Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Biol Chem. Jun 5, 2026; 17(2): 118440
Published online Jun 5, 2026. doi: 10.4331/wjbc.v17.i2.118440
Published online Jun 5, 2026. doi: 10.4331/wjbc.v17.i2.118440
Glycemic status, antioxidant enzyme and lipid peroxidation among patients with diabetes mellitus in Buea Regional Hospital in Cameroon
Ebot Walter Ojong, Leon Brandon Nyake Mbu Akime, Elvis Amih Ofon, Chugbe Nathaneal Sawah, Medical Laboratory Science, Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, South-West, Cameroon
Ayuk Betrand Tambe, Tabe Cletus Akwa, Department of Public Health and Hygiene, Faculty of Health Sciences, University of Buea, Buea P.O. Box 63, South-West, Cameroon
Armel Jackson Seukep, Sino-Africa Joint Research Center, Innovation Academy for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China
Armel Jackson Seukep, Department of Biomedical Sciences, University of Buea, Buea P.O. Box 63, South-West, Cameroon
Co-first authors: Ebot Walter Ojong and Leon Brandon Nyake Mbu Akime.
Author contributions: Ojong EW, Nyake Mbu Akime LB, and Tambe AB drafted the manuscript; Ojong EW, Nyake Mbu Akime LB, Tambe AB, Seukep AJ, Ofon EA, Akwa TC, and Sawah CN participated in data collection and data and entry; Ojong EW, Tambe AB, Seukep AJ, Ofon EA, and Akwa TC analyzed the data and performed the background literature review for the manuscript; Ojong EW, Tambe AB, and Sawah CN designed and supervised the study; Ojong EW and Nyake Mbu Akime LB contributed equally to this manuscript and are co-first authors. All authors reviewed, edited and approved the final version of the manuscript.
AI contribution statement: Portions of this manuscript were edited using Trinka AI solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Institutional review board statement: This study was approved by the Institutional Review Board of the Faculty of Health Sciences, University of Buea (Approval No. 2024/2425-02/UB/SG/IRB/FHS). After assessment of the research protocol, questionnaire, participants’ information leaflet and consent form. Further permission was obtained from the Regional Delegation of Public Health, Buea, South West Region Cameroon (No. P42/MPH//SWR/RDPH/CBPT/613/518) and from the Internal Review Board of the Regional Hospital Buea (No. MPH/SWRDPH/BRH/IRB).
Informed consent statement: A written informed consent was provided by each participant before enrolment into the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author.
Corresponding author: Ebot Walter Ojong, PhD, Academic Fellow, Lecturer, Medical Labo
Received: January 4, 2026
Revised: February 3, 2026
Accepted: May 21, 2026
Published online: June 5, 2026
Processing time: 154 Days and 16.3 Hours
Revised: February 3, 2026
Accepted: May 21, 2026
Published online: June 5, 2026
Processing time: 154 Days and 16.3 Hours
Core Tip
Core Tip: Hyperglycemia in type 2 diabetes mellitus (T2DM) generates free radicals which reduce antioxidant enzyme activities leading to oxidative stress. The influence of glycemic control on enhanced free-radical activity is poorly under