired by MRI or echocardiography. A random effects model was used to estimate pooled mean changes in hemodynamics. Results: One hundred and twenty-eight study arms with a total of 3,139 stress-examinations were included. In healthy subjects/(where available) in AS, pooled mean changes (95% CIs) during light dynamic stress were 31.78 (27.82–35.74) bpm in heart rate (HR) and 6.59 (2.58–10.61) ml in stroke volume (SV). Changes during light pharmacological stress were 13.71 (7.87–19.56)/14.0 (9.82–18.18) bpm in HR, and 5.47 (0.3–10.63)/8.0 (3.82–12.18) ml in SV. Changes during light isometric stress were 18.44 (10.74–26.14)/5.0 (−1.17–11.17) bpm in HR and −4.17 (−14.37–6.03)/−4.0 (−16.43–8.43) ml in SV. Changes during moderate dynamic stress were 49.57 (40.03–59.1)/46.45 (42.63–50.27) bpm in HR and 11.64 (5.87–17.42) ml in SV. During moderate pharmacological stress, changes in HR were 42.83 (36.94–48.72)/18.66 (2.38–34.93) bpm and in SV 6.29 (−2.0–14.58)/13.11 (7.99–18.23) ml. During high intensity dynamic stress changes in HR were 89.31 (81.46–97.17)/55.32 (47.31–63.33) bpm and in SV 21.31 (13.42–29.21)/−0.96 (−5.27–3.35) ml. During high pharmacological stress, changes in HR were 53.58 (36.53–70.64)/42.52 (32.77–52.28) bpm, and in SV 0.98 (−9.32–11.27)/14.06 (−1.62–29.74) ml. HR increase and age were inversely correlated at high stress intensities. In CoA, evidence was limited to single studies. Conclusion: This systematic review and meta-analysis presents pooled hemodynamic changes under light, moderate and high intensity exercise and pharmacological stress, while considering the potential influence of age. Despite limited availability of comparative studies, the reference values presented in this review allow estimation of the expected individual range of a circulatory response in healthy individuals and patients with AS and may contribute to future study planning and patient-specific models even when stress testing is contraindicated.
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Affiliation(s)
- Kilian Runte
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.,Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany
| | - Kay Brosien
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
| | - Maximilian Salcher-Konrad
- Personal Social Services Research Unit, London School of Economics and Political Science, London, United Kingdom.,LSE Health, London School of Economics and Political Science, London, United Kingdom
| | - Charlotte Schubert
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.,Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany
| | - Leonid Goubergrits
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
| | - Sebastian Kelle
- Department of Internal Medicine/Cardiology, German Heart Center Berlin, Berlin, Germany.,Department of Internal Medicine/Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.,German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany
| | - Stephan Schubert
- Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany.,German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany
| | - Felix Berger
- Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany.,German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany
| | - Titus Kuehne
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.,Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany.,German Center for Cardiovascular Research, Partner Site Berlin, Berlin, Germany
| | - Marcus Kelm
- Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.,Department of Congenital Heart Disease, German Heart Center Berlin, Berlin, Germany
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Cao G, Chen W, Pan K, Sun H, Wang Z. Reduced artifacts and improved diagnostic value of 640-slice computed tomography in patients with cardiac pacemakers. J Int Med Res 2019; 47:1916-1926. [PMID: 30810074 PMCID: PMC6567773 DOI: 10.1177/0300060519825986] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022] Open
Abstract
Objective The aim of this study was to compare the feasibility of 640-slice with 64-slice computed tomography (CT) coronary angiography for diagnosing coronary lesions in patients with pacemakers. Methods Forty-five and 50 patients with pacemakers and with suspected or known coronary artery disease underwent 64-slice (64 group) and 640-slice (640 group) CT scans, respectively. All segments of the vessels were evaluated according to the 15-segment model recommended by the American Heart Association. Results The incidence of moderate or severe artifacts was significantly lower (7.27% vs. 32.17%) and the diagnosable rate for coronary lesions was higher (98.91% vs. 94.19%) in the 640 compared with the 64 group. In the 64 group, the incidence of artifacts in patients with a heart rate >65 bpm (20.98%) was higher than in those with a heart rate <65 bpm (15.67%), although the difference was not significant, while the incidence of artifacts was significantly higher in patients with heart arrhythmia (21.40%) compared with in those with normal heart rhythm (15.09%). Conclusions Among patients with pacemakers and a higher heart rate or heart arrhythmia, 640-slice CT may be more effective than 64-slice CT for diagnosing coronary lesions, by reducing moderate and severe artifacts.
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Affiliation(s)
- Guoquan Cao
- 1 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
| | - Weijian Chen
- 1 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
| | - Kehua Pan
- 1 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
| | - Houchang Sun
- 1 Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
| | - Zhen Wang
- 2 Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang Province, China
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23
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Patel N, Kolakalapudi P, Arora G. Contrast - in cardiac magnetic resonance imaging. Echocardiography 2018; 35:401-409. [PMID: 29474744 DOI: 10.1111/echo.13845] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/12/2023] Open
Abstract
The utility and role of cardiac magnetic resonance (CMR) as a non-invasive diagnostic imaging modality has been well recognized in the field of cardiovascular disease. Use of late gadolinium enhancement (LGE) has further enhanced CMR's ability to determine structural, functional, and prognostic information in various cardiovascular diseases. The delivery and distribution of gadolinium as an extracellular agent allows the detection of edema, fibrosis, and infiltration in the myocardium. The pattern of LGE in cardiomyopathies enables us to distinguish among various disease processes non-invasively. Additionally, in patients with hypertrophic cardiomyopathy and sudden cardiac death, it helps in decision making in regards to use of implantable cardioverter defibrillator. In the evaluation of cardiac masses, LGE-CMR can often times differentiate between neoplastic and non-neoplastic conditions. In this review, we will discuss the various aspects of gadolinium-based contrast agents, and its application in CMR.
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Affiliation(s)
- Nirav Patel
- Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA
| | - Pavani Kolakalapudi
- The Heart Center of Northeast Georgia Medical Center, Northeast Georgia Medical Center, Gainesville, GA, USA
| | - Garima Arora
- Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA
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24
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Noel C. Cardiac stress MRI evaluation of anomalous aortic origin of a coronary artery. CONGENIT HEART DIS 2017; 12:627-629. [DOI: 10.1111/chd.12501] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/11/2017] [Accepted: 05/20/2017] [Indexed: 11/29/2022]
Affiliation(s)
- Cory Noel
- Coronary Anomalies Program, Division of Pediatric Cardiology; Texas Children's Hospital; Houston Texas, USA
- Department of Pediatrics; Baylor College of Medicine; Houston Texas, USA
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25
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Foley JRJ, Plein S, Greenwood JP. Assessment of stable coronary artery disease by cardiovascular magnetic resonance imaging: Current and emerging techniques. World J Cardiol 2017; 9:92-108. [PMID: 28289524 PMCID: PMC5329750 DOI: 10.4330/wjc.v9.i2.92] [Citation(s) in RCA: 18] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/14/2016] [Revised: 09/15/2016] [Accepted: 12/02/2016] [Indexed: 02/07/2023] Open
Abstract
Coronary artery disease (CAD) is a leading cause of death and disability worldwide. Cardiovascular magnetic resonance (CMR) is established in clinical practice guidelines with a growing evidence base supporting its use to aid the diagnosis and management of patients with suspected or established CAD. CMR is a multi-parametric imaging modality that yields high spatial resolution images that can be acquired in any plane for the assessment of global and regional cardiac function, myocardial perfusion and viability, tissue characterisation and coronary artery anatomy, all within a single study protocol and without exposure to ionising radiation. Advances in technology and acquisition techniques continue to progress the utility of CMR across a wide spectrum of cardiovascular disease, and the publication of large scale clinical trials continues to strengthen the role of CMR in daily cardiology practice. This article aims to review current practice and explore the future directions of multi-parametric CMR imaging in the investigation of stable CAD.
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26
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Sawlani RN, Collins JD. Cardiac MRI and Ischemic Heart Disease: Role in Diagnosis and Risk Stratification. Curr Atheroscler Rep 2016; 18:23. [DOI: 10.1007/s11883-016-0576-3] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/27/2023]
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27
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Cardiovascular magnetic resonance for the assessment of coronary artery disease. Int J Cardiol 2015; 193:84-92. [DOI: 10.1016/j.ijcard.2014.11.098] [Citation(s) in RCA: 13] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/27/2014] [Revised: 10/13/2014] [Accepted: 11/10/2014] [Indexed: 11/20/2022]
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28
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Mirelis JG, García-Pavía P, Cavero MA, González-López E, Echavarria-Pinto M, Pastrana M, Segovia J, Oteo JF, Alonso-Pulpón L, Escaned J. Resonancia magnética para la detección no invasiva de la enfermedad microcirculatoria asociada a la vasculopatía de alotrasplante: validación de la determinación intracoronaria. Rev Esp Cardiol 2015. [DOI: 10.1016/j.recesp.2014.07.031] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022]
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29
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Mirelis JG, García-Pavía P, Cavero MA, González-López E, Echavarria-Pinto M, Pastrana M, Segovia J, Oteo JF, Alonso-Pulpón L, Escaned J. Magnetic Resonance for Noninvasive Detection of Microcirculatory Disease Associated With Allograft Vasculopathy: Intracoronary Measurement Validation. ACTA ACUST UNITED AC 2015; 68:571-8. [DOI: 10.1016/j.rec.2014.07.030] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/16/2014] [Accepted: 07/18/2014] [Indexed: 01/13/2023]
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30
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Monmeneu Menadas JV, Lopez-Lereu MP, Estornell Erill J, Garcia Gonzalez P, Igual Muñoz B, Maceira Gonzalez A. Pharmacological stress cardiovascular magnetic resonance: feasibility and safety in a large multicentre prospective registry. Eur Heart J Cardiovasc Imaging 2015; 17:308-15. [PMID: 26108417 DOI: 10.1093/ehjci/jev153] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/08/2015] [Accepted: 05/23/2015] [Indexed: 11/13/2022] Open
Abstract
AIMS To assess the feasibility and incidence of immediate complications of stress cardiovascular magnetic resonance (CMR) and to determine associated factors. METHODS AND RESULTS This was a large multicentre, prospective registry of pharmacologic stress CMR in a referral population. We used dipyridamole when no contraindication was present and dobutamine in the remaining patients. Stress CMR was performed at 1.5 T. We recorded the clinical and demographic data, quality of test, CMR findings, haemodynamic data, and complications. Stress CMR was performed in 11 984 patients (98.2% of requested), using dipyridamole in 95.4% and dobutamine in 4.6%. The study could not be performed due to claustrophobia in 0.2%. Quality was optimal in 93.4%, suboptimal in 6.2%, and poor in 0.4% of studies. Images were diagnostic in 97.6% of patients (98.7% with dipyridamole and 75.1% with dobutamine, P < 0.0001). No patient died or had acute myocardial infarction during the test. Ten patients (0.08%) had severe immediate complications, seven after dipyridamole and two after dobutamine (P = 0.062), and one anaphylactic shock post-gadolinium. The only factor significantly associated with higher incidence of serious complications was the detection of inducible ischaemia. Incidence of non-severe complications was low (1.5%), severe controlled chest pain being the most frequent. Minor symptoms occurred frequently (24.8%). Both were significantly more frequent when dobutamine was used. CONCLUSION Performance of stress CMR is safe in a referral population. Inducible ischaemia was the only factor identified which was associated with serious complications. The incidence of non-severe complications and minor symptoms was greater with dobutamine.
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Dundon BK, Pisaniello AD, Nelson AJ, Maia M, Teo KS, Worthley SG, Coates PT, Russ GR, Faull RJ, Bannister K, Worthley MI. Dobutamine Stress Cardiac MRI for Assessment of Coronary Artery Disease Prior to Kidney Transplantation. Am J Kidney Dis 2015; 65:808-9. [DOI: 10.1053/j.ajkd.2015.02.319] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2015] [Accepted: 02/10/2015] [Indexed: 11/11/2022]
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Neglia D, Rovai D, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Perrone Filardi P, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Fiechter M, Stehli J, Gaemperli O, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Marinelli M, Puzzuoli S, Mangione M, Marcheschi P, Mariani F, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Kaufmann PA, Underwood SR, Knuuti J. Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging. Circ Cardiovasc Imaging 2015; 8:CIRCIMAGING.114.002179. [DOI: 10.1161/circimaging.114.002179] [Citation(s) in RCA: 237] [Impact Index Per Article: 23.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/17/2022]
Affiliation(s)
- Danilo Neglia
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Daniele Rovai
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Chiara Caselli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Mikko Pietila
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Anna Teresinska
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Santiago Aguadé-Bruix
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Maria Nazarena Pizzi
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Giancarlo Todiere
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Alessia Gimelli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Stephen Schroeder
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Tanja Drosch
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Rosa Poddighe
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Giancarlo Casolo
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Constantinos Anagnostopoulos
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Francesca Pugliese
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Francois Rouzet
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Dominique Le Guludec
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Francesco Cappelli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Serafina Valente
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Gian Franco Gensini
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Camilla Zawaideh
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Selene Capitanio
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Gianmario Sambuceti
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Fabio Marsico
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Pasquale Perrone Filardi
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Covadonga Fernández-Golfín
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Luis M Rincón
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Frank P Graner
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Michiel A. de Graaf
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Michael Fiechter
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Julia Stehli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Oliver Gaemperli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Eliana Reyes
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Sandy Nkomo
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Maija Mäki
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Valentina Lorenzoni
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Giuseppe Turchetti
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Clara Carpeggiani
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Martina Marinelli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Stefano Puzzuoli
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Maurizio Mangione
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Paolo Marcheschi
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Fabio Mariani
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Daniela Giannessi
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Stephan Nekolla
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Massimo Lombardi
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Rosa Sicari
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Arthur J.H.A. Scholte
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - José L. Zamorano
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Philipp A. Kaufmann
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - S. Richard Underwood
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
| | - Juhani Knuuti
- From the Institute of Clinical Physiology, CNR, Pisa, Italy (D.N., D.R., C. Caselli, C. Carpeggiani, M. Marinelli, F. Mariani, D.G., R.S.); Cardiothoracic Department (D.N., G. Todiere), Imaging Department (A.G., M.L.) and Technology Department (S.P., M. Mangione, P.M.), Fondazione Toscana G. Monasterio, Pisa, Italy; Heart Center (M.P.) and Turku PET Center (M.Mäki, J.K.), University of Turku and Turku University Hospital, Turku, Finland; Department of Nuclear Medicine, Institute of Cardiology,
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Heydari B, Kwong RY, Jerosch-Herold M. Technical advances and clinical applications of quantitative myocardial blood flow imaging with cardiac MRI. Prog Cardiovasc Dis 2015; 57:615-22. [PMID: 25727176 DOI: 10.1016/j.pcad.2015.02.003] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/02/2023]
Abstract
The recent FAME 2 study highlights the importance of myocardial ischemia assessment, particularly in the post-COURAGE trial era of managing patients with stable coronary artery disease. Qualitative assessment of myocardial ischemia by stress cardiovascular magnetic resonance imaging (CMR) has gained widespread clinical acceptance and utility. Despite the high diagnostic and prognostic performance of qualitative stress CMR, the ability to quantitatively assess myocardial perfusion reserve and absolute myocardial blood flow remains an important and ambitious goal for non-invasive imagers. Quantitative perfusion by stress CMR remains a research technique that has yielded progressively more encouraging results in more recent years. The ability to safely, rapidly, and precisely procure quantitative myocardial perfusion data would provide clinicians with a powerful tool that may substantially alter clinical practice and improve downstream patient outcomes and the cost effectiveness of healthcare delivery. This may also provide a surrogate endpoint for clinical trials, reducing study population sizes and costs through increased power. This review will cover emerging quantitative CMR techniques for myocardial perfusion assessment by CMR, including novel methods, such as 3-dimensional quantitative myocardial perfusion, and some of the challenges that remain before more widespread clinical adoption of these techniques may take place.
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Affiliation(s)
- Bobak Heydari
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115
| | - Raymond Y Kwong
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115
| | - Michael Jerosch-Herold
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115.
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Caselli C, Rovai D, Lorenzoni V, Carpeggiani C, Teresinska A, Aguade S, Todiere G, Gimelli A, Schroeder S, Casolo G, Poddighe R, Pugliese F, Le Guludec D, Valente S, Sambuceti G, Perrone-Filardi P, Del Ry S, Marinelli M, Nekolla S, Pietila M, Lombardi M, Sicari R, Scholte A, Zamorano J, Kaufmann PA, Underwood SR, Knuuti J, Giannessi D, Neglia D. A New Integrated Clinical-Biohumoral Model to Predict Functionally Significant Coronary Artery Disease in Patients With Chronic Chest Pain. Can J Cardiol 2015; 31:709-16. [PMID: 26022987 DOI: 10.1016/j.cjca.2015.01.035] [Citation(s) in RCA: 17] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2014] [Revised: 01/23/2015] [Accepted: 01/29/2015] [Indexed: 01/17/2023] Open
Abstract
BACKGROUND In patients with chronic angina-like chest pain, the probability of coronary artery disease (CAD) is estimated by symptoms, age, and sex according to the Genders clinical model. We investigated the incremental value of circulating biomarkers over the Genders model to predict functionally significant CAD in patients with chronic chest pain. METHODS In 527 patients (60.4 years, standard deviation, 8.9 years; 61.3% male participants) enrolled in the European Evaluation of Integrated Cardiac Imaging (EVINCI) study, clinical and biohumoral data were collected. RESULTS Functionally significant CAD-ie, obstructive coronary disease seen at invasive angiography causing myocardial ischemia at stress imaging or associated with reduced fractional flow reserve (FFR < 0.8), or both-was present in 15.2% of patients. High-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST) levels, and high-sensitivity C-reactive protein (hs-CRP) were the only independent predictors of disease among 31 biomarkers analyzed. The model integrating these biohumoral markers with clinical variables outperformed the Genders model by receiver operating characteristic curve (ROC) (area under the curve [AUC], 0.70 [standard error (SE), 0.03] vs 0.58 [SE, 0.03], respectively, P < 0.001) and reclassification analysis (net reclassification improvement, 0.15 [SE, 0.07]; P = 0.04). Cross-validation of the ROC analysis confirmed the discrimination ability of the new model (AUC, 0.66). As many as 56% of patients who were assigned to a higher pretest probability by the Genders model were correctly reassigned to a low probability class (< 15%) by the new integrated model. CONCLUSIONS The Genders model has a low accuracy for predicting functionally significant CAD. A new model integrating HDL cholesterol, AST, and hs-CRP levels with common clinical variables has a higher predictive accuracy for functionally significant CAD and allows the reclassification of patients from an intermediate/high to a low pretest likelihood of CAD.
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Affiliation(s)
- Chiara Caselli
- Institute of Clinical Physiology, National Research Council, Pisa, Italy.
| | - Daniele Rovai
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | | | - Clara Carpeggiani
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | | | | | | | | | | | | | | | - Francesca Pugliese
- Centre for Advanced Cardiovascular Imaging, NIHR Cardiovascular Biomedical Research Unit at Barts, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom
| | - Dominique Le Guludec
- APHP, Groupe Hospitalier Bichat-Claude Bernard, Département Hospitalo-Universitaire FIRE and Université Paris Diderot, Paris, France
| | | | | | | | - Silvia Del Ry
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | - Martina Marinelli
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | - Stephan Nekolla
- Klinikum rechts der Isar der Technischen Universitat Munchen, Munchen, Germany
| | - Mikko Pietila
- University of Turku and Turku University Hospital, Turku, Finland
| | | | - Rosa Sicari
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | - Arthur Scholte
- Leiden University Medical Center, Leiden, The Netherlands
| | - José Zamorano
- University Hospital Clinico San Carlos, Madrid, Spain
| | | | | | - Juhani Knuuti
- University of Turku and Turku University Hospital, Turku, Finland
| | - Daniela Giannessi
- Institute of Clinical Physiology, National Research Council, Pisa, Italy
| | - Danilo Neglia
- Institute of Clinical Physiology, National Research Council, Pisa, Italy; Fondazione Toscana G. Monasterio, Pisa, Italy
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Ripley DP, Kannoly S, Gosling OE, Hossain E, Chawner RR, Moore J, Shore AC, Bellenger NG. Safety and feasibility of dobutamine stress cardiac magnetic resonance for cardiovascular assessment prior to renal transplantation. J Cardiovasc Med (Hagerstown) 2014; 15:288-94. [PMID: 24699013 DOI: 10.2459/jcm.0000000000000029] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/31/2022]
Abstract
AIMS Current guidelines recommend cardiovascular risk assessment prior to renal transplantation. There is currently no evidence for the role of cardiovascular magnetic resonance (CMR) in this population, despite an established evidence base in the non-chronic kidney disease (CKD) population. Our aim is to determine the feasibility and safety of dobutamine stress CMR (DSCMR) imaging in the risk stratification of CKD patients awaiting renal transplantation. METHODS CKD patients who were deemed at high risk for coronary artery disease (CAD) and awaiting renal transplantation underwent DSCMR. RESULTS Forty-one patients whose median age was 56 years (range 28–73 years) underwent DSCMR. Nineteen were undergoing haemodialysis, 10 peritoneal dialysis and 12 pre-dialysis. The aetiology of the renal failure was diabetes mellitus in 29%, glomerulonephritis in 24%, hypertension in 22% and autosomal dominant polycystic kidney disease in 10%. Thirty-eight patients (93%) achieved the end point, either positive for ischaemia or negative, achieving at least 85% of age-predicted heart rate. Two of them did not achieve target heart rate and one was discontinued because of severe headache. Of the 38 patients who achieved the end point, 35 (92%) were negative for inducible wall motion abnormalities and four (10%) were positive. There were no serious adverse effects. CONCLUSION DSCMR is a well tolerated and viable investigation for the cardiovascular risk stratification of high-risk CKD patients prior to renal transplantation. DSCMR already has an established evidence base in the non-CKD population with superiority over other noninvasive techniques. Larger studies with outcome data are now required to define its true utility in the CKD population.
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36
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Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. Radiol Clin North Am 2014; 53:335-44. [PMID: 25726998 DOI: 10.1016/j.rcl.2014.11.002] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
Abstract
Cardiac magnetic resonance (CMR) imaging is increasingly being used to evaluate patients with known or suspected ischemic heart disease, because of its ability to acquire images in any orientation and the wide variety of sequences available to characterize normal and abnormal structure and function. Substantial improvements have been made in the hardware and software used to perform CMR, resulting in better and more consistent image quality. There has been a greater emphasis recently in developing and validating quantitative CMR techniques. This article reviews advances in CMR techniques for assessing cardiac function, myocardial perfusion, late gadolinium enhancement, and tissue characterization with T1 and T2 mapping sequences.
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Yoon YE, Hong YJ, Kim HK, Kim JA, Na JO, Yang DH, Kim YJ, Choi EY. 2014 korean guidelines for appropriate utilization of cardiovascular magnetic resonance imaging: a joint report of the korean society of cardiology and the korean society of radiology. Korean Circ J 2014; 44:359-85. [PMID: 25469139 PMCID: PMC4248609 DOI: 10.4070/kcj.2014.44.6.359] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/25/2014] [Revised: 10/17/2014] [Accepted: 10/19/2014] [Indexed: 12/19/2022] Open
Abstract
Cardiac magnetic resonance (CMR) imaging is now widely used in several fields of cardiovascular disease assessment due to recent technical developments. CMR can give physicians information that cannot be found with other imaging modalities. However, there is no guideline which is suitable for Korean people for the use of CMR. Therefore, we have prepared a Korean guideline for the appropriate utilization of CMR to guide Korean physicians, imaging specialists, medical associates and patients to improve the overall medical system performances. By addressing CMR usage and creating these guidelines we hope to contribute towards the promotion of public health. This guideline is a joint report of the Korean Society of Cardiology and the Korean Society of Radiology.
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Affiliation(s)
- Yeonyee E Yoon
- Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea
| | - Yoo Jin Hong
- Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
| | - Hyung-Kwan Kim
- Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
| | - Jeong A Kim
- Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
| | - Jin Oh Na
- Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
| | - Dong Hyun Yang
- Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
| | - Young Jin Kim
- Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
| | - Eui-Young Choi
- Division of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
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Ripley DP, Motwani M, Plein S, Greenwood JP. Established and emerging cardiovascular magnetic resonance techniques for the assessment of stable coronary heart disease and acute coronary syndromes. Quant Imaging Med Surg 2014; 4:330-44. [PMID: 25392820 DOI: 10.3978/j.issn.2223-4292.2014.07.16] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/20/2014] [Accepted: 04/23/2014] [Indexed: 12/30/2022]
Abstract
Coronary heart disease (CHD) is a leading cause of death and disability worldwide. International guidelines recommend cardiovascular magnetic resonance (CMR) as an investigative option in those presenting with chest pain to inform diagnosis, risk stratify and determine the need for revascularization. CMR offers a unique method to assess global and regional cardiac function, myocardial perfusion, myocardial viability, tissue characterisation and proximal coronary anatomy all within a single study. This results in high diagnostic accuracy for the detection of significant coronary stenoses and an established role in the management of both stable CHD and acute coronary syndromes (ACS). The growing evidence base for the prognostic value of CMR, emerging advances in acquisition techniques, improvements in hardware and the completion of current major multi-centre clinical CMR trials will further raise its prominence in international guidelines and routine cardiological practice. This article will focus on the rapidly evolving role of the multi-parametric CMR examination in the assessment of patients with stable and unstable CHD.
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Affiliation(s)
- David P Ripley
- Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
| | - Manish Motwani
- Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
| | - Sven Plein
- Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
| | - John P Greenwood
- Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
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39
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Yoon YE, Hong YJ, Kim HK, Kim JA, Na JO, Yang DH, Kim YJ, Choi EY, The Korean Society of Cardiology and the Korean Society of Radiology. 2014 Korean guidelines for appropriate utilization of cardiovascular magnetic resonance imaging: a joint report of the Korean Society of Cardiology and the Korean Society of Radiology. Korean J Radiol 2014; 15:659-88. [PMID: 25469078 PMCID: PMC4248622 DOI: 10.3348/kjr.2014.15.6.659] [Citation(s) in RCA: 25] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2014] [Accepted: 09/25/2014] [Indexed: 12/18/2022] Open
Abstract
Cardiac magnetic resonance (CMR) imaging is now widely used in several fields of cardiovascular disease assessment due to recent technical developments. CMR can give physicians information that cannot be found with other imaging modalities. However, there is no guideline which is suitable for Korean people for the use of CMR. Therefore, we have prepared a Korean guideline for the appropriate utilization of CMR to guide Korean physicians, imaging specialists, medical associates and patients to improve the overall medical system performances. By addressing CMR usage and creating these guidelines we hope to contribute towards the promotion of public health. This guideline is a joint report of the Korean Society of Cardiology and the Korean Society of Radiology.
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Affiliation(s)
- Yeonyee E Yoon
- Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam 463-707, Korea
| | - Yoo Jin Hong
- Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, Korea
| | - Hyung-Kwan Kim
- Division of Cardiology, Department of Internal Medicine, Cardiovascular Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul 110-744, Korea
| | - Jeong A Kim
- Department of Radiology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 411-706, Korea
| | - Jin Oh Na
- Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Seoul 152-703, Korea
| | - Dong Hyun Yang
- Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea
| | - Young Jin Kim
- Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, Korea
| | - Eui-Young Choi
- Division of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea
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Russel S, Darmon S, Vermillet A, Haziza F. [Stress cardiac MRI in management of ischemic heart disease]. Ann Cardiol Angeiol (Paris) 2014; 63:345-352. [PMID: 25281219 DOI: 10.1016/j.ancard.2014.08.014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/18/2014] [Accepted: 08/24/2014] [Indexed: 06/03/2023]
Abstract
Stress magnetic cardiac resonance imaging (MRI) development is in progress. Many cardiac imaging technics already known are completed by this safe radiation free exam with a short time acquisition (30minutes) and a good diagnostic performance in particular for patients with three vessels coronary artery diseases. Best indication concerns symptomatic patients unable to exercise with intermediate or high pretest probability. Pharmacological heart stress can be induced with vasodilatators or dobutamine to identify the presence and extent of myocardial ischemia, with high precision to guide coronary vessels revascularization. MRI gives many other interesting informations like heart anatomy, left ventricular function. Myocardial viability can be assessed with study of late gadolinium enhancement or analysis of contractile reserve with low dose of dobutamine.
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Affiliation(s)
- S Russel
- Service de cardiologie, hôpital Foch, 40, rue Worth, 92150 Suresnes, France.
| | - S Darmon
- Service de radiologie, hôpital Foch, 92150 Suresnes, France
| | - A Vermillet
- Service de cardiologie, hôpital Foch, 40, rue Worth, 92150 Suresnes, France
| | - F Haziza
- Service de cardiologie, hôpital Foch, 40, rue Worth, 92150 Suresnes, France
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Cardiac magnetic resonance imaging for ischemic heart disease: update on diagnosis and prognosis. Top Magn Reson Imaging 2014; 23:21-31. [PMID: 24509621 DOI: 10.1097/rmr.0000000000000014] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2023]
Abstract
Despite significant advancements in the treatment of ischemic heart disease (IHD), IHD remains a leading cause of mortality and morbidity. In addition, there remains clinical equipoise regarding a number of important management issues across the spectrum of IHD, from evaluating patients with chest pain in the emergency department, to deciding whether patients with chronic stable angina or severe ischemic cardiomyopathies should undergo invasive revascularization procedures. Recent data over the past 2 decades has demonstrated that cardiac magnetic resonance imaging is highly accurate and carries robust prognostic value in the evaluation of patients with both acute and chronic IHD. The combination of cine imaging for cardiac structure and function, late gadolinium enhancement imaging of myocardial scar, qualitative and quantitative measures of myocardial fibrosis, and stress perfusion imaging for the presence and extent of ischemia provides a comprehensive and detailed characterization of cardiac anatomy and physiology that guides critical treatment decisions for patients. This review aims to cover both the diagnostic and prognostic utility of cardiac magnetic resonance imaging for the spectrum of IHD.
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Forouzan O, Flink E, Warczytowa J, Thate N, Hanske A, Lee T, Roldan-Alzate A, François C, Wieben O, Chesler NC. Low Cost Magnetic Resonance Imaging-Compatible Stepper Exercise Device for Use in Cardiac Stress Tests. J Med Device 2014; 8:0450021-450028. [PMID: 25699131 DOI: 10.1115/1.4027343] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2013] [Revised: 03/26/2014] [Indexed: 12/13/2022] Open
Abstract
Cardiovascular disease is the leading cause of death worldwide. Many cardiovascular diseases are better diagnosed during a cardiac stress test. Current approaches include either exercise or pharmacological stress echocardiography and pharmacological stress magnetic resonance imaging (MRI). MRI is the most accurate noninvasive method of assessing cardiac function. Currently there are very few exercise devices that allow collection of cardiovascular MRI data during exercise. We developed a low-cost exercise device that utilizes adjustable weight resistance and is compatible with magnetic resonance (MR) imaging. It is equipped with electronics that measure power output. Our device allows subjects to exercise with a leg-stepping motion while their torso is in the MR imager. The device is easy to mount on the MRI table and can be adjusted for different body sizes. Pilot tests were conducted with 5 healthy subjects (3 male and 2 female, 29.2 ± 3.9 yr old) showing significant exercise-induced changes in heart rate (+42%), cardiac output (+40%) and mean pulmonary artery (PA) flow (+%49) post exercise. These data demonstrate that our MR compatible stepper exercise device successfully generated a hemodynamically stressed state while allowing for high quality imaging. The adjustable weight resistance allows exercise stress testing of subjects with variable exercise capacities. This low-cost device has the potential to be used in a variety of pathologies that require a cardiac stress test for diagnosis and assessment of disease progression.
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Affiliation(s)
- Omid Forouzan
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Evan Flink
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Jared Warczytowa
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Nick Thate
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Andrew Hanske
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Tongkeun Lee
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
| | - Alejandro Roldan-Alzate
- Department of Medical Physics, Wisconsin Institutes for Medical Research , 1111 Highland Avenue, Madison, WI 53705-2275
| | - Chris François
- Department of Radiology, University of Wisconsin , School of Medicine and Public Health, E3/366 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3252 e-mail:
| | - Oliver Wieben
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706
| | - Naomi C Chesler
- Department of Biomedical Engineering, University of Wisconsin-Madison , Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 e-mail:
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Mieres JH, Gulati M, Bairey Merz N, Berman DS, Gerber TC, Hayes SN, Kramer CM, Min JK, Newby LK, Nixon JVI, Srichai MB, Pellikka PA, Redberg RF, Wenger NK, Shaw LJ. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association. Circulation 2014; 130:350-79. [PMID: 25047587 DOI: 10.1161/cir.0000000000000061] [Citation(s) in RCA: 170] [Impact Index Per Article: 15.5] [Reference Citation Analysis] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/06/2023]
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Small, short-duration, dobutamine-induced perfusion defects are not associated with adverse prognosis in intermediate-risk individuals receiving cardiovascular magnetic resonance stress imaging. J Comput Assist Tomogr 2014; 38:427-33. [PMID: 24651743 DOI: 10.1097/rct.0000000000000046] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Abstract
OBJECTIVE The objective of this study was to assess the frequency and prognostic utility of small, short-duration left ventricular myocardial perfusion defects during dobutamine cardiovascular magnetic resonance (DCMR) stress imaging. METHODS We performed first-pass contrast-enhanced DCMR at peak stress in 331 consecutively recruited individuals (aged 68 ± 8 years, 50% men) at intermediate risk for a future cardiac event. Size, location, and persistence of low-signal intensity perfusion defects were recorded. Cardiac events were assessed by personnel blinded to imaging results for a median of 24 months after the DCMR. RESULTS Among the 55 individuals (16.6%) who exhibited small (<25% myocardial thickness) and short-duration (<5 frames in persistence) perfusion defects, diabetes was more prevalent (P = 0.019) and no cardiac events were observed. Large, persistent perfusion defects were associated with coronary artery disease, prior myocardial infarction, and decreased left ventricular function (P < 0.001 for all) and increased 2-year risk for a cardiac event (hazard ratio, 10.3; P < 0.001; confidence interval, 3.3-33.0). CONCLUSIONS In individuals with diabetes, hypertension, or coronary artery disease at intermediate risk for a future cardiac event, small, short-duration DCMR perfusion defects are not associated with increased 2-year risk for a subsequent cardiac event.
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Francone M. Role of cardiac magnetic resonance in the evaluation of dilated cardiomyopathy: diagnostic contribution and prognostic significance. ISRN RADIOLOGY 2014; 2014:365404. [PMID: 24967294 PMCID: PMC4045555 DOI: 10.1155/2014/365404] [Citation(s) in RCA: 44] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/12/2013] [Accepted: 11/05/2013] [Indexed: 01/07/2023]
Abstract
Dilated cardiomyopathy (DCM) represents the final common morphofunctional pathway of various pathological conditions in which a combination of myocyte injury and necrosis associated with tissue fibrosis results in impaired mechanical function. Recognition of the underlying aetiology of disease and accurate disease monitoring may be crucial to individually optimize therapeutic strategies and stratify patient's prognosis. In this regard, CMR has emerged as a new reference gold standard providing important information for differential diagnosis and new insight about individual risk stratification. The present review article will focus on the role of CMR in the evaluation of present condition, analysing respective strengths and limitations in the light of current literature and technological developments.
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Affiliation(s)
- Marco Francone
- Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Viale Regina Elena, 324 00161 Rome, Italy
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Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Sabaté M, Senior R, Paul Taggart D, van der Wall EE, Vrints CJ, Luis Zamorano J, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Anton Sirnes P, Luis Tamargo J, Tendera M, Torbicki A, Wijns W, Windecker S, Knuuti J, Valgimigli M, Bueno H, Claeys MJ, Donner-Banzhoff N, Erol C, Frank H, Funck-Brentano C, Gaemperli O, González-Juanatey JR, Hamilos M, Hasdai D, Husted S, James SK, Kervinen K, Kolh P, Dalby Kristensen S, Lancellotti P, Pietro Maggioni A, Piepoli MF, Pries AR, Romeo F, Rydén L, Simoons ML, Anton Sirnes P, Gabriel Steg P, Timmis A, Wijns W, Windecker S, Yildirir A, Luis Zamorano J. Guía de Práctica Clínica de la ESC 2013 sobre diagnóstico y tratamiento de la cardiopatía isquémica estable. Rev Esp Cardiol 2014. [DOI: 10.1016/j.recesp.2013.11.007] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/08/2023]
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Francone M, Di Cesare E, Cademartiri F, Pontone G, Lovato L, Matta G, Secchi F, Maffei E, Pradella S, Carbone I, Marano R, Bacigalupo L, Chiodi E, Donato R, Sbarbati S, De Cobelli F, di Renzi P, Ligabue G, Mancini A, Palmierir F, Restaino G, Puppini G, Centonze M, Toscano W, Tessa C, Faletti R, Conti M, Scardapane A, Galea S, Liguori C, Pagliacci M, Lumia D, di Girolamo M, Romagnoli A, Guarise A, Cirillo S, Gagliardi B, Borghi C, Quarenghi M, Contin F, Scaranello F, Tartaro A, Marinucci C, Monti L. Italian registry of cardiac magnetic resonance. Eur J Radiol 2013; 83:e15-22. [PMID: 24225204 DOI: 10.1016/j.ejrad.2013.10.006] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/25/2013] [Revised: 09/11/2013] [Accepted: 10/09/2013] [Indexed: 11/20/2022]
Abstract
OBJECTIVES Forty sites were involved in this multicenter and multivendor registry, which sought to evaluate indications, spectrum of protocols, impact on clinical decision making and safety profile of cardiac magnetic resonance (CMR). MATERIALS AND METHODS Data were prospectively collected on a 6-month period and included 3376 patients (47.2 ± 19 years; range 1-92 years). Recruited centers were asked to complete a preliminary general report followed by a single form/patient. Referral physicians were not required to exhibit any specific certificate of competency in CMR imaging. RESULTS Exams were performed with 1.5T scanners in 96% of cases followed by 3T (3%) and 1T (1%) magnets and contrast was administered in 84% of cases. The majority of cases were performed for the workup of inflammatory heart disease/cardiomyopathies representing overall 55.7% of exams followed by the assessment of myocardial viability and acute infarction (respectively 6.9% and 5.9% of patients). In 49% of cases the final diagnosis provided was considered relevant and with impact on patient's clinical/therapeutic management. Safety evaluation revealed 30 (0.88%) clinical events, most of which due to patient's preexisting conditions. Radiological reporting was recorded in 73% of exams. CONCLUSIONS CMR is performed in a large number of centers in Italy with relevant impact on clinical decision making and high safety profile.
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Affiliation(s)
- Marco Francone
- Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Italy
| | - Ernesto Di Cesare
- Dipartimento di Scienze Cliniche Applicate e Biotecnologie, Università di L'Aquila, Italy.
| | - Filippo Cademartiri
- Cardio-Vascular Imaging Unit, Giovanni XXIII Hospital, Monastier di Treviso, TV, Italy; Erasmus Medical Center University, Rotterdam, The Netherlands
| | | | | | - Gildo Matta
- Azienda ospedaliera G Brotzu Cagliari, Italy
| | | | - Erica Maffei
- Cardio-Vascular Imaging Unit, Giovanni XXIII Hospital, Monastier di Treviso, TV, Italy; Erasmus Medical Center University, Rotterdam, The Netherlands
| | | | - Iacopo Carbone
- Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Italy
| | | | | | | | - Rocco Donato
- Azienda Ospedaliera Universitaria G. Martino, Me, Italy
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Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR, Gersh BJ, Gitt AK, Hulot JS, Marx N, Opie LH, Pfisterer M, Prescott E, Ruschitzka F, Sabaté M, Senior R, Taggart DP, van der Wall EE, Vrints CJM, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Knuuti J, Valgimigli M, Bueno H, Claeys MJ, Donner-Banzhoff N, Erol C, Frank H, Funck-Brentano C, Gaemperli O, Gonzalez-Juanatey JR, Hamilos M, Hasdai D, Husted S, James SK, Kervinen K, Kolh P, Kristensen SD, Lancellotti P, Maggioni AP, Piepoli MF, Pries AR, Romeo F, Rydén L, Simoons ML, Sirnes PA, Steg PG, Timmis A, Wijns W, Windecker S, Yildirir A, Zamorano JL. 2013 ESC guidelines on the management of stable coronary artery disease. Eur Heart J 2013; 34:2949-3003. [PMID: 23996286 DOI: 10.1093/eurheartj/eht296] [Citation(s) in RCA: 2976] [Impact Index Per Article: 248.0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/12/2022] Open
Affiliation(s)
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- The disclosure forms of the authors and reviewers are available on the ESC website www.escardio.org/guidelines
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Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, Coke LA, Fleg JL, Forman DE, Gerber TC, Gulati M, Madan K, Rhodes J, Thompson PD, Williams MA. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation 2013; 128:873-934. [PMID: 23877260 DOI: 10.1161/cir.0b013e31829b5b44] [Citation(s) in RCA: 1313] [Impact Index Per Article: 109.4] [Reference Citation Analysis] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]
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