Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase

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Feb 26, 2014 (publication date) through Nov 2, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Feb 26, 2014; 5(1): 68-74
Published online Feb 26, 2014. doi: 10.4331/wjbc.v5.i1.68

Table 1 Kinetic parameters of thioredoxin 1, glutaredoxins (1, 2, 2C40S) for reduction of mouse ribonucleotide reductase complex

Electron donor system	v_max (nmol/L per second per/microgram of R1)	k_m (μmol/L)
Trx1	22.2	1.90
Grx1	2.3	0.18
Grx2	1.5	0.30
Grx2C40S	1.5	0.36

Data adapted from Zahedi Avval et al[26]. Trx: Thioredoxin; Grx: Glutaredoxins.

Citation: Sengupta R, Holmgren A. Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase. World J Biol Chem 2014; 5(1): 68-74
URL: https://www.wjgnet.com/1949-8454/full/v5/i1/68.htm
DOI: https://dx.doi.org/10.4331/wjbc.v5.i1.68