Alcoholic liver disease: Current insights into cellular mechanisms

doi:10.4331/wjbc.v12.i5.87

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Sep 27, 2021 (publication date) through Nov 2, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Sep 27, 2021; 12(5): 87-103
Published online Sep 27, 2021. doi: 10.4331/wjbc.v12.i5.87

Alcoholic liver disease: Current insights into cellular mechanisms

Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B Patel

Lucy Petagine, Mohammed Gulrez Zariwala, Vinood B Patel, Center for Nutraceuticals, School of Life Sciences, University of Westminster, London W1W 6UW, United Kingdom

Author contributions: Petagine L performed the literature search, wrote the original draft, designed the figures; Petagine L, Patel VB and Zariwala MG reviewed and edited the final manuscript; all authors have read and agreed to the published version of the manuscript.

Conflict-of-interest statement: There is no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Vinood B Patel, FRSC, PhD, Reader (Associate Professor), Center for Nutraceuticals, School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom. v.b.patel@westminster.ac.uk

Received: April 30, 2021
Peer-review started: April 30, 2021
First decision: July 8, 2021
Revised: July 20, 2021
Accepted: August 12, 2021
Article in press: August 12, 2021
Published online: September 27, 2021
Processing time: 144 Days and 22.3 Hours

Core Tip

Core Tip: Alcoholic liver disease (ALD) causes significant global disease burden inducing both cellular and molecular modifications in hepatocytes. Although the spectrum of disease is widely recognized, the precise disease pathogenesis is yet to be fully elucidated. In this review we summarize some of the key pathways responsible for the pathogenesis of ALD and highlight current available treatments.