Proteomics: Concepts and applications in human medicine

doi:10.4331/wjbc.v12.i5.57

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Sep 27, 2021 (publication date) through Mar 10, 2026

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Sep 27, 2021; 12(5): 57-69
Published online Sep 27, 2021. doi: 10.4331/wjbc.v12.i5.57

Proteomics: Concepts and applications in human medicine

Safa Al-Amrani, Zaaima Al-Jabri, Adhari Al-Zaabi, Jalila Alshekaili, Murtadha Al-Khabori

Safa Al-Amrani, Zaaima Al-Jabri, Department of Microbiology and Immunology, Sultan Qaboos University, Muscat 123, Oman

Adhari Al-Zaabi, Department of Human and Clinical Anatomy, Sultan Qaboos University, Muscat 123, Oman

Jalila Alshekaili, Department of Microbiology and Immunology, Sultan Qaboos University Hospital, Muscat 123, Oman

Murtadha Al-Khabori, Department of Hematology, Sultan Qaboos University, Muscat 123, Oman

Author contributions: Al-Amrani S drafted the first draft and approved the final version; Al-Jabri Z, Al-Zaabi A, Alshekaili J, and Al-Khabori M critically edited the manuscript and approved the final version.

Conflict-of-interest statement: All authors declare no conflict of interest.

Corresponding author: Murtadha Al-Khabori, BSc, MD, MSc, Associate Professor, Staff Physician, Department of Hematology, Sultan Qaboos University, Al-Khod, Sultan Qaboos University Street, Muscat 123, Oman. khabori@squ.edu.om

Received: February 22, 2021
Peer-review started: February 22, 2021
First decision: April 20, 2021
Revised: May 4, 2021
Accepted: July 15, 2021
Article in press: July 15, 2021
Published online: September 27, 2021
Processing time: 212 Days and 3.6 Hours

Core Tip

Core Tip: Proteomics is the complete evaluation of the structure and function of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used to profile proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of the complexity and dynamicity. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields.