BPG is committed to discovery and dissemination of knowledge
Home / Archive / Volume 6, Issue 4
  • This Article
Peer-Review Report of This Article
CrossCheck and Google Search of This Article
Academic Rules and Norms of This Article
Citation of this article
Corresponding Author of This Article
Research Domain of This Article
Article-Type of This Article
Open-Access Policy of This Article
Times Cited Counts in Google of This Article
Number of Hits and Downloads for This Article
  • Total Article Views (18090)
All Articles published online
The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-1) series.
Item 
Count 
PDF1122
WORD426
HTML11343
Figures (1-2)636
Tables (1-1)476
 Sum=14003
Publishing Process of This Article
The chart showing Browse series, Download series.
Item 
Count 
Browse1503
Download2581
 Sum=4084
Nov 26, 2015 (publication date) through Mar 8, 2026
Times Cited of This Article
Journal Information of This Article
Publication Name
World Journal of Biological Chemistry
ISSN
1949-8454
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 26, 2015; 6(4): 333-345
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.333
Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?
Shafqat Ali Khan, Divya Reddy, Sanjay Gupta
Shafqat Ali Khan, Divya Reddy, Sanjay Gupta, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India
Author contributions: Khan SA and Gupta S contributed to the conception, design and major portion of the manuscript writing; Reddy D contributed in manuscript writing and editing.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Correspondence to: Dr. Sanjay Gupta, PhD, Principal Investigator, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Centre, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Sector 22, Navi Mumbai 410210, India. sgupta@actrec.gov.in
Telephone: +91-022-27405086
Received: June 1, 2015
Peer-review started: June 2, 2015
First decision: June 18, 2015
Revised: September 21, 2015
Accepted: October 1, 2015
Article in press: October 8, 2015
Published online: November 26, 2015
Processing time: 174 Days and 17.4 Hours
Abstract

Global alterations in epigenetic landscape are now recognized as a hallmark of cancer. Epigenetic mechanisms such as DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs are proven to have strong association with cancer. In particular, covalent post-translational modifications of histone proteins are known to play an important role in chromatin remodeling and thereby in regulation of gene expression. Further, histone modifications have also been associated with different aspects of carcinogenesis and have been studied for their role in the better management of cancer patients. In this review, we will explore and discuss how histone modifications are involved in cancer diagnosis, prognosis and treatment.

Keywords: Epigenetics; Cancer; Diagnosis; Prognosis; Histone post-translational modifications; Treatment

Core tip: The purpose of the review is to describe the potential of histone post-translational modifications in the field of cancer.
Write to the Help Desk
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

California Corporate Number: 3537345