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World J Biol Chem. Nov 26, 2013; 4(4): 111-118
Published online Nov 26, 2013. doi: 10.4331/wjbc.v4.i4.111
Published online Nov 26, 2013. doi: 10.4331/wjbc.v4.i4.111
Adaptive and maladaptive expression of the mRNA regulatory protein HuR
Suman Govindaraju, Beth S Lee, Department of Physiology and Cell Biology, Ohio State University College of Medicine, Columbus, OH 43210, United States
Author contributions: Both authors contributed equally to this work in generating the text and figures.
Correspondence to: Beth S Lee, PhD, Associate Professor, Department of Physiology and Cell Biology, Ohio State University College of Medicine, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, United States. lee.2076@osu.edu
Telephone: +1-614-6883585 Fax: +1-614-2924888
Received: June 28, 2013
Revised: October 1, 2013
Accepted: November 2, 2013
Published online: November 26, 2013
Processing time: 161 Days and 15.1 Hours
Revised: October 1, 2013
Accepted: November 2, 2013
Published online: November 26, 2013
Processing time: 161 Days and 15.1 Hours
Core Tip
Core tip: HuR is an RNA-binding protein that regulates post-transcriptional processing of thousands of mRNAs, including many that encode proteins that are critical to basic cellular functions. Thus, while loss of HuR can lead to cell death, pathological overexpression of HuR is associated with numerous types of cancer. However, the mechanisms that govern expression of HuR have only begun to be delineated. This review summarizes the current state of knowledge of these mechanisms and how they may contribute to cell survival and pathology.