Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies

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Dec 5, 2025 (publication date) through Dec 6, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Reviews

World J Biol Chem. Dec 5, 2025; 16(4): 112221
Published online Dec 5, 2025. doi: 10.4331/wjbc.v16.i4.112221

Table 1 Search strategy summary

Database	Date range	Search terms (MeSH + keywords + Boolean)	Limits applied
PubMed	January 2013 – December 2024	("gut microbiome"[MeSH] OR "intestinal microbiota" OR "gut bacteria") AND ("cardiotoxicity"[MeSH] OR "cardiac toxicity") AND ("chemotherapy"[MeSH] OR "doxorubicin" OR "anthracyclines") AND ("SCFAs" OR "TMAO" OR "gut-heart axis")	English language; human and animal studies; peer-reviewed only
Scopus	January 2013 – December 2024	TITLE-ABS-KEY (("gut microbiome" OR "intestinal microbiota") AND ("cardiotoxicity" OR "cardiac toxicity") AND ("chemotherapy" OR "doxorubicin" OR "anthracyclines") AND ("SCFAs" OR "TMAO" OR "gut-heart axis"))	English language; peer-reviewed; exclude conference papers
Web of Science	January 2013 – December 2024	TS = ("gut microbiome" OR "intestinal microbiota") AND TS = ("cardiotoxicity" OR "cardiac toxicity") AND TS = ("chemotherapy" OR "anthracyclines") AND TS=("SCFAs" OR "TMAO")	English language; document types: Article, Review

Citation: Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221
URL: https://www.wjgnet.com/1949-8454/full/v16/i4/112221.htm
DOI: https://dx.doi.org/10.4331/wjbc.v16.i4.112221