Signal transducer and activator of transcription 3 regulation by novel binding partners

Core Tip

Core tip: Signal transducer and activator of transcription 3 (STAT3) has been proposed its physiological and pathological significance in malignant and inflammatory diseases; therefore, the targeting of the STAT3 pathways is likely to be suitable for clinical application. In this review, we introduced novel regulatory molecules of STAT3 binding partners, such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2. These proteins positively or negatively regulate critical steps of STAT3-mediated signals via individually unique mechanism. We hope that the information described here will help to develop a new strategy to clinically control the STAT3 activities.