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World J Biol Chem. Sep 5, 2026; 17(3): 119936
Published online Sep 5, 2026. doi: 10.4331/wjbc.119936
Published online Sep 5, 2026. doi: 10.4331/wjbc.119936
Regenerative potential of von Hippel-Lindau tumor suppressor protein
Hiroshi Kanno, Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan
Hiroshi Kanno, Department of Neurosurgery, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan
Kimihiro Nakahara, Department of Neurosurgery, International University of Health and Welfare, Narita 286-0048, Japan
Co-first authors: Hiroshi Kanno and Kimihiro Nakahara.
Author contributions: Kanno K researched, wrote, and integrated the information in the manuscript and figures; Nakahara K researched and integrated the information in the manuscript; both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper.
AI contribution statement: Microsoft Copilot has been partially used. The main content of the manuscript was not entirely generated by the AI. Only the language was polished using AI tools. The AI tools did not participate in the research design or the interpretation of the results. All the images were not completely generated by the AI.
Supported by Ministry of Education, Culture, Sports, Science, and Technology of Japan, No. 32713.
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors who contributed their efforts in this manuscript.
Corresponding author: Hiroshi Kanno, MD, PhD, Academic Fellow, Professor, Department of Neurosurgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. hiroshikannomd@nifty.com
Received: February 11, 2026
Revised: March 11, 2026
Accepted: June 17, 2026
Published online: September 5, 2026
Processing time: 204 Days and 14.1 Hours
Revised: March 11, 2026
Accepted: June 17, 2026
Published online: September 5, 2026
Processing time: 204 Days and 14.1 Hours
Core Tip
Core Tip: The mechanism of action of von Hippel-Lindau (VHL) involved in neuronal differentiation is mediated through the inhibition of downstream signaling pathways, JAK-STAT, and HIF-VEGF pathways. In addition, because VHL promotes nerve regeneration, it is expected to be applied in neuronal regenerative medicine for traumatic brain injury and stroke.